Incidental Mutation 'R2232:Or4c3d'
ID 240083
Institutional Source Beutler Lab
Gene Symbol Or4c3d
Ensembl Gene ENSMUSG00000075068
Gene Name olfactory receptor family 4 subfamily C member 3D
Synonyms Olfr140, MOR235-1, GA_x6K02T2Q125-51484508-51483600, A16
MMRRC Submission 040233-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.104) question?
Stock # R2232 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 89881758-89882666 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 89882569 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Tyrosine at position 33 (F33Y)
Ref Sequence ENSEMBL: ENSMUSP00000150438 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099757] [ENSMUST00000111506] [ENSMUST00000216475]
AlphaFold Q60878
Predicted Effect probably benign
Transcript: ENSMUST00000099757
AA Change: F33Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097346
Gene: ENSMUSG00000075068
AA Change: F33Y

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 1.3e-30 PFAM
Pfam:7tm_4 137 278 7e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111506
AA Change: F33Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000107131
Gene: ENSMUSG00000075068
AA Change: F33Y

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 2.9e-48 PFAM
Pfam:7tm_1 39 285 9.9e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216475
AA Change: F33Y

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam1a A C 5: 121,657,795 (GRCm39) D499E possibly damaging Het
Adamtsl2 G A 2: 26,993,190 (GRCm39) G740E probably damaging Het
Adgrf4 C T 17: 42,977,789 (GRCm39) R518Q possibly damaging Het
Akap9 G A 5: 4,096,603 (GRCm39) V2493I probably damaging Het
Ankra2 T C 13: 98,407,646 (GRCm39) F199L probably damaging Het
Ankrd63 A G 2: 118,533,846 (GRCm39) probably benign Het
Asns A G 6: 7,689,316 (GRCm39) I62T possibly damaging Het
Celf3 T A 3: 94,387,566 (GRCm39) probably null Het
Cyp4f37 A G 17: 32,853,244 (GRCm39) T403A probably benign Het
Dennd2b T C 7: 109,156,414 (GRCm39) D112G probably benign Het
Dgkd T A 1: 87,857,464 (GRCm39) S725R probably benign Het
Dnah5 G A 15: 28,408,563 (GRCm39) probably null Het
Entrep2 G A 7: 64,408,970 (GRCm39) H475Y probably damaging Het
Ergic3 A G 2: 155,859,736 (GRCm39) T346A probably damaging Het
Fam227a T A 15: 79,499,582 (GRCm39) Y591F possibly damaging Het
Gal3st1 T C 11: 3,948,282 (GRCm39) I163T probably benign Het
Ghrhr T C 6: 55,362,444 (GRCm39) F347S probably damaging Het
Htr2a A T 14: 74,882,469 (GRCm39) I152F probably damaging Het
Il17re T C 6: 113,441,761 (GRCm39) C219R probably damaging Het
Kansl2 A G 15: 98,422,359 (GRCm39) L403S probably damaging Het
Kif21a G A 15: 90,869,565 (GRCm39) Q429* probably null Het
L1cam T A X: 72,904,947 (GRCm39) N503I possibly damaging Het
Lrrk2 A G 15: 91,648,919 (GRCm39) K1638E probably benign Het
Mcpt9 A T 14: 56,265,445 (GRCm39) C85S probably benign Het
Mindy3 C A 2: 12,408,856 (GRCm39) R73M probably benign Het
Mrgprb3 T C 7: 48,292,770 (GRCm39) I260M probably benign Het
Nes T A 3: 87,886,238 (GRCm39) I1499N possibly damaging Het
Ninl A G 2: 150,791,970 (GRCm39) V851A probably benign Het
Oaz3 T C 3: 94,341,846 (GRCm39) T130A probably benign Het
Or10j7 A G 1: 173,011,182 (GRCm39) I273T probably benign Het
