Incidental Mutation 'R2282:Eif1ad8'
ID 243189
Institutional Source Beutler Lab
Gene Symbol Eif1ad8
Ensembl Gene ENSMUSG00000079034
Gene Name eukaryotic translation initiation factor 1A domain containing 8
Synonyms Gm8300
MMRRC Submission 040281-MU
Accession Numbers
Essential gene? Not available question?
Stock # R2282 (G1)
Quality Score 142
Status Not validated
Chromosome 12
Chromosomal Location 87561086-87565035 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 87564087 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 141 (I141F)
Ref Sequence ENSEMBL: ENSMUSP00000105780 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110152]
AlphaFold Q3UTA4
Predicted Effect unknown
Transcript: ENSMUST00000110152
AA Change: I141F
SMART Domains Protein: ENSMUSP00000105780
Gene: ENSMUSG00000079034
AA Change: I141F

DomainStartEndE-ValueType
low complexity region 3 25 N/A INTRINSIC
eIF1a 28 110 2.58e-46 SMART
low complexity region 125 144 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221512
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk2 A G 18: 65,440,697 (GRCm39) L232P probably benign Het
Ap5b1 A T 19: 5,619,665 (GRCm39) T362S possibly damaging Het
Ash2l A G 8: 26,325,070 (GRCm39) M163T probably damaging Het
Atp13a5 T C 16: 29,056,073 (GRCm39) Y1029C probably damaging Het
Baz1a G T 12: 54,963,597 (GRCm39) S829* probably null Het
Cd1d2 A G 3: 86,894,558 (GRCm39) K109E probably benign Het
Col4a3 T C 1: 82,686,359 (GRCm39) F1309L unknown Het
Dnah5 A T 15: 28,327,448 (GRCm39) E2055V probably damaging Het
Epha5 A T 5: 84,298,269 (GRCm39) I542N probably damaging Het
Hectd1 A T 12: 51,815,791 (GRCm39) V1432D possibly damaging Het
Klf12 C T 14: 100,137,581 (GRCm39) E322K probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Or1j11 G A 2: 36,312,012 (GRCm39) V201I probably benign Het
Or2y1c T G 11: 49,361,470 (GRCm39) M164R probably damaging Het
Or4k5 A G 14: 50,385,776 (GRCm39) V185A probably benign Het
Or8c16 A G 9: 38,130,124 (GRCm39) M2V probably benign Het
Pde6b A G 5: 108,571,452 (GRCm39) probably null Het
Pdzd2 C T 15: 12,373,934 (GRCm39) G2067D possibly damaging Het
Rfx2 T C 17: 57,110,722 (GRCm39) Y88C probably damaging Het
S100a1 A G 3: 90,418,599 (GRCm39) F72L probably damaging Het
Smg5 A G 3: 88,252,705 (GRCm39) M164V probably benign Het
Snx5 T A 2: 144,095,595 (GRCm39) E355D probably benign Het
Tmbim6 T C 15: 99,302,407 (GRCm39) F93S probably damaging Het
Trp53bp1 G A 2: 121,100,754 (GRCm39) Q77* probably null Het
Ttn A G 2: 76,629,882 (GRCm39) V14216A possibly damaging Het
Vmn2r68 C T 7: 84,870,859 (GRCm39) C808Y possibly damaging Het
Wnt10b A G 15: 98,672,102 (GRCm39) F205S probably damaging Het
Other mutations in Eif1ad8
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1566:Eif1ad8 UTSW 12 87,564,001 (GRCm39) missense probably benign
R2049:Eif1ad8 UTSW 12 87,564,046 (GRCm39) missense unknown
R2071:Eif1ad8 UTSW 12 87,563,822 (GRCm39) missense probably benign 0.07
R4236:Eif1ad8 UTSW 12 87,563,935 (GRCm39) missense probably damaging 1.00
R5818:Eif1ad8 UTSW 12 87,563,830 (GRCm39) missense possibly damaging 0.59
R6970:Eif1ad8 UTSW 12 87,563,388 (GRCm39) start gained probably benign
R7238:Eif1ad8 UTSW 12 87,564,006 (GRCm39) nonsense probably null
R7868:Eif1ad8 UTSW 12 87,563,388 (GRCm39) start gained probably benign
R7943:Eif1ad8 UTSW 12 87,563,773 (GRCm39) missense probably damaging 1.00
R8050:Eif1ad8 UTSW 12 87,563,911 (GRCm39) missense possibly damaging 0.92
R8819:Eif1ad8 UTSW 12 87,563,910 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CGAGACTATCAAGATAACAAAGCTG -3'
(R):5'- ACAAATGGAATGGCAGTCCC -3'

Sequencing Primer
(F):5'- GGAGAACTTCCAGAACATG -3'
(R):5'- ATGGCAGTCCCTTAACAGTG -3'
Posted On 2014-10-16