Incidental Mutation 'R2290:Or2y1'
ID 244285
Institutional Source Beutler Lab
Gene Symbol Or2y1
Ensembl Gene ENSMUSG00000059729
Gene Name olfactory receptor family 2 subfamily Y member 1
Synonyms Olfr1385, Olfr1549-ps1, MOR256-42P, MOR256-42P, GA_x6K02T2QP88-5941817-5940888, MOR256-41P
MMRRC Submission 040289-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R2290 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 49385362-49386291 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 49385857 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 166 (M166V)
Ref Sequence ENSEMBL: ENSMUSP00000150035 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071807] [ENSMUST00000214948]
AlphaFold Q7TQT1
Predicted Effect probably benign
Transcript: ENSMUST00000071807
AA Change: M166V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000071710
Gene: ENSMUSG00000059729
AA Change: M166V

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 2.1e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 214 9.5e-6 PFAM
Pfam:7tm_1 41 289 2.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214948
AA Change: M166V

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216450
Meta Mutation Damage Score 0.0843 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.2%
Validation Efficiency 100% (73/73)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aldh1l2 T C 10: 83,363,177 (GRCm39) D62G probably damaging Het
Ambp T C 4: 63,061,924 (GRCm39) Y335C probably damaging Het
Arid4a G T 12: 71,108,315 (GRCm39) G40V probably damaging Het
Asb13 G A 13: 3,699,418 (GRCm39) G206D probably damaging Het
Ccdc7b A G 8: 129,857,587 (GRCm39) probably benign Het
Cdh15 A T 8: 123,586,056 (GRCm39) N145I probably damaging Het
Celsr3 T C 9: 108,720,423 (GRCm39) I2565T probably damaging Het
Cfap43 A T 19: 47,761,574 (GRCm39) M840K probably damaging Het
Clip4 T C 17: 72,117,948 (GRCm39) V331A possibly damaging Het
Cnnm1 A G 19: 43,479,941 (GRCm39) T829A probably benign Het
Col24a1 G A 3: 145,218,950 (GRCm39) G1457E probably damaging Het
D6Ertd527e A G 6: 87,088,527 (GRCm39) N230S unknown Het
Dll1 T C 17: 15,595,010 (GRCm39) D89G probably benign Het
Dst T A 1: 34,268,281 (GRCm39) V2901E probably damaging Het
Dvl1 G A 4: 155,932,273 (GRCm39) V28I possibly damaging Het
Efl1 A T 7: 82,426,878 (GRCm39) K1125N probably damaging Het
Efr3a T A 15: 65,721,688 (GRCm39) F437L probably benign Het
Eqtn GTTCTTCTTC GTTCTTC 4: 94,815,179 (GRCm39) probably benign Het
Ermp1 T C 19: 29,601,178 (GRCm39) D523G probably damaging Het
Gm38999 A G 7: 43,077,123 (GRCm39) E5G probably benign Het
Gm5828 C T 1: 16,838,568 (GRCm39) noncoding transcript Het
Gnas T C 2: 174,141,803 (GRCm39) F717L probably benign Het
H6pd T A 4: 150,066,338 (GRCm39) S683C probably damaging Het
Il23r G A 6: 67,400,845 (GRCm39) T495I probably benign Het
Itpr2 T C 6: 146,324,326 (GRCm39) N135D probably damaging Het
Kcns2 T A 15: 34,838,655 (GRCm39) L6Q possibly damaging Het
Khdrbs3 C T 15: 68,901,610 (GRCm39) R132C probably damaging Het
Kif2b A G 11: 91,466,522 (GRCm39) V587A probably benign Het
Kng1 A T 16: 22,897,875 (GRCm39) H425L possibly damaging Het
Letm1 A AG 5: 33,926,859 (GRCm39) probably null Het
Lrrc8e T C 8: 4,281,770 (GRCm39) M35T probably damaging Het
Med12l A G 3: 59,152,359 (GRCm39) N1048S probably damaging Het
Mex3c A C 18: 73,723,764 (GRCm39) N619T probably damaging Het
Mfsd4b1 G A 10: 39,879,327 (GRCm39) T190I probably damaging Het
Ncam1 A G 9: 49,434,951 (GRCm39) probably benign Het
Nlrp6 G A 7: 140,502,076 (GRCm39) G133S probably damaging Het
Oplah A G 15: 76,186,925 (GRCm39) V630A probably benign Het
Or1e26 G T 11: 73,479,745 (GRCm39) A273D probably benign Het
Or5ak24 C T 2: 85,260,544 (GRCm39) V210M possibly damaging Het
Or8g36 A G 9: 39,422,974 (GRCm39) L14P possibly damaging Het
