Incidental Mutation 'R2267:Ido2'
ID 242134
Institutional Source Beutler Lab
Gene Symbol Ido2
Ensembl Gene ENSMUSG00000031549
Gene Name indoleamine 2,3-dioxygenase 2
Synonyms Ido2, C230043N17Rik, Indol1
MMRRC Submission 040267-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R2267 (G1)
Quality Score 175
Status Validated
Chromosome 8
Chromosomal Location 25021908-25066349 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 25025268 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 253 (Y253C)
Ref Sequence ENSEMBL: ENSMUSP00000113979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000121992]
AlphaFold Q8R0V5
Predicted Effect probably damaging
Transcript: ENSMUST00000121992
AA Change: Y253C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113979
Gene: ENSMUSG00000031549
AA Change: Y253C

DomainStartEndE-ValueType
Pfam:IDO 15 399 1.4e-124 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138335
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140417
Meta Mutation Damage Score 0.8495 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 98% (108/110)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired T cell function and decreased susceptibility to type IV hypersensitivity reaction. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 104 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadac T A 3: 59,944,737 (GRCm39) D136E probably damaging Het
Abca16 A G 7: 120,030,383 (GRCm39) D165G probably benign Het
Abca8b G A 11: 109,845,974 (GRCm39) T820M probably benign Het
Acot2 C T 12: 84,037,334 (GRCm39) A216V probably damaging Het
Agap2 T A 10: 126,918,297 (GRCm39) probably benign Het
Ak7 T C 12: 105,713,473 (GRCm39) V419A probably benign Het
Apmap A G 2: 150,430,821 (GRCm39) probably null Het
Apob T C 12: 8,065,475 (GRCm39) F4115S possibly damaging Het
Cachd1 T A 4: 100,806,266 (GRCm39) probably benign Het
Ccdc39 T A 3: 33,869,633 (GRCm39) E731D probably damaging Het
Ces2a A T 8: 105,466,822 (GRCm39) I65F probably benign Het
Commd8 A G 5: 72,322,765 (GRCm39) W51R probably damaging Het
D2hgdh C T 1: 93,763,157 (GRCm39) A314V probably damaging Het
Dcun1d4 T A 5: 73,638,618 (GRCm39) probably benign Het
Dgke T A 11: 88,943,295 (GRCm39) E231D probably benign Het
Dhrs9 A G 2: 69,223,197 (GRCm39) probably benign Het
Dhx30 C T 9: 109,916,102 (GRCm39) G662R probably damaging Het
Dipk2b A G X: 18,289,926 (GRCm39) S179P possibly damaging Het
Dnah7b T A 1: 46,273,075 (GRCm39) M2401K probably damaging Het
Dnmt3a T A 12: 3,947,551 (GRCm39) probably null Het
Dst C T 1: 34,334,547 (GRCm39) T4874I probably damaging Het
Eef2kmt G A 16: 5,073,804 (GRCm39) probably benign Het
Ess2 T C 16: 17,727,859 (GRCm39) T107A probably damaging Het
Etfa A T 9: 55,394,015 (GRCm39) L212Q probably damaging Het
Exosc5 T C 7: 25,363,809 (GRCm39) L107P possibly damaging Het
Fam117b T C 1: 59,952,789 (GRCm39) L156P probably damaging Het
Fam186b T G 15: 99,183,524 (GRCm39) D40A probably damaging Het
Fga T C 3: 82,940,257 (GRCm39) L637P probably damaging Het
Foxn4 T C 5: 114,393,662 (GRCm39) T486A probably damaging Het
Gcc1 A G 6: 28,418,498 (GRCm39) S612P probably benign Het
Gjd3 C T 11: 98,873,227 (GRCm39) V206M probably damaging Het
Gpam A T 19: 55,061,142 (GRCm39) probably null Het
Gpc6 A T 14: 118,125,932 (GRCm39) probably null Het
Gphb5 C G 12: 75,459,720 (GRCm39) V92L probably benign Het
