Incidental Mutation 'R2284:Vmn1r67'
ID 243242
Institutional Source Beutler Lab
Gene Symbol Vmn1r67
Ensembl Gene ENSMUSG00000046716
Gene Name vomeronasal 1 receptor 67
Synonyms V1re10
MMRRC Submission 040283-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R2284 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 10180716-10181714 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 10181600 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 288 (H288L)
Ref Sequence ENSEMBL: ENSMUSP00000060746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055964] [ENSMUST00000226237]
AlphaFold G5E8C1
Predicted Effect probably damaging
Transcript: ENSMUST00000055964
AA Change: H288L

PolyPhen 2 Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000060746
Gene: ENSMUSG00000046716
AA Change: H288L

DomainStartEndE-ValueType
Pfam:V1R 34 292 4.3e-31 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000226237
AA Change: H227L

PolyPhen 2 Score 0.960 (Sensitivity: 0.78; Specificity: 0.95)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency 100% (32/32)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adipoq C T 16: 22,976,237 (GRCm39) Q213* probably null Het
Adsl C T 15: 80,848,096 (GRCm39) P278L probably damaging Het
Bcas2 T C 3: 103,085,678 (GRCm39) S187P probably damaging Het
Ccdc88a T C 11: 29,444,099 (GRCm39) probably null Het
Cryzl1 C T 16: 91,491,193 (GRCm39) probably benign Het
Csl T A 10: 99,594,321 (GRCm39) D248V possibly damaging Het
Dip2a A C 10: 76,149,027 (GRCm39) V247G probably benign Het
Fat2 T C 11: 55,173,186 (GRCm39) D2509G probably damaging Het
Gldn G A 9: 54,193,849 (GRCm39) W14* probably null Het
Gm5698 C T 1: 31,016,964 (GRCm39) R29Q possibly damaging Het
Gm5830 A T 1: 78,945,415 (GRCm39) noncoding transcript Het
Gtf2ird2 A G 5: 134,246,025 (GRCm39) D761G probably benign Het
Hdac10 T C 15: 89,011,607 (GRCm39) Q159R probably benign Het
Hhatl T C 9: 121,618,648 (GRCm39) Y118C probably damaging Het
Iho1 C T 9: 108,298,672 (GRCm39) E49K probably damaging Het
Klrd1 A G 6: 129,575,344 (GRCm39) H127R probably benign Het
Krtap31-1 C T 11: 99,799,081 (GRCm39) Q95* probably null Het
Map2 C T 1: 66,453,227 (GRCm39) P548S probably damaging Het
Mki67 A G 7: 135,301,674 (GRCm39) V1120A probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Mtmr12 T A 15: 12,245,097 (GRCm39) M204K probably damaging Het
Muc6 T C 7: 141,217,837 (GRCm39) T2279A possibly damaging Het
Naip6 C T 13: 100,437,108 (GRCm39) A472T probably benign Het
Nlrp1b A G 11: 71,047,110 (GRCm39) S1084P probably benign Het
Nr2f1 C A 13: 78,343,581 (GRCm39) V81F probably damaging Het
Nrxn3 T A 12: 89,477,135 (GRCm39) N803K probably damaging Het
Or5l14 A G 2: 87,793,137 (GRCm39) L33P probably damaging Het
Ptpre A G 7: 135,271,510 (GRCm39) H375R probably benign Het
Tsc1 G A 2: 28,555,109 (GRCm39) V200I possibly damaging Het
Vmn1r42 A G 6: 89,821,681 (GRCm39) I296T probably benign Het
Vmn2r45 A T 7: 8,488,765 (GRCm39) N88K probably benign Het
Wt1 A G 2: 105,002,666 (GRCm39) T511A probably benign Het
Other mutations in Vmn1r67
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01690:Vmn1r67 APN 7 10,180,767 (GRCm39) missense possibly damaging 0.96
IGL02812:Vmn1r67 APN 7 10,180,945 (GRCm39) missense probably benign 0.01
IGL03121:Vmn1r67 APN 7 10,181,394 (GRCm39) missense probably benign 0.00
IGL03208:Vmn1r67 APN 7 10,181,025 (GRCm39) missense possibly damaging 0.94
PIT4142001:Vmn1r67 UTSW 7 10,180,877 (GRCm39) missense probably benign 0.13
R0048:Vmn1r67 UTSW 7 10,180,793 (GRCm39) missense probably damaging 1.00
R0549:Vmn1r67 UTSW 7 10,181,641 (GRCm39) missense probably damaging 1.00
R1595:Vmn1r67 UTSW 7 10,181,597 (GRCm39) missense probably benign 0.18
R1608:Vmn1r67 UTSW 7 10,180,907 (GRCm39) missense possibly damaging 0.82
R3614:Vmn1r67 UTSW 7 10,181,356 (GRCm39) missense probably damaging 0.98
R4399:Vmn1r67 UTSW 7 10,181,476 (GRCm39) missense possibly damaging 0.89
R4542:Vmn1r67 UTSW 7 10,181,357 (GRCm39) missense probably damaging 0.99
R5216:Vmn1r67 UTSW 7 10,181,090 (GRCm39) missense probably benign 0.00
R5655:Vmn1r67 UTSW 7 10,181,315 (GRCm39) missense probably benign 0.43
R5837:Vmn1r67 UTSW 7 10,180,949 (GRCm39) missense probably benign 0.26
R6526:Vmn1r67 UTSW 7 10,181,598 (GRCm39) missense probably benign 0.05
R6735:Vmn1r67 UTSW 7 10,181,138 (GRCm39) missense probably damaging 1.00
R6846:Vmn1r67 UTSW 7 10,180,840 (GRCm39) missense probably benign 0.04
R7086:Vmn1r67 UTSW 7 10,181,044 (GRCm39) missense possibly damaging 0.93
R7227:Vmn1r67 UTSW 7 10,181,475 (GRCm39) nonsense probably null
R7594:Vmn1r67 UTSW 7 10,181,342 (GRCm39) missense possibly damaging 0.95
R7608:Vmn1r67 UTSW 7 10,181,290 (GRCm39) missense possibly damaging 0.89
R7797:Vmn1r67 UTSW 7 10,180,903 (GRCm39) missense probably benign 0.30
R8681:Vmn1r67 UTSW 7 10,181,128 (GRCm39) missense probably benign 0.30
Predicted Primers PCR Primer
(F):5'- GGAATCCAGAGCCACTCAGAAG -3'
(R):5'- GTGAGCTCATGTAGGCTTCAAC -3'

Sequencing Primer
(F):5'- ACTCAGAAGATCCTAGTCCTGGTG -3'
(R):5'- CCTTTTGATGAAGAGTGTGA -3'
Posted On 2014-10-16