Pcnx2 A T 8: 126,604,334 (GRCm39) probably benign Het
Pkhd1l1 A T 15: 44,391,646 (GRCm39) T1571S probably benign Het
Pramel13 T A 4: 144,121,269 (GRCm39) T252S probably benign Het
Pramel13 G T 4: 144,121,692 (GRCm39) H111N probably benign Het
Prr22 T G 17: 57,078,884 (GRCm39) F346V probably benign Het
Prr30 T C 14: 101,436,211 (GRCm39) N117S possibly damaging Het
Ptgfrn A G 3: 100,984,677 (GRCm39) S172P possibly damaging Het
Ptprc C T 1: 138,038,926 (GRCm39) V364I probably benign Het
Ptprz1 T C 6: 23,000,990 (GRCm39) S1027P probably damaging Het
Rinl T C 7: 28,491,696 (GRCm39) V83A probably benign Het
Ros1 A T 10: 51,994,477 (GRCm39) S1268T probably damaging Het
Scly T C 1: 91,226,172 (GRCm39) probably null Het
Slc25a1 C T 16: 17,743,712 (GRCm39) V186M possibly damaging Het
Stk36 T G 1: 74,665,303 (GRCm39) probably benign Het
Syn2 A G 6: 115,251,190 (GRCm39) T449A possibly damaging Het
Tecpr1 T C 5: 144,150,881 (GRCm39) D309G probably damaging Het
Tent4b T C 8: 88,978,603 (GRCm39) S435P probably damaging Het
Tns2 T A 15: 102,020,458 (GRCm39) Y775N probably damaging Het
Tril G T 6: 53,795,012 (GRCm39) R737S probably damaging Het
Ttl G A 2: 128,923,190 (GRCm39) G177D possibly damaging Het
Twf1 A G 15: 94,484,400 (GRCm39) S41P probably damaging Het
Unc79 C T 12: 103,112,625 (GRCm39) T2174M probably damaging Het
Vangl2 T A 1: 171,836,113 (GRCm39) K340* probably null Het
Vmn2r72 T A 7: 85,387,549 (GRCm39) T672S probably damaging Het
Vwa7 A G 17: 35,236,187 (GRCm39) D47G probably damaging Het
Zc3h12d A G 10: 7,743,223 (GRCm39) H331R probably benign Het
Zfa-ps T C 10: 52,421,112 (GRCm39) noncoding transcript Het
Zfp141 A T 7: 42,124,649 (GRCm39) C608S probably damaging Het
Zfp422 A G 6: 116,603,603 (GRCm39) I132T possibly damaging Het
Zfp652 A G 11: 95,640,849 (GRCm39) Y258C possibly damaging Het
Other mutations in Or2y1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Or2y1 APN 11 49,385,793 (GRCm39) missense probably damaging 0.99
IGL02098:Or2y1 APN 11 49,386,224 (GRCm39) missense probably damaging 1.00
IGL03206:Or2y1 APN 11 49,385,536 (GRCm39) missense probably benign 0.05
IGL03402:Or2y1 APN 11 49,385,873 (GRCm39) missense probably benign
R0412:Or2y1 UTSW 11 49,385,594 (GRCm39) missense probably damaging 1.00
R1263:Or2y1 UTSW 11 49,385,848 (GRCm39) missense probably benign
R1371:Or2y1 UTSW 11 49,385,650 (GRCm39) missense probably damaging 1.00
R1488:Or2y1 UTSW 11 49,385,945 (GRCm39) missense probably benign 0.07
R1835:Or2y1 UTSW 11 49,385,497 (GRCm39) missense probably damaging 1.00
R1923:Or2y1 UTSW 11 49,386,131 (GRCm39) missense probably damaging 0.97
R3738:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R3739:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R4034:Or2y1 UTSW 11 49,386,287 (GRCm39) missense possibly damaging 0.56
R4193:Or2y1 UTSW 11 49,386,134 (GRCm39) missense probably damaging 1.00
R4406:Or2y1 UTSW 11 49,385,744 (GRCm39) missense probably benign 0.01
R5239:Or2y1 UTSW 11 49,385,555 (GRCm39) missense possibly damaging 0.93
R6713:Or2y1 UTSW 11 49,385,784 (GRCm39) missense probably damaging 1.00
R6861:Or2y1 UTSW 11 49,385,632 (GRCm39) missense probably benign 0.00
R7916:Or2y1 UTSW 11 49,385,543 (GRCm39) missense probably benign
R8712:Or2y1 UTSW 11 49,385,671 (GRCm39) missense probably benign
R9509:Or2y1 UTSW 11 49,385,476 (GRCm39) missense probably benign
R9624:Or2y1 UTSW 11 49,385,834 (GRCm39) missense possibly damaging 0.94
R9793:Or2y1 UTSW 11 49,385,882 (GRCm39) missense probably damaging 1.00
R9795:Or2y1 UTSW 11 49,385,882 (GRCm39) missense probably damaging 1.00
Z1176:Or2y1 UTSW 11 49,385,894 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGGGATCCACTGAGTGTG -3'
(R):5'- TGTCCCAAAAGCTTTTCTGC -3'

Sequencing Primer
(F):5'- ATCCACTGAGTGTGTGCTC -3'
(R):5'- AAAAGCTTTTCTGCGTCCAG -3'
Posted On 2014-10-30