Incidental Mutation 'R2263:Armh3'
ID 243965
Institutional Source Beutler Lab
Gene Symbol Armh3
Ensembl Gene ENSMUSG00000039901
Gene Name armadillo-like helical domain containing 3
Synonyms 9130011E15Rik
MMRRC Submission 040263-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2263 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 45805803-45986927 bp(-) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 45920788 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000048454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045396]
AlphaFold Q6PD19
Predicted Effect probably null
Transcript: ENSMUST00000045396
SMART Domains Protein: ENSMUSP00000048454
Gene: ENSMUSG00000039901

DomainStartEndE-ValueType
low complexity region 155 167 N/A INTRINSIC
low complexity region 327 348 N/A INTRINSIC
DUF1741 435 671 5.65e-139 SMART
Meta Mutation Damage Score 0.9580 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.5%
Validation Efficiency 98% (57/58)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T C 11: 9,224,702 (GRCm39) S472P probably benign Het
Arsi T C 18: 61,049,737 (GRCm39) Y207H probably damaging Het
Atp2b4 C T 1: 133,654,271 (GRCm39) R778Q probably benign Het
Bdp1 T A 13: 100,202,545 (GRCm39) D693V probably damaging Het
Car12 C A 9: 66,654,913 (GRCm39) Y114* probably null Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Col4a1 A G 8: 11,362,586 (GRCm39) probably benign Het
Cryl1 G T 14: 57,523,865 (GRCm39) Y232* probably null Het
Dnah11 T A 12: 117,843,760 (GRCm39) M4362L probably benign Het
Dnah11 T C 12: 117,930,374 (GRCm39) T3324A probably damaging Het
Dnah8 A G 17: 30,892,809 (GRCm39) N798S probably damaging Het
Dok4 A T 8: 95,593,140 (GRCm39) C182S probably damaging Het
Ehbp1 A T 11: 22,045,462 (GRCm39) N737K probably benign Het
Eif2b4 T C 5: 31,349,918 (GRCm39) probably benign Het
Elp1 A G 4: 56,755,298 (GRCm39) probably null Het
Fat4 T C 3: 38,943,138 (GRCm39) V677A possibly damaging Het
Fbn2 A G 18: 58,228,248 (GRCm39) probably benign Het
Fbxl3 G T 14: 103,320,648 (GRCm39) Y314* probably null Het
Fgf12 T A 16: 28,008,363 (GRCm39) K84* probably null Het
Flt3 G A 5: 147,284,873 (GRCm39) P748L probably benign Het
Folh1 C T 7: 86,368,973 (GRCm39) S685N probably benign Het
Gpr65 A T 12: 98,241,494 (GRCm39) N49I probably damaging Het
Hdac7 A G 15: 97,708,732 (GRCm39) probably null Het
Heatr5a A T 12: 51,962,933 (GRCm39) V989E probably damaging Het
Kif12 A G 4: 63,087,758 (GRCm39) S242P probably benign Het
Ltbp3 G A 19: 5,804,050 (GRCm39) R854Q probably benign Het
Mia3 A G 1: 183,115,647 (GRCm39) Y295H probably benign Het
Nell1 C T 7: 50,210,569 (GRCm39) T494I possibly damaging Het
Nmur2 A T 11: 55,920,387 (GRCm39) V286E probably damaging Het
Or1ad6 G A 11: 50,860,696 (GRCm39) V284I possibly damaging Het
Or1e1 T A 11: 73,245,131 (GRCm39) L184Q possibly damaging Het
Or51t4 T C 7: 102,598,464 (GRCm39) F254S probably damaging Het
Pcdh1 A T 18: 38,331,710 (GRCm39) L431H probably benign Het
Pramel31 A G 4: 144,090,111 (GRCm39) I384V probably benign Het
Prex1 A T 2: 166,430,988 (GRCm39) probably benign Het
Prim1 T A 10: 127,851,132 (GRCm39) D5E probably benign Het
Rubcnl A T 14: 75,278,260 (GRCm39) N348I possibly damaging Het
Shisa9 G T 16: 11,802,631 (GRCm39) A63S possibly damaging Het
Shpk G A 11: 73,097,319 (GRCm39) probably benign Het
Slx4ip T C 2: 136,885,935 (GRCm39) I85T probably damaging Het
Sptbn4 T A 7: 27,133,782 (GRCm39) D77V probably damaging Het
Strn3 A T 12: 51,690,006 (GRCm39) probably null Het
Synrg T C 11: 83,867,978 (GRCm39) M61T possibly damaging Het
Tekt4 T A 17: 25,695,485 (GRCm39) S439R possibly damaging Het
Ticam1 A T 17: 56,578,888 (GRCm39) V69E possibly damaging Het
Trpv1 C T 11: 73,132,508 (GRCm39) A374V probably damaging Het
Ubqln3 A T 7: 103,790,842 (GRCm39) L416* probably null Het
Uqcrfs1 G A 13: 30,725,090 (GRCm39) S150L probably benign Het
Utp15 T C 13: 98,394,433 (GRCm39) N153S probably benign Het
Vmn2r63 G T 7: 42,578,031 (GRCm39) T169N probably benign Het
