Mutagenetix > Incidental Mutation

Incidental Mutation 'R2267:Trps1'

242173

Institutional Source

Beutler Lab

Gene Symbol

Trps1

Ensembl Gene

ENSMUSG00000038679

Gene Name

transcriptional repressor GATA binding 1

Synonyms

D15Ertd586e, trichorhinophalangeal syndrome I (human)

MMRRC Submission

040267-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R2267 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

50518148-50753859 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 50685794 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Cysteine at position 544 (R544C)

Ref Sequence

ENSEMBL: ENSMUSP00000138905 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077935] [ENSMUST00000165201] [ENSMUST00000183421] [ENSMUST00000183757] [ENSMUST00000183997] [ENSMUST00000184458] [ENSMUST00000184885]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000077935
AA Change: R790C

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000077089
Gene: ENSMUSG00000038679
AA Change: R790C

Domain	Start	End	E-Value	Type
ZnF_C2H2	222	247	1.41e0	SMART
ZnF_C2H2	333	358	4.45e0	SMART
ZnF_C2H2	434	459	1.31e2	SMART
ZnF_C2H2	523	554	1.93e2	SMART
low complexity region	597	602	N/A	INTRINSIC
ZnF_C2H2	614	637	8.67e-1	SMART
ZnF_C2H2	666	689	2.29e0	SMART
ZnF_C2H2	692	715	8.22e-2	SMART
low complexity region	766	779	N/A	INTRINSIC
ZnF_GATA	890	940	3.95e-16	SMART
low complexity region	1050	1062	N/A	INTRINSIC
ZnF_C2H2	1215	1237	4.34e0	SMART
ZnF_C2H2	1243	1267	5.72e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000165201
AA Change: R790C

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000129779
Gene: ENSMUSG00000038679
AA Change: R790C

Domain	Start	End	E-Value	Type
ZnF_C2H2	222	247	1.41e0	SMART
ZnF_C2H2	333	358	4.45e0	SMART
ZnF_C2H2	434	459	1.31e2	SMART
ZnF_C2H2	523	554	1.93e2	SMART
low complexity region	597	602	N/A	INTRINSIC
ZnF_C2H2	614	637	8.67e-1	SMART
ZnF_C2H2	666	689	2.29e0	SMART
ZnF_C2H2	692	715	8.22e-2	SMART
low complexity region	766	779	N/A	INTRINSIC
ZnF_GATA	890	940	3.95e-16	SMART
low complexity region	1050	1062	N/A	INTRINSIC
ZnF_C2H2	1215	1237	4.34e0	SMART
ZnF_C2H2	1243	1267	5.72e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000183421
AA Change: R124C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138835
Gene: ENSMUSG00000038679
AA Change: R124C

Domain	Start	End	E-Value	Type
ZnF_C2H2	26	49	8.22e-2	SMART
low complexity region	100	113	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000183757
AA Change: R794C

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000139017
Gene: ENSMUSG00000038679
AA Change: R794C

Domain	Start	End	E-Value	Type
ZnF_C2H2	226	251	1.41e0	SMART
ZnF_C2H2	337	362	4.45e0	SMART
ZnF_C2H2	438	463	1.31e2	SMART
ZnF_C2H2	527	558	1.93e2	SMART
low complexity region	601	606	N/A	INTRINSIC
ZnF_C2H2	618	641	8.67e-1	SMART
ZnF_C2H2	670	693	2.29e0	SMART
ZnF_C2H2	696	719	8.22e-2	SMART
low complexity region	770	783	N/A	INTRINSIC
ZnF_GATA	894	944	3.95e-16	SMART
low complexity region	1054	1066	N/A	INTRINSIC
ZnF_C2H2	1219	1241	4.34e0	SMART
ZnF_C2H2	1247	1271	5.72e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000183997
AA Change: R594C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000139115
Gene: ENSMUSG00000038679
AA Change: R594C

