Incidental Mutation 'R2257:Acp7'
ID 243454
Institutional Source Beutler Lab
Gene Symbol Acp7
Ensembl Gene ENSMUSG00000037469
Gene Name acid phosphatase 7, tartrate resistant
Synonyms C330005M16Rik, Papl
MMRRC Submission 040257-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.294) question?
Stock # R2257 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 28306701-28330757 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 28313838 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Glycine at position 399 (W399G)
Ref Sequence ENSEMBL: ENSMUSP00000045437 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040112] [ENSMUST00000159418] [ENSMUST00000159560]
AlphaFold Q8BX37
Predicted Effect probably damaging
Transcript: ENSMUST00000040112
AA Change: W399G

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000045437
Gene: ENSMUSG00000037469
AA Change: W399G

DomainStartEndE-ValueType
Pfam:Pur_ac_phosph_N 90 183 2.2e-19 PFAM
Pfam:Metallophos 192 395 6.4e-27 PFAM
Pfam:Metallophos_C 420 482 4.5e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159418
Predicted Effect probably benign
Transcript: ENSMUST00000159560
Meta Mutation Damage Score 0.8290 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency 96% (70/73)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Purple acid phosphatases (PAPs), including PAPL, are a family of binuclear metallohydrolases that have been identified in plants, animals, and fungi (Flanagan et al., 2006 [PubMed 16793224]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930567H17Rik A T X: 69,438,012 (GRCm39) W94R probably damaging Het
Abcc3 C T 11: 94,254,420 (GRCm39) V693M probably damaging Het
Ap1s1 T C 5: 137,070,633 (GRCm39) Y94C possibly damaging Het
Arhgap32 T C 9: 32,158,793 (GRCm39) I186T probably damaging Het
Atg4a A G X: 139,890,984 (GRCm39) I91V probably benign Het
Atp7b T G 8: 22,488,282 (GRCm39) T1102P probably damaging Het
Cabs1 T C 5: 88,128,074 (GRCm39) S242P probably damaging Het
Cass4 T C 2: 172,269,390 (GRCm39) F493L probably damaging Het
Cass4 C T 2: 172,274,478 (GRCm39) P753L probably damaging Het
Cdk14 T A 5: 4,938,924 (GRCm39) M433L probably benign Het
Cep162 C A 9: 87,088,967 (GRCm39) D972Y probably damaging Het
Cfap100 C G 6: 90,390,802 (GRCm39) R184P possibly damaging Het
Cimip3 AC A 17: 47,744,348 (GRCm39) probably benign Het
Clasrp A G 7: 19,320,510 (GRCm39) probably benign Het
Copb1 T A 7: 113,853,110 (GRCm39) D29V possibly damaging Het
Cyp2b9 G A 7: 25,873,030 (GRCm39) probably null Het
Dhx36 C T 3: 62,385,064 (GRCm39) G683S probably damaging Het
Dnaaf11 T A 15: 66,309,436 (GRCm39) probably benign Het
Dnah10 T A 5: 124,838,301 (GRCm39) I1110N probably damaging Het
Dnajc3 C G 14: 119,210,114 (GRCm39) P322A probably benign Het
Eml4 A G 17: 83,785,189 (GRCm39) T785A probably damaging Het
Fam228a T C 12: 4,787,775 (GRCm39) probably benign Het
Fam83e A T 7: 45,378,193 (GRCm39) K406* probably null Het
