Incidental Mutation 'R2310:Vmn2r112'
ID 244758
Institutional Source Beutler Lab
Gene Symbol Vmn2r112
Ensembl Gene ENSMUSG00000094921
Gene Name vomeronasal 2, receptor 112
Synonyms EG628185
MMRRC Submission 040309-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R2310 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 22820129-22838114 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 22822096 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 258 (V258E)
Ref Sequence ENSEMBL: ENSMUSP00000094994 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097381]
AlphaFold L7N221
Predicted Effect probably damaging
Transcript: ENSMUST00000097381
AA Change: V258E

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: V258E

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 73 471 2.8e-32 PFAM
Pfam:NCD3G 512 565 5.8e-21 PFAM
Pfam:7tm_3 598 833 6.5e-54 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.5%
  • 3x: 98.7%
  • 10x: 97.2%
  • 20x: 94.5%
Validation Efficiency 100% (39/39)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgef10l A C 4: 140,320,429 (GRCm39) C136W probably damaging Het
Ascc3 T A 10: 50,624,988 (GRCm39) H1625Q probably benign Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Cpa3 C T 3: 20,281,387 (GRCm39) C173Y probably damaging Het
Cyp2c65 A G 19: 39,081,826 (GRCm39) T451A probably benign Het
Ddx41 G A 13: 55,682,293 (GRCm39) R205W possibly damaging Het
Efhd1 T C 1: 87,192,350 (GRCm39) L60P probably damaging Het
Flrt2 A G 12: 95,746,864 (GRCm39) T401A probably benign Het
Frmd4a GAA G 2: 4,577,210 (GRCm39) probably null Het
Gas2l2 A G 11: 83,318,265 (GRCm39) V148A possibly damaging Het
Golga5 A G 12: 102,458,420 (GRCm39) E621G probably damaging Het
Gsap A T 5: 21,401,088 (GRCm39) R74* probably null Het
Intu C T 3: 40,608,243 (GRCm39) A85V probably benign Het
Kansl3 T A 1: 36,382,445 (GRCm39) I860F probably damaging Het
Kif23 A G 9: 61,831,426 (GRCm39) S715P probably damaging Het
Map3k8 A T 18: 4,349,001 (GRCm39) C106S probably benign Het
Mcc T C 18: 44,564,433 (GRCm39) E934G probably damaging Het
Mrpl19 A T 6: 81,941,054 (GRCm39) probably null Het
Msl3l2 C A 10: 55,991,421 (GRCm39) R49S probably benign Het
Muc6 T A 7: 141,217,444 (GRCm39) I2410F possibly damaging Het
Or2t6 A G 14: 14,175,836 (GRCm38) V82A probably benign Het
Or4a73 A G 2: 89,420,794 (GRCm39) S222P probably damaging Het
Pip5k1c T G 10: 81,142,142 (GRCm39) S117R probably damaging Het
Ppfia2 T C 10: 106,690,841 (GRCm39) S561P probably damaging Het
Pramel13 A T 4: 144,119,475 (GRCm39) probably null Het
Rassf5 A T 1: 131,172,477 (GRCm39) W131R probably damaging Het
Shq1 C T 6: 100,607,963 (GRCm39) W316* probably null Het
Slc45a4 A G 15: 73,461,409 (GRCm39) Y87H probably damaging Het
Sptbn2 A G 19: 4,768,963 (GRCm39) D32G probably benign Het
Tjp1 C T 7: 64,979,490 (GRCm39) R345Q possibly damaging Het
Tnrc18 C G 5: 142,774,308 (GRCm39) V174L probably damaging Het
Trmt6 G T 2: 132,650,832 (GRCm39) P259T probably damaging Het
Ubap1 T A 4: 41,379,341 (GRCm39) V185E possibly damaging Het
Ulk1 C T 5: 110,937,223 (GRCm39) R691Q probably benign Het
Wnk2 T C 13: 49,204,053 (GRCm39) T1979A probably damaging Het
Xirp2 A G 2: 67,356,591 (GRCm39) D3784G probably benign Het
Zfp119a A T 17: 56,172,440 (GRCm39) Y468N probably benign Het
Other mutations in Vmn2r112
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00341:Vmn2r112 APN 17 22,837,917 (GRCm39) missense probably benign 0.13
IGL01021:Vmn2r112 APN 17 22,837,885 (GRCm39) missense probably damaging 1.00
IGL01122:Vmn2r112 APN 17 22,821,988 (GRCm39) missense probably benign 0.00
IGL01360:Vmn2r112 APN 17 22,837,603 (GRCm39) missense probably benign 0.03
IGL01536:Vmn2r112 APN 17 22,824,136 (GRCm39) missense probably damaging 1.00
IGL02148:Vmn2r112 APN 17 22,838,013 (GRCm39) missense probably damaging 1.00
IGL02465:Vmn2r112 APN 17 22,833,975 (GRCm39) missense probably damaging 1.00
PIT4576001:Vmn2r112 UTSW 17 22,833,912 (GRCm39) missense probably benign 0.00
R0278:Vmn2r112 UTSW 17 22,821,987 (GRCm39) missense probably benign 0.44
R0328:Vmn2r112 UTSW 17 22,824,251 (GRCm39) missense probably benign 0.01
R0583:Vmn2r112 UTSW 17 22,837,930 (GRCm39) missense probably damaging 1.00
R0831:Vmn2r112 UTSW 17 22,833,980 (GRCm39) missense probably damaging 0.99
R1080:Vmn2r112 UTSW 17 22,837,980 (GRCm39) missense probably damaging 1.00
R1245:Vmn2r112 UTSW 17 22,822,228 (GRCm39) missense probably benign 0.03
