Incidental Mutation 'R2289:Zfp870'
ID 244234
Institutional Source Beutler Lab
Gene Symbol Zfp870
Ensembl Gene ENSMUSG00000095325
Gene Name zinc finger protein 870
Synonyms
MMRRC Submission 040288-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R2289 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 33098193-33110616 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 33102334 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 333 (S333T)
Ref Sequence ENSEMBL: ENSMUSP00000154207 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000178401] [ENSMUST00000228075]
AlphaFold Q6NZJ3
Predicted Effect probably benign
Transcript: ENSMUST00000178401
AA Change: S332T

PolyPhen 2 Score 0.177 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000136197
Gene: ENSMUSG00000095325
AA Change: S332T

DomainStartEndE-ValueType
KRAB 3 60 1.01e-19 SMART
ZnF_C2H2 193 215 4.5e1 SMART
ZnF_C2H2 221 241 6.4e0 SMART
ZnF_C2H2 277 299 2.24e-3 SMART
ZnF_C2H2 305 327 9.58e-3 SMART
ZnF_C2H2 333 355 2.86e-1 SMART
ZnF_C2H2 361 383 6.42e-4 SMART
ZnF_C2H2 389 411 1.18e-2 SMART
ZnF_C2H2 417 439 3.89e-3 SMART
ZnF_C2H2 445 467 5.5e-3 SMART
ZnF_C2H2 473 495 4.47e-3 SMART
ZnF_C2H2 501 523 5.9e-3 SMART
ZnF_C2H2 529 551 3.11e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000228075
AA Change: S333T

PolyPhen 2 Score 0.271 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000228410
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atp12a G A 14: 56,610,719 (GRCm39) V288I possibly damaging Het
Cntn6 C T 6: 104,545,989 (GRCm39) probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cplx3 T A 9: 57,520,941 (GRCm39) E220V possibly damaging Het
Cracdl T C 1: 37,651,342 (GRCm39) K1175R possibly damaging Het
Dcaf10 T A 4: 45,359,816 (GRCm39) W244R probably damaging Het
Dixdc1 A G 9: 50,595,172 (GRCm39) probably null Het
Dlg4 T A 11: 69,917,752 (GRCm39) Y12N probably damaging Het
Fsd1l T A 4: 53,696,931 (GRCm39) Y442N possibly damaging Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Hcrt C A 11: 100,652,745 (GRCm39) A90S probably damaging Het
Itga6 T A 2: 71,648,873 (GRCm39) V119D probably damaging Het
Klrh1 T C 6: 129,745,140 (GRCm39) N152S probably null Het
Lmtk2 T A 5: 144,112,924 (GRCm39) S1215T possibly damaging Het
Loxl2 G A 14: 69,930,524 (GRCm39) E763K probably benign Het
Mcrip1 T C 11: 120,435,530 (GRCm39) E35G probably damaging Het
Nle1 T A 11: 82,793,879 (GRCm39) I386F probably benign Het
Nqo1 T C 8: 108,119,630 (GRCm39) I8V probably benign Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Pax8 T C 2: 24,330,752 (GRCm39) D227G probably benign Het
Phf14 T C 6: 12,047,845 (GRCm39) C885R probably damaging Het
Rhobtb3 A C 13: 76,059,046 (GRCm39) C251G probably damaging Het
Samd13 C T 3: 146,368,446 (GRCm39) A49T probably damaging Het
Snrpa1 T A 7: 65,713,586 (GRCm39) V101E probably benign Het
Styx A G 14: 45,592,404 (GRCm39) E20G possibly damaging Het
Thoc1 T C 18: 9,984,488 (GRCm39) Y325H probably damaging Het
Tmem163 T A 1: 127,423,477 (GRCm39) T262S possibly damaging Het
Tsr1 T G 11: 74,790,111 (GRCm39) L102R probably damaging Het
Vash1 G C 12: 86,726,952 (GRCm39) R64P probably damaging Het
Vps13b A C 15: 35,572,251 (GRCm39) D956A probably damaging Het
Vrk1 G A 12: 106,024,120 (GRCm39) G199S probably damaging Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Zranb1 T C 7: 132,551,768 (GRCm39) Y140H probably damaging Het
Zscan4b A G 7: 10,635,789 (GRCm39) probably null Het
Other mutations in Zfp870
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01304:Zfp870 APN 17 33,101,980 (GRCm39) missense possibly damaging 0.72
R1591:Zfp870 UTSW 17 33,102,990 (GRCm39) missense probably damaging 1.00
R1892:Zfp870 UTSW 17 33,102,863 (GRCm39) missense possibly damaging 0.66
R1941:Zfp870 UTSW 17 33,101,778 (GRCm39) missense possibly damaging 0.71
R1997:Zfp870 UTSW 17 33,103,027 (GRCm39) missense possibly damaging 0.66
R4240:Zfp870 UTSW 17 33,104,710 (GRCm39) missense probably benign 0.00
R4860:Zfp870 UTSW 17 33,102,314 (GRCm39) nonsense probably null
R4860:Zfp870 UTSW 17 33,102,314 (GRCm39) nonsense probably null
R5306:Zfp870 UTSW 17 33,102,627 (GRCm39) missense probably damaging 1.00
R6425:Zfp870 UTSW 17 33,102,045 (GRCm39) missense possibly damaging 0.66
R6736:Zfp870 UTSW 17 33,102,570 (GRCm39) missense probably benign
R7054:Zfp870 UTSW 17 33,102,456 (GRCm39) missense probably damaging 0.97
R7291:Zfp870 UTSW 17 33,102,828 (GRCm39) missense probably damaging 0.97
R7466:Zfp870 UTSW 17 33,102,736 (GRCm39) missense possibly damaging 0.66
R7681:Zfp870 UTSW 17 33,101,664 (GRCm39) missense probably benign
R8230:Zfp870 UTSW 17 33,102,663 (GRCm39) missense possibly damaging 0.46
R8346:Zfp870 UTSW 17 33,102,843 (GRCm39) missense possibly damaging 0.92
R8673:Zfp870 UTSW 17 33,101,904 (GRCm39) missense probably damaging 0.97
R8695:Zfp870 UTSW 17 33,102,679 (GRCm39) missense possibly damaging 0.46
R8736:Zfp870 UTSW 17 33,104,966 (GRCm39) missense possibly damaging 0.92
R9057:Zfp870 UTSW 17 33,102,793 (GRCm39) missense probably benign 0.27
Predicted Primers PCR Primer
(F):5'- TTACACACATAGGGCTTCTGACC -3'
(R):5'- CTCGTTCTGCTTGCCTTAGAAG -3'

Sequencing Primer
(F):5'- ACCAGTGTGAATTCGCTCATG -3'
(R):5'- CGTTCTGCTTGCCTTAGAAGAAGAAC -3'
Posted On 2014-10-30