Incidental Mutation 'R0277:Thsd7b'
| ID |
24395 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Thsd7b
|
| Ensembl Gene |
ENSMUSG00000042581 |
| Gene Name |
thrombospondin, type I, domain containing 7B |
| Synonyms |
1700074E13Rik, D130067I03Rik |
| MMRRC Submission |
038499-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.116)
|
| Stock # |
R0277 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
129201039-130147015 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 130123000 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 1540
(I1540V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000073220
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000073527]
|
| AlphaFold |
Q6P4U0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000073527
AA Change: I1540V
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000073220
Gene: ENSMUSG00000042581
AA Change: I1540V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
36 |
N/A |
INTRINSIC |
|
Blast:TSP1
|
43 |
98 |
5e-29 |
BLAST |
|
Blast:TSP1
|
122 |
177 |
9e-24 |
BLAST |
|
TSP1
|
182 |
233 |
2.47e-9 |
SMART |
|
TSP1
|
339 |
399 |
7e-9 |
SMART |
|
Blast:TSP1
|
402 |
482 |
2e-27 |
BLAST |
|
TSP1
|
487 |
543 |
2.12e-1 |
SMART |
|
TSP1
|
604 |
661 |
3.9e-7 |
SMART |
|
TSP1
|
664 |
735 |
2.73e-2 |
SMART |
|
TSP1
|
740 |
796 |
1.01e-5 |
SMART |
|
Blast:TSP1
|
799 |
869 |
6e-35 |
BLAST |
|
TSP1
|
874 |
922 |
9.68e-3 |
SMART |
|
TSP1
|
952 |
999 |
2.42e0 |
SMART |
|
TSP1
|
1004 |
1059 |
3.96e-8 |
SMART |
|
TSP1
|
1062 |
1126 |
1.73e0 |
SMART |
|
TSP1
|
1131 |
1182 |
6.05e-4 |
SMART |
|
TSP1
|
1185 |
1246 |
9.52e-1 |
SMART |
|
TSP1
|
1251 |
1303 |
3.21e-8 |
SMART |
|
TSP1
|
1304 |
1369 |
5.52e-1 |
SMART |
|
TSP1
|
1374 |
1432 |
3.92e-2 |
SMART |
|
transmembrane domain
|
1558 |
1580 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140834
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000190086
|
| Meta Mutation Damage Score |
0.0685 |
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.7%
- 10x: 95.0%
- 20x: 89.3%
|
| Validation Efficiency |
99% (111/112) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 109 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930533L02Rik |
A |
G |
7: 124,917,815 (GRCm39) |
K69R |
unknown |
Het |
| Abca13 |
A |
C |
11: 9,244,701 (GRCm39) |
D2188A |
probably benign |
Het |
| Acad11 |
T |
C |
9: 104,001,224 (GRCm39) |
M708T |
probably damaging |
Het |
| Adam7 |
T |
C |
14: 68,748,306 (GRCm39) |
|
probably null |
Het |
| Adgre1 |
T |
A |
17: 57,751,060 (GRCm39) |
I578N |
probably benign |
Het |
| Agbl4 |
T |
C |
4: 111,474,419 (GRCm39) |
S403P |
probably damaging |
Het |
| Ak3 |
A |
G |
19: 29,025,192 (GRCm39) |
M13T |
possibly damaging |
Het |
| Ap2s1 |
T |
C |
7: 16,481,305 (GRCm39) |
|
probably benign |
Het |
| Arhgef1 |
A |
T |
7: 24,623,224 (GRCm39) |
|
probably benign |
Het |
| Arsk |
T |
C |
13: 76,223,051 (GRCm39) |
N182S |
probably benign |
Het |
| Aspscr1 |
G |
A |
11: 120,569,246 (GRCm39) |
V15I |
probably damaging |
Het |
| Asxl2 |
A |
G |
12: 3,492,487 (GRCm39) |
Y24C |
probably damaging |
Het |
| Atp8b1 |
A |
G |
18: 64,701,323 (GRCm39) |
F345S |
possibly damaging |
Het |
| Atp8b3 |
T |
C |
10: 80,362,743 (GRCm39) |
K672E |
probably benign |
Het |
| Bltp1 |
T |
