Incidental Mutation 'R2249:Or6s1'
ID 240805
Institutional Source Beutler Lab
Gene Symbol Or6s1
Ensembl Gene ENSMUSG00000035932
Gene Name olfactory receptor family 6 subfamily S member 1
Synonyms GA_x6K02T2PMLR-6808276-6807281, MOR103-18, Olfr750
MMRRC Submission 040249-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.146) question?
Stock # R2249 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 51307768-51308899 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 51307870 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 327 (K327*)
Ref Sequence ENSEMBL: ENSMUSP00000150180 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048478] [ENSMUST00000216202]
AlphaFold E9Q0Z1
Predicted Effect probably null
Transcript: ENSMUST00000048478
AA Change: K327*
SMART Domains Protein: ENSMUSP00000036596
Gene: ENSMUSG00000035932
AA Change: K327*

DomainStartEndE-ValueType
Pfam:7tm_4 33 311 4.5e-49 PFAM
Pfam:7TM_GPCR_Srsx 37 183 1.3e-6 PFAM
Pfam:7tm_1 43 293 6.1e-22 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000216202
AA Change: K327*
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1b G A 15: 101,100,975 (GRCm39) R379Q probably null Het
Adam23 C T 1: 63,574,335 (GRCm39) Q276* probably null Het
Apob A T 12: 8,057,499 (GRCm39) S1961C probably damaging Het
Atxn7l1 C T 12: 33,408,839 (GRCm39) P334S probably damaging Het
Ccnb1 T C 13: 100,917,827 (GRCm39) M258V possibly damaging Het
Cd34 A C 1: 194,630,260 (GRCm39) T65P possibly damaging Het
Cog6 A G 3: 52,907,900 (GRCm39) probably null Het
Cp T C 3: 20,041,734 (GRCm39) M953T probably damaging Het
Cwc27 C T 13: 104,768,130 (GRCm39) R455Q unknown Het
Dhx57 A T 17: 80,588,663 (GRCm39) D63E probably damaging Het
Elapor1 A T 3: 108,378,726 (GRCm39) Y409* probably null Het
Flt4 T A 11: 49,536,786 (GRCm39) M1252K possibly damaging Het
Gfral C T 9: 76,100,631 (GRCm39) C269Y probably damaging Het
Itih4 C T 14: 30,621,351 (GRCm39) Q788* probably null Het
Kif18b A G 11: 102,803,214 (GRCm39) S499P probably benign Het
Map1a G C 2: 121,130,768 (GRCm39) R528P probably damaging Het
Map3k5 T C 10: 20,003,443 (GRCm39) F1152L probably damaging Het
Marveld2 T C 13: 100,748,599 (GRCm39) D160G probably benign Het
Mtcl2 A T 2: 156,882,013 (GRCm39) C680S probably benign Het
Mug1 A T 6: 121,847,469 (GRCm39) M616L probably benign Het
Ndst4 A T 3: 125,231,823 (GRCm39) I131F probably benign Het
Neto1 G T 18: 86,479,399 (GRCm39) A196S probably benign Het
Notum A G 11: 120,545,237 (GRCm39) F441L probably benign Het
Nsmce4a A G 7: 130,140,769 (GRCm39) I239T probably benign Het
Or51g1 A T 7: 102,633,647 (GRCm39) N241K possibly damaging Het
Or52z14 T A 7: 103,252,943 (GRCm39) D27E probably benign Het
Or5d35 A T 2: 87,855,707 (GRCm39) I214F probably damaging Het
Or6x1 A T 9: 40,098,980 (GRCm39) T190S possibly damaging Het
Or8k40 A G 2: 86,584,398 (GRCm39) M228T probably damaging Het
Pde4dip A T 3: 97,700,841 (GRCm39) V221D probably damaging Het
Pkp1 T C 1: 135,808,545 (GRCm39) Y474C probably damaging Het
Ptk6 A C 2: 180,838,173 (GRCm39) H363Q probably benign Het
Rb1cc1 T C 1: 6,342,948 (GRCm39) W187R probably damaging Het
Rbfox3 A T 11: 118,394,564 (GRCm39) F132L probably damaging Het
Rcl1 A T 19: 29,099,268 (GRCm39) I188F possibly damaging Het
Scfd1 T A 12: 51,462,299 (GRCm39) S385T possibly damaging Het
Sema6d A G 2: 124,501,508 (GRCm39) E483G possibly damaging Het
Semp2l2b T C 10: 21,943,015 (GRCm39) I322V possibly damaging Het
Sipa1l1 T C 12: 82,388,890 (GRCm39) V372A probably benign Het
Slc17a6 G A 7: 51,317,654 (GRCm39) G429D probably damaging Het
Slc22a5 A G 11: 53,774,532 (GRCm39) V151A possibly damaging Het
Spidr T C 16: 15,936,787 (GRCm39) D106G probably damaging Het
Tekt3 A T 11: 62,974,778 (GRCm39) T366S probably benign Het
Trpm3 T C 19: 22,710,398 (GRCm39) M281T probably benign Het
Ttn A G 2: 76,782,485 (GRCm39) V917A probably damaging Het
Tubgcp4 A T 2: 121,014,110 (GRCm39) D221V possibly damaging Het
Ubr4 C T 4: 139,176,232 (GRCm39) R3153W probably damaging Het
Vmn1r89 A C 7: 12,954,187 (GRCm39) T308P possibly damaging Het
Vmn2r59 A G 7: 41,708,326 (GRCm39) I27T probably benign Het
Vps13c T G 9: 67,895,335 (GRCm39) probably null Het
Zfp142 A G 1: 74,606,191 (GRCm39) V1793A probably damaging Het
Zfp472 T A 17: 33,197,109 (GRCm39) C395S possibly damaging Het
Other mutations in Or6s1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02024:Or6s1 APN 14 51,308,766 (GRCm39) missense probably benign 0.02
IGL03179:Or6s1 APN 14 51,308,467 (GRCm39) missense probably benign 0.01
IGL03047:Or6s1 UTSW 14 51,308,613 (GRCm39) missense possibly damaging 0.66
R0519:Or6s1 UTSW 14 51,308,614 (GRCm39) missense probably damaging 1.00
R1503:Or6s1 UTSW 14 51,308,191 (GRCm39) missense probably damaging 1.00
R1966:Or6s1 UTSW 14 51,308,614 (GRCm39) missense probably damaging 1.00
R2179:Or6s1 UTSW 14 51,308,238 (GRCm39) missense probably benign 0.00
R5878:Or6s1 UTSW 14 51,308,449 (GRCm39) missense probably damaging 1.00
R5940:Or6s1 UTSW 14 51,308,179 (GRCm39) missense probably damaging 1.00
R6709:Or6s1 UTSW 14 51,308,286 (GRCm39) missense probably damaging 1.00
R7157:Or6s1 UTSW 14 51,308,616 (GRCm39) missense possibly damaging 0.49
R8904:Or6s1 UTSW 14 51,308,665 (GRCm39) missense probably damaging 1.00
RF013:Or6s1 UTSW 14 51,308,469 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCACATGGCATACCCCATATTC -3'
(R):5'- AGCGGCTCTGTGGATACTAAC -3'

Sequencing Primer
(F):5'- GCATACCCCATATTCCCCACATAGG -3'
(R):5'- CTGTGGATACTAACTGGTCTGTAACC -3'
Posted On 2014-10-15