Grid2ip C T 5: 143,371,847 (GRCm39) P690L probably benign Het
Gsdmc T C 15: 63,648,647 (GRCm39) E429G probably benign Het
H2bc9 T C 13: 23,727,162 (GRCm39) K121E possibly damaging Het
Heatr5a T C 12: 51,940,528 (GRCm39) D1444G possibly damaging Het
Hmcn1 T C 1: 150,474,761 (GRCm39) S4709G probably benign Het
Hr A T 14: 70,795,547 (GRCm39) D393V probably benign Het
Itgal A G 7: 126,905,873 (GRCm39) I352V possibly damaging Het
Itih4 A G 14: 30,614,385 (GRCm39) D445G probably damaging Het
Kcnh8 GAGACCAACGAGCAGCTGATGCTTCAGA GAGA 17: 53,032,934 (GRCm39) 74 probably benign Het
Kcnt2 G A 1: 140,501,421 (GRCm39) probably null Het
Klk1b21 T C 7: 43,753,863 (GRCm39) I49T possibly damaging Het
Klrb1 A T 6: 128,699,937 (GRCm39) S25T probably damaging Het
L3mbtl3 C T 10: 26,207,755 (GRCm39) W321* probably null Het
Lama2 T A 10: 26,868,932 (GRCm39) I2838F probably damaging Het
Lrrtm1 C A 6: 77,220,996 (GRCm39) A151E probably damaging Het
Lsmem1 GTACATACATACATACATACATACATACA GTACATACATACATACATACATACATACATACA 12: 40,235,260 (GRCm39) probably null Het
Magi3 G A 3: 103,928,382 (GRCm39) probably benign Het
Mamdc2 A T 19: 23,281,267 (GRCm39) probably benign Het
Mcc T C 18: 44,652,608 (GRCm39) D272G probably damaging Het
Mgst3 T A 1: 167,201,368 (GRCm39) T106S probably benign Het
Mink1 G A 11: 70,492,550 (GRCm39) probably null Het
Mlh3 G T 12: 85,307,585 (GRCm39) H1181N possibly damaging Het
Mmrn2 A G 14: 34,121,449 (GRCm39) K773R probably benign Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Mro T C 18: 74,006,368 (GRCm39) I104T probably benign Het
Mtbp G A 15: 55,432,556 (GRCm39) probably null Het
Mtss2 A G 8: 111,455,362 (GRCm39) K92E possibly damaging Het
Mybphl A G 3: 108,272,317 (GRCm39) E2G probably damaging Het
Nbeal1 T A 1: 60,370,037 (GRCm39) probably benign Het
Neurod2 C A 11: 98,218,582 (GRCm39) C194F probably damaging Het
Nr4a2 T A 2: 57,002,018 (GRCm39) D145V possibly damaging Het
Ntmt1 C A 2: 30,710,472 (GRCm39) N58K probably benign Het
Nup205 T C 6: 35,218,284 (GRCm39) S1819P possibly damaging Het
Obsl1 T C 1: 75,482,342 (GRCm39) H176R probably damaging Het
Or51f1d G A 7: 102,701,344 (GRCm39) V280I probably benign Het
Or7g21 A T 9: 19,032,737 (GRCm39) H162L probably benign Het
Or8d2b A G 9: 38,789,359 (GRCm39) T296A probably benign Het
P2ry13 T C 3: 59,117,449 (GRCm39) M110V probably damaging Het
P2ry14 T C 3: 59,022,992 (GRCm39) N165S probably damaging Het
Phka1 A G X: 101,584,716 (GRCm39) probably benign Het
Plxnd1 A G 6: 115,939,704 (GRCm39) V1425A probably benign Het
Ppp2ca G A 11: 52,008,913 (GRCm39) G138R probably damaging Het
Ptpn12 A T 5: 21,203,409 (GRCm39) N456K probably damaging Het
Scarb1 A T 5: 125,364,439 (GRCm39) S97T possibly damaging Het
Scyl1 C T 19: 5,811,749 (GRCm39) D440N possibly damaging Het
Sema5a C A 15: 32,575,065 (GRCm39) T391K probably benign Het
Sipa1l3 T A 7: 29,099,027 (GRCm39) N414I probably damaging Het
Skint6 T C 4: 112,700,019 (GRCm39) probably null Het
Slc35a3 T C 3: 116,467,285 (GRCm39) K325E possibly damaging Het
Spag17 C A 3: 99,969,182 (GRCm39) probably null Het
Spib T A 7: 44,178,348 (GRCm39) M141L probably benign Het
Srebf1 A G 11: 60,097,973 (GRCm39) S44P probably damaging Het
Styk1 T C 6: 131,289,539 (GRCm39) E25G probably benign Het
Taar8b T C 10: 23,967,270 (GRCm39) N308S probably damaging Het
Taf15 T G 11: 83,388,088 (GRCm39) S200R probably damaging Het