Domain	Start	End	E-Value	Type
ZnF_C2H2	226	251	1.41e0	SMART
ZnF_C2H2	337	362	4.45e0	SMART
ZnF_C2H2	470	493	2.29e0	SMART
ZnF_C2H2	496	519	8.22e-2	SMART
low complexity region	570	583	N/A	INTRINSIC
ZnF_GATA	705	755	3.95e-16	SMART
low complexity region	865	877	N/A	INTRINSIC
ZnF_C2H2	1030	1052	4.34e0	SMART
ZnF_C2H2	1058	1082	5.72e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000184458
AA Change: R503C

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000139063
Gene: ENSMUSG00000038679
AA Change: R503C

Domain	Start	End	E-Value	Type
ZnF_C2H2	46	71	4.45e0	SMART
ZnF_C2H2	147	172	1.31e2	SMART
ZnF_C2H2	236	267	1.93e2	SMART
low complexity region	310	315	N/A	INTRINSIC
ZnF_C2H2	327	350	8.67e-1	SMART
ZnF_C2H2	379	402	2.29e0	SMART
ZnF_C2H2	405	428	8.22e-2	SMART
low complexity region	479	492	N/A	INTRINSIC
ZnF_GATA	603	653	3.95e-16	SMART
low complexity region	763	775	N/A	INTRINSIC
ZnF_C2H2	928	950	4.34e0	SMART
ZnF_C2H2	956	980	5.72e-1	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000184885
AA Change: R544C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138905
Gene: ENSMUSG00000038679
AA Change: R544C

Domain	Start	End	E-Value	Type
ZnF_C2H2	176	201	1.41e0	SMART
ZnF_C2H2	287	312	4.45e0	SMART
ZnF_C2H2	420	443	2.29e0	SMART
ZnF_C2H2	446	469	8.22e-2	SMART
low complexity region	520	533	N/A	INTRINSIC
ZnF_GATA	644	694	3.95e-16	SMART
low complexity region	804	816	N/A	INTRINSIC
ZnF_C2H2	969	991	4.34e0	SMART
ZnF_C2H2	997	1021	5.72e-1	SMART

