Incidental Mutation 'R2253:Lgals12'
ID 241838
Institutional Source Beutler Lab
Gene Symbol Lgals12
Ensembl Gene ENSMUSG00000024972
Gene Name lectin, galactose binding, soluble 12
Synonyms galectin-12, galectin-related inhibitor of proliferation, GRIP1
MMRRC Submission 040253-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2253 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 7574025-7584558 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) T to A at 7584130 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124610 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079902] [ENSMUST00000099729] [ENSMUST00000159983]
AlphaFold Q91VD1
Predicted Effect probably benign
Transcript: ENSMUST00000079902
SMART Domains Protein: ENSMUSP00000078824
Gene: ENSMUSG00000024972

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 181 301 3.6e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000099729
SMART Domains Protein: ENSMUSP00000097318
Gene: ENSMUSG00000024972

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 194 314 3.6e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000159983
SMART Domains Protein: ENSMUSP00000124610
Gene: ENSMUSG00000024972

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 194 314 3.6e-12 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lipolysis, reduced adiposity, and enhanced insulin sensitivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700129C05Rik G A 14: 59,380,061 (GRCm39) S79F probably damaging Het
Acss3 G A 10: 106,840,609 (GRCm39) A384V probably damaging Het
Aff2 G A X: 68,878,409 (GRCm39) E732K possibly damaging Het
Atp12a A G 14: 56,613,715 (GRCm39) T496A probably benign Het
B3gnt3 A T 8: 72,145,462 (GRCm39) M302K probably damaging Het
Bptf G T 11: 107,002,148 (GRCm39) D321E probably damaging Het
C1ql3 C T 2: 13,015,130 (GRCm39) V177I possibly damaging Het
C2cd5 A T 6: 142,982,042 (GRCm39) Y607* probably null Het
Casp3 G T 8: 47,090,990 (GRCm39) W214L probably damaging Het
Cd248 A G 19: 5,118,154 (GRCm39) M1V probably null Het
Cdh18 A G 15: 23,410,891 (GRCm39) T405A probably benign Het
Cldn24 G T 8: 48,275,363 (GRCm39) R62S probably benign Het
Cnot1 A G 8: 96,489,814 (GRCm39) V463A probably benign Het
Cul2 A T 18: 3,399,876 (GRCm39) L3F probably damaging Het
Ep400 A T 5: 110,866,957 (GRCm39) N1062K unknown Het
Gch1 T C 14: 47,426,798 (GRCm39) probably benign Het
Gzf1 T C 2: 148,525,856 (GRCm39) M109T probably damaging Het
Itch T A 2: 155,054,259 (GRCm39) M701K probably benign Het
Kank4 A T 4: 98,667,463 (GRCm39) I328N probably damaging Het
Krt9 A T 11: 100,081,685 (GRCm39) N281K possibly damaging Het
Lrrc37a T C 11: 103,392,293 (GRCm39) Q1044R probably benign Het
Mbtps2 A T X: 156,342,029 (GRCm39) F270L probably benign Het
Nr3c1 G T 18: 39,619,804 (GRCm39) T161K probably benign Het
Or2w3b T C 11: 58,623,821 (GRCm39) T57A probably benign Het
Or4g16 A G 2: 111,136,655 (GRCm39) Y35C probably damaging Het
Or5ak20 A G 2: 85,184,202 (GRCm39) S23P possibly damaging Het
Or5b116 T C 19: 13,422,549 (GRCm39) Y58H probably damaging Het
Pla2g4d T C 2: 120,101,622 (GRCm39) K453E probably damaging Het
Plcb2 T C 2: 118,554,246 (GRCm39) N69S probably benign Het
Prl3d1 T C 13: 27,278,981 (GRCm39) Y59H possibly damaging Het
Rnf133 T C 6: 23,649,174 (GRCm39) M252V probably benign Het
Rnf181 G T 6: 72,338,467 (GRCm39) H14N possibly damaging Het
Sash1 A T 10: 8,605,741 (GRCm39) M883K probably benign Het
Secisbp2l C T 2: 125,582,657 (GRCm39) G933D possibly damaging Het
Slc13a4 A G 6: 35,257,418 (GRCm39) V240A probably benign Het
Slc2a5 T C 4: 150,224,447 (GRCm39) Y315H possibly damaging Het
Slc7a2 T C 8: 41,358,658 (GRCm39) Y334H probably benign Het
Spib A G 7: 44,179,392 (GRCm39) S23P probably benign Het
Tbc1d1 A G 5: 64,442,143 (GRCm39) N721S probably benign Het
Tcf25 A G 8: 124,100,772 (GRCm39) E54G probably benign Het
Tesl2 G A X: 23,824,950 (GRCm39) A75V probably benign Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Uba7 A G 9: 107,853,563 (GRCm39) H131R probably benign Het
Vmn2r6 C T 3: 64,467,139 (GRCm39) C120Y probably damaging Het
Zdhhc18 A T 4: 133,360,388 (GRCm39) probably null Het
Zfp970 T A 2: 177,166,614 (GRCm39) probably null Het
Other mutations in Lgals12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02442:Lgals12 APN 19 7,584,019 (GRCm39) splice site probably benign
IGL02630:Lgals12 APN 19 7,578,607 (GRCm39) splice site probably benign
IGL02700:Lgals12 APN 19 7,575,455 (GRCm39) missense probably benign 0.01
R0129:Lgals12 UTSW 19 7,580,403 (GRCm39) missense probably damaging 0.99
R1398:Lgals12 UTSW 19 7,581,322 (GRCm39) splice site probably benign
R1421:Lgals12 UTSW 19 7,584,079 (GRCm39) missense probably benign 0.08
R1548:Lgals12 UTSW 19 7,581,677 (GRCm39) missense probably benign 0.12
R1697:Lgals12 UTSW 19 7,581,530 (GRCm39) missense possibly damaging 0.91
R2075:Lgals12 UTSW 19 7,576,210 (GRCm39) missense possibly damaging 0.81
R2192:Lgals12 UTSW 19 7,578,606 (GRCm39) splice site probably null
R4256:Lgals12 UTSW 19 7,584,081 (GRCm39) missense possibly damaging 0.93
R4738:Lgals12 UTSW 19 7,581,464 (GRCm39) missense probably benign 0.01
R5495:Lgals12 UTSW 19 7,581,495 (GRCm39) missense probably damaging 1.00
R5810:Lgals12 UTSW 19 7,584,085 (GRCm39) missense probably benign 0.00
R6139:Lgals12 UTSW 19 7,581,742 (GRCm39) missense probably benign 0.07
R7414:Lgals12 UTSW 19 7,581,335 (GRCm39) missense probably damaging 1.00
R8755:Lgals12 UTSW 19 7,581,345 (GRCm39) missense possibly damaging 0.95
R8920:Lgals12 UTSW 19 7,576,166 (GRCm39) missense possibly damaging 0.55
R9334:Lgals12 UTSW 19 7,578,086 (GRCm39) missense probably benign 0.01
R9441:Lgals12 UTSW 19 7,581,356 (GRCm39) missense probably damaging 1.00
X0067:Lgals12 UTSW 19 7,581,329 (GRCm39) splice site probably null
Z1177:Lgals12 UTSW 19 7,575,445 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TTCTTCTAGCCATCTATCCCAGAAG -3'
(R):5'- TGCTGTACCATCATAGCGGG -3'

Sequencing Primer
(F):5'- CATCTATCCCAGAAGAGGCGTATTG -3'
(R):5'- ACCATCATAGCGGGGGTTG -3'
Posted On 2014-10-16