R1321:Vmn2r112 UTSW 17 22,837,500 (GRCm39) nonsense probably null
R1381:Vmn2r112 UTSW 17 22,837,467 (GRCm39) missense probably damaging 1.00
R1514:Vmn2r112 UTSW 17 22,821,825 (GRCm39) missense probably benign 0.40
R1519:Vmn2r112 UTSW 17 22,837,884 (GRCm39) missense possibly damaging 0.83
R1572:Vmn2r112 UTSW 17 22,822,125 (GRCm39) missense possibly damaging 0.61
R1590:Vmn2r112 UTSW 17 22,833,989 (GRCm39) critical splice donor site probably null
R1640:Vmn2r112 UTSW 17 22,824,097 (GRCm39) missense probably benign 0.01
R2221:Vmn2r112 UTSW 17 22,820,214 (GRCm39) missense possibly damaging 0.86
R2223:Vmn2r112 UTSW 17 22,820,214 (GRCm39) missense possibly damaging 0.86
R2312:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2337:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2339:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2340:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2341:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2342:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2401:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2860:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2861:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R2926:Vmn2r112 UTSW 17 22,833,984 (GRCm39) missense possibly damaging 0.90
R3236:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R3237:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R3977:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R3979:Vmn2r112 UTSW 17 22,822,096 (GRCm39) missense probably damaging 0.98
R4168:Vmn2r112 UTSW 17 22,822,069 (GRCm39) missense probably benign 0.01
R4256:Vmn2r112 UTSW 17 22,837,393 (GRCm39) missense probably damaging 1.00
R4386:Vmn2r112 UTSW 17 22,820,303 (GRCm39) missense probably benign 0.36
R4912:Vmn2r112 UTSW 17 22,822,363 (GRCm39) missense probably damaging 0.99
R4947:Vmn2r112 UTSW 17 22,821,860 (GRCm39) missense probably benign 0.02
R5446:Vmn2r112 UTSW 17 22,837,231 (GRCm39) missense probably damaging 1.00
R5870:Vmn2r112 UTSW 17 22,838,004 (GRCm39) missense probably benign 0.00
R6351:Vmn2r112 UTSW 17 22,820,259 (GRCm39) missense probably benign
R6384:Vmn2r112 UTSW 17 22,824,136 (GRCm39) missense probably damaging 1.00
R6390:Vmn2r112 UTSW 17 22,824,230 (GRCm39) missense probably benign 0.01
R6401:Vmn2r112 UTSW 17 22,822,532 (GRCm39) nonsense probably null
R6405:Vmn2r112 UTSW 17 22,837,216 (GRCm39) missense probably damaging 1.00
R6620:Vmn2r112 UTSW 17 22,822,082 (GRCm39) missense probably benign 0.00
R6648:Vmn2r112 UTSW 17 22,837,467 (GRCm39) missense probably damaging 1.00
R6649:Vmn2r112 UTSW 17 22,820,160 (GRCm39) missense probably null 1.00
R6653:Vmn2r112 UTSW 17 22,820,160 (GRCm39) missense probably null 1.00
R6654:Vmn2r112 UTSW 17 22,822,450 (GRCm39) missense possibly damaging 0.89
R6700:Vmn2r112 UTSW 17 22,822,462 (GRCm39) missense possibly damaging 0.53
R6993:Vmn2r112 UTSW 17 22,822,195 (GRCm39) missense probably benign 0.01
R7052:Vmn2r112 UTSW 17 22,821,507 (GRCm39) missense probably benign
R7454:Vmn2r112 UTSW 17 22,822,288 (GRCm39) missense probably benign 0.00
R7763:Vmn2r112 UTSW 17 22,822,099 (GRCm39) missense probably damaging 1.00
R8032:Vmn2r112 UTSW 17 22,822,375 (GRCm39) missense probably benign 0.21
R8177:Vmn2r112 UTSW 17 22,822,594 (GRCm39) missense possibly damaging 0.47
R8263:Vmn2r112 UTSW 17 22,824,140 (GRCm39) missense probably damaging 1.00
R8395:Vmn2r112 UTSW 17 22,837,587 (GRCm39) missense possibly damaging 0.94
R8492:Vmn2r112 UTSW 17 22,821,470 (GRCm39) missense probably benign 0.03
R8889:Vmn2r112 UTSW 17 22,837,612 (GRCm39) missense probably damaging 1.00
R8892:Vmn2r112 UTSW 17 22,837,612 (GRCm39) missense probably damaging 1.00
R9246:Vmn2r112 UTSW 17 22,824,088 (GRCm39) missense probably benign 0.21
R9269:Vmn2r112 UTSW 17 22,820,213 (GRCm39) missense probably benign
R9273:Vmn2r112 UTSW 17 22,837,721 (GRCm39) missense probably damaging 1.00
R9288:Vmn2r112 UTSW 17 22,822,323 (GRCm39) missense probably damaging 1.00
R9352:Vmn2r112 UTSW 17 22,822,479 (GRCm39) missense probably damaging 0.98
R9406:Vmn2r112 UTSW 17 22,824,223 (GRCm39) nonsense probably null
R9432:Vmn2r112 UTSW 17 22,821,233 (GRCm39) missense
R9728:Vmn2r112 UTSW 17 22,824,108 (GRCm39) missense probably damaging 0.96
Z1088:Vmn2r112 UTSW 17 22,824,059 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- ATGGCCTCTGATCATACATCTC -3'
(R):5'- TGACTGAGTTCAATGTCTGCAC -3'

Sequencing Primer
(F):5'- GGCCTCTGATCATACATCTCTAGCC -3'
(R):5'- CCAGAAATCTCACTATTGTGTTGTTG -3'
Posted On 2014-10-30