Incidental Mutation 'R2262:Rexo1'
ID 243883
Institutional Source Beutler Lab
Gene Symbol Rexo1
Ensembl Gene ENSMUSG00000047417
Gene Name REX1, RNA exonuclease 1
Synonyms Rex1, Tceb3bp1, 2610511M11Rik, 1700021P10Rik
MMRRC Submission 040262-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.413) question?
Stock # R2262 (G1)
Quality Score 224
Status Validated
Chromosome 10
Chromosomal Location 80376756-80397394 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 80385403 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 552 (E552K)
Ref Sequence ENSEMBL: ENSMUSP00000049705 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057910]
AlphaFold Q7TT28
Predicted Effect probably benign
Transcript: ENSMUST00000057910
AA Change: E552K

PolyPhen 2 Score 0.018 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000049705
Gene: ENSMUSG00000047417
AA Change: E552K

DomainStartEndE-ValueType
low complexity region 34 53 N/A INTRINSIC
coiled coil region 83 113 N/A INTRINSIC
low complexity region 180 188 N/A INTRINSIC
low complexity region 365 381 N/A INTRINSIC
low complexity region 383 396 N/A INTRINSIC
low complexity region 440 453 N/A INTRINSIC
low complexity region 468 479 N/A INTRINSIC
low complexity region 507 525 N/A INTRINSIC
low complexity region 533 551 N/A INTRINSIC
low complexity region 561 583 N/A INTRINSIC
low complexity region 667 682 N/A INTRINSIC
Pfam:EloA-BP1 794 954 3.8e-72 PFAM
EXOIII 1051 1210 2.36e-38 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000182260
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182604
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182682
Predicted Effect probably benign
Transcript: ENSMUST00000183073
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183139
Predicted Effect noncoding transcript
Transcript: ENSMUST00000183233
Meta Mutation Damage Score 0.1036 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 94.9%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ahdc1 A G 4: 132,790,474 (GRCm39) T572A unknown Het
Bco1 T C 8: 117,859,764 (GRCm39) L489S probably damaging Het
Brinp1 A G 4: 68,747,591 (GRCm39) Y171H probably damaging Het
C1rl A T 6: 124,483,907 (GRCm39) I186F probably damaging Het
Cacna1d A G 14: 30,212,973 (GRCm39) V29A possibly damaging Het
Calcrl T C 2: 84,175,517 (GRCm39) D279G probably damaging Het
Cass4 T C 2: 172,269,174 (GRCm39) S421P probably damaging Het
Casz1 G T 4: 149,013,556 (GRCm39) R40L probably damaging Het
Cdh23 A G 10: 60,152,907 (GRCm39) V2372A probably damaging Het
Cdk17 T A 10: 93,047,820 (GRCm39) S56T possibly damaging Het
Ces2h T A 8: 105,743,191 (GRCm39) M142K probably damaging Het
Cfap161 C T 7: 83,442,580 (GRCm39) V78I probably benign Het
Chst8 T A 7: 34,375,435 (GRCm39) M135L probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Dcc C T 18: 71,507,622 (GRCm39) E917K probably damaging Het
Dnah11 T A 12: 117,843,760 (GRCm39) M4362L probably benign Het
Dnah11 T C 12: 117,930,374 (GRCm39) T3324A probably damaging Het
Dnah8 A G 17: 30,892,809 (GRCm39) N798S probably damaging Het
Dnajc3 A G 14: 119,198,232 (GRCm39) Q118R probably damaging Het
Dok4 A T 8: 95,593,140 (GRCm39) C182S probably damaging Het
Fnbp4 G T 2: 90,587,748 (GRCm39) L375F probably damaging Het
Gbp8 T C 5: 105,163,999 (GRCm39) Q433R possibly damaging Het
Glt1d1 A G 5: 127,734,176 (GRCm39) M117V probably benign Het
Hcar1 A C 5: 124,016,649 (GRCm39) D347E probably benign Het
Kif16b T C 2: 142,582,837 (GRCm39) K563E probably damaging Het
Klra17 A G 6: 129,851,757 (GRCm39) probably null Het
Krt35 C T 11: 99,986,593 (GRCm39) M140I probably benign Het
Lamb2 A T 9: 108,357,809 (GRCm39) I111F probably damaging Het
Nell1 C T 7: 50,210,569 (GRCm39) T494I possibly damaging Het
Noa1 G A 5: 77,457,651 (GRCm39) Q85* probably null Het
Nsun4 A T 4: 115,910,147 (GRCm39) S138T probably benign Het
Pcdh1 A T 18: 38,331,710 (GRCm39) L431H probably benign Het
Pde1a T A 2: 79,959,275 (GRCm39) probably benign Het
Pdgfra T C 5: 75,346,184 (GRCm39) V778A probably benign Het
Plekhj1 A T 10: 80,632,306 (GRCm39) N55K probably benign Het
Ptpn20 A G 14: 33,334,268 (GRCm39) M49V probably benign Het
Rbm6 A G 9: 107,668,289 (GRCm39) L547P probably damaging Het
Ryr3 C G 2: 112,506,218 (GRCm39) R3443P probably damaging Het
Saxo1 C T 4: 86,397,212 (GRCm39) D109N probably damaging Het