Vps13b T A 15: 35,646,327 (GRCm39) V1477E probably benign Het
Wdr87-ps T C 7: 29,231,987 (GRCm39) noncoding transcript Het
Xpo1 T A 11: 23,234,634 (GRCm39) probably null Het
Xpo5 A G 17: 46,541,269 (GRCm39) I769V probably benign Het
Zc3h14 A T 12: 98,724,773 (GRCm39) H252L probably benign Het
Zfp410 G T 12: 84,369,794 (GRCm39) probably null Het
Zfp521 T C 18: 13,979,297 (GRCm39) E372G possibly damaging Het
Other mutations in Armh3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00392:Armh3 APN 19 45,928,927 (GRCm39) missense probably benign 0.19
IGL00788:Armh3 APN 19 45,920,789 (GRCm39) critical splice donor site probably null
IGL01356:Armh3 APN 19 45,954,742 (GRCm39) missense possibly damaging 0.94
IGL01477:Armh3 APN 19 45,967,043 (GRCm39) missense probably damaging 0.99
IGL01660:Armh3 APN 19 45,928,915 (GRCm39) missense probably damaging 1.00
IGL02193:Armh3 APN 19 45,961,323 (GRCm39) missense probably benign 0.02
IGL02863:Armh3 APN 19 45,946,850 (GRCm39) missense probably damaging 1.00
IGL03108:Armh3 APN 19 45,808,792 (GRCm39) missense probably damaging 0.99
R0035:Armh3 UTSW 19 45,879,679 (GRCm39) missense probably damaging 1.00
R0791:Armh3 UTSW 19 45,922,307 (GRCm39) splice site probably null
R0792:Armh3 UTSW 19 45,922,307 (GRCm39) splice site probably null
R1487:Armh3 UTSW 19 45,928,882 (GRCm39) critical splice donor site probably null
R1843:Armh3 UTSW 19 45,963,691 (GRCm39) missense probably benign 0.17
R2061:Armh3 UTSW 19 45,967,106 (GRCm39) missense probably damaging 1.00
R2070:Armh3 UTSW 19 45,879,724 (GRCm39) missense probably damaging 1.00
R2072:Armh3 UTSW 19 45,953,820 (GRCm39) missense probably damaging 0.99
R2073:Armh3 UTSW 19 45,953,820 (GRCm39) missense probably damaging 0.99
R2074:Armh3 UTSW 19 45,953,820 (GRCm39) missense probably damaging 0.99
R2091:Armh3 UTSW 19 45,941,119 (GRCm39) missense probably damaging 1.00
R2863:Armh3 UTSW 19 45,874,396 (GRCm39) missense probably damaging 1.00
R3236:Armh3 UTSW 19 45,963,722 (GRCm39) splice site probably benign
R3796:Armh3 UTSW 19 45,910,049 (GRCm39) splice site probably benign
R4044:Armh3 UTSW 19 45,808,763 (GRCm39) missense probably damaging 1.00
R4716:Armh3 UTSW 19 45,948,781 (GRCm39) missense probably damaging 1.00
R4974:Armh3 UTSW 19 45,808,726 (GRCm39) missense probably damaging 1.00
R4983:Armh3 UTSW 19 45,939,146 (GRCm39) missense probably benign
R5063:Armh3 UTSW 19 45,874,394 (GRCm39) missense possibly damaging 0.95
R5313:Armh3 UTSW 19 45,807,414 (GRCm39) missense probably damaging 1.00
R5782:Armh3 UTSW 19 45,874,466 (GRCm39) missense probably benign 0.08
R5985:Armh3 UTSW 19 45,808,763 (GRCm39) missense probably damaging 1.00
R6220:Armh3 UTSW 19 45,834,554 (GRCm39) missense possibly damaging 0.79
R6379:Armh3 UTSW 19 45,910,136 (GRCm39) missense possibly damaging 0.46
R6674:Armh3 UTSW 19 45,963,437 (GRCm39) missense probably benign 0.06
R6842:Armh3 UTSW 19 45,807,416 (GRCm39) missense probably benign 0.05
R6890:Armh3 UTSW 19 45,948,796 (GRCm39) missense probably damaging 1.00
R7034:Armh3 UTSW 19 45,953,688 (GRCm39) missense probably damaging 0.98
R7036:Armh3 UTSW 19 45,953,688 (GRCm39) missense probably damaging 0.98
R7305:Armh3 UTSW 19 45,880,560 (GRCm39) missense probably benign 0.35
R7411:Armh3 UTSW 19 45,953,874 (GRCm39) missense probably benign 0.00
R7762:Armh3 UTSW 19 45,928,882 (GRCm39) critical splice donor site probably null
R8021:Armh3 UTSW 19 45,945,180 (GRCm39) critical splice acceptor site probably null
R8366:Armh3 UTSW 19 45,920,793 (GRCm39) missense probably damaging 1.00
R9336:Armh3 UTSW 19 45,945,120 (GRCm39) missense probably damaging 1.00
X0060:Armh3 UTSW 19 45,920,832 (GRCm39) missense possibly damaging 0.95
Z1088:Armh3 UTSW 19 45,807,344 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AACCCAAACTGTAGCTTGTACTTTC -3'
(R):5'- TCATGCAGATAGATGTCCGC -3'

Sequencing Primer
(F):5'- TACAGGCTATTGTGAACCGC -3'
(R):5'- GCAGGGCTGTACTCAGTGAG -3'
Posted On 2014-10-16