Mutagenetix > Incidental Mutation

Incidental Mutation 'R2286:Vmn2r120'

243317

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r120

Ensembl Gene

ENSMUSG00000090655

Gene Name

vomeronasal 2, receptor 120

Synonyms

EG224916

MMRRC Submission

040285-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R2286 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

57815783-57852314 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 57815958 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 799 (L799P)

Ref Sequence

ENSEMBL: ENSMUSP00000129296 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165781]

AlphaFold

A0A3Q4EG79

Predicted Effect

probably damaging
Transcript: ENSMUST00000165781
AA Change: L799P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000129296
Gene: ENSMUSG00000090655
AA Change: L799P

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	80	474	5.9e-42	PFAM
Pfam:NCD3G	517	570	7.5e-22	PFAM
Pfam:7tm_3	598	836	1.3e-54	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.2%
20x: 94.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 22 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam22	C	T	5: 8,195,616 (GRCm39)	R308H	probably damaging	Het
Alox5ap	G	A	5: 149,222,240 (GRCm39)		probably null	Het
Ap2s1	T	C	7: 16,482,901 (GRCm39)	V131A	possibly damaging	Het
Cdr2l	GAA	GA	11: 115,283,626 (GRCm39)		probably null	Het
Cpsf7	T	C	19: 10,512,660 (GRCm39)	L248P	probably damaging	Het
Dtd1	T	C	2: 144,477,786 (GRCm39)		probably null	Het
Eci1	A	G	17: 24,652,203 (GRCm39)	D75G	probably damaging	Het
Kremen1	CGGG	CGGGGGG	11: 5,151,791 (GRCm39)		probably benign	Het
Luc7l	A	G	17: 26,499,020 (GRCm39)		probably benign	Het
Med13	A	C	11: 86,210,515 (GRCm39)	D542E	probably benign	Het
Myo6	T	C	9: 80,173,494 (GRCm39)	S545P	possibly damaging	Het
Naip6	C	T	13: 100,437,108 (GRCm39)	A472T	probably benign	Het
Or4k37	A	G	2: 111,159,252 (GRCm39)	I163V	probably benign	Het
Rsad2	T	A	12: 26,500,675 (GRCm39)	N204I	probably benign	Het
Setd5	T	G	6: 113,096,571 (GRCm39)	N592K	possibly damaging	Het
Sgip1	G	T	4: 102,724,844 (GRCm39)	S59I	possibly damaging	Het
Slc39a5	A	G	10: 128,231,929 (GRCm39)	V532A	probably benign	Het
Smarcc2	G	A	10: 128,299,612 (GRCm39)	M123I	possibly damaging	Het
Tdrd1	A	G	19: 56,827,551 (GRCm39)	T185A	probably benign	Het
Tnn	T	C	1: 159,938,079 (GRCm39)	E1146G	possibly damaging	Het
Unc13a	T	C	8: 72,083,203 (GRCm39)	K1618E	probably damaging	Het
Vps26c	C	T	16: 94,313,112 (GRCm39)	E60K	possibly damaging	Het