Pacs2 G A 12: 113,026,987 (GRCm39) D605N probably damaging Het
Pcare A G 17: 72,056,279 (GRCm39) S1133P probably benign Het
Pdk3 G T X: 92,857,604 (GRCm39) N59K probably damaging Het
Pigq T C 17: 26,151,183 (GRCm39) H322R probably benign Het
Ppp3r1 G A 11: 17,143,115 (GRCm39) G68R probably damaging Het
Proz A G 8: 13,113,356 (GRCm39) Y59C probably damaging Het
Prpf39 C T 12: 65,090,786 (GRCm39) R32* probably null Het
Prr5 T C 15: 84,586,981 (GRCm39) S244P probably benign Het
Pth2r G T 1: 65,375,928 (GRCm39) W62L probably damaging Het
Scin T A 12: 40,118,930 (GRCm39) K622I probably damaging Het
Serpinb6a T C 13: 34,109,303 (GRCm39) K143R probably damaging Het
Ska1 G T 18: 74,330,137 (GRCm39) probably null Het
Slc30a8 G T 15: 52,169,960 (GRCm39) R62S probably benign Het
Slc8a3 A C 12: 81,361,994 (GRCm39) I275S probably damaging Het
Sp2 C T 11: 96,846,762 (GRCm39) C527Y probably damaging Het
Spmap2l A G 5: 77,207,252 (GRCm39) I337V possibly damaging Het
Sspo A G 6: 48,425,606 (GRCm39) I76V probably damaging Het
Sult1c2 G T 17: 54,138,848 (GRCm39) T243K probably benign Het
Svil T A 18: 5,046,640 (GRCm39) M1K probably null Het
Tet3 T C 6: 83,346,453 (GRCm39) D1328G probably damaging Het
Tnfsf14 T C 17: 57,500,876 (GRCm39) D65G probably benign Het
Trmt9b T A 8: 36,979,707 (GRCm39) C437S probably damaging Het
Ttc3 T C 16: 94,260,831 (GRCm39) S1439P probably benign Het
Ttn A T 2: 76,774,497 (GRCm39) F2136L probably damaging Het
Usb1 T G 8: 96,070,674 (GRCm39) L200R probably damaging Het
Usp20 A G 2: 30,908,750 (GRCm39) N777S probably benign Het
Zfp92 G T X: 72,466,358 (GRCm39) L450F possibly damaging Het
Other mutations in Or4c3d
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02220:Or4c3d APN 2 89,882,038 (GRCm39) missense probably damaging 1.00
IGL02631:Or4c3d APN 2 89,881,786 (GRCm39) missense probably damaging 0.97
IGL03354:Or4c3d APN 2 89,881,911 (GRCm39) missense probably damaging 1.00
3-1:Or4c3d UTSW 2 89,882,496 (GRCm39) missense possibly damaging 0.48
R0673:Or4c3d UTSW 2 89,882,596 (GRCm39) missense probably benign 0.04
R1355:Or4c3d UTSW 2 89,881,957 (GRCm39) missense probably benign 0.29
R1452:Or4c3d UTSW 2 89,882,015 (GRCm39) missense possibly damaging 0.68
R1719:Or4c3d UTSW 2 89,882,128 (GRCm39) missense probably damaging 1.00
R2230:Or4c3d UTSW 2 89,882,569 (GRCm39) missense probably benign
R2231:Or4c3d UTSW 2 89,882,569 (GRCm39) missense probably benign
R4540:Or4c3d UTSW 2 89,882,494 (GRCm39) missense probably damaging 1.00
R4710:Or4c3d UTSW 2 89,882,494 (GRCm39) missense probably damaging 1.00
R5304:Or4c3d UTSW 2 89,882,257 (GRCm39) missense probably benign 0.29
R5599:Or4c3d UTSW 2 89,882,563 (GRCm39) missense probably benign 0.00
R7309:Or4c3d UTSW 2 89,881,801 (GRCm39) missense probably damaging 1.00
R7361:Or4c3d UTSW 2 89,882,089 (GRCm39) missense probably benign 0.01
R8314:Or4c3d UTSW 2 89,882,441 (GRCm39) missense probably benign 0.00
R8922:Or4c3d UTSW 2 89,882,695 (GRCm39) start gained probably benign
Z1176:Or4c3d UTSW 2 89,882,609 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGAGCCACAAAGAACTGGGC -3'
(R):5'- AAAACTGTTTTCCTTCAGCCTCCAG -3'

Sequencing Primer
(F):5'- GCCCTCAAAAGAGATGGCTC -3'
(R):5'- CAGCCTCCAGTTACTTGAAATG -3'
Posted On 2014-10-15