|Institutional Source||Beutler Lab|
|Gene Name||tumor necrosis factor (ligand) superfamily, member 18|
|Synonyms||GITR ligand, Gitrl|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R0165 (G1)|
|Chromosomal Location||161494655-161505290 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 161494731 bp|
|Amino Acid Change||Arginine to Glycine at position 7 (R7G)|
|Ref Sequence||ENSEMBL: ENSMUSP00000083251 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000086084]|
|Predicted Effect||probably benign
AA Change: R7G
PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
AA Change: R7G
|Meta Mutation Damage Score||0.1272|
|Coding Region Coverage||
|Validation Efficiency||96% (81/84)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Tnfsf18||
(F):5'- AGCGAGTGCTTAGCAGTGTTCC -3'
(R):5'- CAATGAGACTACAGCTTGTCTGGGG -3'
(F):5'- GCTTAGCAGTGTTCCAAAGG -3'
(R):5'- CTCTAGCAATGCTGAATGGC -3'