Incidental Mutation 'R2347:Or8g21'
ID 246008
Institutional Source Beutler Lab
Gene Symbol Or8g21
Ensembl Gene ENSMUSG00000059595
Gene Name olfactory receptor family 8 subfamily G member 21
Synonyms MOR171-11, GA_x6K02T2PVTD-32691280-32690354, Olfr935
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R2347 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 38905803-38906729 bp(-) (GRCm39)
Type of Mutation makesense
DNA Base Change (assembly) A to T at 38905805 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Stop codon to Lysine at position 309 (*309K)
Ref Sequence ENSEMBL: ENSMUSP00000149193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080748] [ENSMUST00000214157]
AlphaFold Q8VG16
Predicted Effect probably null
Transcript: ENSMUST00000080748
AA Change: *309K
SMART Domains Protein: ENSMUSP00000079572
Gene: ENSMUSG00000059595
AA Change: *309K

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4e-53 PFAM
Pfam:7tm_1 41 290 1.2e-22 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214157
AA Change: *309K
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 12 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ces1a C T 8: 93,751,947 (GRCm39) V396M probably benign Het
Ddx6 A G 9: 44,518,888 (GRCm39) K67E probably benign Het
Fut2 T C 7: 45,299,752 (GRCm39) D340G probably damaging Het
Gm128 A G 3: 95,148,241 (GRCm39) Y18H probably benign Het
Gon4l A G 3: 88,770,824 (GRCm39) D502G probably damaging Het
Lman2 T A 13: 55,500,812 (GRCm39) N129I possibly damaging Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Or12j2 T A 7: 139,916,060 (GRCm39) M95K probably damaging Het
Or4c52 G T 2: 89,845,958 (GRCm39) R228L possibly damaging Het
Pappa2 C A 1: 158,592,613 (GRCm39) C1588F probably damaging Het
Piwil2 T C 14: 70,646,366 (GRCm39) D390G probably damaging Het
Rest A G 5: 77,416,440 (GRCm39) Y218C probably damaging Het
Other mutations in Or8g21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01522:Or8g21 APN 9 38,906,396 (GRCm39) missense probably benign 0.08
IGL01671:Or8g21 APN 9 38,906,149 (GRCm39) missense probably benign 0.05
IGL02331:Or8g21 APN 9 38,906,402 (GRCm39) missense probably damaging 0.99
IGL03069:Or8g21 APN 9 38,906,728 (GRCm39) start codon destroyed probably null 0.98
IGL03143:Or8g21 APN 9 38,906,732 (GRCm39) utr 5 prime probably benign
R0149:Or8g21 UTSW 9 38,905,880 (GRCm39) missense probably benign 0.05
R0400:Or8g21 UTSW 9 38,906,494 (GRCm39) missense probably damaging 1.00
R1818:Or8g21 UTSW 9 38,905,902 (GRCm39) missense possibly damaging 0.61
R2092:Or8g21 UTSW 9 38,906,485 (GRCm39) missense probably damaging 1.00
R2151:Or8g21 UTSW 9 38,906,012 (GRCm39) missense probably damaging 1.00
R2166:Or8g21 UTSW 9 38,906,513 (GRCm39) nonsense probably null
R4404:Or8g21 UTSW 9 38,905,865 (GRCm39) missense possibly damaging 0.77
R4406:Or8g21 UTSW 9 38,905,865 (GRCm39) missense possibly damaging 0.77
R5152:Or8g21 UTSW 9 38,906,473 (GRCm39) missense possibly damaging 0.88
R5467:Or8g21 UTSW 9 38,906,200 (GRCm39) missense probably benign 0.14
R5509:Or8g21 UTSW 9 38,905,924 (GRCm39) missense probably benign 0.03
R5954:Or8g21 UTSW 9 38,906,711 (GRCm39) missense probably damaging 1.00
R6647:Or8g21 UTSW 9 38,906,210 (GRCm39) missense possibly damaging 0.55
R6680:Or8g21 UTSW 9 38,905,954 (GRCm39) missense probably damaging 1.00
R6928:Or8g21 UTSW 9 38,905,928 (GRCm39) missense probably benign 0.03
R7242:Or8g21 UTSW 9 38,906,437 (GRCm39) missense probably benign 0.31
R7271:Or8g21 UTSW 9 38,905,953 (GRCm39) nonsense probably null
R7309:Or8g21 UTSW 9 38,906,576 (GRCm39) missense probably damaging 1.00
R7775:Or8g21 UTSW 9 38,906,203 (GRCm39) missense probably damaging 1.00
R7778:Or8g21 UTSW 9 38,906,203 (GRCm39) missense probably damaging 1.00
R7866:Or8g21 UTSW 9 38,906,027 (GRCm39) missense not run
R8280:Or8g21 UTSW 9 38,906,075 (GRCm39) missense probably benign
R8334:Or8g21 UTSW 9 38,905,889 (GRCm39) missense probably benign 0.00
R8841:Or8g21 UTSW 9 38,905,879 (GRCm39) missense possibly damaging 0.95
R9161:Or8g21 UTSW 9 38,905,816 (GRCm39) missense possibly damaging 0.70
R9169:Or8g21 UTSW 9 38,906,573 (GRCm39) missense probably benign 0.23
R9659:Or8g21 UTSW 9 38,906,296 (GRCm39) missense possibly damaging 0.64
R9739:Or8g21 UTSW 9 38,906,302 (GRCm39) nonsense probably null
R9788:Or8g21 UTSW 9 38,906,296 (GRCm39) missense possibly damaging 0.64
Predicted Primers PCR Primer
(F):5'- TGACCCTGGAATTGAAGACAC -3'
(R):5'- GGGCAGATCTAAAACCTTCAGC -3'

Sequencing Primer
(F):5'- CCCTGGAATTGAAGACACAAGGTG -3'
(R):5'- TGCAGCTCCCACATCTCAG -3'
Posted On 2014-10-30