A |
3: 36,997,331 (GRCm39) |
C1129* |
probably null |
Het |
| Bmp2k |
A |
G |
5: 97,235,682 (GRCm39) |
|
probably benign |
Het |
| Casp6 |
T |
A |
3: 129,704,172 (GRCm39) |
V86E |
probably benign |
Het |
| Cdca5 |
A |
G |
19: 6,140,742 (GRCm39) |
E260G |
unknown |
Het |
| Cpb2 |
T |
A |
14: 75,502,898 (GRCm39) |
V159D |
probably damaging |
Het |
| Cylc2 |
T |
A |
4: 51,228,477 (GRCm39) |
S183T |
unknown |
Het |
| Dhtkd1 |
T |
A |
2: 5,919,699 (GRCm39) |
M561L |
probably benign |
Het |
| Dync2h1 |
T |
C |
9: 7,129,046 (GRCm39) |
D1823G |
probably benign |
Het |
| Efcab5 |
G |
A |
11: 77,031,749 (GRCm39) |
R42W |
probably damaging |
Het |
| Erc1 |
T |
C |
6: 119,597,289 (GRCm39) |
K1003E |
probably damaging |
Het |
| Ezr |
G |
A |
17: 7,022,164 (GRCm39) |
Q105* |
probably null |
Het |
| Fam83d |
T |
A |
2: 158,627,467 (GRCm39) |
D385E |
probably benign |
Het |
| Fbn2 |
A |
G |
18: 58,178,389 (GRCm39) |
C1950R |
probably damaging |
Het |
| Fbxo32 |
A |
T |
15: 58,047,605 (GRCm39) |
I236N |
probably damaging |
Het |
| Fcgbp |
G |
T |
7: 27,784,918 (GRCm39) |
|
probably null |
Het |
| Foxe3 |
T |
C |
4: 114,782,805 (GRCm39) |
N136D |
probably damaging |
Het |
| Fscn2 |
A |
T |
11: 120,258,837 (GRCm39) |
I461F |
probably damaging |
Het |
| Gldc |
A |
G |
19: 30,093,851 (GRCm39) |
I722T |
possibly damaging |
Het |
| Gm10717 |
T |
G |
9: 3,025,619 (GRCm39) |
V68G |
possibly damaging |
Het |
| Gm4841 |
A |
G |
18: 60,403,718 (GRCm39) |
L125S |
possibly damaging |
Het |
| Gnl3 |
A |
C |
14: 30,735,384 (GRCm39) |
|
probably null |
Het |
| Gsto1 |
A |
T |
19: 47,846,416 (GRCm39) |
I88F |
probably damaging |
Het |
| Gucy1b1 |
T |
A |
3: 81,945,463 (GRCm39) |
|
probably null |
Het |
| Hhla1 |
C |
A |
15: 65,820,352 (GRCm39) |
V133F |
probably benign |
Het |
| Hipk3 |
T |
A |
2: 104,271,593 (GRCm39) |
L446F |
probably damaging |
Het |
| Hscb |
T |
C |
5: 110,982,556 (GRCm39) |
E177G |
possibly damaging |
Het |
| Hsd17b6 |
T |
C |
10: 127,827,274 (GRCm39) |
D266G |
probably benign |
Het |
| Ipo4 |
T |
C |
14: 55,869,572 (GRCm39) |
S363G |
probably benign |
Het |
| Kcnip3 |
A |
G |
2: 127,301,899 (GRCm39) |
|
probably benign |
Het |
| Klhl41 |
A |
G |
2: 69,501,640 (GRCm39) |
Y367C |
probably damaging |
Het |
| Klk1b4 |
C |
G |
7: 43,861,053 (GRCm39) |
P232R |
possibly damaging |
Het |
| Lcp2 |
A |
G |
11: 34,004,322 (GRCm39) |
D53G |
probably damaging |
Het |
| Llgl2 |
A |
G |
11: 115,741,546 (GRCm39) |
K559E |
probably damaging |
Het |
| Lrrc59 |
A |
C |
11: 94,534,248 (GRCm39) |
T269P |
probably damaging |
Het |
| Mark1 |
A |
G |
1: 184,677,149 (GRCm39) |
S34P |
possibly damaging |
Het |
| Megf11 |
G |
A |
9: 64,598,632 (GRCm39) |
|
probably null |
Het |
| Mplkip |
A |
G |
13: 17,871,565 (GRCm39) |
I159V |
possibly damaging |
Het |
| Muc4 |
C |
A |
16: 32,755,690 (GRCm38) |
|
probably benign |
Het |
| Myo18b |
A |
G |
5: 112,841,213 (GRCm39) |
|
probably benign |
Het |
| Myo9b |
T |
C |
8: 71,808,596 (GRCm39) |
|
probably benign |
Het |
| Napg |
C |
T |
18: 63,120,034 (GRCm39) |
R149C |
probably damaging |
Het |
| Ndrg3 |
A |
G |
2: 156,776,855 (GRCm39) |
|
probably benign |
Het |
| Nfe2l3 |
T |
A |
6: 51,434,448 (GRCm39) |
M336K |
probably benign |
Het |
| Nrxn1 |
A |
C |
17: 91,008,170 (GRCm39) |
|
