Incidental Mutation 'R2256:Clasrp'
ID 243367
Institutional Source Beutler Lab
Gene Symbol Clasrp
Ensembl Gene ENSMUSG00000061028
Gene Name CLK4-associating serine/arginine rich protein
Synonyms SWAP2, Sfrs16, Srsf16
MMRRC Submission 040256-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2256 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 19314960-19338411 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) A to G at 19320510 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000147069 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086041] [ENSMUST00000207524] [ENSMUST00000207663] [ENSMUST00000207907] [ENSMUST00000208068]
AlphaFold Q8CFC7
Predicted Effect unknown
Transcript: ENSMUST00000086041
AA Change: S383P
SMART Domains Protein: ENSMUSP00000083205
Gene: ENSMUSG00000061028
AA Change: S383P

DomainStartEndE-ValueType
low complexity region 19 35 N/A INTRINSIC
DRY_EERY 39 171 1.28e-64 SMART
low complexity region 172 212 N/A INTRINSIC
low complexity region 241 260 N/A INTRINSIC
low complexity region 263 283 N/A INTRINSIC
low complexity region 302 324 N/A INTRINSIC
low complexity region 339 368 N/A INTRINSIC
low complexity region 372 446 N/A INTRINSIC
low complexity region 453 476 N/A INTRINSIC
low complexity region 480 532 N/A INTRINSIC
coiled coil region 574 630 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207264
Predicted Effect noncoding transcript
Transcript: ENSMUST00000207447
Predicted Effect probably benign
Transcript: ENSMUST00000207524
Predicted Effect probably benign
Transcript: ENSMUST00000207663
Predicted Effect unknown
Transcript: ENSMUST00000207907
AA Change: S383P
Predicted Effect unknown
Transcript: ENSMUST00000208068
AA Change: S383P
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208464
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208427
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208716
Meta Mutation Damage Score 0.0757 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.7%
  • 20x: 96.3%
Validation Efficiency 98% (97/99)
MGI Phenotype FUNCTION: The protein encoded by this gene contains serine/arginine (SR) dipeptide repeat domains, and is thought to be involved in the regulation of alternative splicing. This protein is thought to interact with, and be phosphorylated by, Clk4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Allele List at MGI
Other mutations in this stock
Total: 98 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 T C 5: 9,008,431 (GRCm39) S1200P probably damaging Het
Acadsb A G 7: 131,045,382 (GRCm39) Y438C probably benign Het
Acp7 A C 7: 28,313,838 (GRCm39) W399G probably damaging Het
Actr3b A G 5: 26,027,403 (GRCm39) T113A possibly damaging Het
Adgrv1 T C 13: 81,654,259 (GRCm39) D2204G probably benign Het
Ago1 A G 4: 126,335,704 (GRCm39) V669A possibly damaging Het
Ang5 T A 14: 44,199,978 (GRCm39) L14Q probably null Het
Aoc1 T C 6: 48,883,374 (GRCm39) Y417H possibly damaging Het
Arhgap32 T C 9: 32,158,793 (GRCm39) I186T probably damaging Het
Atf2 A T 2: 73,675,855 (GRCm39) probably null Het
Atg4a A G X: 139,890,984 (GRCm39) I91V probably benign Het
Atp7b T G 8: 22,488,282 (GRCm39) T1102P probably damaging Het
Bend5 A C 4: 111,288,207 (GRCm39) probably benign Het
Camkk2 T C 5: 122,884,398 (GRCm39) D341G probably damaging Het
Cast T A 13: 74,888,024 (GRCm39) I208L probably damaging Het
Ccdc141 A T 2: 76,962,606 (GRCm39) W113R probably damaging Het
Cdk14 T A 5: 4,938,924 (GRCm39) M433L probably benign Het
Cel A G 2: 28,451,204 (GRCm39) F51S probably damaging Het
Cenpc1 A G 5: 86,164,062 (GRCm39) L853S probably damaging Het
Cep162 C A 9: 87,088,967 (GRCm39) D972Y probably damaging Het
Cimip3 AC A 17: 47,744,348 (GRCm39) probably benign Het
Cntnap5c T A 17: 58,637,310 (GRCm39) N1062K probably benign Het
Col3a1 A G 1: 45,360,792 (GRCm39) D74G unknown Het