Tanc1 G A 2: 59,667,563 (GRCm39) probably null Het
Tas2r134 A G 2: 51,518,249 (GRCm39) T243A probably benign Het
Tatdn1 A T 15: 58,777,601 (GRCm39) M218K probably damaging Het
Tbc1d14 A G 5: 36,700,561 (GRCm39) L269P possibly damaging Het
Tbx1 T C 16: 18,400,744 (GRCm39) probably null Het
Tgfbr3l A G 8: 4,300,506 (GRCm39) E228G probably benign Het
Tmem233 G C 5: 116,189,517 (GRCm39) probably benign Het
Tmprss11d A G 5: 86,521,208 (GRCm39) Y2H probably benign Het
Trps1 G A 15: 50,685,794 (GRCm39) R544C probably damaging Het
Ttc22 T C 4: 106,496,282 (GRCm39) V444A possibly damaging Het
Ttc28 A G 5: 111,373,869 (GRCm39) T1071A possibly damaging Het
Tymp A T 15: 89,258,011 (GRCm39) V378D probably damaging Het
Ube2j1 T A 4: 33,049,943 (GRCm39) F257I possibly damaging Het
Vmn2r18 T C 5: 151,510,127 (GRCm39) E82G probably damaging Het
Wwp1 T C 4: 19,638,618 (GRCm39) D575G probably damaging Het
Other mutations in Ido2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0413:Ido2 UTSW 8 25,048,159 (GRCm39) splice site probably null
R1103:Ido2 UTSW 8 25,066,239 (GRCm39) missense probably benign 0.08
R1601:Ido2 UTSW 8 25,066,205 (GRCm39) missense possibly damaging 0.57
R1868:Ido2 UTSW 8 25,043,776 (GRCm39) missense possibly damaging 0.90
R2158:Ido2 UTSW 8 25,030,652 (GRCm39) missense probably damaging 1.00
R2266:Ido2 UTSW 8 25,025,268 (GRCm39) missense probably damaging 1.00
R2268:Ido2 UTSW 8 25,025,268 (GRCm39) missense probably damaging 1.00
R2484:Ido2 UTSW 8 25,023,831 (GRCm39) missense probably damaging 1.00
R3151:Ido2 UTSW 8 25,023,776 (GRCm39) missense possibly damaging 0.61
R3735:Ido2 UTSW 8 25,025,209 (GRCm39) missense probably damaging 0.98
R3820:Ido2 UTSW 8 25,023,771 (GRCm39) missense probably benign 0.00
R3821:Ido2 UTSW 8 25,023,771 (GRCm39) missense probably benign 0.00
R3822:Ido2 UTSW 8 25,023,771 (GRCm39) missense probably benign 0.00
R4520:Ido2 UTSW 8 25,066,194 (GRCm39) missense probably damaging 0.99
R4824:Ido2 UTSW 8 25,023,875 (GRCm39) missense probably benign 0.12
R4949:Ido2 UTSW 8 25,023,970 (GRCm39) critical splice acceptor site probably null
R5235:Ido2 UTSW 8 25,037,202 (GRCm39) missense probably damaging 0.99
R5580:Ido2 UTSW 8 25,040,882 (GRCm39) missense possibly damaging 0.67
R5961:Ido2 UTSW 8 25,023,786 (GRCm39) missense probably damaging 1.00
R6433:Ido2 UTSW 8 25,023,939 (GRCm39) missense probably damaging 1.00
R7085:Ido2 UTSW 8 25,048,212 (GRCm39) missense probably benign 0.09
R7186:Ido2 UTSW 8 25,040,826 (GRCm39) splice site probably null
R7248:Ido2 UTSW 8 25,038,839 (GRCm39) missense probably damaging 0.97
R7248:Ido2 UTSW 8 25,030,657 (GRCm39) nonsense probably null
R7287:Ido2 UTSW 8 25,025,154 (GRCm39) splice site probably null
R7788:Ido2 UTSW 8 25,037,242 (GRCm39) missense probably damaging 0.99
R7923:Ido2 UTSW 8 25,066,209 (GRCm39) missense probably damaging 1.00
R8026:Ido2 UTSW 8 25,025,156 (GRCm39) critical splice donor site probably null
R8191:Ido2 UTSW 8 25,023,696 (GRCm39) missense probably damaging 1.00
R9132:Ido2 UTSW 8 25,023,933 (GRCm39) missense probably damaging 1.00
R9429:Ido2 UTSW 8 25,037,194 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGTTGCTAGAGATGTCTCCC -3'
(R):5'- AAAGGCTCCACCATGACGTG -3'

Sequencing Primer
(F):5'- AGTTGCTAGAGATGTCTCCCTAGTC -3'
(R):5'- GGATACTCTAGCAAGCTTCATTCAC -3'
Posted On 2014-10-16