Incidental Mutation 'R0165:Adgrl2'
| ID |
24094 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrl2
|
| Ensembl Gene |
ENSMUSG00000028184 |
| Gene Name |
adhesion G protein-coupled receptor L2 |
| Synonyms |
Lphn2, Lphh1, Lec1 |
| MMRRC Submission |
038441-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0165 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
3 |
| Chromosomal Location |
148521219-148696191 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 148558499 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142336
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106128]
[ENSMUST00000195988]
[ENSMUST00000196526]
[ENSMUST00000197567]
[ENSMUST00000198779]
[ENSMUST00000199059]
[ENSMUST00000199238]
[ENSMUST00000200543]
[ENSMUST00000200154]
[ENSMUST00000199750]
|
| AlphaFold |
Q8JZZ7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000106128
|
| SMART Domains |
Protein: ENSMUSP00000101734
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
2.5e-26 |
PFAM |
|
OLF
|
142 |
398 |
5.22e-140 |
SMART |
|
HormR
|
469 |
534 |
3.14e-20 |
SMART |
|
Pfam:GAIN
|
537 |
764 |
1.3e-58 |
PFAM |
|
GPS
|
788 |
840 |
3.47e-25 |
SMART |
|
Pfam:7tm_2
|
848 |
1108 |
4.6e-69 |
PFAM |
|
Pfam:Latrophilin
|
1128 |
1487 |
6.4e-181 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000195988
|
| SMART Domains |
Protein: ENSMUSP00000143444
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.3e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.1e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1189 |
2.2e-28 |
PFAM |
|
Pfam:Latrophilin
|
1184 |
1435 |
5.5e-123 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000196526
|
| SMART Domains |
Protein: ENSMUSP00000143788
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
8.7e-24 |
PFAM |
|
OLF
|
138 |
394 |
3.4e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
Pfam:GAIN
|
533 |
747 |
1.1e-54 |
PFAM |
|
GPS
|
771 |
823 |
2.2e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
6.5e-68 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1158 |
9.9e-36 |
PFAM |
|
low complexity region
|
1163 |
1173 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000197567
|
| SMART Domains |
Protein: ENSMUSP00000143626
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
1.9e-26 |
PFAM |
|
OLF
|
142 |
398 |
5.22e-140 |
SMART |
|
HormR
|
469 |
534 |
3.14e-20 |
SMART |
|
Pfam:GAIN
|
537 |
764 |
1.1e-58 |
PFAM |
|
GPS
|
788 |
840 |
3.47e-25 |
SMART |
|
Pfam:7tm_2
|
848 |
1108 |
6.4e-69 |
PFAM |
|
Pfam:Latrophilin
|
1128 |
1487 |
2.8e-181 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000198779
|
| SMART Domains |
Protein: ENSMUSP00000142347
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1084 |
1.8e-66 |
PFAM |
|
Pfam:Latrophilin
|
1104 |
1452 |
7e-174 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199059
|
| SMART Domains |
Protein: ENSMUSP00000143150
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.3e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1467 |
7.1e-174 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199238
|
| SMART Domains |
Protein: ENSMUSP00000142405
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.4e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
469 |
534 |
2e-22 |
SMART |
|
GPS
|
788 |
840 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
848 |
1099 |
8.4e-66 |
PFAM |
|
Pfam:Latrophilin
|
1119 |
1478 |
1.6e-187 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200543
|
| SMART Domains |
Protein: ENSMUSP00000142336
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.2e-23 |
