Incidental Mutation 'R2268:Vmn2r15'
| ID |
242221 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r15
|
| Ensembl Gene |
ENSMUSG00000091375 |
| Gene Name |
vomeronasal 2, receptor 15 |
| Synonyms |
EG211223 |
| MMRRC Submission |
040268-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.090)
|
| Stock # |
R2268 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
109434135-109445422 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 109441073 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 262
(Y262H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000128333
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167133]
|
| AlphaFold |
L7N2A0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167133
AA Change: Y262H
PolyPhen 2
Score 0.311 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000128333
Gene: ENSMUSG00000091375
AA Change: Y262H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
75 |
472 |
1e-29 |
PFAM |
|
Pfam:NCD3G
|
514 |
568 |
5.8e-18 |
PFAM |
|
Pfam:7tm_3
|
601 |
836 |
9.1e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.2%
- 20x: 94.7%
|
| Validation Efficiency |
100% (82/82) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acox2 |
A |
T |
14: 8,253,496 (GRCm38) |
M217K |
probably damaging |
Het |
| Adam34 |
C |
T |
8: 44,103,647 (GRCm39) |
R666H |
probably benign |
Het |
| Adap2 |
G |
T |
11: 80,056,552 (GRCm39) |
Q188H |
probably damaging |
Het |
| Adgrb3 |
T |
C |
1: 25,150,898 (GRCm39) |
T872A |
possibly damaging |
Het |
| Ahnak |
A |
G |
19: 8,987,938 (GRCm39) |
K3074R |
possibly damaging |
Het |
| Ano7 |
A |
T |
1: 93,308,161 (GRCm39) |
D64V |
possibly damaging |
Het |
| Apob |
T |
C |
12: 8,065,475 (GRCm39) |
F4115S |
possibly damaging |
Het |
| Arl13a |
A |
G |
X: 133,106,162 (GRCm39) |
Q236R |
possibly damaging |
Het |
| Astn1 |
T |
C |
1: 158,329,669 (GRCm39) |
Y175H |
probably damaging |
Het |
| Atn1 |
C |
G |
6: 124,723,203 (GRCm39) |
|
probably benign |
Het |
| Ccser1 |
C |
T |
6: 61,547,827 (GRCm39) |
T118M |
probably damaging |
Het |
| Cenpe |
A |
G |
3: 134,967,397 (GRCm39) |
T2180A |
probably benign |
Het |
| Col17a1 |
G |
A |
19: 47,638,550 (GRCm39) |
P1173S |
probably benign |
Het |
| Commd8 |
A |
G |
5: 72,322,765 (GRCm39) |
W51R |
probably damaging |
Het |
| Cyp4f17 |
G |
T |
17: 32,736,928 (GRCm39) |
V87F |
probably benign |
Het |
| D2hgdh |
C |
T |
1: 93,763,157 (GRCm39) |
A314V |
probably damaging |
Het |
| Dcun1d4 |
T |
A |
5: 73,638,618 (GRCm39) |
|
probably benign |
Het |
| Dhodh |
A |
G |
8: 110,321,306 (GRCm39) |
F360S |
possibly damaging |
Het |
| Dipk2b |
A |
G |
X: 18,289,926 (GRCm39) |
S179P |
possibly damaging |
Het |
| Dynap |
C |
T |
18: 70,374,218 (GRCm39) |
A103T |
probably benign |
Het |
| Edem2 |
G |
A |
2: 155,544,137 (GRCm39) |
P538S |
probably benign |
Het |
| Egfl8 |
C |
T |
17: 34,832,832 (GRCm39) |
V253M |
probably damaging |
Het |
| Erich6 |
A |
T |
3: 58,526,260 (GRCm39) |
S581T |
probably benign |
Het |
| Fam117b |
T |
C |
1: 59,952,789 (GRCm39) |
L156P |
probably damaging |
Het |
| Fbn1 |
G |
T |
2: 125,163,661 (GRCm39) |
A2065E |
possibly damaging |
Het |
| Foxn4 |
T |
C |
5: 114,393,662 (GRCm39) |
T486A |
probably damaging |
Het |
| Fzd9 |
A |
G |
5: 135,279,148 (GRCm39) |
S246P |
probably damaging |
Het |
| Hdhd2 |
C |
T |
18: 77,052,866 (GRCm39) |
T172M |
probably benign |
Het |
| Heatr5a |
T |
C |
12: 51,940,528 (GRCm39) |
D1444G |
possibly damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,500,349 (GRCm39) |
|
probably benign |
Het |
| Hps3 |
G |
A |
3: 20,067,099 (GRCm39) |
|
probably benign |
Het |