Other mutations in Vmn2r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01335:Vmn2r120	APN	17	57,832,732 (GRCm39)	missense	possibly damaging	0.86
IGL01346:Vmn2r120	APN	17	57,852,232 (GRCm39)	missense	probably benign	0.11
IGL01996:Vmn2r120	APN	17	57,832,222 (GRCm39)	missense	possibly damaging	0.92
IGL02503:Vmn2r120	APN	17	57,816,385 (GRCm39)	missense	probably benign	0.40
IGL02582:Vmn2r120	APN	17	57,831,724 (GRCm39)	missense	probably damaging	0.99
IGL02747:Vmn2r120	APN	17	57,831,719 (GRCm39)	missense	probably benign	0.19
IGL02896:Vmn2r120	APN	17	57,816,008 (GRCm39)	missense	probably damaging	1.00
IGL03139:Vmn2r120	APN	17	57,831,742 (GRCm39)	missense	probably benign	0.39
IGL03342:Vmn2r120	APN	17	57,816,372 (GRCm39)	missense	probably benign	0.03
A4554:Vmn2r120	UTSW	17	57,832,715 (GRCm39)	missense	probably benign	0.01
R0207:Vmn2r120	UTSW	17	57,832,052 (GRCm39)	missense	probably benign	0.17
R0472:Vmn2r120	UTSW	17	57,831,518 (GRCm39)	missense	probably benign	0.03
R0517:Vmn2r120	UTSW	17	57,815,949 (GRCm39)	missense	probably damaging	1.00
R1109:Vmn2r120	UTSW	17	57,832,829 (GRCm39)	missense	probably benign	0.09
R1316:Vmn2r120	UTSW	17	57,832,939 (GRCm39)	missense	probably benign	0.28
R1543:Vmn2r120	UTSW	17	57,829,374 (GRCm39)	missense	probably benign	0.09
R1795:Vmn2r120	UTSW	17	57,832,038 (GRCm39)	missense	probably benign	0.35
R1850:Vmn2r120	UTSW	17	57,832,826 (GRCm39)	missense	probably benign	0.19
R1920:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R1921:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R1922:Vmn2r120	UTSW	17	57,831,839 (GRCm39)	missense	probably benign	0.01
R2063:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2064:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2065:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2067:Vmn2r120	UTSW	17	57,831,553 (GRCm39)	missense	possibly damaging	0.88
R2291:Vmn2r120	UTSW	17	57,816,479 (GRCm39)	missense	probably damaging	1.00
R3416:Vmn2r120	UTSW	17	57,816,241 (GRCm39)	missense	possibly damaging	0.89
R3874:Vmn2r120	UTSW	17	57,831,954 (GRCm39)	missense	probably benign	0.40
R4023:Vmn2r120	UTSW	17	57,843,718 (GRCm39)	missense	possibly damaging	0.92
R4024:Vmn2r120	UTSW	17	57,843,718 (GRCm39)	missense	possibly damaging	0.92
R4348:Vmn2r120	UTSW	17	57,829,466 (GRCm39)	missense	possibly damaging	0.47
R4409:Vmn2r120	UTSW	17	57,816,477 (GRCm39)	missense	probably damaging	1.00
R4610:Vmn2r120	UTSW	17	57,816,120 (GRCm39)	missense	probably damaging	1.00
R4771:Vmn2r120	UTSW	17	57,831,887 (GRCm39)	missense	probably damaging	1.00
R4786:Vmn2r120	UTSW	17	57,829,048 (GRCm39)	missense	probably benign	0.14
R4927:Vmn2r120	UTSW	17	57,816,125 (GRCm39)	missense	probably damaging	1.00
R5285:Vmn2r120	UTSW	17	57,843,703 (GRCm39)	missense	probably damaging	1.00
R5566:Vmn2r120	UTSW	17	57,852,290 (GRCm39)	missense	possibly damaging	0.95
R5578:Vmn2r120	UTSW	17	57,829,514 (GRCm39)	missense	probably benign	0.01
R5643:Vmn2r120	UTSW	17	57,831,977 (GRCm39)	missense	probably benign	0.01
R5644:Vmn2r120	UTSW	17	57,831,977 (GRCm39)	missense	probably benign	0.01
R5781:Vmn2r120	UTSW	17	57,831,938 (GRCm39)	missense	probably benign	0.00
R6084:Vmn2r120	UTSW	17	57,832,721 (GRCm39)	missense	probably benign	0.15
R6120:Vmn2r120	UTSW	17	57,832,973 (GRCm39)	missense	probably benign	0.02
R6160:Vmn2r120	UTSW	17	57,816,418 (GRCm39)	missense	probably benign	0.03
R6248:Vmn2r120	UTSW	17	57,852,287 (GRCm39)	missense	probably benign	0.03
R6256:Vmn2r120	UTSW	17	57,831,700 (GRCm39)	nonsense	probably null
R6730:Vmn2r120	UTSW	17	57,832,012 (GRCm39)	missense	probably benign	0.03
R6821:Vmn2r120	UTSW	17	57,843,659 (GRCm39)	missense	probably benign	0.00
R6868:Vmn2r120	UTSW	17	57,852,218 (GRCm39)	missense	probably benign	0.00
R6880:Vmn2r120	UTSW	17	57,816,187 (GRCm39)	missense	probably damaging	1.00
R6986:Vmn2r120	UTSW	17	57,816,340 (GRCm39)	missense	probably damaging	1.00
R7276:Vmn2r120	UTSW	17	57,831,881 (GRCm39)	missense	probably benign	0.11
R7373:Vmn2r120	UTSW	17	57,816,406 (GRCm39)	missense	probably benign	0.35
R7653:Vmn2r120	UTSW	17	57,816,258 (GRCm39)	missense	possibly damaging	0.93
R7667:Vmn2r120	UTSW	17	57,843,657 (GRCm39)	missense	probably benign	0.04
R7775:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7778:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7797:Vmn2r120	UTSW	17	57,815,874 (GRCm39)	missense	probably damaging	1.00
R7824:Vmn2r120	UTSW	17	57,832,942 (GRCm39)	missense	probably damaging	1.00
R7902:Vmn2r120	UTSW	17	57,816,244 (GRCm39)	missense	possibly damaging	0.87
R7922:Vmn2r120	UTSW	17	57,831,683 (GRCm39)	missense	probably damaging	0.99
R8508:Vmn2r120	UTSW	17	57,832,843 (GRCm39)	missense	probably benign	0.03
R8847:Vmn2r120	UTSW	17	57,816,217 (GRCm39)	missense	probably benign	0.01
R8882:Vmn2r120	UTSW	17	57,852,229 (GRCm39)	missense	probably benign	0.01
R9134:Vmn2r120	UTSW	17	57,832,093 (GRCm39)	missense	probably damaging	1.00
R9161:Vmn2r120	UTSW	17	57,831,864 (GRCm39)	missense
R9336:Vmn2r120	UTSW	17	57,832,201 (GRCm39)	missense	possibly damaging	0.91
RF005:Vmn2r120	UTSW	17	57,828,991 (GRCm39)	missense	possibly damaging	0.65
Z1177:Vmn2r120	UTSW	17	57,816,245 (GRCm39)	missense	probably benign	0.00
Z1188:Vmn2r120	UTSW	17	57,829,436 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCAGACATGTAAGGCAATCTTG -3'
(R):5'- GCCACATCACCATCATGTGC -3'

Sequencing Primer
(F):5'- GCATACTGAATATTTCACTTGCACAC -3'
(R):5'- TGCAACAAGGGATCCGCTACTG -3'

Posted On

2014-10-16