probably null |
Het |
| Nsun3 |
A |
T |
16: 62,597,007 (GRCm39) |
|
probably benign |
Het |
| Nuak1 |
T |
C |
10: 84,210,315 (GRCm39) |
E591G |
probably benign |
Het |
| Or10g1b |
T |
C |
14: 52,627,846 (GRCm39) |
Y128C |
probably damaging |
Het |
| Or10s1 |
G |
A |
9: 39,986,010 (GRCm39) |
V140I |
probably benign |
Het |
| Or1e17 |
A |
T |
11: 73,831,773 (GRCm39) |
I234F |
probably benign |
Het |
| Or4k2 |
T |
C |
14: 50,423,789 (GRCm39) |
N296S |
probably null |
Het |
| Or6c70 |
T |
A |
10: 129,709,936 (GRCm39) |
Q230L |
probably damaging |
Het |
| Or6d15 |
A |
T |
6: 116,559,562 (GRCm39) |
V115E |
probably damaging |
Het |
| Or6z6 |
T |
A |
7: 6,491,433 (GRCm39) |
M147L |
probably benign |
Het |
| Orc4 |
A |
T |
2: 48,827,479 (GRCm39) |
V38E |
possibly damaging |
Het |
| Ovgp1 |
T |
C |
3: 105,887,208 (GRCm39) |
|
probably benign |
Het |
| Palm3 |
T |
A |
8: 84,755,349 (GRCm39) |
V287D |
probably damaging |
Het |
| Pde4dip |
T |
A |
3: 97,751,028 (GRCm39) |
H62L |
probably benign |
Het |
| Pdk4 |
G |
T |
6: 5,491,620 (GRCm39) |
P100Q |
probably damaging |
Het |
| Pdss2 |
T |
A |
10: 43,248,172 (GRCm39) |
H225Q |
probably benign |
Het |
| Pkhd1 |
A |
T |
1: 20,345,762 (GRCm39) |
D2755E |
probably benign |
Het |
| Prune2 |
A |
T |
19: 17,098,753 (GRCm39) |
D1419V |
probably damaging |
Het |
| Pth2r |
A |
C |
1: 65,427,775 (GRCm39) |
I483L |
probably benign |
Het |
| Qrsl1 |
A |
G |
10: 43,772,003 (GRCm39) |
|
probably null |
Het |
| Rab11fip4 |
A |
G |
11: 79,577,455 (GRCm39) |
H403R |
possibly damaging |
Het |
| Ralgapa1 |
A |
T |
12: 55,724,023 (GRCm39) |
I1548N |
probably damaging |
Het |
| Ric8a |
T |
G |
7: 140,437,813 (GRCm39) |
|
probably benign |
Het |
| Rsbn1 |
T |
C |
3: 103,821,897 (GRCm39) |
F44S |
possibly damaging |
Het |
| Serpinc1 |
T |
A |
1: 160,817,272 (GRCm39) |
M1K |
probably null |
Het |
| Sf3b1 |
T |
C |
1: 55,058,416 (GRCm39) |
I58V |
probably damaging |
Het |
| Sh3d19 |
T |
A |
3: 86,033,978 (GRCm39) |
M777K |
probably benign |
Het |
| Sipa1 |
A |
T |
19: 5,704,093 (GRCm39) |
M743K |
probably benign |
Het |
| Skint5 |
T |
C |
4: 113,794,818 (GRCm39) |
H255R |
probably benign |
Het |
| Slco6b1 |
A |
T |
1: 96,916,398 (GRCm39) |
|
noncoding transcript |
Het |
| Slfn4 |
A |
T |
11: 83,077,777 (GRCm39) |
R188S |
probably damaging |
Het |
| Sort1 |
T |
C |
3: 108,231,908 (GRCm39) |
|
probably benign |
Het |
| Spg21 |
A |
T |
9: 65,372,629 (GRCm39) |
K20N |
possibly damaging |
Het |
| Sptbn2 |
A |
T |
19: 4,795,173 (GRCm39) |
I1544F |
probably benign |
Het |
| Srf |
T |
C |
17: 46,860,415 (GRCm39) |
T456A |
possibly damaging |
Het |
| Ssbp2 |
T |
A |
13: 91,712,715 (GRCm39) |
|
probably benign |
Het |
| Stx2 |
C |
T |
5: 129,065,967 (GRCm39) |
V230I |
probably benign |
Het |
| Sv2b |
A |
T |
7: 74,856,187 (GRCm39) |
D34E |
possibly damaging |
Het |
| Synpo2l |
A |
G |
14: 20,711,856 (GRCm39) |
S255P |
probably damaging |
Het |
| Tbx15 |
C |
T |
3: 99,259,707 (GRCm39) |
P526L |
probably damaging |
Het |
| Tenm4 |
C |
A |
7: 96,344,157 (GRCm39) |
P250Q |
possibly damaging |
Het |
| Tgm1 |
C |
A |
14: 55,948,384 (GRCm39) |
|
probably benign |
Het |
| Tgm1 |
T |
C |
14: 55,950,109 (GRCm39) |
|
probably benign |
Het |
| Tnrc6c |
A |
G |
11: 117,630,707 (GRCm39) |
K1023E |
