Incidental Mutation 'R2247:Bicra'
ID 240894
Institutional Source Beutler Lab
Gene Symbol Bicra
Ensembl Gene ENSMUSG00000070808
Gene Name BRD4 interacting chromatin remodeling complex associated protein
Synonyms Gltscr1
MMRRC Submission 040247-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.176) question?
Stock # R2247 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 15704597-15781846 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 15723159 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 119 (E119D)
Ref Sequence ENSEMBL: ENSMUSP00000148012 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094821] [ENSMUST00000210781]
AlphaFold F8VPZ9
Predicted Effect probably benign
Transcript: ENSMUST00000094821
AA Change: E119D

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000092416
Gene: ENSMUSG00000070808
AA Change: E119D

DomainStartEndE-ValueType
low complexity region 86 96 N/A INTRINSIC
low complexity region 140 155 N/A INTRINSIC
internal_repeat_1 156 298 1.03e-6 PROSPERO
low complexity region 308 323 N/A INTRINSIC
low complexity region 427 443 N/A INTRINSIC
internal_repeat_1 479 614 1.03e-6 PROSPERO
low complexity region 619 638 N/A INTRINSIC
low complexity region 642 676 N/A INTRINSIC
low complexity region 719 732 N/A INTRINSIC
low complexity region 756 782 N/A INTRINSIC
low complexity region 790 819 N/A INTRINSIC
low complexity region 827 843 N/A INTRINSIC
low complexity region 852 906 N/A INTRINSIC
low complexity region 940 950 N/A INTRINSIC
low complexity region 987 1006 N/A INTRINSIC
Pfam:GLTSCR1 1094 1202 4.6e-43 PFAM
low complexity region 1232 1251 N/A INTRINSIC
low complexity region 1275 1294 N/A INTRINSIC
low complexity region 1349 1371 N/A INTRINSIC
low complexity region 1460 1473 N/A INTRINSIC
low complexity region 1535 1555 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210035
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210713
Predicted Effect probably benign
Transcript: ENSMUST00000210781
AA Change: E119D

