Incidental Mutation 'R2224:Il17f'
ID 241524
Institutional Source Beutler Lab
Gene Symbol Il17f
Ensembl Gene ENSMUSG00000041872
Gene Name interleukin 17F
Synonyms
MMRRC Submission 040225-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.108) question?
Stock # R2224 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 20847370-20855498 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20849599 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 55 (V55A)
Ref Sequence ENSEMBL: ENSMUSP00000046960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039046] [ENSMUST00000189301]
AlphaFold Q7TNI7
Predicted Effect probably damaging
Transcript: ENSMUST00000039046
AA Change: V55A

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000046960
Gene: ENSMUSG00000041872
AA Change: V55A

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
Pfam:IL17 75 153 3.8e-32 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000189301
AA Change: V55A

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000140122
Gene: ENSMUSG00000041872
AA Change: V55A

DomainStartEndE-ValueType
signal peptide 1 28 N/A INTRINSIC
Pfam:IL17 74 154 5.4e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191111
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for one null allele exhibit increased susceptibility to oral bacterial infection while mice homozygous for another null allele exhibit decreased susceptibility to experimental models of colitis and CNS inflammation but have enhanced inflammatory responses to a chronic asthma model. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 T G 16: 14,289,932 (GRCm39) L1416R probably damaging Het
Aen C A 7: 78,552,199 (GRCm39) T15K probably benign Het
Ahnak G A 19: 8,990,355 (GRCm39) probably benign Het
Ar T A X: 97,194,937 (GRCm39) M517K probably benign Het
Arsb T A 13: 93,930,679 (GRCm39) F216I probably damaging Het
Atg9b A G 5: 24,591,393 (GRCm39) V735A possibly damaging Het
Brinp3 C T 1: 146,777,658 (GRCm39) Q702* probably null Het
Btbd9 C A 17: 30,746,320 (GRCm39) A169S probably damaging Het
Cacna1h T C 17: 25,604,917 (GRCm39) N1132S probably benign Het
Ccdc33 A G 9: 57,989,305 (GRCm39) S123P probably damaging Het
Cep250 A C 2: 155,833,737 (GRCm39) E1886D possibly damaging Het
Chd9 A C 8: 91,737,913 (GRCm39) H1515P probably benign Het
Cyp2c68 A G 19: 39,724,026 (GRCm39) C213R probably benign Het
Ddx41 G A 13: 55,679,214 (GRCm39) T544I probably damaging Het
Dgkk T A X: 6,741,487 (GRCm39) D102E probably damaging Het
Eea1 T A 10: 95,855,874 (GRCm39) V637D probably damaging Het
Emcn T C 3: 137,109,778 (GRCm39) I140T possibly damaging Het
Exo1 A G 1: 175,714,254 (GRCm39) probably null Het
Fbxo21 T G 5: 118,146,188 (GRCm39) Y597D probably damaging Het
Fbxw20 G C 9: 109,062,650 (GRCm39) Q59E possibly damaging Het
Fpr3 T A 17: 18,191,455 (GRCm39) V242D probably damaging Het
Fyb1 A G 15: 6,681,864 (GRCm39) Y737C probably damaging Het
Gm17661 GG GGG 2: 90,748,052 (GRCm39) noncoding transcript Het
Hdac9 C T 12: 34,457,801 (GRCm39) V251I probably benign Het
Hoxa10 T C 6: 52,209,616 (GRCm39) E52G probably damaging Het
Inpp1 T A 1: 52,829,290 (GRCm39) E243V probably benign Het
Leap2 A G 11: 53,313,634 (GRCm39) L46P probably damaging Het
Map4k3 A T 17: 80,937,883 (GRCm39) D339E probably benign Het
Met A G 6: 17,563,721 (GRCm39) probably null Het
Mgam G T 6: 40,741,208 (GRCm39) probably null Het
Mrgpra1 A G 7: 46,984,854 (GRCm39) V275A possibly damaging Het
Mrgprx2 T A 7: 48,132,608 (GRCm39) Q70L probably benign Het
Mtus1 C T 8: 41,535,812 (GRCm39) V635M probably damaging Het
Mup18 G T 4: 61,590,128 (GRCm39) F133L possibly damaging Het
Naalad2 A T 9: 18,287,829 (GRCm39) V267E possibly damaging Het
Nin A T 12: 70,108,004 (GRCm39) I196N probably damaging Het
Nkpd1 A T 7: 19,253,745 (GRCm39) Y37F probably benign Het
Odc1 A G 12: 17,597,336 (GRCm39) I13V probably benign Het
Or1ad1 T C 11: 50,876,059 (GRCm39) F177S probably damaging Het
Or4a67 A T 2: 88,597,930 (GRCm39) M243K possibly damaging Het
Or5m12 T A 2: 85,735,099 (GRCm39) I100F probably benign Het
Pard3 A G 8: 128,086,257 (GRCm39) I286V probably damaging Het
Pcx T C 19: 4,668,026 (GRCm39) I516T possibly damaging Het
Ppp1r9a G T 6: 5,154,074 (GRCm39) R1081L probably benign Het
Prpf40b C T 15: 99,201,172 (GRCm39) probably benign Het
Rnmt C T 18: 68,438,854 (GRCm39) probably benign Het
Saxo5 A G 8: 3,529,249 (GRCm39) T245A probably benign Het
Sfxn1 A G 13: 54,239,536 (GRCm39) T20A possibly damaging Het
Sirt2 A G 7: 28,471,637 (GRCm39) probably null Het
Spata31d1a T A 13: 59,851,529 (GRCm39) I200L probably benign Het
Spin2g A T X: 33,656,599 (GRCm39) I171N possibly damaging Het
Tesl2 T A X: 23,825,173 (GRCm39) M1L probably null Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Tsbp1 C A 17: 34,667,737 (GRCm39) probably null Het
Uqcrc2 T A 7: 120,240,937 (GRCm39) V73E probably damaging Het
Vmn2r100 A G 17: 19,742,634 (GRCm39) K336R probably benign Het
Vmn2r108 A T 17: 20,701,295 (GRCm39) Y68* probably null Het
Zbtb4 C T 11: 69,667,184 (GRCm39) T163I probably benign Het
Other mutations in Il17f
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0800:Il17f UTSW 1 20,848,177 (GRCm39) nonsense probably null
R4074:Il17f UTSW 1 20,847,987 (GRCm39) unclassified probably benign
R4594:Il17f UTSW 1 20,848,026 (GRCm39) missense probably damaging 1.00
R5386:Il17f UTSW 1 20,848,181 (GRCm39) missense probably benign 0.00
R6009:Il17f UTSW 1 20,849,510 (GRCm39) splice site probably null
R6416:Il17f UTSW 1 20,848,131 (GRCm39) missense probably benign 0.00
R6751:Il17f UTSW 1 20,849,713 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGTGAATGTGAGTCCTGAATACTC -3'
(R):5'- GGGCTCTAACCTGTGGTAATCTC -3'

Sequencing Primer
(F):5'- GGCTGTCCTGGAACTCATTACATAG -3'
(R):5'- GGTAATCTCTATTTTCCAGGTCAAG -3'
Posted On 2014-10-15