PFAM |
|
OLF
|
138 |
394 |
3.3e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
GPS
|
771 |
823 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
1.7e-66 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1157 |
2.1e-28 |
PFAM |
|
Pfam:Latrophilin
|
1152 |
1403 |
5.3e-123 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000200154
|
| SMART Domains |
Protein: ENSMUSP00000142865
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
2.5e-23 |
PFAM |
|
OLF
|
138 |
394 |
3.3e-142 |
SMART |
|
HormR
|
465 |
530 |
2e-22 |
SMART |
|
GPS
|
771 |
823 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
831 |
1067 |
1.2e-66 |
PFAM |
|
Pfam:Latrophilin
|
1087 |
1123 |
2.2e-4 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199750
|
| SMART Domains |
Protein: ENSMUSP00000143320
Gene: ENSMUSG00000028184
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:Gal_Lectin
|
49 |
129 |
3.1e-23 |
PFAM |
|
OLF
|
142 |
398 |
3.3e-142 |
SMART |
|
HormR
|
403 |
468 |
1.9e-22 |
SMART |
|
GPS
|
709 |
761 |
2.1e-27 |
SMART |
|
Pfam:7tm_2
|
769 |
1005 |
1.6e-66 |
PFAM |
|
Pfam:Latrophilin
|
1025 |
1095 |
2e-28 |
PFAM |
|
Pfam:Latrophilin
|
1090 |
1341 |
4.9e-123 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.5%
- 10x: 96.2%
- 20x: 91.4%
|
| Validation Efficiency |
96% (81/84) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor proteolysis site into two chains that are non-covalently bound at the cell membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
PHENOTYPE: Homozygous null mice die prenatally at fetal stages. Heterozygous mice exhibit decreased locomotor activity in an open field test. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700049A03Rik |
T |
C |
12: 71,213,924 (GRCm39) |
I717T |
possibly damaging |
Het |
| 6430571L13Rik |
A |
G |
9: 107,223,383 (GRCm39) |
|
probably benign |
Het |
| Abca15 |
T |
A |
7: 119,950,126 (GRCm39) |
|
probably benign |
Het |
| Abca6 |
A |
G |
11: 110,110,430 (GRCm39) |
V573A |
possibly damaging |
Het |
| Agap3 |
A |
G |
5: 24,684,743 (GRCm39) |
T544A |
probably damaging |
Het |
| Ahrr |
G |
A |
13: 74,431,143 (GRCm39) |
|
probably benign |
Het |
| Akr1c20 |
T |
C |
13: 4,573,295 (GRCm39) |
T7A |
probably benign |
Het |
| Ankrd26 |
A |
G |
6: 118,517,445 (GRCm39) |
S459P |
probably benign |
Het |
| Armh4 |
A |
G |
14: 50,011,243 (GRCm39) |
S155P |
probably benign |
Het |
| Ascc3 |
T |
A |
10: 50,718,223 (GRCm39) |
|
probably null |
Het |
| Brd1 |
T |
C |
15: 88,613,980 (GRCm39) |
N305S |
probably damaging |
Het |
| Catip |
T |
A |
1: 74,407,628 (GRCm39) |
L320Q |
possibly damaging |
Het |
| Cplane1 |
G |
A |
15: 8,245,866 (GRCm39) |
V1413M |
probably damaging |
Het |
| Cttnbp2 |
G |
A |
6: 18,435,409 (GRCm39) |
Q150* |
probably null |
Het |
| Cyp2d22 |
T |
G |
15: 82,257,481 (GRCm39) |
N228T |
probably benign |
Het |
| Dapk1 |
T |
C |
13: 60,909,407 (GRCm39) |
V1340A |
probably benign |
Het |
| Dcaf4 |
G |
A |
12: 83,582,762 (GRCm39) |
|
probably benign |
Het |
| Ddhd1 |
G |
A |
14: 45,833,049 (GRCm39) |
T849M |
probably damaging |
Het |
| Dnah6 |
A |
G |
6: 72,998,306 (GRCm39) |
S3987P |
probably benign |
Het |
| Dst |
C |
A |
1: 34,193,727 (GRCm39) |
|
probably benign |
Het |
| Epha2 |
T |
C |
4: 141,049,203 (GRCm39) |
|
probably null |
Het |
| Ern2 |
T |
C |
7: 121,779,002 (GRCm39) |
T281A |
probably benign |
Het |
| Extl1 |
A |
G |
4: 134,085,014 (GRCm39) |
F652S |
probably damaging |
Het |
| Gckr |
A |
G |
5: 31,484,292 (GRCm39) |
S541G |
possibly damaging |
Het |
| Gdap1l1 |
A |
G |
2: 163,293,419 (GRCm39) |
|
probably null |
Het |
