Incidental Mutation 'R2303:Gkn3'
ID |
244492 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gkn3
|
Ensembl Gene |
ENSMUSG00000030048 |
Gene Name |
gastrokine 3 |
Synonyms |
1190003M12Rik |
MMRRC Submission |
040302-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.054)
|
Stock # |
R2303 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
6 |
Chromosomal Location |
87360301-87365917 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to T
at 87360507 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Alanine to Threonine
at position 163
(A163T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000032127
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032127]
[ENSMUST00000032128]
|
AlphaFold |
Q9D0T7 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000032127
AA Change: A163T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000032127 Gene: ENSMUSG00000030048 AA Change: A163T
Domain | Start | End | E-Value | Type |
transmembrane domain
|
13 |
32 |
N/A |
INTRINSIC |
BRICHOS
|
63 |
155 |
1.47e-26 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000032128
|
SMART Domains |
Protein: ENSMUSP00000032128 Gene: ENSMUSG00000030049
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
BRICHOS
|
54 |
151 |
6.63e-34 |
SMART |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 94.9%
|
Validation Efficiency |
100% (40/40) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 36 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4930583I09Rik |
T |
G |
17: 65,141,561 (GRCm39) |
D14A |
unknown |
Het |
Aars1 |
C |
A |
8: 111,779,134 (GRCm39) |
T756K |
possibly damaging |
Het |
Abca9 |
A |
T |
11: 110,049,052 (GRCm39) |
M252K |
probably benign |
Het |
Acan |
A |
G |
7: 78,749,705 (GRCm39) |
E1492G |
probably benign |
Het |
Arid1a |
C |
A |
4: 133,414,562 (GRCm39) |
R1223L |
unknown |
Het |
Ash1l |
T |
C |
3: 88,933,733 (GRCm39) |
L2003S |
probably damaging |
Het |
Cct8 |
A |
T |
16: 87,287,220 (GRCm39) |
|
probably null |
Het |
Dagla |
T |
C |
19: 10,229,467 (GRCm39) |
T598A |
probably damaging |
Het |
Ercc3 |
A |
G |
18: 32,378,600 (GRCm39) |
I194V |
probably benign |
Het |
Fbxo46 |
A |
G |
7: 18,870,541 (GRCm39) |
N387D |
possibly damaging |
Het |
Fn1 |
C |
T |
1: 71,653,195 (GRCm39) |
|
probably null |
Het |
Gnrhr |
C |
T |
5: 86,345,608 (GRCm39) |
G26D |
probably benign |
Het |
Hmcn1 |
A |
T |
1: 150,579,977 (GRCm39) |
L1920Q |
probably damaging |
Het |
Kank2 |
T |
A |
9: 21,681,061 (GRCm39) |
I823F |
probably benign |
Het |
Kcnh8 |
GAGACCAACGAGCAGCTGATGCTTCAGA |
GAGA |
17: 53,032,934 (GRCm39) |
74 |
probably benign |
Het |
Kdm1b |
TCATTGTCC |
TCATTGTCCATTGTCC |
13: 47,217,564 (GRCm39) |
|
probably null |
Het |
Mfsd6 |
T |
A |
1: 52,715,672 (GRCm39) |
N535I |
probably damaging |
Het |
Mgat5 |
T |
C |
1: 127,374,036 (GRCm39) |
Y479H |
probably benign |
Het |
Ncoa7 |
G |
A |
10: 30,530,431 (GRCm39) |
T701I |
probably damaging |
Het |
Or6c2 |
T |
C |
10: 129,362,918 (GRCm39) |
V274A |
probably benign |
Het |
Pcdh18 |
T |
C |
3: 49,709,723 (GRCm39) |
R531G |
probably damaging |
Het |
Pcdhb6 |
A |
G |
18: 37,469,284 (GRCm39) |
H51R |
probably damaging |
Het |
Pdik1l |
G |
A |
4: 134,011,559 (GRCm39) |
Q95* |
probably null |
Het |
Ppp4r3b |
A |
T |
11: 29,150,741 (GRCm39) |
H469L |
possibly damaging |
Het |
Prnp |
A |
G |
2: 131,779,046 (GRCm39) |
T233A |
probably benign |
Het |
Rcan1 |
T |
C |
16: 92,190,484 (GRCm39) |
T152A |
possibly damaging |
Het |
Sema3g |
T |
C |
14: 30,944,572 (GRCm39) |
F329L |
probably damaging |
Het |
Setd1a |
G |
A |
7: 127,398,327 (GRCm39) |
|
probably benign |
Het |
Slc40a1 |
G |
A |
1: 45,950,044 (GRCm39) |
|
probably benign |
Het |
Slco5a1 |
C |
T |
1: 12,949,486 (GRCm39) |
G635S |
probably damaging |
Het |
Spg11 |
C |
T |
2: 121,899,318 (GRCm39) |
C1589Y |
probably damaging |
Het |
Stab1 |
T |
C |
14: 30,868,027 (GRCm39) |
T1616A |
probably damaging |
Het |
Trappc11 |
A |
G |
8: 47,956,451 (GRCm39) |
Y842H |
probably damaging |
Het |
Vwde |
T |
A |
6: 13,215,806 (GRCm39) |
|
probably benign |
Het |
Zcchc8 |
A |
G |
5: 123,838,660 (GRCm39) |
L626P |
probably benign |
Het |
Zfhx4 |
A |
G |
3: 5,462,120 (GRCm39) |
H1240R |
probably damaging |
Het |
|
Other mutations in Gkn3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02170:Gkn3
|
APN |
6 |
87,360,493 (GRCm39) |
missense |
possibly damaging |
0.70 |
IGL02746:Gkn3
|
APN |
6 |
87,364,339 (GRCm39) |
splice site |
probably benign |
|
IGL03345:Gkn3
|
APN |
6 |
87,365,798 (GRCm39) |
missense |
probably null |
0.09 |
R1758:Gkn3
|
UTSW |
6 |
87,365,817 (GRCm39) |
start codon destroyed |
probably benign |
|
R2304:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R2363:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R2365:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R2897:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R2898:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R2983:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R3031:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R3426:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R3433:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4085:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4086:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4087:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4088:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4089:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4090:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4163:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4164:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4720:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4721:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4722:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4723:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4766:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R4941:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R5004:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R5163:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R6078:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R6079:Gkn3
|
UTSW |
6 |
87,360,507 (GRCm39) |
missense |
probably damaging |
1.00 |
R6502:Gkn3
|
UTSW |
6 |
87,365,786 (GRCm39) |
missense |
probably benign |
0.01 |
R6924:Gkn3
|
UTSW |
6 |
87,365,784 (GRCm39) |
missense |
probably benign |
0.05 |
R7695:Gkn3
|
UTSW |
6 |
87,361,422 (GRCm39) |
missense |
probably damaging |
1.00 |
R9240:Gkn3
|
UTSW |
6 |
87,365,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
Predicted Primers |
PCR Primer
(F):5'- ACAAGGTAGAAATGCACTTATTCCC -3'
(R):5'- GCTAAGGGGTTACAAAGCGC -3'
Sequencing Primer
(F):5'- CCAGATCACAAGGTTCCATGGG -3'
(R):5'- GGTTACAAAGCGCAATAAAAGAACC -3'
|
Posted On |
2014-10-30 |