Meta Mutation Damage Score

0.2929

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.1%

Validation Efficiency

98% (108/110)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]
PHENOTYPE: Newborn mice homozygous for a knock-out allele exhibit craniofacial and hair anomalies and die of respiratory failure due to thoracic spine and rib defects. Mice homozygous for a reporter allele show additional defects in chondrocyte proliferation and apoptosis as well as reduced nephron formation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 104 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadac	T	A	3: 59,944,737 (GRCm39)	D136E	probably damaging	Het
Abca16	A	G	7: 120,030,383 (GRCm39)	D165G	probably benign	Het
Abca8b	G	A	11: 109,845,974 (GRCm39)	T820M	probably benign	Het
Acot2	C	T	12: 84,037,334 (GRCm39)	A216V	probably damaging	Het
Agap2	T	A	10: 126,918,297 (GRCm39)		probably benign	Het
Ak7	T	C	12: 105,713,473 (GRCm39)	V419A	probably benign	Het
Apmap	A	G	2: 150,430,821 (GRCm39)		probably null	Het
Apob	T	C	12: 8,065,475 (GRCm39)	F4115S	possibly damaging	Het
Cachd1	T	A	4: 100,806,266 (GRCm39)		probably benign	Het
Ccdc39	T	A	3: 33,869,633 (GRCm39)	E731D	probably damaging	Het
Ces2a	A	T	8: 105,466,822 (GRCm39)	I65F	probably benign	Het
Commd8	A	G	5: 72,322,765 (GRCm39)	W51R	probably damaging	Het
D2hgdh	C	T	1: 93,763,157 (GRCm39)	A314V	probably damaging	Het
Dcun1d4	T	A	5: 73,638,618 (GRCm39)		probably benign	Het
Dgke	T	A	11: 88,943,295 (GRCm39)	E231D	probably benign	Het
Dhrs9	A	G	2: 69,223,197 (GRCm39)		probably benign	Het
Dhx30	C	T	9: 109,916,102 (GRCm39)	G662R	probably damaging	Het
Dipk2b	A	G	X: 18,289,926 (GRCm39)	S179P	possibly damaging	Het
Dnah7b	T	A	1: 46,273,075 (GRCm39)	M2401K	probably damaging	Het
Dnmt3a	T	A	12: 3,947,551 (GRCm39)		probably null	Het
Dst	C	T	1: 34,334,547 (GRCm39)	T4874I	probably damaging	Het
Eef2kmt	G	A	16: 5,073,804 (GRCm39)		probably benign	Het
Ess2	T	C	16: 17,727,859 (GRCm39)	T107A	probably damaging	Het
Etfa	A	T	9: 55,394,015 (GRCm39)	L212Q	probably damaging	Het
Exosc5	T	C	7: 25,363,809 (GRCm39)	L107P	possibly damaging	Het
Fam117b	T	C	1: 59,952,789 (GRCm39)	L156P	probably damaging	Het
Fam186b	T	G	15: 99,183,524 (GRCm39)	D40A	probably damaging	Het
Fga	T	C	3: 82,940,257 (GRCm39)	L637P	probably damaging	Het