| Hr |
A |
T |
14: 70,795,547 (GRCm39) |
D393V |
probably benign |
Het |
| Ido2 |
T |
C |
8: 25,025,268 (GRCm39) |
Y253C |
probably damaging |
Het |
| Irs2 |
T |
C |
8: 11,057,586 (GRCm39) |
E282G |
probably damaging |
Het |
| Itih4 |
A |
G |
14: 30,614,385 (GRCm39) |
D445G |
probably damaging |
Het |
| Kif14 |
T |
A |
1: 136,447,486 (GRCm39) |
C1430* |
probably null |
Het |
| Kir3dl1 |
A |
G |
X: 135,425,784 (GRCm39) |
R53G |
probably benign |
Het |
| Lama2 |
T |
A |
10: 26,868,932 (GRCm39) |
I2838F |
probably damaging |
Het |
| Lamb1 |
A |
T |
12: 31,377,644 (GRCm39) |
I1630F |
probably damaging |
Het |
| Lsmem1 |
GTACATACATACATACATACATACATACA |
GTACATACATACATACATACATACATACATACA |
12: 40,235,260 (GRCm39) |
|
probably null |
Het |
| Magi3 |
G |
A |
3: 103,928,382 (GRCm39) |
|
probably benign |
Het |
| Mink1 |
G |
A |
11: 70,492,550 (GRCm39) |
|
probably null |
Het |
| Mmrn2 |
A |
G |
14: 34,121,449 (GRCm39) |
K773R |
probably benign |
Het |
| Mpdz |
A |
G |
4: 81,301,628 (GRCm39) |
S266P |
probably damaging |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Mtbp |
G |
A |
15: 55,432,556 (GRCm39) |
|
probably null |
Het |
| Mybphl |
A |
G |
3: 108,272,317 (GRCm39) |
E2G |
probably damaging |
Het |
| Myoc |
C |
T |
1: 162,476,625 (GRCm39) |
T443M |
probably damaging |
Het |
| Nav1 |
A |
T |
1: 135,399,974 (GRCm39) |
L532* |
probably null |
Het |
| Nbeal1 |
T |
A |
1: 60,370,037 (GRCm39) |
|
probably benign |
Het |
| Nfix |
CAAAAA |
CAAAA |
8: 85,442,876 (GRCm39) |
|
probably null |
Het |
| Opcml |
T |
C |
9: 28,814,651 (GRCm39) |
I301T |
possibly damaging |
Het |
| Or10ak16 |
A |
T |
4: 118,751,071 (GRCm39) |
R264W |
probably damaging |
Het |
| Or8b1 |
T |
A |
9: 38,399,504 (GRCm39) |
Y60N |
probably damaging |
Het |
| Pappa2 |
A |
G |
1: 158,684,841 (GRCm39) |
M766T |
probably damaging |
Het |
| Phf8 |
T |
C |
X: 150,355,597 (GRCm39) |
L520S |
possibly damaging |
Het |
| Phka1 |
A |
G |
X: 101,584,716 (GRCm39) |
|
probably benign |
Het |
| Ppp2ca |
G |
A |
11: 52,008,913 (GRCm39) |
G138R |
probably damaging |
Het |
| Prrc1 |
G |
T |
18: 57,514,718 (GRCm39) |
D312Y |
probably damaging |
Het |
| Rdh7 |
A |
G |
10: 127,720,530 (GRCm39) |
S281P |
probably benign |
Het |
| Rps17 |
C |
T |
7: 80,994,746 (GRCm39) |
R5H |
probably benign |
Het |
| Scgb1b2 |
T |
A |
7: 30,991,201 (GRCm39) |
|
probably benign |
Het |
| Skic3 |
T |
G |
13: 76,260,393 (GRCm39) |
|
probably benign |
Het |
| Slc35a3 |
T |
C |
3: 116,467,285 (GRCm39) |
K325E |
possibly damaging |
Het |
| Snap23 |
A |
G |
2: 120,429,793 (GRCm39) |
T213A |
probably benign |
Het |
| Spag17 |
C |
A |
3: 99,969,182 (GRCm39) |
|
probably null |
Het |
| Srebf1 |
A |
G |
11: 60,097,973 (GRCm39) |
S44P |
probably damaging |
Het |
| St8sia5 |
T |
C |
18: 77,320,526 (GRCm39) |
S93P |
probably damaging |
Het |
| Styk1 |
T |
C |
6: 131,289,539 (GRCm39) |
E25G |
probably benign |
Het |
| Taar8b |
T |
C |
10: 23,967,270 (GRCm39) |
N308S |
probably damaging |
Het |
| Tbc1d14 |
A |
G |
5: 36,700,561 (GRCm39) |
L269P |
possibly damaging |
Het |
| Tbc1d22b |
A |
G |
17: 29,818,828 (GRCm39) |
H394R |
probably damaging |
Het |
| Tbx5 |
A |
T |
5: 119,983,174 (GRCm39) |
|
probably null |
Het |
| Tgfbr3l |
A |
G |
8: 4,300,506 (GRCm39) |
E228G |
probably benign |
Het |
| Tlr5 |
T |
A |
1: 182,802,600 (GRCm39) |
S635T |
possibly damaging |
Het |
| Tmem233 |
G |
C |
5: 116,189,517 (GRCm39) |
|
probably benign |
Het |
| Tymp |
A |
T |
15: 89,258,011 (GRCm39) |
V378D |
probably damaging |
Het |
| Vangl1 |
A |
T |
3: 102,104,160 (GRCm39) |
Y7N |
probably damaging |
Het |
| Vav2 |