| Gm7535 |
T |
C |
17: 18,131,437 (GRCm39) |
|
probably benign |
Het |
| Gmps |
T |
A |
3: 63,901,375 (GRCm39) |
I398N |
probably damaging |
Het |
| Igf2r |
A |
G |
17: 12,917,414 (GRCm39) |
V1556A |
probably benign |
Het |
| Il3ra |
T |
A |
14: 14,350,967 (GRCm38) |
N283K |
probably benign |
Het |
| Ist1 |
A |
G |
8: 110,401,998 (GRCm39) |
|
probably benign |
Het |
| Lama3 |
A |
T |
18: 12,657,867 (GRCm39) |
I1934F |
probably damaging |
Het |
| Lars1 |
A |
T |
18: 42,335,762 (GRCm39) |
M1118K |
possibly damaging |
Het |
| Lpin2 |
C |
T |
17: 71,553,514 (GRCm39) |
S846L |
probably damaging |
Het |
| Lrrc4b |
C |
A |
7: 44,111,739 (GRCm39) |
T537K |
probably damaging |
Het |
| Ltn1 |
G |
A |
16: 87,202,407 (GRCm39) |
|
probably benign |
Het |
| Meiob |
A |
G |
17: 25,054,135 (GRCm39) |
T401A |
probably benign |
Het |
| Mettl21e |
G |
A |
1: 44,250,283 (GRCm39) |
T41M |
probably damaging |
Het |
| Miga1 |
C |
T |
3: 151,996,480 (GRCm39) |
E323K |
probably damaging |
Het |
| Ndufs1 |
A |
T |
1: 63,198,907 (GRCm39) |
|
probably null |
Het |
| Or5p62 |
T |
C |
7: 107,771,882 (GRCm39) |
D23G |
probably benign |
Het |
| Otog |
G |
A |
7: 45,953,655 (GRCm39) |
V2638M |
probably damaging |
Het |
| Parp6 |
T |
C |
9: 59,540,208 (GRCm39) |
Y274H |
probably damaging |
Het |
| Prom2 |
A |
T |
2: 127,381,434 (GRCm39) |
|
probably benign |
Het |
| Prune2 |
T |
A |
19: 17,099,974 (GRCm39) |
M1826K |
probably benign |
Het |
| Qki |
T |
A |
17: 10,457,892 (GRCm39) |
D159V |
probably damaging |
Het |
| Rab12 |
A |
T |
17: 66,807,312 (GRCm39) |
I139N |
probably damaging |
Het |
| Rab25 |
T |
A |
3: 88,455,362 (GRCm39) |
E7D |
probably benign |
Het |
| Rala |
A |
T |
13: 18,063,174 (GRCm39) |
V139E |
probably benign |
Het |
| Ralgapa2 |
A |
G |
2: 146,230,407 (GRCm39) |
|
probably benign |
Het |
| Rbl2 |
T |
A |
8: 91,800,804 (GRCm39) |
Y89N |
probably damaging |
Het |
| Rho |
A |
T |
6: 115,909,188 (GRCm39) |
I75F |
probably damaging |
Het |
| Slc38a4 |
C |
A |
15: 96,906,830 (GRCm39) |
A303S |
probably benign |
Het |
| Slc6a15 |
A |
G |
10: 103,245,670 (GRCm39) |
D551G |
probably null |
Het |
| Smyd3 |
T |
C |
1: 178,871,437 (GRCm39) |
N314S |
probably benign |
Het |
| Speer4f1 |
T |
A |
5: 17,684,512 (GRCm39) |
L180* |
probably null |
Het |
| Stat6 |
T |
C |
10: 127,493,096 (GRCm39) |
V576A |
probably damaging |
Het |
| Strn |
T |
C |
17: 78,984,803 (GRCm39) |
D127G |
possibly damaging |
Het |
| Syne1 |
T |
C |
10: 4,983,096 (GRCm39) |
R8610G |
probably benign |
Het |
| Tbc1d7 |
A |
C |
13: 43,306,678 (GRCm39) |
|
probably null |
Het |
| Tcf3 |
C |
T |
10: 80,248,831 (GRCm39) |
R548Q |
probably damaging |
Het |
| Tlr9 |
C |
A |
9: 106,103,286 (GRCm39) |
A859D |
probably benign |
Het |
| Tmem106c |
T |
A |
15: 97,866,020 (GRCm39) |
|
probably benign |
Het |
| Tmprss11c |
A |
T |
5: 86,379,786 (GRCm39) |
|
probably benign |
Het |
| Tnfsf18 |
A |
G |
1: 161,322,300 (GRCm39) |
R7G |
probably benign |
Het |
| Tnrc6b |
T |
A |
15: 80,742,871 (GRCm39) |
|
probably null |
Het |
| Trpm7 |
A |
T |
2: 126,639,433 (GRCm39) |
F1684I |
probably damaging |
Het |
| Ttbk1 |
C |
A |
17: 46,789,864 (GRCm39) |
R133L |
possibly damaging |
Het |
| Ttn |
A |
G |
2: 76,551,686 (GRCm39) |
S22962P |
probably damaging |
Het |
| Ube2q1 |
T |
A |
3: 89,683,460 (GRCm39) |
L135Q |
probably damaging |
Het |
| Vmn1r28 |
G |
A |
6: 58,242,702 (GRCm39) |
A182T |
probably benign |
Het |
| Vwce |
T |
C |
19: 10,637,337 (GRCm39) |
|
probably benign |
Het |
| Wdhd1 |
A |
G |
14: 47,504,525 (GRCm39) |
S350P |
probably benign |
Het |
| Zbtb21 |
A |
G |
