Incidental Mutation 'R0167:Or5ac23'
ID 24241
Institutional Source Beutler Lab
Gene Symbol Or5ac23
Ensembl Gene ENSMUSG00000094422
Gene Name olfactory receptor family 5 subfamily AC member 23
Synonyms Olfr205, MOR182-11P, GA_x54KRFPKG5P-55543875-55542958
MMRRC Submission 038443-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.099) question?
Stock # R0167 (G1)
Quality Score 225
Status Validated (trace)
Chromosome 16
Chromosomal Location 59148953-59149870 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 59149337 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 178 (C178*)
Ref Sequence ENSEMBL: ENSMUSP00000149415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074125] [ENSMUST00000213910]
AlphaFold Q7TS37
Predicted Effect probably null
Transcript: ENSMUST00000074125
AA Change: C178*
SMART Domains Protein: ENSMUSP00000073762
Gene: ENSMUSG00000094422
AA Change: C178*

DomainStartEndE-ValueType
Pfam:7tm_4 30 305 1.6e-49 PFAM
Pfam:7TM_GPCR_Srsx 34 302 1.6e-7 PFAM
Pfam:7tm_1 40 289 7.8e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213910
AA Change: C178*
Meta Mutation Damage Score 0.9717 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.4%
  • 20x: 92.7%
Validation Efficiency 95% (58/61)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl11 T C 9: 107,806,969 (GRCm39) F431L probably damaging Het
Ahrr G A 13: 74,431,143 (GRCm39) probably benign Het
Bltp3a C T 17: 28,099,176 (GRCm39) T246M possibly damaging Het
Bsn T C 9: 108,003,185 (GRCm39) T407A probably benign Het
Ccdc96 T C 5: 36,642,497 (GRCm39) F168L probably benign Het
Cckar A T 5: 53,863,795 (GRCm39) S55R probably damaging Het
Cdh5 A C 8: 104,863,367 (GRCm39) I426L possibly damaging Het
Clcn1 T C 6: 42,263,770 (GRCm39) Y24H probably damaging Het
Clpx G A 9: 65,224,019 (GRCm39) R271K possibly damaging Het
Col6a3 C T 1: 90,725,895 (GRCm39) G1978D probably damaging Het
Cpne2 T C 8: 95,295,207 (GRCm39) probably benign Het
D630023F18Rik A G 1: 65,156,340 (GRCm39) V51A possibly damaging Het
Dcaf4 G A 12: 83,582,762 (GRCm39) probably benign Het
Dlk2 C A 17: 46,613,530 (GRCm39) R262S possibly damaging Het
Dubr G T 16: 50,553,007 (GRCm39) noncoding transcript Het
Elane T A 10: 79,722,933 (GRCm39) probably null Het
Eya2 T G 2: 165,558,032 (GRCm39) S209R possibly damaging Het
Fam171a1 C T 2: 3,187,469 (GRCm39) S112L probably damaging Het
Fsip2 T A 2: 82,811,151 (GRCm39) M2490K possibly damaging Het
Galnt14 T C 17: 73,829,715 (GRCm39) T277A probably damaging Het
Golga1 T C 2: 38,937,660 (GRCm39) N128S probably benign Het
H1f6 T C 13: 23,879,886 (GRCm39) V13A probably benign Het
Hdac2 T C 10: 36,876,368 (GRCm39) V461A probably benign Het
Hey2 A G 10: 30,716,661 (GRCm39) V34A probably benign Het
Ift22 T C 5: 136,940,745 (GRCm39) C137R probably benign Het
Lrp2 T C 2: 69,256,002 (GRCm39) D4657G possibly damaging Het
Lrrn3 T A 12: 41,504,014 (GRCm39) Q101L probably damaging Het
Med25 A G 7: 44,532,521 (GRCm39) probably null Het
Mup5 T A 4: 61,752,019 (GRCm39) probably null Het
Or51aa5 A T 7: 103,166,708 (GRCm39) Y294* probably null Het
Or9q2 T C 19: 13,772,931 (GRCm39) T15A probably benign Het
Otog G A 7: 45,953,655 (GRCm39) V2638M probably damaging Het
Parg T C 14: 31,939,693 (GRCm39) probably null Het
Prep A G 10: 45,034,326 (GRCm39) probably null Het
Prss1l T A 6: 41,373,195 (GRCm39) probably benign Het
Psip1 T C 4: 83,385,055 (GRCm39) probably null Het