Foxn4	T	C	5: 114,393,662 (GRCm39)	T486A	probably damaging	Het
Gcc1	A	G	6: 28,418,498 (GRCm39)	S612P	probably benign	Het
Gjd3	C	T	11: 98,873,227 (GRCm39)	V206M	probably damaging	Het
Gpam	A	T	19: 55,061,142 (GRCm39)		probably null	Het
Gpc6	A	T	14: 118,125,932 (GRCm39)		probably null	Het
Gphb5	C	G	12: 75,459,720 (GRCm39)	V92L	probably benign	Het
Grid2ip	C	T	5: 143,371,847 (GRCm39)	P690L	probably benign	Het
Gsdmc	T	C	15: 63,648,647 (GRCm39)	E429G	probably benign	Het
H2bc9	T	C	13: 23,727,162 (GRCm39)	K121E	possibly damaging	Het
Heatr5a	T	C	12: 51,940,528 (GRCm39)	D1444G	possibly damaging	Het
Hmcn1	T	C	1: 150,474,761 (GRCm39)	S4709G	probably benign	Het
Hr	A	T	14: 70,795,547 (GRCm39)	D393V	probably benign	Het
Ido2	T	C	8: 25,025,268 (GRCm39)	Y253C	probably damaging	Het
Itgal	A	G	7: 126,905,873 (GRCm39)	I352V	possibly damaging	Het
Itih4	A	G	14: 30,614,385 (GRCm39)	D445G	probably damaging	Het
Kcnh8	GAGACCAACGAGCAGCTGATGCTTCAGA	GAGA	17: 53,032,934 (GRCm39)	74	probably benign	Het
Kcnt2	G	A	1: 140,501,421 (GRCm39)		probably null	Het
Klk1b21	T	C	7: 43,753,863 (GRCm39)	I49T	possibly damaging	Het
Klrb1	A	T	6: 128,699,937 (GRCm39)	S25T	probably damaging	Het
L3mbtl3	C	T	10: 26,207,755 (GRCm39)	W321*	probably null	Het
Lama2	T	A	10: 26,868,932 (GRCm39)	I2838F	probably damaging	Het
Lrrtm1	C	A	6: 77,220,996 (GRCm39)	A151E	probably damaging	Het
Lsmem1	GTACATACATACATACATACATACATACA	GTACATACATACATACATACATACATACATACA	12: 40,235,260 (GRCm39)		probably null	Het
Magi3	G	A	3: 103,928,382 (GRCm39)		probably benign	Het
Mamdc2	A	T	19: 23,281,267 (GRCm39)		probably benign	Het
Mcc	T	C	18: 44,652,608 (GRCm39)	D272G	probably damaging	Het
Mgst3	T	A	1: 167,201,368 (GRCm39)	T106S	probably benign	Het
Mink1	G	A	11: 70,492,550 (GRCm39)		probably null	Het
Mlh3	G	T	12: 85,307,585 (GRCm39)	H1181N	possibly damaging	Het
Mmrn2	A	G	14: 34,121,449 (GRCm39)	K773R	probably benign	Het
Mrc2	G	A	11: 105,239,257 (GRCm39)		probably null	Het
Mro	T	C	18: 74,006,368 (GRCm39)	I104T	probably benign	Het
Mtbp	G	A	15: 55,432,556 (GRCm39)		probably null	Het
Mtss2	A	G	8: 111,455,362 (GRCm39)	K92E	possibly damaging	Het
Mybphl	A	G	3: 108,272,317 (GRCm39)	E2G	probably damaging	Het
Nbeal1	T	A	1: 60,370,037 (GRCm39)		probably benign	Het
Neurod2	C	A	11: 98,218,582 (GRCm39)	C194F	probably damaging	Het
Nr4a2	T	A	2: 57,002,018 (GRCm39)	D145V	possibly damaging	Het