probably damaging |
Het |
| Ube2l6 |
A |
T |
2: 84,636,771 (GRCm39) |
|
probably null |
Het |
| Uty |
T |
A |
Y: 1,169,979 (GRCm39) |
I326F |
probably damaging |
Het |
| Wdfy4 |
T |
C |
14: 32,805,742 (GRCm39) |
D1735G |
possibly damaging |
Het |
| Wnt11 |
A |
G |
7: 98,496,590 (GRCm39) |
K177E |
probably damaging |
Het |
| Wnt5a |
A |
T |
14: 28,235,225 (GRCm39) |
M70L |
possibly damaging |
Het |
| Wwc1 |
T |
A |
11: 35,743,175 (GRCm39) |
E882V |
probably damaging |
Het |
| Zfp455 |
G |
T |
13: 67,346,728 (GRCm39) |
|
probably null |
Het |
| Zmpste24 |
A |
G |
4: 120,940,050 (GRCm39) |
Y199H |
probably damaging |
Het |
|
| Other mutations in Thsd7b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00417:Thsd7b
|
APN |
1 |
129,523,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00850:Thsd7b
|
APN |
1 |
130,092,814 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00987:Thsd7b
|
APN |
1 |
129,541,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01068:Thsd7b
|
APN |
1 |
129,523,883 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01091:Thsd7b
|
APN |
1 |
129,704,071 (GRCm39) |
missense |
probably benign |
0.29 |
|
IGL01535:Thsd7b
|
APN |
1 |
129,605,954 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL01560:Thsd7b
|
APN |
1 |
130,145,918 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01701:Thsd7b
|
APN |
1 |
129,358,665 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL01775:Thsd7b
|
APN |
1 |
129,556,676 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02077:Thsd7b
|
APN |
1 |
129,744,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02338:Thsd7b
|
APN |
1 |
129,523,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02340:Thsd7b
|
APN |
1 |
130,087,369 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02404:Thsd7b
|
APN |
1 |
129,540,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02519:Thsd7b
|
APN |
1 |
129,540,932 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02543:Thsd7b
|
APN |
1 |
130,092,840 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02740:Thsd7b
|
APN |
1 |
129,540,864 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02793:Thsd7b
|
APN |
1 |
129,879,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02875:Thsd7b
|
APN |
1 |
129,879,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02986:Thsd7b
|
APN |
1 |
129,843,352 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03108:Thsd7b
|
APN |
1 |
130,138,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03114:Thsd7b
|
APN |
1 |
130,116,288 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03195:Thsd7b
|
APN |
1 |
129,556,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03291:Thsd7b
|
APN |
1 |
129,688,092 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03397:Thsd7b
|
APN |
1 |
129,523,901 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03399:Thsd7b
|
APN |
1 |
129,556,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0184:Thsd7b
|
UTSW |
1 |
129,358,701 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0526:Thsd7b
|
UTSW |
1 |
129,879,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0633:Thsd7b
|
UTSW |
1 |
130,116,263 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0746:Thsd7b
|
UTSW |
1 |