Rbbp8 T A 18: 11,793,979 (GRCm39) Y30* probably null Het
Rhbdd1 T C 1: 82,320,505 (GRCm39) V163A probably benign Het
Setd2 T A 9: 110,402,850 (GRCm39) N1830K probably damaging Het
Shc4 T G 2: 125,564,933 (GRCm39) N122T probably benign Het
Shroom3 T C 5: 93,096,254 (GRCm39) probably benign Het
Snx14 A T 9: 88,289,469 (GRCm39) L261Q probably damaging Het
St8sia1 A G 6: 142,859,907 (GRCm39) probably benign Het
Thbs2 A T 17: 14,887,787 (GRCm39) probably benign Het
Tpp2 T C 1: 44,009,648 (GRCm39) V494A probably benign Het
Trdmt1 A T 2: 13,520,829 (GRCm39) F358I probably damaging Het
Ttn T A 2: 76,719,867 (GRCm39) probably benign Het
Uggt1 A G 1: 36,209,278 (GRCm39) probably null Het
Vmn1r28 G A 6: 58,242,702 (GRCm39) A182T probably benign Het
Vstm2a T A 11: 16,208,044 (GRCm39) F13I probably damaging Het
Zfp804a T G 2: 82,086,860 (GRCm39) F230V probably damaging Het
Other mutations in Or5ac23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02475:Or5ac23 APN 16 59,149,088 (GRCm39) missense probably benign 0.21
IGL03236:Or5ac23 APN 16 59,149,200 (GRCm39) missense probably damaging 0.97
R0054:Or5ac23 UTSW 16 59,149,428 (GRCm39) missense possibly damaging 0.57
R0054:Or5ac23 UTSW 16 59,149,428 (GRCm39) missense possibly damaging 0.57
R0178:Or5ac23 UTSW 16 59,149,783 (GRCm39) missense probably damaging 1.00
R0371:Or5ac23 UTSW 16 59,149,585 (GRCm39) missense possibly damaging 0.60
R0577:Or5ac23 UTSW 16 59,149,061 (GRCm39) missense probably benign 0.01
R0597:Or5ac23 UTSW 16 59,149,123 (GRCm39) missense probably damaging 1.00
R0967:Or5ac23 UTSW 16 59,149,546 (GRCm39) missense possibly damaging 0.66
R1670:Or5ac23 UTSW 16 59,149,607 (GRCm39) missense probably benign 0.03
R1702:Or5ac23 UTSW 16 59,149,504 (GRCm39) missense probably benign 0.12
R1995:Or5ac23 UTSW 16 59,149,654 (GRCm39) missense probably damaging 1.00
R2239:Or5ac23 UTSW 16 59,149,738 (GRCm39) missense probably damaging 0.99
R4063:Or5ac23 UTSW 16 59,149,243 (GRCm39) missense probably benign 0.05
R4400:Or5ac23 UTSW 16 59,148,961 (GRCm39) missense probably benign
R4666:Or5ac23 UTSW 16 59,149,573 (GRCm39) missense possibly damaging 0.91
R4795:Or5ac23 UTSW 16 59,149,213 (GRCm39) missense probably benign 0.09
R5327:Or5ac23 UTSW 16 59,149,461 (GRCm39) missense probably benign 0.01
R5471:Or5ac23 UTSW 16 59,148,994 (GRCm39) missense probably damaging 1.00
R5770:Or5ac23 UTSW 16 59,149,514 (GRCm39) nonsense probably null
R6195:Or5ac23 UTSW 16 59,149,785 (GRCm39) missense possibly damaging 0.81
R6702:Or5ac23 UTSW 16 59,148,961 (GRCm39) missense probably benign
R7686:Or5ac23 UTSW 16 59,149,379 (GRCm39) missense probably damaging 1.00
R7908:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7911:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7912:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7913:Or5ac23 UTSW 16 59,149,606 (GRCm39) missense possibly damaging 0.48
R7998:Or5ac23 UTSW 16 59,149,633 (GRCm39) missense probably benign 0.09
R8772:Or5ac23 UTSW 16 59,149,051 (GRCm39) missense probably damaging 1.00
R9563:Or5ac23 UTSW 16 59,149,765 (GRCm39) missense probably benign 0.00
X0026:Or5ac23 UTSW 16 59,149,713 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TTTCACCTGGTGCAGACCCATGAC -3'
(R):5'- GTAGCCATATGCAACCCTCTGCTC -3'

Sequencing Primer
(F):5'- CCATGACTCACATACATGAAGAGG -3'
(R):5'- CTATCTAGTGGTGATGTCCAAGAGAC -3'
Posted On 2013-04-16