Incidental Mutation 'R2264:Armc1'
ID 243976
Institutional Source Beutler Lab
Gene Symbol Armc1
Ensembl Gene ENSMUSG00000027599
Gene Name armadillo repeat containing 1
Synonyms Arcp, 2310016N05Rik, 2900046P06Rik, C330014L16Rik, 3110009G21Rik
MMRRC Submission 040264-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.178) question?
Stock # R2264 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 19185566-19217229 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 19189033 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 211 (V211I)
Ref Sequence ENSEMBL: ENSMUSP00000029125 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029125]
AlphaFold Q9D7A8
Predicted Effect probably damaging
Transcript: ENSMUST00000029125
AA Change: V211I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029125
Gene: ENSMUSG00000027599
AA Change: V211I

DomainStartEndE-ValueType
Pfam:Arm 27 68 1.1e-6 PFAM
SCOP:d1fvqa_ 142 203 6e-10 SMART
Meta Mutation Damage Score 0.1437 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency 94% (65/69)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk A G 11: 119,901,100 (GRCm39) S1042P probably damaging Het
B4galnt3 T C 6: 120,180,771 (GRCm39) *986W probably null Het
BC024139 T A 15: 76,010,117 (GRCm39) D105V probably damaging Het
BC049715 C T 6: 136,817,434 (GRCm39) Q225* probably null Het
Cadps2 T C 6: 23,323,339 (GRCm39) H1043R probably benign Het
Ccdc42 T C 11: 68,478,477 (GRCm39) V33A probably benign Het
Cldn1 A G 16: 26,177,949 (GRCm39) Y159H probably damaging Het
Cog6 A T 3: 52,900,332 (GRCm39) C476* probably null Het
Col14a1 T G 15: 55,330,086 (GRCm39) probably null Het
Crisp1 C T 17: 40,623,965 (GRCm39) M1I probably null Het
Dip2b T A 15: 100,101,097 (GRCm39) S1297T probably benign Het
Dlgap4 A G 2: 156,543,383 (GRCm39) E262G probably benign Het
Dnai7 A G 6: 145,154,155 (GRCm39) probably benign Het
Dpp4 A C 2: 62,208,583 (GRCm39) V187G possibly damaging Het
F5 A G 1: 164,021,971 (GRCm39) D1482G probably benign Het
Fads6 T A 11: 115,177,061 (GRCm39) T132S probably damaging Het
Fat4 A G 3: 38,944,571 (GRCm39) I1155V probably benign Het
Fermt1 C T 2: 132,757,110 (GRCm39) probably null Het
Fstl1 C T 16: 37,597,653 (GRCm39) probably benign Het
Get3 G A 8: 85,751,887 (GRCm39) probably benign Het
Gm5089 T C 14: 122,673,514 (GRCm39) Y69C unknown Het
Gm9871 T C 6: 101,773,201 (GRCm39) noncoding transcript Het
Gpr89 A G 3: 96,779,831 (GRCm39) S375P probably damaging Het
Gtf2h4 A G 17: 35,979,556 (GRCm39) probably benign Het
Gtsf1 T A 15: 103,328,391 (GRCm39) N148I possibly damaging Het
Hexa T C 9: 59,462,660 (GRCm39) S129P probably damaging Het
Iigp1 A T 18: 60,523,738 (GRCm39) E285D probably benign Het
Il23r T A 6: 67,403,651 (GRCm39) probably null Het
Iqch T C 9: 63,419,581 (GRCm39) K463R probably benign Het
Kcnd1 A G X: 7,690,323 (GRCm39) probably null Het
Kif26b A T 1: 178,756,407 (GRCm39) probably null Het
Loxl1 A G 9: 58,204,961 (GRCm39) V418A probably damaging Het
Lrp2 T C 2: 69,312,710 (GRCm39) D2526G possibly damaging Het
Map4 G T 9: 109,910,525 (GRCm39) G851C probably damaging Het
Mtmr11 A T 3: 96,076,413 (GRCm39) E456V possibly damaging Het
Muc13 G A 16: 33,628,409 (GRCm39) probably null Het
Myo18a C A 11: 77,710,798 (GRCm39) probably benign Het
Nphp4 T A 4: 152,587,465 (GRCm39) probably benign Het
