Mutagenetix > Incidental Mutation

Incidental Mutation 'R2245:Vmn2r106'

240644

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r106

Ensembl Gene

ENSMUSG00000091656

Gene Name

vomeronasal 2, receptor 106

Synonyms

EG224576

MMRRC Submission

040245-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.166) question?

Stock #

R2245 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20487809-20505692 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 20488423 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 659 (T659A)

Ref Sequence

ENSEMBL: ENSMUSP00000126534 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167464]

AlphaFold

E9PY92

Predicted Effect

probably benign
Transcript: ENSMUST00000167464
AA Change: T659A

PolyPhen 2 Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: T659A

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	471	3.8e-37	PFAM
Pfam:NCD3G	514	567	5.7e-22	PFAM
Pfam:7tm_3	596	835	1.3e-49	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.6%
10x: 97.2%
20x: 94.9%

Validation Efficiency

100% (31/31)

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamtsl3	A	G	7: 82,099,308 (GRCm39)	Q154R	probably damaging	Het
Alpk2	A	G	18: 65,438,234 (GRCm39)	L1520P	probably benign	Het
Brd1	A	G	15: 88,574,063 (GRCm39)		probably null	Het
Ccdc158	A	G	5: 92,757,811 (GRCm39)		probably benign	Het
Cep350	C	A	1: 155,754,766 (GRCm39)	V1950F	probably benign	Het
Csnk1d	A	G	11: 120,863,229 (GRCm39)	I237T	probably damaging	Het
Ddah2	T	C	17: 35,280,561 (GRCm39)	L234P	probably damaging	Het
Dysf	G	A	6: 84,163,491 (GRCm39)		probably null	Het
Ephb1	A	C	9: 101,873,973 (GRCm39)		probably benign	Het
Jarid2	T	A	13: 45,059,752 (GRCm39)	N661K	probably damaging	Het
Muc6	G	A	7: 141,218,313 (GRCm39)	S2120F	possibly damaging	Het
Myadml2	A	T	11: 120,538,656 (GRCm39)	F60I	probably damaging	Het
Myo15a	T	C	11: 60,399,925 (GRCm39)	V2893A	probably damaging	Het
Ntn1	A	G	11: 68,276,120 (GRCm39)	V276A	probably benign	Het
Or11h6	T	A	14: 50,880,062 (GRCm39)	I102N	probably damaging	Het
Or4c111	A	T	2: 88,843,493 (GRCm39)	I305K	probably benign	Het
Or7a39	A	G	10: 78,715,765 (GRCm39)	Y253C	probably damaging	Het
Otof	T	C	5: 30,527,551 (GRCm39)	Y1962C	probably damaging	Het
Pcf11	T	C	7: 92,315,080 (GRCm39)		probably benign	Het
Polr2a	A	G	11: 69,626,009 (GRCm39)	S1676P	unknown	Het
Prpf40b	A	G	15: 99,203,047 (GRCm39)		probably benign	Het
Ptprh	T	C	7: 4,576,345 (GRCm39)	D305G	probably benign	Het
Rdh16f2	A	G	10: 127,712,145 (GRCm39)	K201E	probably damaging	Het
Slc19a3	T	C	1: 82,991,691 (GRCm39)	Y439C	possibly damaging	Het
Son	G	T	16: 91,444,848 (GRCm39)		probably null	Het
Specc1	T	C	11: 62,022,713 (GRCm39)	L710P	probably damaging	Het
Tex15	A	G	8: 34,061,524 (GRCm39)	D592G	possibly damaging	Het
Tmem237	A	T	1: 59,147,863 (GRCm39)	D209E	probably damaging	Het
Vmn2r71	T	A	7: 85,273,388 (GRCm39)	I734N	probably damaging	Het
Wdr7	A	T	18: 64,057,980 (GRCm39)	I1270F	possibly damaging	Het