Fam83e A T 7: 45,378,194 (GRCm39) K406M possibly damaging Het
Fam90a1a T A 8: 22,453,533 (GRCm39) L296Q possibly damaging Het
Fat1 A G 8: 45,403,408 (GRCm39) Y53C probably damaging Het
Fcrl2 T C 3: 87,166,928 (GRCm39) I22V probably damaging Het
Fryl T A 5: 73,230,187 (GRCm39) N1657Y possibly damaging Het
Greb1l A G 18: 10,503,307 (GRCm39) M453V possibly damaging Het
Grm8 A T 6: 27,760,224 (GRCm39) C369S probably damaging Het
Hdc G A 2: 126,458,000 (GRCm39) probably null Het
Hsf3 A T X: 95,363,928 (GRCm39) L191* probably null Het
Iqca1l C T 5: 24,757,038 (GRCm39) probably benign Het
Kif4 A T X: 99,769,737 (GRCm39) N1126Y probably benign Het
Lat2 T C 5: 134,631,481 (GRCm39) D191G probably damaging Het
Lipt2 C T 7: 99,808,601 (GRCm39) T38I probably benign Het
Lmo7 T C 14: 102,137,566 (GRCm39) L634P probably damaging Het
Magea2 A T X: 153,810,855 (GRCm39) L243Q probably damaging Het
Mctp2 A G 7: 71,835,568 (GRCm39) L543P probably damaging Het
Mgat4a T C 1: 37,529,394 (GRCm39) N24D probably benign Het
Mical3 A T 6: 121,010,696 (GRCm39) S429T possibly damaging Het
Mrps35 A G 6: 146,972,125 (GRCm39) E256G possibly damaging Het
Mybbp1a T A 11: 72,337,021 (GRCm39) S586T probably benign Het
Myo1e G A 9: 70,285,655 (GRCm39) probably null Het
Nob1 A G 8: 108,143,729 (GRCm39) probably benign Het
Nom1 T A 5: 29,642,750 (GRCm39) V417D probably damaging Het
Nphs1 A T 7: 30,167,417 (GRCm39) I782F possibly damaging Het
Numa1 A G 7: 101,649,998 (GRCm39) E1243G probably damaging Het
Or52e7 A G 7: 104,685,026 (GRCm39) Y207C probably benign Het
Or7g27 A G 9: 19,249,789 (GRCm39) E11G probably benign Het
Padi4 G A 4: 140,487,251 (GRCm39) T217I possibly damaging Het
Pias3 C T 3: 96,606,962 (GRCm39) T75I probably benign Het
Ppp1r37 G T 7: 19,295,943 (GRCm39) probably benign Het
Prrc2a G A 17: 35,380,044 (GRCm39) P185L unknown Het
Prss57 C T 10: 79,623,204 (GRCm39) C81Y probably damaging Het
Psen1 C T 12: 83,761,594 (GRCm39) S132L probably damaging Het
Ranbp6 A G 19: 29,788,949 (GRCm39) S468P possibly damaging Het
Sla2 G A 2: 156,717,862 (GRCm39) R137C probably damaging Het
Slc2a9 T C 5: 38,610,542 (GRCm39) T86A probably damaging Het
Slco1a6 A T 6: 142,036,742 (GRCm39) M555K probably benign Het
Thoc1 C A 18: 9,993,466 (GRCm39) D608E possibly damaging Het
Tmem121b A T 6: 120,469,030 (GRCm39) Y562* probably null Het
Tmem121b A G 6: 120,469,032 (GRCm39) Y562H probably damaging Het
Tmprss7 A T 16: 45,506,696 (GRCm39) M122K possibly damaging Het
Tmub1 C A 5: 24,651,922 (GRCm39) G14V possibly damaging Het
Uap1 A T 1: 169,986,312 (GRCm39) probably benign Het
Ugdh A T 5: 65,574,458 (GRCm39) probably benign Het
Vmn2r59 A T 7: 41,661,669 (GRCm39) C715* probably null Het
Vps13a G A 19: 16,659,538 (GRCm39) T1663I possibly damaging Het
Vps13c A C 9: 67,860,228 (GRCm39) I2815L possibly damaging Het
Zc3h3 G T 15: 75,711,415 (GRCm39) Q349K possibly damaging Het
