Mutagenetix > Incidental Mutation

Incidental Mutation 'R2319:Gm7489'

245595

Institutional Source

Beutler Lab

Gene Symbol

Gm7489

Ensembl Gene

ENSMUSG00000072584

Gene Name

predicted gene 7489

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.231) question?

Stock #

R2319 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

53748302-53749993 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to T at 53748445 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000123446 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000078673] [ENSMUST00000100666] [ENSMUST00000132059]

AlphaFold

Q3UT34

Predicted Effect

probably benign
Transcript: ENSMUST00000078673

SMART Domains

Protein: ENSMUSP00000077741
Gene: ENSMUSG00000058656

Domain	Start	End	E-Value	Type
SAM	74	143	1e-8	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000100666

Predicted Effect

probably benign
Transcript: ENSMUST00000132059

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132362

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154119

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 94.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 23 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	C	T	6: 128,557,349 (GRCm39)	A115T	probably benign	Het
Atp11a	T	A	8: 12,897,505 (GRCm39)	H273Q	probably damaging	Het
Ccdc186	A	G	19: 56,785,999 (GRCm39)	S679P	possibly damaging	Het
Chac2	T	A	11: 30,936,252 (GRCm39)		probably benign	Het
Col6a5	T	C	9: 105,814,417 (GRCm39)	T532A	unknown	Het
Dsg1c	A	T	18: 20,408,235 (GRCm39)	Y428F	probably damaging	Het
F11	A	G	8: 45,701,675 (GRCm39)	S353P	probably damaging	Het
Gnat3	T	G	5: 18,224,624 (GRCm39)	D341E	probably benign	Het
Lrpprc	G	A	17: 85,033,818 (GRCm39)	P1020S	probably benign	Het
Niban3	T	C	8: 72,055,408 (GRCm39)	F273L	probably benign	Het
Nlrp4a	A	G	7: 26,149,319 (GRCm39)	S309G	probably benign	Het
Pik3cg	T	C	12: 32,226,735 (GRCm39)	I1051V	probably damaging	Het
Plod3	G	C	5: 137,017,000 (GRCm39)	A50P	probably benign	Het
Rmnd1	A	G	10: 4,372,099 (GRCm39)	V200A	possibly damaging	Het
Rrbp1	T	C	2: 143,799,479 (GRCm39)	N1076S	probably benign	Het
Rtn4	A	G	11: 29,657,154 (GRCm39)	D436G	probably benign	Het
Spta1	A	G	1: 174,006,222 (GRCm39)		probably null	Het
Srsf3	G	A	17: 29,257,520 (GRCm39)	R88Q	unknown	Het
Stxbp2	T	C	8: 3,683,834 (GRCm39)	I90T	possibly damaging	Het
Tnr	T	A	1: 159,677,618 (GRCm39)	M1K	probably null	Het
Tns3	G	A	11: 8,491,200 (GRCm39)	S119L	probably damaging	Het
Vmn1r2	A	G	4: 3,172,083 (GRCm39)	M1V	probably null	Het
Vpreb3	C	T	10: 75,779,056 (GRCm39)		probably benign	Het

Other mutations in Gm7489

Allele	Source	Chr	Coord	Type	Predicted Effect
PIT4458001:Gm7489	UTSW	15	53,749,195 (GRCm39)	missense	unknown
R4852:Gm7489	UTSW	15	53,749,434 (GRCm39)	intron	probably benign
R5212:Gm7489	UTSW	15	53,749,016 (GRCm39)	intron	probably benign
R6778:Gm7489	UTSW	15	53,749,348 (GRCm39)	intron	probably benign
R7832:Gm7489	UTSW	15	53,749,402 (GRCm39)	missense	unknown
R9612:Gm7489	UTSW	15	53,749,369 (GRCm39)	missense	unknown
R9612:Gm7489	UTSW	15	53,749,368 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- CCGAAGTGTTACTTATTCAGCC -3'
(R):5'- AGACAGACCACTGAATAGTCATGG -3'

Sequencing Primer
(F):5'- CGAAGTGTTACTTATTCAGCCTCATG -3'
(R):5'- GCACATTGTATGTTTAAACCGAAG -3'

Posted On

2014-10-30