Incidental Mutation 'R2231:Or4c3d'
ID 240027
Institutional Source Beutler Lab
Gene Symbol Or4c3d
Ensembl Gene ENSMUSG00000075068
Gene Name olfactory receptor family 4 subfamily C member 3D
Synonyms Olfr140, MOR235-1, GA_x6K02T2Q125-51484508-51483600, A16
MMRRC Submission 040232-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.104) question?
Stock # R2231 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 89881758-89882666 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 89882569 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 33 (F33Y)
Ref Sequence ENSEMBL: ENSMUSP00000150438 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099757] [ENSMUST00000111506] [ENSMUST00000216475]
AlphaFold Q60878
Predicted Effect probably benign
Transcript: ENSMUST00000099757
AA Change: F33Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097346
Gene: ENSMUSG00000075068
AA Change: F33Y

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 1.3e-30 PFAM
Pfam:7tm_4 137 278 7e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111506
AA Change: F33Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000107131
Gene: ENSMUSG00000075068
AA Change: F33Y

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 2.9e-48 PFAM
Pfam:7tm_1 39 285 9.9e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216475
AA Change: F33Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actr1b G A 1: 36,739,440 (GRCm39) R336W probably damaging Het
Alkbh6 G A 7: 30,012,015 (GRCm39) probably null Het
Ankrd63 A G 2: 118,533,846 (GRCm39) probably benign Het
Arsa T C 15: 89,359,925 (GRCm39) M1V probably null Het
Cblb T A 16: 52,014,635 (GRCm39) S895T probably benign Het
Cdk8 A T 5: 146,168,414 (GRCm39) probably benign Het
Coch G A 12: 51,649,648 (GRCm39) V320I probably benign Het
Cyp2c68 T A 19: 39,687,804 (GRCm39) S398C probably benign Het
Cyp2e1 T C 7: 140,344,827 (GRCm39) S98P probably damaging Het
Dnah5 G A 15: 28,408,563 (GRCm39) probably null Het
Eif2b5 T C 16: 20,323,520 (GRCm39) Y424H probably benign Het
Enoph1 C T 5: 100,188,136 (GRCm39) T20I probably damaging Het
Entpd7 T C 19: 43,710,255 (GRCm39) V304A probably benign Het
Fam227a T A 15: 79,499,582 (GRCm39) Y591F possibly damaging Het
Gal3st1 T C 11: 3,948,282 (GRCm39) I163T probably benign Het
Kif21a G A 15: 90,869,565 (GRCm39) Q429* probably null Het
L1cam T A X: 72,904,947 (GRCm39) N503I possibly damaging Het
Myl3 T C 9: 110,596,979 (GRCm39) L113P probably damaging Het
Nup153 A G 13: 46,863,103 (GRCm39) probably null Het
Oaz3 T C 3: 94,341,846 (GRCm39) T130A probably benign Het
Or5b12b A G 19: 12,861,313 (GRCm39) I23V probably benign Het
Pacs2 G A 12: 113,026,987 (GRCm39) D605N probably damaging Het
Pdk3 G T X: 92,857,604 (GRCm39) N59K probably damaging Het
Piezo2 A T 18: 63,278,143 (GRCm39) C254S probably damaging Het
Plekhd1 T C 12: 80,768,725 (GRCm39) F403L possibly damaging Het
Pou5f1 A G 17: 35,820,959 (GRCm39) T134A probably benign Het
Ppp3r1 G A 11: 17,143,115 (GRCm39) G68R probably damaging Het
Prr5 T C 15: 84,586,981 (GRCm39) S244P probably benign Het
Sacs A G 14: 61,443,378 (GRCm39) probably null Het
Sbno1 A T 5: 124,543,767 (GRCm39) D257E probably damaging Het
Scn10a T C 9: 119,462,916 (GRCm39) E1040G possibly damaging Het
Sgce T C 6: 4,730,066 (GRCm39) K53E probably benign Het
Slc6a11 A G 6: 114,171,590 (GRCm39) T254A probably damaging Het
Spag1 A G 15: 36,191,313 (GRCm39) Y180C probably benign Het
Ssna1 G T 2: 25,162,019 (GRCm39) N58K possibly damaging Het
Tbx3 C A 5: 119,815,589 (GRCm39) N296K probably damaging Het
Tcerg1 A G 18: 42,657,309 (GRCm39) T264A unknown Het
Trdmt1 A T 2: 13,530,436 (GRCm39) F82I probably damaging Het
Ttn A T 2: 76,774,497 (GRCm39) F2136L probably damaging Het
Usb1 T G 8: 96,070,674 (GRCm39) L200R probably damaging Het
Usp33 C T 3: 152,079,023 (GRCm39) A425V probably benign Het
Zfp92 G T X: 72,466,358 (GRCm39) L450F possibly damaging Het
Zw10 C T 9: 48,975,421 (GRCm39) T282M possibly damaging Het
Other mutations in Or4c3d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02220:Or4c3d APN 2 89,882,038 (GRCm39) missense probably damaging 1.00
IGL02631:Or4c3d APN 2 89,881,786 (GRCm39) missense probably damaging 0.97
IGL03354:Or4c3d APN 2 89,881,911 (GRCm39) missense probably damaging 1.00
3-1:Or4c3d UTSW 2 89,882,496 (GRCm39) missense possibly damaging 0.48
R0673:Or4c3d UTSW 2 89,882,596 (GRCm39) missense probably benign 0.04
R1355:Or4c3d UTSW 2 89,881,957 (GRCm39) missense probably benign 0.29
R1452:Or4c3d UTSW 2 89,882,015 (GRCm39) missense possibly damaging 0.68
R1719:Or4c3d UTSW 2 89,882,128 (GRCm39) missense probably damaging 1.00
R2230:Or4c3d UTSW 2 89,882,569 (GRCm39) missense probably benign
R2232:Or4c3d UTSW 2 89,882,569 (GRCm39) missense probably benign
R4540:Or4c3d UTSW 2 89,882,494 (GRCm39) missense probably damaging 1.00
R4710:Or4c3d UTSW 2 89,882,494 (GRCm39) missense probably damaging 1.00
R5304:Or4c3d UTSW 2 89,882,257 (GRCm39) missense probably benign 0.29
R5599:Or4c3d UTSW 2 89,882,563 (GRCm39) missense probably benign 0.00
R7309:Or4c3d UTSW 2 89,881,801 (GRCm39) missense probably damaging 1.00
R7361:Or4c3d UTSW 2 89,882,089 (GRCm39) missense probably benign 0.01
R8314:Or4c3d UTSW 2 89,882,441 (GRCm39) missense probably benign 0.00
R8922:Or4c3d UTSW 2 89,882,695 (GRCm39) start gained probably benign
Z1176:Or4c3d UTSW 2 89,882,609 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GCCATCACTGTGAGCAGAATG -3'
(R):5'- CAGCCTCCAGTTACTTGAAATG -3'

Sequencing Primer
(F):5'- GTGAGCAGAATGATCTCAGTTCCTC -3'
(R):5'- TGTTTCAAAGAGTCAGTAACTGAAC -3'
Posted On 2014-10-15