Incidental Mutation 'R2274:Zkscan8'
ID 245000
Institutional Source Beutler Lab
Gene Symbol Zkscan8
Ensembl Gene ENSMUSG00000063894
Gene Name zinc finger with KRAB and SCAN domains 8
Synonyms 2510038J07Rik, Zfp192, LD5-1, D430019P06Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.089) question?
Stock # R2274 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 21697391-21715284 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 21705966 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 265 (M265I)
Ref Sequence ENSEMBL: ENSMUSP00000040248 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045228] [ENSMUST00000110481] [ENSMUST00000156674] [ENSMUST00000224362]
AlphaFold Q8BSL0
Predicted Effect probably benign
Transcript: ENSMUST00000045228
AA Change: M265I

PolyPhen 2 Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000040248
Gene: ENSMUSG00000063894
AA Change: M265I

DomainStartEndE-ValueType
low complexity region 8 22 N/A INTRINSIC
SCAN 48 160 1.07e-68 SMART
KRAB 230 289 1.64e-10 SMART
ZnF_C2H2 332 354 6.42e-4 SMART
ZnF_C2H2 360 382 3.95e-4 SMART
ZnF_C2H2 388 410 8.47e-4 SMART
ZnF_C2H2 416 438 3.69e-4 SMART
ZnF_C2H2 444 466 8.47e-4 SMART
ZnF_C2H2 472 494 3.44e-4 SMART
ZnF_C2H2 500 522 5.67e-5 SMART
ZnF_C2H2 528 550 3.44e-4 SMART
ZnF_C2H2 556 578 1.84e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000110481
SMART Domains Protein: ENSMUSP00000106107
Gene: ENSMUSG00000063894

DomainStartEndE-ValueType
low complexity region 8 22 N/A INTRINSIC
SCAN 48 145 3.33e-56 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000156674
SMART Domains Protein: ENSMUSP00000116058
Gene: ENSMUSG00000063894