Other mutations in Vmn2r106

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00979:Vmn2r106	APN	17	20,497,837 (GRCm39)	missense	possibly damaging	0.90
IGL01313:Vmn2r106	APN	17	20,498,651 (GRCm39)	missense	probably damaging	0.99
IGL01419:Vmn2r106	APN	17	20,499,807 (GRCm39)	missense	probably benign	0.06
IGL01574:Vmn2r106	APN	17	20,488,572 (GRCm39)	missense	possibly damaging	0.94
IGL01796:Vmn2r106	APN	17	20,488,314 (GRCm39)	missense	possibly damaging	0.79
IGL01893:Vmn2r106	APN	17	20,497,730 (GRCm39)	missense	probably benign	0.06
IGL01895:Vmn2r106	APN	17	20,499,227 (GRCm39)	missense	probably benign	0.02
IGL02378:Vmn2r106	APN	17	20,497,791 (GRCm39)	missense	probably damaging	1.00
IGL02430:Vmn2r106	APN	17	20,499,158 (GRCm39)	missense	probably benign	0.38
IGL02664:Vmn2r106	APN	17	20,488,344 (GRCm39)	missense	possibly damaging	0.88
IGL03308:Vmn2r106	APN	17	20,498,785 (GRCm39)	nonsense	probably null
IGL03384:Vmn2r106	APN	17	20,488,405 (GRCm39)	missense	probably damaging	0.99
R0401:Vmn2r106	UTSW	17	20,499,281 (GRCm39)	missense	possibly damaging	0.86
R0842:Vmn2r106	UTSW	17	20,488,465 (GRCm39)	missense	probably damaging	1.00
R0964:Vmn2r106	UTSW	17	20,487,859 (GRCm39)	missense	probably benign	0.00
R1235:Vmn2r106	UTSW	17	20,499,741 (GRCm39)	missense	probably benign	0.00
R1709:Vmn2r106	UTSW	17	20,499,373 (GRCm39)	missense	probably benign	0.12
R1712:Vmn2r106	UTSW	17	20,498,997 (GRCm39)	missense	probably benign	0.01
R1770:Vmn2r106	UTSW	17	20,488,560 (GRCm39)	missense	probably damaging	0.99
R2049:Vmn2r106	UTSW	17	20,488,566 (GRCm39)	missense	possibly damaging	0.90
R2336:Vmn2r106	UTSW	17	20,488,470 (GRCm39)	missense	probably benign	0.18
R2910:Vmn2r106	UTSW	17	20,498,946 (GRCm39)	missense	probably damaging	1.00
R3025:Vmn2r106	UTSW	17	20,499,147 (GRCm39)	missense	probably benign	0.00
R3944:Vmn2r106	UTSW	17	20,487,913 (GRCm39)	missense	probably damaging	1.00
R4081:Vmn2r106	UTSW	17	20,487,818 (GRCm39)	nonsense	probably null
R4153:Vmn2r106	UTSW	17	20,488,080 (GRCm39)	missense	probably damaging	1.00
R4356:Vmn2r106	UTSW	17	20,499,910 (GRCm39)	missense	probably benign	0.06
R4426:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.00
R4590:Vmn2r106	UTSW	17	20,497,728 (GRCm39)	missense	probably damaging	0.99
R4661:Vmn2r106	UTSW	17	20,487,885 (GRCm39)	missense	probably benign	0.10
R5106:Vmn2r106	UTSW	17	20,499,395 (GRCm39)	critical splice acceptor site	probably null
R5341:Vmn2r106	UTSW	17	20,497,788 (GRCm39)	missense	probably benign	0.00
R5509:Vmn2r106	UTSW	17	20,498,684 (GRCm39)	missense	probably damaging	0.99
R5826:Vmn2r106	UTSW	17	20,499,133 (GRCm39)	missense	probably benign
R5859:Vmn2r106	UTSW	17	20,505,583 (GRCm39)	missense	possibly damaging	0.72
R5937:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	nonsense	probably null
R5972:Vmn2r106	UTSW	17	20,498,738 (GRCm39)	missense	probably benign
R6056:Vmn2r106	UTSW	17	20,487,806 (GRCm39)	splice site	probably null
R6108:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6114:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6115:Vmn2r106	UTSW	17	20,488,638 (GRCm39)	missense	probably benign	0.11
R6132:Vmn2r106	UTSW	17	20,488,666 (GRCm39)	missense	probably benign
R6208:Vmn2r106	UTSW	17	20,488,591 (GRCm39)	missense	probably damaging	0.99
R6217:Vmn2r106	UTSW	17	20,488,501 (GRCm39)	missense	probably benign	0.10
R6289:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6378:Vmn2r106	UTSW	17	20,498,667 (GRCm39)	missense	probably benign	0.19
R6390:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6391:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6392:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6405:Vmn2r106	UTSW	17	20,499,361 (GRCm39)	missense	probably benign	0.22
R6427:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6428:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6435:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6436:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6437:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6511:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6512:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6587:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6703:Vmn2r106	UTSW	17	20,488,725 (GRCm39)	missense	probably damaging	1.00
R6730:Vmn2r106	UTSW	17	20,499,096 (GRCm39)	missense	possibly damaging	0.64
R6961:Vmn2r106	UTSW	17	20,488,646 (GRCm39)	nonsense	probably null
R7054:Vmn2r106	UTSW	17	20,499,182 (GRCm39)	missense	probably damaging	0.96
R7379:Vmn2r106	UTSW	17	20,488,037 (GRCm39)	missense	possibly damaging	0.75
R7402:Vmn2r106	UTSW	17	20,487,883 (GRCm39)	missense	probably damaging	0.99
R7497:Vmn2r106	UTSW	17	20,488,201 (GRCm39)	missense	probably damaging	1.00
R7692:Vmn2r106	UTSW	17	20,505,490 (GRCm39)	missense	possibly damaging	0.96
R8539:Vmn2r106	UTSW	17	20,499,271 (GRCm39)	missense	probably benign	0.00
R8827:Vmn2r106	UTSW	17	20,487,868 (GRCm39)	missense	probably benign	0.05
R8872:Vmn2r106	UTSW	17	20,488,401 (GRCm39)	missense	probably benign	0.19
R9118:Vmn2r106	UTSW	17	20,505,667 (GRCm39)	missense	probably benign	0.00
R9254:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9379:Vmn2r106	UTSW	17	20,496,066 (GRCm39)	missense	probably damaging	1.00
R9571:Vmn2r106	UTSW	17	20,505,641 (GRCm39)	missense	probably benign	0.17

Predicted Primers

PCR Primer
(F):5'- GGAGAGATTGCCATCCATATTCC -3'
(R):5'- GATGACACTGGCCTGTATAGC -3'

Sequencing Primer
(F):5'- CCATATTCCACAAAGAAGAAGTTGG -3'
(R):5'- ACACTGGCCTGTATAGCTTTGTG -3'

Posted On

2014-10-15