Ntmt1	C	A	2: 30,710,472 (GRCm39)	N58K	probably benign	Het
Nup205	T	C	6: 35,218,284 (GRCm39)	S1819P	possibly damaging	Het
Obsl1	T	C	1: 75,482,342 (GRCm39)	H176R	probably damaging	Het
Or51f1d	G	A	7: 102,701,344 (GRCm39)	V280I	probably benign	Het
Or7g21	A	T	9: 19,032,737 (GRCm39)	H162L	probably benign	Het
Or8d2b	A	G	9: 38,789,359 (GRCm39)	T296A	probably benign	Het
P2ry13	T	C	3: 59,117,449 (GRCm39)	M110V	probably damaging	Het
P2ry14	T	C	3: 59,022,992 (GRCm39)	N165S	probably damaging	Het
Phka1	A	G	X: 101,584,716 (GRCm39)		probably benign	Het
Plxnd1	A	G	6: 115,939,704 (GRCm39)	V1425A	probably benign	Het
Ppp2ca	G	A	11: 52,008,913 (GRCm39)	G138R	probably damaging	Het
Ptpn12	A	T	5: 21,203,409 (GRCm39)	N456K	probably damaging	Het
Scarb1	A	T	5: 125,364,439 (GRCm39)	S97T	possibly damaging	Het
Scyl1	C	T	19: 5,811,749 (GRCm39)	D440N	possibly damaging	Het
Sema5a	C	A	15: 32,575,065 (GRCm39)	T391K	probably benign	Het
Sipa1l3	T	A	7: 29,099,027 (GRCm39)	N414I	probably damaging	Het
Skint6	T	C	4: 112,700,019 (GRCm39)		probably null	Het
Slc35a3	T	C	3: 116,467,285 (GRCm39)	K325E	possibly damaging	Het
Spag17	C	A	3: 99,969,182 (GRCm39)		probably null	Het
Spib	T	A	7: 44,178,348 (GRCm39)	M141L	probably benign	Het
Srebf1	A	G	11: 60,097,973 (GRCm39)	S44P	probably damaging	Het
Styk1	T	C	6: 131,289,539 (GRCm39)	E25G	probably benign	Het
Taar8b	T	C	10: 23,967,270 (GRCm39)	N308S	probably damaging	Het
Taf15	T	G	11: 83,388,088 (GRCm39)	S200R	probably damaging	Het
Tanc1	G	A	2: 59,667,563 (GRCm39)		probably null	Het
Tas2r134	A	G	2: 51,518,249 (GRCm39)	T243A	probably benign	Het
Tatdn1	A	T	15: 58,777,601 (GRCm39)	M218K	probably damaging	Het
Tbc1d14	A	G	5: 36,700,561 (GRCm39)	L269P	possibly damaging	Het
Tbx1	T	C	16: 18,400,744 (GRCm39)		probably null	Het
Tgfbr3l	A	G	8: 4,300,506 (GRCm39)	E228G	probably benign	Het
Tmem233	G	C	5: 116,189,517 (GRCm39)		probably benign	Het
Tmprss11d	A	G	5: 86,521,208 (GRCm39)	Y2H	probably benign	Het
Ttc22	T	C	4: 106,496,282 (GRCm39)	V444A	possibly damaging	Het
Ttc28	A	G	5: 111,373,869 (GRCm39)	T1071A	possibly damaging	Het
Tymp	A	T	15: 89,258,011 (GRCm39)	V378D	probably damaging	Het
Ube2j1	T	A	4: 33,049,943 (GRCm39)	F257I	possibly damaging	Het
Vmn2r18	T	C	5: 151,510,127 (GRCm39)	E82G	probably damaging	Het
Wwp1	T	C	4: 19,638,618 (GRCm39)	D575G	probably damaging	Het