16: 97,752,604 (GRCm39) |
S560P |
probably damaging |
Het |
|
| Other mutations in Adgrl2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00426:Adgrl2
|
APN |
3 |
148,571,244 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00572:Adgrl2
|
APN |
3 |
148,532,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01624:Adgrl2
|
APN |
3 |
148,542,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01796:Adgrl2
|
APN |
3 |
148,564,611 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02380:Adgrl2
|
APN |
3 |
148,534,125 (GRCm39) |
nonsense |
probably null |
|
|
IGL02468:Adgrl2
|
APN |
3 |
148,596,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Adgrl2
|
APN |
3 |
148,532,161 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02869:Adgrl2
|
APN |
3 |
148,596,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03248:Adgrl2
|
APN |
3 |
148,523,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03343:Adgrl2
|
APN |
3 |
148,565,016 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0157:Adgrl2
|
UTSW |
3 |
148,564,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4382001:Adgrl2
|
UTSW |
3 |
148,522,934 (GRCm39) |
missense |
|
|
|
PIT4544001:Adgrl2
|
UTSW |
3 |
148,596,157 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0242:Adgrl2
|
UTSW |
3 |
148,544,821 (GRCm39) |
splice site |
probably null |
|
|
R0242:Adgrl2
|
UTSW |
3 |
148,544,821 (GRCm39) |
splice site |
probably null |
|
|
R0344:Adgrl2
|
UTSW |
3 |
148,571,231 (GRCm39) |
splice site |
probably null |
|
|
R0488:Adgrl2
|
UTSW |
3 |
148,552,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0542:Adgrl2
|
UTSW |
3 |
148,564,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Adgrl2
|
UTSW |
3 |
148,544,880 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0674:Adgrl2
|
UTSW |
3 |
148,543,315 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1401:Adgrl2
|
UTSW |
3 |
148,528,617 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1543:Adgrl2
|
UTSW |
3 |
148,564,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1575:Adgrl2
|
UTSW |
3 |
148,558,398 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1645:Adgrl2
|
UTSW |
3 |
148,571,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Adgrl2
|
UTSW |
3 |
148,558,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1992:Adgrl2
|
UTSW |
3 |
148,522,880 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2014:Adgrl2
|
UTSW |
3 |
148,532,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2130:Adgrl2
|
UTSW |
3 |
148,596,124 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2131:Adgrl2
|
UTSW |
3 |
148,596,124 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2400:Adgrl2
|
UTSW |
3 |
148,557,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2997:Adgrl2
|
UTSW |
3 |
148,523,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3161:Adgrl2
|
UTSW |
3 |
148,523,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3416:Adgrl2
|
UTSW |
3 |
148,564,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3417:Adgrl2
|
UTSW |
3 |
148,564,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3551:Adgrl2
|
UTSW |
3 |
148,564,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3760:Adgrl2
|
UTSW |
3 |
148,522,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4355:Adgrl2
|
UTSW |
3 |
148,544,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4850:Adgrl2
|
UTSW |
3 |
148,564,656 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4911:Adgrl2
|
UTSW |
3 |
148,596,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4945:Adgrl2
|
UTSW |
3 |
