Incidental Mutation 'R2218:Or10al4'
ID 241291
Institutional Source Beutler Lab
Gene Symbol Or10al4
Ensembl Gene ENSMUSG00000063994
Gene Name olfactory receptor family 10 subfamily AL member 4
Synonyms Olfr120, MOR263-3, GA_x6K02T2PSCP-2184981-2185946
MMRRC Submission 040220-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R2218 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 38036890-38037882 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38037145 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 77 (I77F)
Ref Sequence ENSEMBL: ENSMUSP00000146861 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077498] [ENSMUST00000207771]
AlphaFold Q8VFQ2
Predicted Effect possibly damaging
Transcript: ENSMUST00000077498
AA Change: I86F

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000094931
Gene: ENSMUSG00000063994
AA Change: I86F

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 50 320 1e-5 PFAM
Pfam:7tm_1 56 305 6e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207771
AA Change: I77F

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abitram G T 4: 56,802,693 (GRCm39) V26L probably damaging Het
Acap3 A G 4: 155,988,319 (GRCm39) probably null Het
Appl2 G T 10: 83,444,601 (GRCm39) F472L possibly damaging Het
Atp13a5 A T 16: 29,140,464 (GRCm39) V319D probably damaging Het
Atxn2 T C 5: 121,941,140 (GRCm39) Y56H probably damaging Het
Brinp1 A G 4: 68,680,952 (GRCm39) L526P probably damaging Het
Cacna1d C T 14: 29,845,048 (GRCm39) D679N probably damaging Het
Canx C T 11: 50,201,694 (GRCm39) V59I probably benign Het
Drd2 T C 9: 49,311,094 (GRCm39) V115A probably damaging Het
Eml6 T A 11: 29,768,907 (GRCm39) Q746L probably damaging Het
F13b G T 1: 139,434,582 (GRCm39) S116I probably benign Het
Flt4 T A 11: 49,515,555 (GRCm39) S48T probably benign Het
Gcn1 C A 5: 115,757,720 (GRCm39) S2475Y probably benign Het
Gls2 T C 10: 128,040,583 (GRCm39) L328P probably damaging Het
Gm7535 A G 17: 18,131,936 (GRCm39) probably benign Het
Htr3a T C 9: 48,819,911 (GRCm39) Y73C probably damaging Het
Iapp G A 6: 142,249,096 (GRCm39) A50T probably benign Het
Il10ra T C 9: 45,176,914 (GRCm39) D137G probably benign Het
Krt35 T C 11: 99,986,988 (GRCm39) S9G probably null Het
Lamc2 T A 1: 153,006,525 (GRCm39) R875S probably benign Het
Mcoln1 C A 8: 3,555,813 (GRCm39) T36K possibly damaging Het
Muc6 T C 7: 141,233,227 (GRCm39) H885R probably benign Het
Nsrp1 A T 11: 76,936,587 (GRCm39) Y536* probably null Het
Polr2a A G 11: 69,633,511 (GRCm39) probably null Het
Pp2d1 C A 17: 53,822,482 (GRCm39) V195L probably benign Het
Rag1 T C 2: 101,474,491 (GRCm39) H217R probably benign Het
Ramp2 A G 11: 101,138,457 (GRCm39) E86G probably benign Het
Rcbtb2 T C 14: 73,416,005 (GRCm39) probably null Het
Sema5a A T 15: 32,631,455 (GRCm39) I613F probably damaging Het
Sgk1 C T 10: 21,872,500 (GRCm39) R171W probably damaging Het
Slc39a11 C A 11: 113,450,376 (GRCm39) probably null Het
Slc47a2 T C 11: 61,204,497 (GRCm39) T285A probably benign Het
Timd2 T A 11: 46,577,844 (GRCm39) I96L probably damaging Het
Tkt G T 14: 30,289,018 (GRCm39) probably null Het
Tle1 A T 4: 72,117,556 (GRCm39) F35I possibly damaging Het
Tmem64 T C 4: 15,266,658 (GRCm39) I236T possibly damaging Het
Ttll13 A G 7: 79,902,250 (GRCm39) K109R probably damaging Het
Virma T C 4: 11,544,924 (GRCm39) S1628P probably damaging Het
Zan C A 5: 137,408,568 (GRCm39) probably benign Het
Zbtb22 T G 17: 34,136,939 (GRCm39) D361E probably damaging Het
Zfp608 T C 18: 55,120,756 (GRCm39) N277S probably benign Het
Other mutations in Or10al4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01402:Or10al4 APN 17 38,037,193 (GRCm39) missense probably benign 0.08
IGL01925:Or10al4 APN 17 38,037,002 (GRCm39) missense probably benign 0.18
IGL02901:Or10al4 APN 17 38,037,311 (GRCm39) missense probably damaging 1.00
PIT4687001:Or10al4 UTSW 17 38,037,082 (GRCm39) missense probably benign 0.01
R1645:Or10al4 UTSW 17 38,037,229 (GRCm39) missense probably benign 0.01
R2336:Or10al4 UTSW 17 38,037,689 (GRCm39) missense probably benign 0.07
R4613:Or10al4 UTSW 17 38,037,587 (GRCm39) missense probably damaging 1.00
R5237:Or10al4 UTSW 17 38,037,268 (GRCm39) missense probably damaging 1.00
R5880:Or10al4 UTSW 17 38,037,545 (GRCm39) missense probably benign 0.09
R6187:Or10al4 UTSW 17 38,037,032 (GRCm39) missense probably damaging 0.99
R9083:Or10al4 UTSW 17 38,037,060 (GRCm39) missense probably damaging 1.00
R9479:Or10al4 UTSW 17 38,036,986 (GRCm39) missense probably damaging 0.99
R9647:Or10al4 UTSW 17 38,037,796 (GRCm39) missense probably damaging 1.00
Z1088:Or10al4 UTSW 17 38,036,983 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTGTCAACTGCTCTCTGTGG -3'
(R):5'- GGGAGCATATGGCCATGTAG -3'

Sequencing Primer
(F):5'- CTCTCTGTGGCAGGAAAATAAGTTG -3'
(R):5'- AGCATATGGCCATGTAGCGGTC -3'
Posted On 2014-10-15