Incidental Mutation 'R1412:Tex19.2'
ID 244136
Institutional Source Beutler Lab
Gene Symbol Tex19.2
Ensembl Gene ENSMUSG00000039337
Gene Name testis expressed gene 19.2
Synonyms 4921530G04Rik, Tex19.2
MMRRC Submission 039468-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.192) question?
Stock # R1412 (G1)
Quality Score 78
Status Validated
Chromosome 11
Chromosomal Location 121007041-121009503 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 121007761 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 229 (V229A)
Ref Sequence ENSEMBL: ENSMUSP00000037027 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039146]
AlphaFold Q9D5S1
Predicted Effect possibly damaging
Transcript: ENSMUST00000039146
AA Change: V229A

PolyPhen 2 Score 0.911 (Sensitivity: 0.81; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000037027
Gene: ENSMUSG00000039337
AA Change: V229A

DomainStartEndE-ValueType
Pfam:TEX19 1 145 7.2e-70 PFAM
low complexity region 184 196 N/A INTRINSIC
low complexity region 292 305 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.8%
  • 10x: 94.4%
  • 20x: 86.5%
Validation Efficiency 98% (48/49)
MGI Phenotype PHENOTYPE: Double homozygous KO with Tex19.1 causes testis degeneration and male infertility owing to meiotic arrest in the germ cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810009A15Rik T C 19: 8,867,359 (GRCm39) probably benign Het
Abca15 C T 7: 119,944,546 (GRCm39) R394C possibly damaging Het
Adamts9 T C 6: 92,773,414 (GRCm39) Q1152R probably benign Het
Adgrv1 C T 13: 81,243,569 (GRCm39) G6277E probably damaging Het
Agbl2 A G 2: 90,619,298 (GRCm39) N41S probably benign Het
Akap7 A T 10: 25,165,495 (GRCm39) probably null Het
Arl6ip1 A G 7: 117,719,591 (GRCm39) I179T possibly damaging Het
Atp1a4 C T 1: 172,059,576 (GRCm39) D839N probably damaging Het
B3galt4 G A 17: 34,169,813 (GRCm39) R142C probably damaging Het
C1qtnf12 T C 4: 156,047,190 (GRCm39) V52A probably benign Het
C1qtnf2 A G 11: 43,381,959 (GRCm39) Y257C probably damaging Het
Cdc123 A T 2: 5,808,776 (GRCm39) D233E possibly damaging Het
Chdh G A 14: 29,756,680 (GRCm39) E369K probably benign Het
D630045J12Rik A G 6: 38,172,695 (GRCm39) V491A probably benign Het
Focad T C 4: 88,196,498 (GRCm39) probably null Het
Gabbr1 T C 17: 37,365,805 (GRCm39) probably null Het
Hat1 G T 2: 71,250,961 (GRCm39) E170* probably null Het
Hs3st5 A T 10: 36,708,672 (GRCm39) H69L probably benign Het
Igsf10 T C 3: 59,235,196 (GRCm39) probably benign Het
Itga2b A T 11: 102,347,831 (GRCm39) L890Q probably benign Het
Or52e8b A G 7: 104,673,402 (GRCm39) F262L probably damaging Het
Or7d11 C G 9: 19,966,711 (GRCm39) G16A possibly damaging Het
Parp10 A G 15: 76,127,284 (GRCm39) L51P probably damaging Het
Pbld2 A G 10: 62,883,301 (GRCm39) T108A probably damaging Het
Pdlim2 A T 14: 70,411,773 (GRCm39) probably benign Het
Pikfyve T C 1: 65,241,989 (GRCm39) V243A possibly damaging Het
Pla2g12b G A 10: 59,239,804 (GRCm39) probably null Het
Raly A G 2: 154,699,315 (GRCm39) T40A possibly damaging Het
Rasgrp3 G T 17: 75,816,822 (GRCm39) probably null Het
Rbpms2 ACTGCTGCTGCTGCTGC ACTGCTGCTGCTGCTGCTGC 9: 65,558,948 (GRCm39) probably benign Het
Smim22 G C 16: 4,825,649 (GRCm39) E11D possibly damaging Het
Socs2 T C 10: 95,250,780 (GRCm39) S18G probably benign Het
Srgap2 T C 1: 131,228,151 (GRCm39) E720G possibly damaging Het
Tas2r135 A G 6: 42,382,768 (GRCm39) I102M probably benign Het
Vmn1r234 T A 17: 21,449,512 (GRCm39) I142N probably benign Het
Vps35l A T 7: 118,409,194 (GRCm39) I612F probably damaging Het
Vwa3a C T 7: 120,379,377 (GRCm39) T494I probably damaging Het
Vwa8 C T 14: 79,145,670 (GRCm39) R116C probably damaging Het
Zfhx3 A G 8: 109,641,199 (GRCm39) D1166G possibly damaging Het
Other mutations in Tex19.2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tex19.2 APN 11 121,007,638 (GRCm39) missense possibly damaging 0.93
R1828:Tex19.2 UTSW 11 121,008,317 (GRCm39) missense probably benign 0.08
R3082:Tex19.2 UTSW 11 121,007,557 (GRCm39) missense probably benign 0.01
R4902:Tex19.2 UTSW 11 121,007,782 (GRCm39) missense probably damaging 0.99
R5486:Tex19.2 UTSW 11 121,008,304 (GRCm39) missense probably benign 0.16
R8271:Tex19.2 UTSW 11 121,008,010 (GRCm39) missense possibly damaging 0.92
R9369:Tex19.2 UTSW 11 121,007,566 (GRCm39) missense possibly damaging 0.96
Predicted Primers PCR Primer
(F):5'- TTGCCCTGCACATGAAGCTGAG -3'
(R):5'- ATTGTTGGAGTTGAGCCCCACC -3'

Sequencing Primer
(F):5'- ATGAAGCTGAGTCTAACCTTCCG -3'
(R):5'- CGCCATTTGCTACATGCTGT -3'
Posted On 2014-10-28