Incidental Mutation 'R2331:Lcn11'
ID 245860
Institutional Source Beutler Lab
Gene Symbol Lcn11
Ensembl Gene ENSMUSG00000069080
Gene Name lipocalin 11
Synonyms
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R2331 (G1)
Quality Score 188
Status Not validated
Chromosome 2
Chromosomal Location 25667029-25670291 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 25670188 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 177 (T177K)
Ref Sequence ENSEMBL: ENSMUSP00000088822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091278] [ENSMUST00000211245]
AlphaFold A2BHR2
Predicted Effect possibly damaging
Transcript: ENSMUST00000091278
AA Change: T177K

PolyPhen 2 Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000088822
Gene: ENSMUSG00000069080
AA Change: T177K

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Lipocalin 34 172 7.5e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143166
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153913
Predicted Effect probably benign
Transcript: ENSMUST00000211245
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aff3 C T 1: 38,243,971 (GRCm39) probably null Het
Cadps A G 14: 12,603,692 (GRCm38) I376T probably damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Gm10295 A C 7: 71,000,437 (GRCm39) S48A unknown Het
Gstcd A G 3: 132,704,641 (GRCm39) C538R probably damaging Het
Hcn3 A T 3: 89,055,397 (GRCm39) S617T probably benign Het
Hectd4 A G 5: 121,458,089 (GRCm39) I752V probably benign Het
Itgb7 G T 15: 102,131,983 (GRCm39) T200K probably damaging Het
Lsm14a A G 7: 34,056,915 (GRCm39) V241A probably benign Het
Magi1 T C 6: 93,662,543 (GRCm39) K1075E probably damaging Het
Or4c111 T C 2: 88,844,265 (GRCm39) I48V probably benign Het
Or4d10c C A 19: 12,065,522 (GRCm39) L211F probably benign Het
P4hb T C 11: 120,459,106 (GRCm39) N129S probably benign Het
Piezo1 C T 8: 123,214,005 (GRCm39) probably null Het
Ppp3ca T C 3: 136,503,580 (GRCm39) M51T probably benign Het
Sema6d T C 2: 124,499,983 (GRCm39) V353A probably damaging Het
Setx GTGGCT GT 2: 29,044,073 (GRCm39) 1814 probably null Het
Sh3rf1 C T 8: 61,679,321 (GRCm39) P121L probably benign Het
Sh3rf2 T C 18: 42,186,928 (GRCm39) F16L probably benign Het
Sparcl1 A G 5: 104,233,660 (GRCm39) L563P probably damaging Het
Stra6l T C 4: 45,858,224 (GRCm39) probably null Het
Sult2a6 A T 7: 13,959,795 (GRCm39) M246K possibly damaging Het
Trpv5 A G 6: 41,636,902 (GRCm39) S399P probably damaging Het
Uggt2 A T 14: 119,264,011 (GRCm39) F1006L possibly damaging Het
Uhrf1 C A 17: 56,617,671 (GRCm39) probably null Het
Wdr72 A G 9: 74,055,608 (GRCm39) Y279C probably damaging Het
Other mutations in Lcn11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02904:Lcn11 APN 2 25,669,278 (GRCm39) missense probably null 0.00
R0220:Lcn11 UTSW 2 25,667,843 (GRCm39) missense probably benign 0.02
R0607:Lcn11 UTSW 2 25,669,305 (GRCm39) missense probably benign 0.00
R1104:Lcn11 UTSW 2 25,669,115 (GRCm39) unclassified probably benign
R2021:Lcn11 UTSW 2 25,668,097 (GRCm39) missense probably benign 0.34
R4295:Lcn11 UTSW 2 25,668,111 (GRCm39) missense possibly damaging 0.83
R6109:Lcn11 UTSW 2 25,669,308 (GRCm39) missense possibly damaging 0.78
R6356:Lcn11 UTSW 2 25,668,132 (GRCm39) nonsense probably null
R6502:Lcn11 UTSW 2 25,669,103 (GRCm39) missense probably benign 0.08
R7754:Lcn11 UTSW 2 25,667,830 (GRCm39) missense probably benign 0.06
R7920:Lcn11 UTSW 2 25,669,343 (GRCm39) missense possibly damaging 0.70
R8389:Lcn11 UTSW 2 25,669,043 (GRCm39) missense probably damaging 0.97
R8752:Lcn11 UTSW 2 25,668,138 (GRCm39) missense probably damaging 1.00
R8765:Lcn11 UTSW 2 25,668,139 (GRCm39) missense probably damaging 1.00
R8881:Lcn11 UTSW 2 25,669,296 (GRCm39) missense probably benign 0.33
R8954:Lcn11 UTSW 2 25,669,265 (GRCm39) missense probably benign 0.01
Z1176:Lcn11 UTSW 2 25,667,736 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GGCAAACTTGGTTTATCTCATTGC -3'
(R):5'- TCAGAAGCTAGGTGAGTGCC -3'

Sequencing Primer
(F):5'- CCTGGGTGTGGAAGGCCTAG -3'
(R):5'- GTGAGTGCCACCCCTCC -3'
Posted On 2014-10-30