130,116,268 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0784:Thsd7b
|
UTSW |
1 |
129,523,096 (GRCm39) |
splice site |
probably benign |
|
|
R1158:Thsd7b
|
UTSW |
1 |
130,117,672 (GRCm39) |
splice site |
probably null |
|
|
R1267:Thsd7b
|
UTSW |
1 |
129,556,577 (GRCm39) |
splice site |
probably null |
|
|
R1375:Thsd7b
|
UTSW |
1 |
130,087,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1565:Thsd7b
|
UTSW |
1 |
129,523,778 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1728:Thsd7b
|
UTSW |
1 |
129,605,920 (GRCm39) |
missense |
probably benign |
|
|
R1728:Thsd7b
|
UTSW |
1 |
129,595,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1728:Thsd7b
|
UTSW |
1 |
129,556,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1728:Thsd7b
|
UTSW |
1 |
130,044,368 (GRCm39) |
missense |
probably benign |
|
|
R1729:Thsd7b
|
UTSW |
1 |
129,605,920 (GRCm39) |
missense |
probably benign |
|
|
R1729:Thsd7b
|
UTSW |
1 |
129,595,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1729:Thsd7b
|
UTSW |
1 |
129,556,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1729:Thsd7b
|
UTSW |
1 |
130,044,368 (GRCm39) |
missense |
probably benign |
|
|
R1730:Thsd7b
|
UTSW |
1 |
129,605,920 (GRCm39) |
missense |
probably benign |
|
|
R1730:Thsd7b
|
UTSW |
1 |
129,595,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1730:Thsd7b
|
UTSW |
1 |
129,556,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1730:Thsd7b
|
UTSW |
1 |
130,044,368 (GRCm39) |
missense |
probably benign |
|
|
R1739:Thsd7b
|
UTSW |
1 |
129,595,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1739:Thsd7b
|
UTSW |
1 |
129,556,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1739:Thsd7b
|
UTSW |
1 |
130,044,368 (GRCm39) |
missense |
probably benign |
|
|
R1739:Thsd7b
|
UTSW |
1 |
129,605,920 (GRCm39) |
missense |
probably benign |
|
|
R1762:Thsd7b
|
UTSW |
1 |
129,595,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1762:Thsd7b
|
UTSW |
1 |
129,556,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1762:Thsd7b
|
UTSW |
1 |
130,044,368 (GRCm39) |
missense |
probably benign |
|
|
R1762:Thsd7b
|
UTSW |
1 |
130,030,813 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1762:Thsd7b
|
UTSW |
1 |
129,605,920 (GRCm39) |
missense |
probably benign |
|
|
R1783:Thsd7b
|
UTSW |
1 |
129,605,920 (GRCm39) |
missense |
probably benign |
|
|
R1783:Thsd7b
|
UTSW |
1 |
129,595,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1783:Thsd7b
|
UTSW |
1 |
129,556,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Thsd7b
|
UTSW |
1 |
130,044,368 (GRCm39) |
missense |
probably benign |
|
|
R1784:Thsd7b
|
UTSW |
1 |
129,595,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1784:Thsd7b
|
UTSW |
1 |
129,556,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Thsd7b
|
UTSW |
1 |
130,044,368 (GRCm39) |
missense |
probably benign |
|
|
R1784:Thsd7b
|
UTSW |
1 |
129,605,920 (GRCm39) |
missense |
probably benign |
|
|
R1785:Thsd7b
|
UTSW |
1 |
129,605,920 (GRCm39) |
missense |
probably benign |
|
|
R1785:Thsd7b
|
UTSW |
1 |
129,595,674 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1785:Thsd7b
|
UTSW |
1 |
129,556,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1785:Thsd7b
|
UTSW |
1 |
130,044,368 (GRCm39) |
missense |
probably benign |
|
|
R1812:Thsd7b