Other mutations in Acp7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00423:Acp7 APN 7 28,314,122 (GRCm39) missense possibly damaging 0.79
IGL00808:Acp7 APN 7 28,314,377 (GRCm39) missense probably damaging 1.00
IGL01085:Acp7 APN 7 28,310,478 (GRCm39) missense probably damaging 1.00
IGL02123:Acp7 APN 7 28,328,914 (GRCm39) missense probably benign
IGL02250:Acp7 APN 7 28,329,135 (GRCm39) splice site probably benign
IGL02255:Acp7 APN 7 28,314,148 (GRCm39) missense probably damaging 1.00
IGL02904:Acp7 APN 7 28,307,428 (GRCm39) missense probably benign 0.11
IGL03110:Acp7 APN 7 28,310,464 (GRCm39) missense probably benign 0.25
R0172:Acp7 UTSW 7 28,314,549 (GRCm39) missense possibly damaging 0.95
R0360:Acp7 UTSW 7 28,310,553 (GRCm39) splice site probably benign
R0364:Acp7 UTSW 7 28,310,553 (GRCm39) splice site probably benign
R1616:Acp7 UTSW 7 28,310,503 (GRCm39) missense probably damaging 1.00
R1973:Acp7 UTSW 7 28,307,414 (GRCm39) missense probably damaging 1.00
R2077:Acp7 UTSW 7 28,328,907 (GRCm39) missense probably damaging 1.00
R2125:Acp7 UTSW 7 28,328,974 (GRCm39) missense probably damaging 0.99
R2256:Acp7 UTSW 7 28,313,838 (GRCm39) missense probably damaging 0.98
R2696:Acp7 UTSW 7 28,314,001 (GRCm39) missense probably benign 0.00
R3103:Acp7 UTSW 7 28,310,409 (GRCm39) critical splice donor site probably null
R3753:Acp7 UTSW 7 28,316,085 (GRCm39) missense probably damaging 1.00
R3833:Acp7 UTSW 7 28,314,519 (GRCm39) missense probably benign 0.00
R4622:Acp7 UTSW 7 28,313,822 (GRCm39) missense probably damaging 1.00
R4849:Acp7 UTSW 7 28,314,877 (GRCm39) missense possibly damaging 0.82
R5364:Acp7 UTSW 7 28,310,448 (GRCm39) missense probably benign 0.25
R5382:Acp7 UTSW 7 28,314,844 (GRCm39) missense possibly damaging 0.80
R5665:Acp7 UTSW 7 28,315,968 (GRCm39) missense probably benign 0.31
R5688:Acp7 UTSW 7 28,315,920 (GRCm39) missense probably benign 0.20
R7278:Acp7 UTSW 7 28,330,307 (GRCm39) missense unknown
R7295:Acp7 UTSW 7 28,328,955 (GRCm39) missense possibly damaging 0.83
R7384:Acp7 UTSW 7 28,314,513 (GRCm39) missense possibly damaging 0.89
R7875:Acp7 UTSW 7 28,314,152 (GRCm39) missense probably damaging 1.00
R8227:Acp7 UTSW 7 28,316,073 (GRCm39) missense probably damaging 1.00
R8772:Acp7 UTSW 7 28,315,909 (GRCm39) missense probably damaging 0.99
R8969:Acp7 UTSW 7 28,307,382 (GRCm39) missense probably damaging 1.00
R9053:Acp7 UTSW 7 28,316,616 (GRCm39) missense possibly damaging 0.81
R9199:Acp7 UTSW 7 28,316,591 (GRCm39) missense probably benign 0.45
R9668:Acp7 UTSW 7 28,314,562 (GRCm39) critical splice acceptor site probably null
RF006:Acp7 UTSW 7 28,314,204 (GRCm39) missense possibly damaging 0.94
X0018:Acp7 UTSW 7 28,307,406 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGATGTGAACTGGGCCTCG -3'
(R):5'- TACTGTTCCAATGCGGACCTG -3'

Sequencing Primer
(F):5'- AACTGGGCCTCGAGGGTTG -3'
(R):5'- TCCCACTAGGTCCGCAAAGG -3'
Posted On 2014-10-16