Copb1 T A 7: 113,853,110 (GRCm39) D29V possibly damaging Het
Cox6a1 C T 5: 115,486,907 (GRCm39) E35K possibly damaging Het
Cyp2b9 G A 7: 25,873,030 (GRCm39) probably null Het
Ddx46 A G 13: 55,795,521 (GRCm39) K177E possibly damaging Het
Dmbt1 T C 7: 130,692,224 (GRCm39) F823L probably benign Het
Drc7 A T 8: 95,801,637 (GRCm39) H666L probably benign Het
Fam228a T C 12: 4,787,775 (GRCm39) probably benign Het
Fam83e A T 7: 45,378,193 (GRCm39) K406* probably null Het
Fam83e A T 7: 45,378,194 (GRCm39) K406M possibly damaging Het
Fam90a1a T A 8: 22,453,533 (GRCm39) L296Q possibly damaging Het
Fat1 A G 8: 45,403,408 (GRCm39) Y53C probably damaging Het
Fhdc1 T C 3: 84,353,353 (GRCm39) E624G probably benign Het
Fryl T A 5: 73,230,187 (GRCm39) N1657Y possibly damaging Het
Fsip2 T A 2: 82,793,095 (GRCm39) D417E probably benign Het
Garin5b T A 7: 4,774,020 (GRCm39) M31L probably benign Het
Greb1l A G 18: 10,503,307 (GRCm39) M453V possibly damaging Het
Gtf2b A G 3: 142,487,185 (GRCm39) D207G probably benign Het
Has3 C A 8: 107,600,888 (GRCm39) L117I probably damaging Het
Iqca1l C T 5: 24,757,038 (GRCm39) probably benign Het
Jmjd1c T A 10: 67,061,073 (GRCm39) I1142N probably damaging Het
Lipt2 C T 7: 99,808,601 (GRCm39) T38I probably benign Het
Magea2 A T X: 153,810,855 (GRCm39) L243Q probably damaging Het
Mast4 A T 13: 102,872,259 (GRCm39) C2178S possibly damaging Het
Mctp2 A G 7: 71,835,568 (GRCm39) L543P probably damaging Het
Mmut A T 17: 41,267,210 (GRCm39) I595F probably benign Het
Mphosph9 C T 5: 124,421,722 (GRCm39) V740I probably benign Het
Mtrex A T 13: 113,013,046 (GRCm39) M890K probably damaging Het
Myo1e G A 9: 70,285,655 (GRCm39) probably null Het
Nlrc4 A G 17: 74,752,625 (GRCm39) I586T probably damaging Het
Nom1 T A 5: 29,642,750 (GRCm39) V417D probably damaging Het
Nphs1 A T 7: 30,167,417 (GRCm39) I782F possibly damaging Het
Numa1 A G 7: 101,649,998 (GRCm39) E1243G probably damaging Het
Or4a81 T C 2: 89,618,814 (GRCm39) H294R probably benign Het
Or4k42 T C 2: 111,320,323 (GRCm39) Y60C probably damaging Het
Or52e7 A G 7: 104,685,026 (GRCm39) Y207C probably benign Het
Or5g23 T A 2: 85,438,807 (GRCm39) Y149F possibly damaging Het
Or5p54 A T 7: 107,554,244 (GRCm39) Y132F probably damaging Het
Orai2 C T 5: 136,190,454 (GRCm39) V52I probably damaging Het
Osbpl5 A G 7: 143,262,831 (GRCm39) C186R probably damaging Het
Osbpl6 A G 2: 76,414,818 (GRCm39) E403G probably damaging Het
Padi4 G A 4: 140,487,251 (GRCm39) T217I possibly damaging Het
Parm1 C T 5: 91,741,980 (GRCm39) T116I possibly damaging Het
Pde4dip T A 3: 97,625,500 (GRCm39) Q1366L probably damaging Het
Phgdh T C 3: 98,235,607 (GRCm39) K108E probably benign Het
Pold1 T C 7: 44,183,223 (GRCm39) probably null Het
Ppp1r37 G T 7: 19,295,943 (GRCm39) probably benign Het
Sdk2 T C 11: 113,721,620 (GRCm39) N1332S probably benign Het
Sema6d A G 2: 124,506,070 (GRCm39) D626G probably damaging Het
Slc18b1 A G 10: 23,686,820 (GRCm39) N212S probably benign Het
Slc2a9 T C 5: 38,610,542 (GRCm39) T86A probably damaging Het
Slco1a6 A T 6: 142,036,742 (GRCm39) M555K probably benign Het
Sntg2 C T 12: 30,286,687 (GRCm39) W302* probably null Het
Spata22 T A 11: 73,231,301 (GRCm39) M185K possibly damaging Het
Stk35 T A 2: 129,652,427 (GRCm39) Y309* probably null Het
Taar8c A G 10: 23,976,969 (GRCm39) V281A probably benign Het
Thoc1 C A 18: 9,993,466 (GRCm39) D608E possibly damaging Het
Tmem121b A T 6: 120,469,030 (GRCm39) Y562* probably null Het
Tmem121b A G 6: 120,469,032 (GRCm39) Y562H probably damaging Het
Tmtc4 A T 14: 123,178,820 (GRCm39) I449N probably benign Het
Tmub1 C A 5: 24,651,922 (GRCm39) G14V possibly damaging Het
Tmub1 G A 5: 24,652,175 (GRCm39) probably benign Het
Tshz2 A G 2: 169,728,397 (GRCm39) T529A probably damaging Het
Ugdh A T 5: 65,574,458 (GRCm39) probably benign Het
Usp25 A G 16: 76,910,682 (GRCm39) K913E probably benign Het