|
UTSW |
1 |
129,686,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1846:Thsd7b
|
UTSW |
1 |
129,540,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Thsd7b
|
UTSW |
1 |
129,605,846 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1996:Thsd7b
|
UTSW |
1 |
129,686,188 (GRCm39) |
nonsense |
probably null |
|
|
R2199:Thsd7b
|
UTSW |
1 |
130,145,895 (GRCm39) |
missense |
probably benign |
0.04 |
|
R2483:Thsd7b
|
UTSW |
1 |
130,030,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Thsd7b
|
UTSW |
1 |
130,117,587 (GRCm39) |
splice site |
probably benign |
|
|
R2935:Thsd7b
|
UTSW |
1 |
129,605,824 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R3113:Thsd7b
|
UTSW |
1 |
129,977,599 (GRCm39) |
missense |
probably benign |
0.23 |
|
R3236:Thsd7b
|
UTSW |
1 |
130,145,855 (GRCm39) |
nonsense |
probably null |
|
|
R3745:Thsd7b
|
UTSW |
1 |
129,605,978 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3877:Thsd7b
|
UTSW |
1 |
130,117,919 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3880:Thsd7b
|
UTSW |
1 |
129,523,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4110:Thsd7b
|
UTSW |
1 |
130,044,356 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4112:Thsd7b
|
UTSW |
1 |
130,044,356 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4255:Thsd7b
|
UTSW |
1 |
129,688,024 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4621:Thsd7b
|
UTSW |
1 |
129,358,652 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R4703:Thsd7b
|
UTSW |
1 |
129,977,646 (GRCm39) |
intron |
probably benign |
|
|
R4732:Thsd7b
|
UTSW |
1 |
129,540,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4733:Thsd7b
|
UTSW |
1 |
129,540,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Thsd7b
|
UTSW |
1 |
130,138,001 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4805:Thsd7b
|
UTSW |
1 |
130,116,276 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4840:Thsd7b
|
UTSW |
1 |
129,523,581 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4879:Thsd7b
|
UTSW |
1 |
130,116,236 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4936:Thsd7b
|
UTSW |
1 |
129,605,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4972:Thsd7b
|
UTSW |
1 |
130,116,309 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5304:Thsd7b
|
UTSW |
1 |
129,605,980 (GRCm39) |
nonsense |
probably null |
|
|
R5422:Thsd7b
|
UTSW |
1 |
129,849,071 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5495:Thsd7b
|
UTSW |
1 |
129,523,570 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5598:Thsd7b
|
UTSW |
1 |
129,523,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5620:Thsd7b
|
UTSW |
1 |
130,090,673 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5638:Thsd7b
|
UTSW |
1 |
129,523,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5640:Thsd7b
|
UTSW |
1 |
130,044,408 (GRCm39) |
nonsense |
probably null |
|
|
R5655:Thsd7b
|
UTSW |
1 |
129,556,671 (GRCm39) |
splice site |
probably null |
|
|
R5711:Thsd7b
|
UTSW |
1 |
129,688,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5823:Thsd7b
|
UTSW |
1 |
129,605,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5888:Thsd7b
|
UTSW |
1 |
130,138,057 (GRCm39) |
nonsense |
probably null |
|
|
R5932:Thsd7b
|
UTSW |
1 |
129,358,575 (GRCm39) |
missense |