Nrg3 T C 14: 38,103,659 (GRCm39) E445G probably damaging Het
Ntrk1 A G 3: 87,686,941 (GRCm39) probably null Het
Or8b1 G T 9: 38,399,351 (GRCm39) V9L possibly damaging Het
Parp6 T C 9: 59,531,288 (GRCm39) S57P probably damaging Het
Pcdhb12 A G 18: 37,569,858 (GRCm39) N335D probably damaging Het
Pdzph1 T C 17: 59,195,162 (GRCm39) probably null Het
Pea15a C T 1: 172,026,704 (GRCm39) R79H probably benign Het
Pik3ca A C 3: 32,492,076 (GRCm39) I225L possibly damaging Het
Pim3 T A 15: 88,748,793 (GRCm39) I270N probably damaging Het
Pkd1l1 T A 11: 8,829,112 (GRCm39) R1043S probably damaging Het
Plekhg6 A G 6: 125,354,431 (GRCm39) S70P probably benign Het
Ptpn13 T A 5: 103,637,527 (GRCm39) D138E possibly damaging Het
Rap1gap T C 4: 137,455,034 (GRCm39) L354P probably benign Het
Rsf1 CG CGACGGCGGTG 7: 97,229,115 (GRCm39) probably benign Het
Sf3a1 T A 11: 4,127,443 (GRCm39) S590T probably benign Het
Slc14a2 T C 18: 78,206,304 (GRCm39) probably benign Het
Slfn3 T G 11: 83,103,798 (GRCm39) I223S probably benign Het
Smarca1 C T X: 46,964,160 (GRCm39) V331I probably benign Het
Soat1 A G 1: 156,265,267 (GRCm39) probably benign Het
Tinagl1 A G 4: 130,061,226 (GRCm39) V308A probably benign Het
Tomm22 T A 15: 79,555,488 (GRCm39) Y78N probably damaging Het
Ttll1 T C 15: 83,380,609 (GRCm39) Y252C probably damaging Het
Ttn C T 2: 76,623,474 (GRCm39) V15368I probably benign Het
Ubr4 T C 4: 139,147,684 (GRCm39) probably benign Het
Wbp2 T C 11: 115,970,424 (GRCm39) probably null Het
Xkr7 A T 2: 152,896,177 (GRCm39) I344F probably damaging Het
Zfp947 A T 17: 22,364,919 (GRCm39) C252S probably benign Het
Other mutations in Armc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00837:Armc1 APN 3 19,198,584 (GRCm39) missense probably benign 0.21
IGL01453:Armc1 APN 3 19,198,594 (GRCm39) missense probably benign 0.03
IGL02012:Armc1 APN 3 19,211,701 (GRCm39) missense possibly damaging 0.57
IGL02586:Armc1 APN 3 19,188,192 (GRCm39) utr 3 prime probably benign
R0512:Armc1 UTSW 3 19,203,659 (GRCm39) missense possibly damaging 0.87
R1694:Armc1 UTSW 3 19,189,050 (GRCm39) missense possibly damaging 0.81
R1878:Armc1 UTSW 3 19,211,708 (GRCm39) missense probably damaging 1.00
R1881:Armc1 UTSW 3 19,189,060 (GRCm39) missense possibly damaging 0.76
R2191:Armc1 UTSW 3 19,188,225 (GRCm39) missense probably damaging 1.00
R2403:Armc1 UTSW 3 19,211,840 (GRCm39) start gained probably benign
R2969:Armc1 UTSW 3 19,189,024 (GRCm39) missense probably benign
R3861:Armc1 UTSW 3 19,189,196 (GRCm39) missense probably damaging 1.00
R4296:Armc1 UTSW 3 19,203,680 (GRCm39) missense probably damaging 0.99
R6753:Armc1 UTSW 3 19,198,562 (GRCm39) missense possibly damaging 0.86
R6891:Armc1 UTSW 3 19,189,205 (GRCm39) missense probably damaging 1.00
R7837:Armc1 UTSW 3 19,198,633 (GRCm39) missense probably benign 0.01
R8373:Armc1 UTSW 3 19,203,731 (GRCm39) missense probably damaging 1.00
R8743:Armc1 UTSW 3 19,211,700 (GRCm39) missense probably benign 0.19
Z1088:Armc1 UTSW 3 19,203,671 (GRCm39) missense probably damaging 1.00
Z1177:Armc1 UTSW 3 19,203,738 (GRCm39) missense probably benign 0.08
Predicted Primers PCR Primer
(F):5'- TCAAGTTCGCCTTACAAGAGCAC -3'
(R):5'- GTTCAAAGATGCGTGGTGC -3'

Sequencing Primer
(F):5'- TTACAAGAGCACCCTGAACTTCAG -3'
(R):5'- CGGATCCGTTCAGACTTGAAG -3'
Posted On 2014-10-16