A |
T |
2: 27,182,667 (GRCm39) |
|
probably null |
Het |
| Vcp |
G |
A |
4: 42,980,833 (GRCm39) |
A759V |
possibly damaging |
Het |
| Vmn2r76 |
T |
C |
7: 85,879,707 (GRCm39) |
M198V |
probably benign |
Het |
| Zfp831 |
A |
C |
2: 174,486,034 (GRCm39) |
R236S |
probably benign |
Het |
|
| Other mutations in Vmn2r15 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01335:Vmn2r15
|
APN |
5 |
109,434,602 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL01367:Vmn2r15
|
APN |
5 |
109,441,075 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01844:Vmn2r15
|
APN |
5 |
109,434,135 (GRCm39) |
makesense |
probably null |
|
|
IGL02190:Vmn2r15
|
APN |
5 |
109,441,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02754:Vmn2r15
|
APN |
5 |
109,441,134 (GRCm39) |
nonsense |
probably null |
|
|
IGL02797:Vmn2r15
|
APN |
5 |
109,445,250 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03301:Vmn2r15
|
APN |
5 |
109,445,221 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03407:Vmn2r15
|
APN |
5 |
109,434,185 (GRCm39) |
nonsense |
probably null |
|
|
BB001:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4445001:Vmn2r15
|
UTSW |
5 |
109,435,008 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4520001:Vmn2r15
|
UTSW |
5 |
109,434,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Vmn2r15
|
UTSW |
5 |
109,441,010 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R0111:Vmn2r15
|
UTSW |
5 |
109,435,022 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0379:Vmn2r15
|
UTSW |
5 |
109,434,344 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0427:Vmn2r15
|
UTSW |
5 |
109,434,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Vmn2r15
|
UTSW |
5 |
109,440,881 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0964:Vmn2r15
|
UTSW |
5 |
109,445,401 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Vmn2r15
|
UTSW |
5 |
109,441,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1232:Vmn2r15
|
UTSW |
5 |
109,441,168 (GRCm39) |
missense |
probably benign |
0.39 |
|
R1241:Vmn2r15
|
UTSW |
5 |
109,440,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1244:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R1394:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1395:Vmn2r15
|
UTSW |
5 |
109,442,014 (GRCm39) |
missense |
probably benign |
0.44 |
|
R1423:Vmn2r15
|
UTSW |
5 |
109,441,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1439:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1513:Vmn2r15
|
UTSW |
5 |
109,441,195 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1777:Vmn2r15
|
UTSW |
5 |
109,442,136 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1844:Vmn2r15
|
UTSW |
5 |
109,434,860 (GRCm39) |
nonsense |
probably null |
|
|
R2072:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2074:Vmn2r15
|
UTSW |
5 |
109,434,619 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2122:Vmn2r15
|
UTSW |
5 |
109,434,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2208:Vmn2r15
|
UTSW |
5 |
109,445,309 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R2831:Vmn2r15
|
UTSW |
5 |
109,434,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3848:Vmn2r15
|
UTSW |
5 |
109,445,312 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4058:Vmn2r15
|
UTSW |
5 |
109,441,312 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4615:Vmn2r15
|
UTSW |
5 |
109,441,348 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4663:Vmn2r15
|
UTSW |
5 |
109,441,940 (GRCm39) |
missense |
probably benign |
|
|
R4681:Vmn2r15
|
UTSW |
5 |
109,434,488 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4751:Vmn2r15