probably benign |
|
|
R6243:Thsd7b
|
UTSW |
1 |
130,090,599 (GRCm39) |
missense |
probably benign |
0.21 |
|
R6258:Thsd7b
|
UTSW |
1 |
129,595,655 (GRCm39) |
missense |
probably benign |
|
|
R6260:Thsd7b
|
UTSW |
1 |
129,595,655 (GRCm39) |
missense |
probably benign |
|
|
R6399:Thsd7b
|
UTSW |
1 |
129,744,385 (GRCm39) |
missense |
probably benign |
0.13 |
|
R6437:Thsd7b
|
UTSW |
1 |
129,744,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6719:Thsd7b
|
UTSW |
1 |
130,087,451 (GRCm39) |
splice site |
probably null |
|
|
R6785:Thsd7b
|
UTSW |
1 |
129,358,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7304:Thsd7b
|
UTSW |
1 |
130,030,890 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7334:Thsd7b
|
UTSW |
1 |
130,123,012 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7414:Thsd7b
|
UTSW |
1 |
129,556,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7673:Thsd7b
|
UTSW |
1 |
129,843,487 (GRCm39) |
splice site |
probably null |
|
|
R7683:Thsd7b
|
UTSW |
1 |
129,523,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7861:Thsd7b
|
UTSW |
1 |
130,087,435 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8145:Thsd7b
|
UTSW |
1 |
129,688,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8241:Thsd7b
|
UTSW |
1 |
130,117,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8296:Thsd7b
|
UTSW |
1 |
129,523,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8355:Thsd7b
|
UTSW |
1 |
129,523,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Thsd7b
|
UTSW |
1 |
129,605,790 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8520:Thsd7b
|
UTSW |
1 |
129,849,157 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8555:Thsd7b
|
UTSW |
1 |
129,523,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8682:Thsd7b
|
UTSW |
1 |
129,688,011 (GRCm39) |
nonsense |
probably null |
|
|
R8981:Thsd7b
|
UTSW |
1 |
129,523,187 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9029:Thsd7b
|
UTSW |
1 |
130,087,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9133:Thsd7b
|
UTSW |
1 |
129,843,382 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9194:Thsd7b
|
UTSW |
1 |
129,843,371 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9229:Thsd7b
|
UTSW |
1 |
129,849,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9239:Thsd7b
|
UTSW |
1 |
130,087,453 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9460:Thsd7b
|
UTSW |
1 |
130,090,674 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9466:Thsd7b
|
UTSW |
1 |
130,122,866 (GRCm39) |
missense |
probably benign |
|
|
R9588:Thsd7b
|
UTSW |
1 |
130,108,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Thsd7b
|
UTSW |
1 |
129,523,809 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Thsd7b
|
UTSW |
1 |
129,556,648 (GRCm39) |
missense |
probably benign |
0.17 |
|
Z1176:Thsd7b
|
UTSW |
1 |
129,523,397 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Thsd7b
|
UTSW |
1 |
129,523,253 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Thsd7b
|
UTSW |
1 |
130,108,161 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGAAACCCCTGGATTTCCAAGAC -3'
(R):5'- TCCTAGCTCACTGCCACTTAGACTG -3'
Sequencing Primer
(F):5'- TGGATTTCCAAGACATACAAAGAC -3'
(R):5'- CCACTTAGACTGTGATTGACAGG -3'
|
| Posted On |
2013-04-16 |
Incidental Mutation