DomainStartEndE-ValueType
low complexity region 8 22 N/A INTRINSIC
SCAN 48 160 1.07e-68 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000224362
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2300003K06Rik A T 11: 99,728,667 (GRCm39) C59S possibly damaging Het
Abca5 A T 11: 110,166,107 (GRCm39) N1556K possibly damaging Het
Abcb10 G T 8: 124,709,491 (GRCm39) A21E probably benign Het
Ackr1 T C 1: 173,160,052 (GRCm39) N156D probably benign Het
Adamtsl3 A T 7: 82,255,766 (GRCm39) S1593C probably benign Het
Ank3 T A 10: 69,786,772 (GRCm39) probably null Het
Aqp4 A G 18: 15,526,537 (GRCm39) S315P probably benign Het
Atp7b T C 8: 22,510,848 (GRCm39) I433V probably benign Het
Bco1 G A 8: 117,835,522 (GRCm39) probably null Het
Cacna1g T A 11: 94,306,762 (GRCm39) E1842V probably damaging Het
Calhm3 T A 19: 47,145,986 (GRCm39) Q73L probably damaging Het
Car5a C T 8: 122,671,408 (GRCm39) probably null Het
Cdk11b T A 4: 155,732,051 (GRCm39) probably benign Het
Cdr2 A T 7: 120,557,732 (GRCm39) H264Q possibly damaging Het
Col9a2 C G 4: 120,911,455 (GRCm39) R599G probably damaging Het
D7Ertd443e A G 7: 133,871,930 (GRCm39) S644P probably damaging Het
Dnlz A T 2: 26,241,483 (GRCm39) C82S probably damaging Het
Egr4 A T 6: 85,489,725 (GRCm39) F112I probably damaging Het
Emilin1 C T 5: 31,075,082 (GRCm39) P441L possibly damaging Het
F11 T C 8: 45,705,184 (GRCm39) D119G possibly damaging Het
Fat4 T A 3: 39,050,048 (GRCm39) V3970D possibly damaging Het
Fbxw5 C A 2: 25,394,773 (GRCm39) C222* probably null Het
Fn1 C T 1: 71,653,102 (GRCm39) G1296R probably null Het
Ghr A G 15: 3,349,507 (GRCm39) V557A probably benign Het
Gm11568 A G 11: 99,749,070 (GRCm39) S92G unknown Het
Gpatch1 A T 7: 34,988,103 (GRCm39) S678T probably benign Het
Gpr155 A G 2: 73,178,479 (GRCm39) probably null Het
Gucy2f A T X: 140,899,269 (GRCm39) M697K probably benign Het
Hecw1 T C 13: 14,520,653 (GRCm39) T195A probably benign Het
Hoxd1 A G 2: 74,594,501 (GRCm39) K252R probably damaging Het
Iqck G A 7: 118,498,880 (GRCm39) D173N possibly damaging Het
Irf8 A G 8: 121,480,266 (GRCm39) E168G probably damaging Het
Kcnh1 T G 1: 192,019,829 (GRCm39) V358G probably damaging Het
Kifap3 T A 1: 163,696,327 (GRCm39) V652D possibly damaging Het
L3hypdh T C 12: 72,131,632 (GRCm39) Y100C possibly damaging Het
Map4k1 T A 7: 28,701,382 (GRCm39) H729Q probably damaging Het
Marchf1 T A 8: 66,840,151 (GRCm39) N311K probably benign Het
Mier2 T C 10: 79,380,368 (GRCm39) I321V probably damaging Het
Mta1 C T 12: 113,091,770 (GRCm39) S291L probably damaging Het
Myh2 A G 11: 67,081,184 (GRCm39) K1267E possibly damaging Het
Nbea A T 3: 55,895,506 (GRCm39) probably null Het
Nexmif T G X: 103,131,452 (GRCm39) E155A possibly damaging Het
Nkpd1 A G 7: 19,257,822 (GRCm39) I534V probably benign Het
Nxph1 G T 6: 9,247,746 (GRCm39) C239F probably damaging Het
Odc1 A G 12: 17,598,425 (GRCm39) I189V probably benign Het
Or1n1 A T 2: 36,750,113 (GRCm39) N82K probably damaging Het
Or2t44 T C 11: 58,677,492 (GRCm39) V144A probably benign Het
Or5d41 A G 2: 88,055,167 (GRCm39) F70L probably benign Het
Or6c35 T C 10: 129,169,326 (GRCm39) I192T probably benign Het
Pcdhb15 T C 18: 37,608,496 (GRCm39) L576P probably damaging Het
Raph1 T C 1: 60,537,659 (GRCm39) D499G probably damaging Het
Rptor T A 11: 119,647,148 (GRCm39) C246* probably null Het
Rtl1 T C 12: 109,561,101 (GRCm39) E246G unknown Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Slc12a3 T A 8: 95,059,915 (GRCm39) I187N possibly damaging Het
Slc46a1 T G 11: 78,357,249 (GRCm39) S101A probably benign Het
Slc4a8 A G 15: 100,705,283 (GRCm39) M830V probably benign Het
Sned1 T A 1: 93,209,364 (GRCm39) probably null Het
St3gal6 T A 16: 58,309,332 (GRCm39) E34D possibly damaging Het
Tcstv3 C T 13: 120,779,190 (GRCm39) Q30* probably null Het
Tex16 T A X: 111,030,838 (GRCm39) D1112E probably damaging Het
Tmcc3 G A 10: 94,414,777 (GRCm39) V160I probably damaging Het
Tmf1 T A 6: 97,140,547 (GRCm39) L776F probably damaging Het
Tsr1 A T 11: 74,795,653 (GRCm39) probably null Het
Tyrp1 A T 4: 80,755,771 (GRCm39) E180V probably damaging Het
Ubr3 T C 2: 69,846,685 (GRCm39) V1636A probably benign Het
Usp1 T C 4: 98,818,079 (GRCm39) L139P probably damaging Het
Vmn1r232 A G 17: 21,134,465 (GRCm39) L45P probably benign Het
Vmn1r49 G A 6: 90,049,126 (GRCm39) T292I probably benign Het
Wdr19 T A 5: 65,398,334 (GRCm39) M853K possibly damaging Het
Other mutations in Zkscan8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01726:Zkscan8 APN 13 21,704,973 (GRCm39) missense probably benign 0.00
IGL01987:Zkscan8 APN 13 21,710,729 (GRCm39) missense probably damaging 1.00
R0129:Zkscan8 UTSW 13 21,706,441 (GRCm39) missense probably benign 0.35
R0371:Zkscan8 UTSW 13 21,710,844 (GRCm39) missense probably damaging 1.00
R0682:Zkscan8 UTSW 13 21,710,930 (GRCm39) missense probably damaging 1.00
R1635:Zkscan8 UTSW 13 21,710,765 (GRCm39) missense possibly damaging 0.84
R1688:Zkscan8 UTSW 13 21,704,324 (GRCm39) missense possibly damaging 0.94
R1908:Zkscan8 UTSW 13 21,709,325 (GRCm39) missense probably damaging 0.96
R1912:Zkscan8 UTSW 13 21,704,927 (GRCm39) nonsense probably null
R2117:Zkscan8 UTSW 13 21,704,488 (GRCm39) missense probably damaging 1.00
R2155:Zkscan8 UTSW 13 21,704,759 (GRCm39) nonsense probably null
R2214:Zkscan8 UTSW 13 21,705,082 (GRCm39) missense probably benign 0.43
R3624:Zkscan8 UTSW 13 21,704,946 (GRCm39) missense probably damaging 1.00
R5528:Zkscan8 UTSW 13 21,704,895 (GRCm39) missense probably damaging 1.00
R5536:Zkscan8 UTSW 13 21,710,838 (GRCm39) missense probably damaging 1.00
R6492:Zkscan8 UTSW 13 21,709,397 (GRCm39) missense probably benign 0.25
R6533:Zkscan8 UTSW 13 21,704,748 (GRCm39) missense probably damaging 1.00
R7131:Zkscan8 UTSW 13 21,709,443 (GRCm39) missense probably damaging 1.00
R7837:Zkscan8 UTSW 13 21,704,598 (GRCm39) missense possibly damaging 0.96
R7877:Zkscan8 UTSW 13 21,704,580 (GRCm39) missense possibly damaging 0.90
R9342:Zkscan8 UTSW 13 21,710,702 (GRCm39) missense probably benign 0.05
R9609:Zkscan8 UTSW 13 21,709,434 (GRCm39) missense possibly damaging 0.68
R9623:Zkscan8 UTSW 13 21,704,763 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTAGACCCCAAGAAGTCTCAATC -3'
(R):5'- CAACACTGGTTTTGAGCTGTGG -3'

Sequencing Primer
(F):5'- CATCCCCTAGAGTTGGAGTACTG -3'
(R):5'- TGGAACCTTTCTAGGCCCCAAATG -3'
Posted On 2014-10-30