PolyPhen 2 Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg3 A G 17: 57,184,435 (GRCm39) E70G possibly damaging Het
Ash1l C A 3: 88,914,674 (GRCm39) P1768Q possibly damaging Het
Brd2 A G 17: 34,333,389 (GRCm39) F421L probably damaging Het
Cspp1 A T 1: 10,136,685 (GRCm39) Q182L possibly damaging Het
Dnah7b A G 1: 46,316,223 (GRCm39) D3112G probably damaging Het
Dsc2 T A 18: 20,168,369 (GRCm39) I697F probably damaging Het
Ephb1 A T 9: 101,874,010 (GRCm39) S555T probably damaging Het
Fat4 A T 3: 38,946,198 (GRCm39) D1697V probably damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Impg2 A G 16: 56,088,627 (GRCm39) K1160R probably damaging Het
Jak2 T C 19: 29,261,036 (GRCm39) V344A probably benign Het
Kcnab3 A G 11: 69,221,016 (GRCm39) T168A probably damaging Het
Kctd18 A T 1: 58,006,801 (GRCm39) H16Q possibly damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Myh11 A G 16: 14,095,423 (GRCm39) L113P probably damaging Het
Myh13 A T 11: 67,225,384 (GRCm39) I250F probably damaging Het
Nin T C 12: 70,101,319 (GRCm39) Y426C probably damaging Het
Or10ab4 C T 7: 107,654,989 (GRCm39) R267C probably benign Het
Or51ab3 T A 7: 103,201,097 (GRCm39) probably null Het
Pbrm1 A G 14: 30,796,850 (GRCm39) H897R probably damaging Het
Pgap4 T C 4: 49,586,209 (GRCm39) S320G probably benign Het
Plcl2 T C 17: 50,913,873 (GRCm39) V294A probably damaging Het
Psapl1 A G 5: 36,362,410 (GRCm39) E334G probably benign Het
Pwwp3a A G 10: 80,076,259 (GRCm39) Y483C probably damaging Het
Raly A G 2: 154,705,953 (GRCm39) H277R possibly damaging Het
Ranbp9 T C 13: 43,565,901 (GRCm39) K462E probably damaging Het
Rptn A G 3: 93,304,136 (GRCm39) T490A probably benign Het
Rtl1 T C 12: 109,561,413 (GRCm39) H142R possibly damaging Het
Scart2 G A 7: 139,829,042 (GRCm39) G234S probably null Het
Shisa3 G A 5: 67,768,666 (GRCm39) V189M probably benign Het
Slc25a36 A T 9: 96,982,191 (GRCm39) L28Q probably damaging Het
Slc38a8 A G 8: 120,212,389 (GRCm39) M318T probably benign Het
Slc4a11 A T 2: 130,529,721 (GRCm39) M328K probably benign Het
Sp2 A C 11: 96,852,844 (GRCm39) probably null Het
Sult2b1 A T 7: 45,384,734 (GRCm39) I114N probably damaging Het
Synrg T C 11: 83,900,202 (GRCm39) S803P probably damaging Het
Tenm4 T A 7: 96,555,216 (GRCm39) D2603E probably benign Het
Tnfaip8 ACTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC ACTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC 18: 50,179,912 (GRCm39) probably null Het
Zfp189 T A 4: 49,530,393 (GRCm39) C499S possibly damaging Het
Zfp236 A G 18: 82,622,423 (GRCm39) F1621S possibly damaging Het
Other mutations in Bicra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00909:Bicra APN 7 15,730,502 (GRCm39) missense possibly damaging 0.70
IGL01521:Bicra APN 7 15,723,113 (GRCm39) missense probably benign 0.18
IGL01690:Bicra APN 7 15,721,678 (GRCm39) missense probably benign 0.09
IGL01721:Bicra APN 7 15,722,624 (GRCm39) missense probably benign
IGL01994:Bicra APN 7 15,706,741 (GRCm39) missense possibly damaging 0.46
IGL02084:Bicra APN 7 15,721,663 (GRCm39) missense probably benign 0.09
IGL02312:Bicra APN 7 15,727,066 (GRCm39) missense possibly damaging 0.85
IGL02686:Bicra APN 7 15,721,840 (GRCm39) missense probably benign 0.02
IGL02727:Bicra APN 7 15,713,390 (GRCm39) missense possibly damaging 0.95
IGL03031:Bicra APN 7 15,709,726 (GRCm39) missense probably benign 0.16
R0003:Bicra UTSW 7 15,705,812 (GRCm39) missense probably benign
R0025:Bicra UTSW 7 15,721,436 (GRCm39) missense possibly damaging 0.53
R0241:Bicra UTSW 7 15,709,070 (GRCm39) missense probably damaging 1.00
R0241:Bicra UTSW 7 15,709,070 (GRCm39) missense probably damaging 1.00
R0417:Bicra UTSW 7 15,706,247 (GRCm39) missense probably damaging 1.00
R0437:Bicra UTSW 7 15,722,687 (GRCm39) missense possibly damaging 0.73
R0547:Bicra UTSW 7 15,706,173 (GRCm39) missense probably damaging 1.00
R0688:Bicra UTSW 7 15,723,247 (GRCm39) missense probably damaging 1.00
R0855:Bicra UTSW 7 15,705,929 (GRCm39) missense probably damaging 1.00
R1448:Bicra UTSW 7 15,722,284 (GRCm39) missense possibly damaging 0.86
R1637:Bicra UTSW 7 15,706,614 (GRCm39) missense probably benign 0.19
R1899:Bicra UTSW 7 15,721,676 (GRCm39) missense possibly damaging 0.53
R2035:Bicra UTSW 7 15,730,338 (GRCm39) missense possibly damaging 0.53
R2471:Bicra UTSW 7 15,706,257 (GRCm39) missense probably benign 0.04
R2484:Bicra UTSW 7 15,722,605 (GRCm39) missense possibly damaging 0.96
R3437:Bicra UTSW 7 15,723,223 (GRCm39) missense possibly damaging 0.85
R3551:Bicra UTSW 7 15,713,658 (GRCm39) missense probably benign 0.33
R4816:Bicra UTSW 7 15,722,831 (GRCm39) missense possibly damaging 0.53
R4901:Bicra UTSW 7 15,721,526 (GRCm39) missense possibly damaging 0.53
R5035:Bicra UTSW 7 15,713,349 (GRCm39) missense possibly damaging 0.90
R5078:Bicra UTSW 7 15,709,382 (GRCm39) missense probably damaging 1.00
R5094:Bicra UTSW 7 15,709,296 (GRCm39) missense probably damaging 1.00
R5195:Bicra UTSW 7 15,713,878 (GRCm39) missense possibly damaging 0.93
R5496:Bicra UTSW 7 15,721,766 (GRCm39) missense probably benign 0.33
R5780:Bicra UTSW 7 15,713,679 (GRCm39) missense possibly damaging 0.96
R6541:Bicra UTSW 7 15,713,054 (GRCm39) missense probably benign 0.00
R6560:Bicra UTSW 7 15,723,119 (GRCm39) missense possibly damaging 0.53
R6575:Bicra UTSW 7 15,713,056 (GRCm39) missense probably benign 0.25
R6854:Bicra UTSW 7 15,722,687 (GRCm39) missense probably benign 0.18
R6967:Bicra UTSW 7 15,706,130 (GRCm39) missense probably damaging 0.97
R7283:Bicra UTSW 7 15,706,425 (GRCm39) missense probably damaging 1.00
R7454:Bicra UTSW 7 15,706,059 (GRCm39) missense probably benign 0.30
R7462:Bicra UTSW 7 15,713,060 (GRCm39) missense possibly damaging 0.84
R7488:Bicra UTSW 7 15,723,367 (GRCm39) critical splice acceptor site probably null
R7506:Bicra UTSW 7 15,722,138 (GRCm39) missense possibly damaging 0.96
R7534:Bicra UTSW 7 15,705,860 (GRCm39) missense probably damaging 0.98
R7915:Bicra UTSW 7 15,722,447 (GRCm39) missense probably benign
R8063:Bicra UTSW 7 15,712,969 (GRCm39) missense probably benign
R8147:Bicra UTSW 7 15,722,395 (GRCm39) missense possibly damaging 0.93
R8699:Bicra UTSW 7 15,723,113 (GRCm39) missense probably benign 0.18
R8784:Bicra UTSW 7 15,705,875 (GRCm39) missense probably damaging 1.00
R8859:Bicra UTSW 7 15,721,737 (GRCm39) missense possibly damaging 0.73
R8971:Bicra UTSW 7 15,721,481 (GRCm39) missense probably benign 0.08
R9487:Bicra UTSW 7 15,705,717 (GRCm39) missense probably damaging 0.99
R9614:Bicra UTSW 7 15,705,880 (GRCm39) missense probably damaging 1.00
R9721:Bicra UTSW 7 15,713,101 (GRCm39) missense probably damaging 1.00
R9777:Bicra UTSW 7 15,705,987 (GRCm39) missense probably benign 0.09
X0064:Bicra UTSW 7 15,709,700 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCCTTGTTGACCACATCC -3'
(R):5'- AGTGTCCCTTTGTTGACCTCAG -3'

Sequencing Primer
(F):5'- GCCTGGTGGGTCAGTACAG -3'
(R):5'- TCCATGTGCAGGAAGCTG -3'
Posted On 2014-10-15