Setd2 A G 9: 110,390,311 (GRCm39) probably benign Het
Slc22a28 T C 19: 8,048,573 (GRCm39) Y358C probably benign Het
Sptbn4 T A 7: 27,133,782 (GRCm39) D77V probably damaging Het
Ssh1 T C 5: 114,080,764 (GRCm39) S867G possibly damaging Het
Stmn2 T C 3: 8,606,955 (GRCm39) F25S probably damaging Het
Tcirg1 C T 19: 3,953,591 (GRCm39) R112H possibly damaging Het
Tekt4 T A 17: 25,695,485 (GRCm39) S439R possibly damaging Het
Trpc1 T A 9: 95,588,986 (GRCm39) N746I probably damaging Het
Tuba1c A G 15: 98,935,757 (GRCm39) H406R probably damaging Het
Uqcrfs1 G A 13: 30,725,090 (GRCm39) S150L probably benign Het
Vcp T C 4: 42,980,828 (GRCm39) T761A probably benign Het
Vmn1r68 T C 7: 10,261,372 (GRCm39) E242G probably damaging Het
Vmn2r29 T A 7: 7,243,085 (GRCm39) H22L possibly damaging Het
Vmn2r32 T A 7: 7,477,618 (GRCm39) I258L probably benign Het
Vmn2r37 T A 7: 9,220,943 (GRCm39) T307S probably damaging Het
Vmn2r6 T C 3: 64,464,090 (GRCm39) N248S probably benign Het
Vmn2r63 G T 7: 42,578,031 (GRCm39) T169N probably benign Het
Vmn2r67 T C 7: 84,786,182 (GRCm39) T608A probably damaging Het
Wdr87-ps T C 7: 29,231,987 (GRCm39) noncoding transcript Het
Xpo1 T A 11: 23,234,634 (GRCm39) probably null Het
Zfp180 T G 7: 23,804,049 (GRCm39) V156G probably benign Het
Zfp37 A T 4: 62,109,873 (GRCm39) L397Q probably damaging Het
Other mutations in Rexo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00970:Rexo1 APN 10 80,386,798 (GRCm39) missense probably damaging 0.99
IGL01128:Rexo1 APN 10 80,385,573 (GRCm39) missense probably benign
IGL01890:Rexo1 APN 10 80,378,845 (GRCm39) missense possibly damaging 0.85
PIT4453001:Rexo1 UTSW 10 80,386,231 (GRCm39) missense probably damaging 0.97
R0044:Rexo1 UTSW 10 80,380,212 (GRCm39) missense probably benign 0.16
R0365:Rexo1 UTSW 10 80,378,410 (GRCm39) missense probably damaging 0.99
R0573:Rexo1 UTSW 10 80,380,684 (GRCm39) missense probably damaging 1.00
R1146:Rexo1 UTSW 10 80,380,239 (GRCm39) missense probably benign 0.04
R1146:Rexo1 UTSW 10 80,380,239 (GRCm39) missense probably benign 0.04
R1511:Rexo1 UTSW 10 80,385,884 (GRCm39) missense possibly damaging 0.93
R1523:Rexo1 UTSW 10 80,378,585 (GRCm39) missense probably benign 0.41
R1807:Rexo1 UTSW 10 80,378,413 (GRCm39) missense possibly damaging 0.95
R1868:Rexo1 UTSW 10 80,378,754 (GRCm39) missense probably damaging 1.00
R1935:Rexo1 UTSW 10 80,386,303 (GRCm39) missense probably benign 0.00
R1936:Rexo1 UTSW 10 80,386,303 (GRCm39) missense probably benign 0.00
R1957:Rexo1 UTSW 10 80,379,200 (GRCm39) missense probably damaging 0.96
R2084:Rexo1 UTSW 10 80,397,100 (GRCm39) missense probably benign 0.01
R2153:Rexo1 UTSW 10 80,379,943 (GRCm39) nonsense probably null
R4471:Rexo1 UTSW 10 80,378,492 (GRCm39) missense probably damaging 1.00
R4472:Rexo1 UTSW 10 80,378,492 (GRCm39) missense probably damaging 1.00
R4690:Rexo1 UTSW 10 80,382,255 (GRCm39) missense probably benign 0.01
R4972:Rexo1 UTSW 10 80,385,527 (GRCm39) missense probably damaging 0.96
R6335:Rexo1 UTSW 10 80,379,915 (GRCm39) missense probably damaging 1.00
R6505:Rexo1 UTSW 10 80,378,845 (GRCm39) missense possibly damaging 0.85
R6615:Rexo1 UTSW 10 80,379,848 (GRCm39) missense possibly damaging 0.68
R6949:Rexo1 UTSW 10 80,386,470 (GRCm39) missense possibly damaging 0.46
R7612:Rexo1 UTSW 10 80,385,497 (GRCm39) missense probably benign 0.40
R7807:Rexo1 UTSW 10 80,385,970 (GRCm39) missense probably benign 0.09
R7840:Rexo1 UTSW 10 80,386,572 (GRCm39) missense probably benign
R8779:Rexo1 UTSW 10 80,384,292 (GRCm39) missense probably benign 0.26
R8897:Rexo1 UTSW 10 80,378,437 (GRCm39) missense probably damaging 0.98
R8995:Rexo1 UTSW 10 80,386,095 (GRCm39) missense probably damaging 0.96
R9094:Rexo1 UTSW 10 80,378,854 (GRCm39) missense probably damaging 1.00
R9411:Rexo1 UTSW 10 80,397,248 (GRCm39) missense
R9438:Rexo1 UTSW 10 80,378,848 (GRCm39) missense possibly damaging 0.46
R9524:Rexo1 UTSW 10 80,386,872 (GRCm39) missense probably damaging 1.00
R9648:Rexo1 UTSW 10 80,385,540 (GRCm39) missense probably damaging 0.97
Z1177:Rexo1 UTSW 10 80,385,609 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTCGTTGAAGATCCGCAG -3'
(R):5'- TCATCGGGAAAGTTGGTGGAAC -3'

Sequencing Primer
(F):5'- AGGCACTCCTCCATAGGGTC -3'
(R):5'- TTGGTGGAACGCAAGGCC -3'
Posted On 2014-10-16