148,528,672 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5313:Adgrl2
|
UTSW |
3 |
148,529,349 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5339:Adgrl2
|
UTSW |
3 |
148,523,480 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5540:Adgrl2
|
UTSW |
3 |
148,543,198 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5583:Adgrl2
|
UTSW |
3 |
148,564,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5890:Adgrl2
|
UTSW |
3 |
148,564,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6170:Adgrl2
|
UTSW |
3 |
148,528,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6197:Adgrl2
|
UTSW |
3 |
148,564,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6284:Adgrl2
|
UTSW |
3 |
148,532,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6877:Adgrl2
|
UTSW |
3 |
148,522,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7048:Adgrl2
|
UTSW |
3 |
148,552,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7205:Adgrl2
|
UTSW |
3 |
148,564,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7326:Adgrl2
|
UTSW |
3 |
148,552,506 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7348:Adgrl2
|
UTSW |
3 |
148,523,402 (GRCm39) |
missense |
|
|
|
R7382:Adgrl2
|
UTSW |
3 |
148,522,919 (GRCm39) |
missense |
|
|
|
R7486:Adgrl2
|
UTSW |
3 |
148,523,330 (GRCm39) |
missense |
|
|
|
R7498:Adgrl2
|
UTSW |
3 |
148,564,852 (GRCm39) |
nonsense |
probably null |
|
|
R7644:Adgrl2
|
UTSW |
3 |
148,544,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7690:Adgrl2
|
UTSW |
3 |
148,522,934 (GRCm39) |
missense |
|
|
|
R7742:Adgrl2
|
UTSW |
3 |
148,542,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7745:Adgrl2
|
UTSW |
3 |
148,542,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8291:Adgrl2
|
UTSW |
3 |
148,556,554 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8326:Adgrl2
|
UTSW |
3 |
148,533,190 (GRCm39) |
missense |
|
|
|
R8343:Adgrl2
|
UTSW |
3 |
148,552,542 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8344:Adgrl2
|
UTSW |
3 |
148,565,161 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8487:Adgrl2
|
UTSW |
3 |
148,565,122 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8748:Adgrl2
|
UTSW |
3 |
148,532,026 (GRCm39) |
missense |
|
|
|
R8769:Adgrl2
|
UTSW |
3 |
148,522,917 (GRCm39) |
missense |
|
|
|
R8804:Adgrl2
|
UTSW |
3 |
148,552,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8911:Adgrl2
|
UTSW |
3 |
148,558,163 (GRCm39) |
intron |
probably benign |
|
|
R8943:Adgrl2
|
UTSW |
3 |
148,534,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8977:Adgrl2
|
UTSW |
3 |
148,660,223 (GRCm39) |
missense |
probably null |
|
|
R9030:Adgrl2
|
UTSW |
3 |
148,544,761 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9105:Adgrl2
|
UTSW |
3 |
148,543,289 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9427:Adgrl2
|
UTSW |
3 |
148,526,068 (GRCm39) |
missense |
|
|
|
R9471:Adgrl2
|
UTSW |
3 |
148,558,365 (GRCm39) |
missense |
probably benign |
|
|
R9646:Adgrl2
|
UTSW |
3 |
148,544,926 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9742:Adgrl2
|
UTSW |
3 |
148,541,986 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF007:Adgrl2
|
UTSW |
3 |
148,544,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0009:Adgrl2
|
UTSW |
3 |
148,558,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0019:Adgrl2
|
UTSW |
3 |
148,571,230 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCCAGTCTAACGCTTCGCAGAATC -3'
(R):5'- GACCATATTGCACCGAGATCCAGG -3'
Sequencing Primer
(F):5'- TCGCAGAATCTCTCTGGCAG -3'
(R):5'- CGAGATCCAGGATCACCTTTTAG -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation