Incidental Mutation 'R2287:Trim34a'
ID 244153
Institutional Source Beutler Lab
Gene Symbol Trim34a
Ensembl Gene ENSMUSG00000056144
Gene Name tripartite motif-containing 34A
Synonyms Trim34-1, Trim34
MMRRC Submission 040286-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R2287 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 103893664-103911441 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 103910262 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 355 (S355T)
Ref Sequence ENSEMBL: ENSMUSP00000102462 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051795] [ENSMUST00000060315] [ENSMUST00000098179] [ENSMUST00000106848] [ENSMUST00000106849]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000051795
SMART Domains Protein: ENSMUSP00000050084
Gene: ENSMUSG00000060441

DomainStartEndE-ValueType
RING 15 58 3.64e-7 SMART
BBOX 91 132 4.83e-12 SMART
coiled coil region 172 232 N/A INTRINSIC
Pfam:SPRY 349 485 9.2e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000060315
AA Change: S355T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000055058
Gene: ENSMUSG00000056144
AA Change: S355T

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 347 474 1e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000098179
SMART Domains Protein: ENSMUSP00000095781
Gene: ENSMUSG00000060441

DomainStartEndE-ValueType
RING 15 58 3.64e-7 SMART
BBOX 91 132 4.83e-12 SMART
Pfam:SPRY 351 493 1.6e-13 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106848
AA Change: S355T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102461
Gene: ENSMUSG00000056144
AA Change: S355T

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 345 484 6.5e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000106849
AA Change: S355T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000102462
Gene: ENSMUSG00000056144
AA Change: S355T

DomainStartEndE-ValueType
RING 15 58 6.79e-7 SMART
BBOX 91 132 1.08e-9 SMART
coiled coil region 194 238 N/A INTRINSIC
Blast:PRY 299 343 2e-21 BLAST
Pfam:SPRY 345 484 6.5e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000158033
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217156
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 21 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Clec4f CTT CT 6: 83,630,247 (GRCm39) probably null Het
Dis3l T A 9: 64,214,779 (GRCm39) Q930L probably benign Het
Edem2 T C 2: 155,555,279 (GRCm39) K275E probably benign Het
Ehf T C 2: 103,097,469 (GRCm39) I193V possibly damaging Het
Gsdma3 A G 11: 98,528,830 (GRCm39) N428S possibly damaging Het
Gtf2h4 C A 17: 35,982,117 (GRCm39) probably null Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Naalad2 A T 9: 18,246,317 (GRCm39) probably null Het
Ndufa8 C T 2: 35,926,554 (GRCm39) A161T probably benign Het
Nlrp14 A T 7: 106,781,869 (GRCm39) L355F probably damaging Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Pcnx4 T C 12: 72,622,172 (GRCm39) I1047T probably benign Het
Pcolce2 G A 9: 95,560,458 (GRCm39) W169* probably null Het
Plxdc2 A G 2: 16,517,001 (GRCm39) D94G probably benign Het
Rp1 A T 1: 4,416,182 (GRCm39) Y1643* probably null Het
Skint4 A G 4: 111,975,402 (GRCm39) T121A possibly damaging Het
Speg A G 1: 75,407,109 (GRCm39) I3133V possibly damaging Het
Top2b T G 14: 16,409,189 (GRCm38) I777M probably damaging Het
Trpv6 T G 6: 41,603,045 (GRCm39) N276H probably damaging Het
Vps8 T C 16: 21,387,163 (GRCm39) V1175A probably damaging Het
Other mutations in Trim34a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00503:Trim34a APN 7 103,910,538 (GRCm39) missense probably damaging 1.00
IGL00826:Trim34a APN 7 103,910,140 (GRCm39) splice site probably null
IGL01526:Trim34a APN 7 103,909,706 (GRCm39) missense probably damaging 1.00
IGL01859:Trim34a APN 7 103,910,149 (GRCm39) missense probably damaging 0.96
IGL02052:Trim34a APN 7 103,897,038 (GRCm39) missense probably benign 0.33
IGL02192:Trim34a APN 7 103,896,939 (GRCm39) start codon destroyed probably null 1.00
IGL02351:Trim34a APN 7 103,910,441 (GRCm39) nonsense probably null
IGL02358:Trim34a APN 7 103,910,441 (GRCm39) nonsense probably null
IGL03326:Trim34a APN 7 103,910,587 (GRCm39) missense probably benign 0.03
IGL03366:Trim34a APN 7 103,910,140 (GRCm39) splice site probably null
Gold_belt UTSW 7 103,910,271 (GRCm39) nonsense probably null
PIT4472001:Trim34a UTSW 7 103,897,155 (GRCm39) missense probably damaging 1.00
PIT4791001:Trim34a UTSW 7 103,909,691 (GRCm39) missense probably benign 0.15
R0115:Trim34a UTSW 7 103,897,109 (GRCm39) missense probably damaging 1.00
R0848:Trim34a UTSW 7 103,910,331 (GRCm39) missense probably benign
R1016:Trim34a UTSW 7 103,897,167 (GRCm39) missense probably benign 0.10
R1477:Trim34a UTSW 7 103,897,287 (GRCm39) missense possibly damaging 0.81
R1622:Trim34a UTSW 7 103,910,545 (GRCm39) splice site probably null
R3685:Trim34a UTSW 7 103,909,333 (GRCm39) splice site probably null
R4166:Trim34a UTSW 7 103,910,223 (GRCm39) missense probably benign 0.02
R4967:Trim34a UTSW 7 103,910,271 (GRCm39) nonsense probably null
R4979:Trim34a UTSW 7 103,897,069 (GRCm39) missense probably benign 0.00
R5194:Trim34a UTSW 7 103,910,200 (GRCm39) missense possibly damaging 0.70
R5443:Trim34a UTSW 7 103,909,420 (GRCm39) missense possibly damaging 0.80
R5631:Trim34a UTSW 7 103,897,946 (GRCm39) missense probably damaging 1.00
R5902:Trim34a UTSW 7 103,910,328 (GRCm39) nonsense probably null
R6147:Trim34a UTSW 7 103,910,398 (GRCm39) missense probably damaging 0.99
R6644:Trim34a UTSW 7 103,910,244 (GRCm39) missense probably damaging 1.00
R7971:Trim34a UTSW 7 103,897,025 (GRCm39) missense probably damaging 0.98
R8060:Trim34a UTSW 7 103,910,183 (GRCm39) missense probably damaging 1.00
R8278:Trim34a UTSW 7 103,898,623 (GRCm39) missense probably damaging 0.99
R8356:Trim34a UTSW 7 103,910,178 (GRCm39) missense probably damaging 0.99
R9275:Trim34a UTSW 7 103,910,201 (GRCm39) missense probably damaging 0.96
R9563:Trim34a UTSW 7 103,910,328 (GRCm39) nonsense probably null
X0023:Trim34a UTSW 7 103,908,622 (GRCm39) missense probably benign 0.43
Predicted Primers PCR Primer
(F):5'- CTCCAGTGTTGGCTTTTCACAG -3'
(R):5'- GGGTCACAGTTGGAAGAATCCTC -3'

Sequencing Primer
(F):5'- GGCTTTTCACAGTGTTTCACAAAC -3'
(R):5'- CAGTTGGAAGAATCCTCAAAGATAC -3'
Posted On 2014-10-30