Other mutations in Trps1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00420:Trps1	APN	15	50,710,266 (GRCm39)	missense	probably benign	0.07
IGL00497:Trps1	APN	15	50,524,703 (GRCm39)	missense	possibly damaging	0.91
IGL00558:Trps1	APN	15	50,524,481 (GRCm39)	missense	probably damaging	1.00
IGL01325:Trps1	APN	15	50,710,210 (GRCm39)	missense	probably benign	0.40
IGL02132:Trps1	APN	15	50,685,674 (GRCm39)	missense	probably damaging	1.00
IGL02631:Trps1	APN	15	50,709,417 (GRCm39)	missense	probably damaging	1.00
IGL02740:Trps1	APN	15	50,709,935 (GRCm39)	missense	probably damaging	1.00
IGL02821:Trps1	APN	15	50,524,273 (GRCm39)	missense	probably damaging	1.00
IGL03096:Trps1	APN	15	50,709,875 (GRCm39)	missense	probably benign
F5770:Trps1	UTSW	15	50,694,973 (GRCm39)	missense	probably damaging	1.00
R0050:Trps1	UTSW	15	50,628,921 (GRCm39)	missense	probably benign	0.18
R0244:Trps1	UTSW	15	50,528,139 (GRCm39)	missense	probably damaging	1.00
R0377:Trps1	UTSW	15	50,695,174 (GRCm39)	nonsense	probably null
R0599:Trps1	UTSW	15	50,695,256 (GRCm39)	nonsense	probably null
R0848:Trps1	UTSW	15	50,524,945 (GRCm39)	missense	possibly damaging	0.54
R1744:Trps1	UTSW	15	50,524,609 (GRCm39)	missense	probably damaging	1.00
R1830:Trps1	UTSW	15	50,524,532 (GRCm39)	missense	probably damaging	0.99
R2083:Trps1	UTSW	15	50,685,701 (GRCm39)	missense	probably damaging	1.00
R2167:Trps1	UTSW	15	50,695,126 (GRCm39)	missense	possibly damaging	0.94
R2314:Trps1	UTSW	15	50,524,742 (GRCm39)	missense	probably damaging	1.00
R3735:Trps1	UTSW	15	50,709,456 (GRCm39)	missense	possibly damaging	0.94
R4133:Trps1	UTSW	15	50,694,783 (GRCm39)	missense	probably damaging	1.00
R4223:Trps1	UTSW	15	50,710,044 (GRCm39)	missense	probably benign
R4280:Trps1	UTSW	15	50,709,478 (GRCm39)	missense	probably benign	0.00
R4566:Trps1	UTSW	15	50,695,074 (GRCm39)	missense	probably damaging	1.00
R4810:Trps1	UTSW	15	50,685,692 (GRCm39)	missense	probably benign	0.14
R4828:Trps1	UTSW	15	50,524,073 (GRCm39)	makesense	probably null
R4838:Trps1	UTSW	15	50,690,712 (GRCm39)	missense	probably benign	0.05
R4852:Trps1	UTSW	15	50,709,705 (GRCm39)	missense	probably damaging	1.00
R5001:Trps1	UTSW	15	50,524,703 (GRCm39)	missense	possibly damaging	0.91
R5311:Trps1	UTSW	15	50,528,156 (GRCm39)	missense	probably damaging	1.00
R5463:Trps1	UTSW	15	50,695,286 (GRCm39)	nonsense	probably null
R5677:Trps1	UTSW	15	50,709,504 (GRCm39)	missense	probably damaging	1.00
R5691:Trps1	UTSW	15	50,690,700 (GRCm39)	missense	probably benign
R6432:Trps1	UTSW	15	50,694,793 (GRCm39)	missense	probably damaging	0.96
R6528:Trps1	UTSW	15	50,685,823 (GRCm39)	missense	probably benign	0.01
R6594:Trps1	UTSW	15	50,694,351 (GRCm39)	missense	probably damaging	0.99
R6827:Trps1	UTSW	15	50,685,959 (GRCm39)	missense	probably benign	0.14
R6862:Trps1	UTSW	15	50,695,001 (GRCm39)	critical splice donor site	probably null
R6912:Trps1	UTSW	15	50,685,694 (GRCm39)	missense	possibly damaging	0.92
R7151:Trps1	UTSW	15	50,685,793 (GRCm39)	missense	possibly damaging	0.95
R7846:Trps1	UTSW	15	50,695,273 (GRCm39)	missense	probably damaging	0.99
R7857:Trps1	UTSW	15	50,524,401 (GRCm39)	missense	probably damaging	1.00
R7986:Trps1	UTSW	15	50,753,019 (GRCm39)	missense	probably benign	0.00
R7986:Trps1	UTSW	15	50,525,132 (GRCm39)	missense	probably damaging	1.00
R8744:Trps1	UTSW	15	50,524,642 (GRCm39)	missense	probably damaging	1.00
R8838:Trps1	UTSW	15	50,753,007 (GRCm39)	missense	probably benign	0.01
R8859:Trps1	UTSW	15	50,685,769 (GRCm39)	missense	possibly damaging	0.77
R8935:Trps1	UTSW	15	50,752,344 (GRCm39)	nonsense	probably null
R9044:Trps1	UTSW	15	50,686,003 (GRCm39)	missense	probably benign	0.11
R9142:Trps1	UTSW	15	50,524,658 (GRCm39)	missense	probably damaging	0.98
R9211:Trps1	UTSW	15	50,694,840 (GRCm39)	missense	probably damaging	1.00
R9283:Trps1	UTSW	15	50,694,447 (GRCm39)	missense	probably damaging	1.00
R9363:Trps1	UTSW	15	50,524,676 (GRCm39)	missense	probably damaging	1.00
R9402:Trps1	UTSW	15	50,709,652 (GRCm39)	missense	probably damaging	1.00
R9562:Trps1	UTSW	15	50,524,657 (GRCm39)	missense	probably damaging	1.00
R9647:Trps1	UTSW	15	50,524,944 (GRCm39)	missense	probably benign	0.09
R9803:Trps1	UTSW	15	50,710,090 (GRCm39)	missense	possibly damaging	0.94
V7580:Trps1	UTSW	15	50,694,973 (GRCm39)	missense	probably damaging	1.00
V7581:Trps1	UTSW	15	50,694,973 (GRCm39)	missense	probably damaging	1.00
V7583:Trps1	UTSW	15	50,694,973 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCAGGAAGCCCTTGGTATC -3'
(R):5'- TCACTACTGCTAATGGCGAAG -3'

Sequencing Primer
(F):5'- CAGGAAGCCCTTGGTATCTACTG -3'
(R):5'- TACTGCTAATGGCGAAGAGGGTG -3'

Posted On

2014-10-16