Vgf A G 5: 137,060,401 (GRCm39) probably benign Het
Vmn2r19 T A 6: 123,306,845 (GRCm39) F451Y probably benign Het
Vmn2r59 A T 7: 41,661,669 (GRCm39) C715* probably null Het
Vps9d1 C A 8: 123,971,860 (GRCm39) A582S probably benign Het
Xbp1 T G 11: 5,474,841 (GRCm39) H247Q probably damaging Het
Zfp1008 A T 13: 62,755,210 (GRCm39) I36N probably benign Het
Zfp319 A T 8: 96,055,129 (GRCm39) M358K possibly damaging Het
Zfp438 A T 18: 5,213,508 (GRCm39) N483K probably damaging Het
Zfp518b T C 5: 38,828,979 (GRCm39) N1009D possibly damaging Het
Zfp644 A T 5: 106,783,711 (GRCm39) H945Q probably damaging Het
Zgrf1 T A 3: 127,355,646 (GRCm39) S291T probably benign Het
Other mutations in Clasrp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02394:Clasrp APN 7 19,337,179 (GRCm39) missense probably damaging 1.00
clarissa UTSW 7 19,324,173 (GRCm39) missense possibly damaging 0.82
suet UTSW 7 19,320,393 (GRCm39) utr 3 prime probably benign
R0518:Clasrp UTSW 7 19,322,528 (GRCm39) missense probably benign 0.32
R0519:Clasrp UTSW 7 19,318,089 (GRCm39) utr 3 prime probably benign
R0521:Clasrp UTSW 7 19,322,528 (GRCm39) missense probably benign 0.32
R0626:Clasrp UTSW 7 19,318,418 (GRCm39) utr 3 prime probably benign
R0826:Clasrp UTSW 7 19,318,226 (GRCm39) utr 3 prime probably benign
R1918:Clasrp UTSW 7 19,319,188 (GRCm39) nonsense probably null
R2044:Clasrp UTSW 7 19,320,640 (GRCm39) utr 3 prime probably benign
R2257:Clasrp UTSW 7 19,320,510 (GRCm39) utr 3 prime probably benign
R2870:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2870:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2871:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2871:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R2940:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R3408:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R3691:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4168:Clasrp UTSW 7 19,315,079 (GRCm39) unclassified probably benign
R4496:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4505:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4507:Clasrp UTSW 7 19,319,165 (GRCm39) utr 3 prime probably benign
R4572:Clasrp UTSW 7 19,318,389 (GRCm39) splice site probably null
R4753:Clasrp UTSW 7 19,328,865 (GRCm39) missense probably damaging 1.00
R4871:Clasrp UTSW 7 19,324,173 (GRCm39) missense possibly damaging 0.82
R4938:Clasrp UTSW 7 19,318,703 (GRCm39) splice site probably null
R5538:Clasrp UTSW 7 19,318,707 (GRCm39) utr 3 prime probably benign
R5582:Clasrp UTSW 7 19,320,781 (GRCm39) missense probably damaging 0.97
R5615:Clasrp UTSW 7 19,320,372 (GRCm39) utr 3 prime probably benign
R5794:Clasrp UTSW 7 19,325,034 (GRCm39) missense probably damaging 0.99
R5944:Clasrp UTSW 7 19,328,431 (GRCm39) missense probably damaging 1.00
R6102:Clasrp UTSW 7 19,320,393 (GRCm39) utr 3 prime probably benign
R6171:Clasrp UTSW 7 19,318,747 (GRCm39) splice site probably benign
R6485:Clasrp UTSW 7 19,320,294 (GRCm39) utr 3 prime probably benign
R6600:Clasrp UTSW 7 19,324,207 (GRCm39) nonsense probably null
R7383:Clasrp UTSW 7 19,319,198 (GRCm39) missense unknown
R7719:Clasrp UTSW 7 19,321,769 (GRCm39) missense probably damaging 0.99
R7750:Clasrp UTSW 7 19,318,516 (GRCm39) makesense probably null
R7808:Clasrp UTSW 7 19,322,671 (GRCm39) splice site probably null
R8192:Clasrp UTSW 7 19,329,387 (GRCm39) missense possibly damaging 0.83
R8820:Clasrp UTSW 7 19,320,362 (GRCm39) missense unknown
R8821:Clasrp UTSW 7 19,320,362 (GRCm39) missense unknown
R8924:Clasrp UTSW 7 19,318,232 (GRCm39) missense unknown
R9471:Clasrp UTSW 7 19,319,172 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AAGTCACAGACCTGCTCCTTC -3'
(R):5'- AGAATCTAGTTCCGAGTCCCGC -3'

Sequencing Primer
(F):5'- AGCGTGAGTAGCGGTGTCC -3'
(R):5'- CAGTTTTGGAGGCAGCGAC -3'
Posted On 2014-10-16