|
UTSW |
5 |
109,434,620 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5095:Vmn2r15
|
UTSW |
5 |
109,436,317 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5300:Vmn2r15
|
UTSW |
5 |
109,441,974 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5309:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5335:Vmn2r15
|
UTSW |
5 |
109,434,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5421:Vmn2r15
|
UTSW |
5 |
109,434,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5805:Vmn2r15
|
UTSW |
5 |
109,434,806 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6280:Vmn2r15
|
UTSW |
5 |
109,441,291 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R6324:Vmn2r15
|
UTSW |
5 |
109,434,137 (GRCm39) |
makesense |
probably null |
|
|
R6383:Vmn2r15
|
UTSW |
5 |
109,441,092 (GRCm39) |
nonsense |
probably null |
|
|
R6772:Vmn2r15
|
UTSW |
5 |
109,434,238 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r15
|
UTSW |
5 |
109,441,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7194:Vmn2r15
|
UTSW |
5 |
109,440,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,445,388 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7365:Vmn2r15
|
UTSW |
5 |
109,441,105 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7423:Vmn2r15
|
UTSW |
5 |
109,445,394 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7552:Vmn2r15
|
UTSW |
5 |
109,440,774 (GRCm39) |
nonsense |
probably null |
|
|
R7619:Vmn2r15
|
UTSW |
5 |
109,436,190 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7892:Vmn2r15
|
UTSW |
5 |
109,434,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7924:Vmn2r15
|
UTSW |
5 |
109,434,254 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8058:Vmn2r15
|
UTSW |
5 |
109,440,956 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8099:Vmn2r15
|
UTSW |
5 |
109,441,185 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8189:Vmn2r15
|
UTSW |
5 |
109,434,713 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8275:Vmn2r15
|
UTSW |
5 |
109,434,150 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,441,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8277:Vmn2r15
|
UTSW |
5 |
109,440,970 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8465:Vmn2r15
|
UTSW |
5 |
109,445,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8679:Vmn2r15
|
UTSW |
5 |
109,434,779 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8682:Vmn2r15
|
UTSW |
5 |
109,441,938 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8809:Vmn2r15
|
UTSW |
5 |
109,434,874 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9016:Vmn2r15
|
UTSW |
5 |
109,442,109 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9372:Vmn2r15
|
UTSW |
5 |
109,441,953 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9596:Vmn2r15
|
UTSW |
5 |
109,440,791 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9619:Vmn2r15
|
UTSW |
5 |
109,440,622 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9685:Vmn2r15
|
UTSW |
5 |
109,440,598 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9716:Vmn2r15
|
UTSW |
5 |
109,445,224 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9772:Vmn2r15
|
UTSW |
5 |
109,434,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0065:Vmn2r15
|
UTSW |
5 |
109,441,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1187:Vmn2r15
|
UTSW |
5 |
109,434,529 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTGCAAAAGTGACAGTTCCG -3'
(R):5'- ACACACATTTGTCCCATGGC -3'
Sequencing Primer
(F):5'- GTGACAGTTCCGTGAAAGAAATC -3'
(R):5'- GCATGGCCTCCTTGATGC -3'
|
| Posted On |
2014-10-16 |
Incidental Mutation