Incidental Mutation 'R2366:Zfp101'
| ID |
246353 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp101
|
| Ensembl Gene |
ENSMUSG00000055240 |
| Gene Name |
zinc finger protein 101 |
| Synonyms |
|
| MMRRC Submission |
040347-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
R2366 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
33599148-33613593 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 33599972 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 595
(C595S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132508
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167107]
[ENSMUST00000174417]
[ENSMUST00000174512]
|
| AlphaFold |
Q8BP18 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167107
AA Change: C595S
PolyPhen 2
Score 0.065 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000132508
Gene: ENSMUSG00000055240
AA Change: C595S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
62 |
9.34e-15 |
SMART |
|
ZnF_C2H2
|
219 |
241 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
247 |
269 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
275 |
297 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
302 |
322 |
1.65e2 |
SMART |
|
ZnF_C2H2
|
330 |
352 |
6.75e0 |
SMART |
|
ZnF_C2H2
|
358 |
380 |
2.75e-3 |
SMART |
|
ZnF_C2H2
|
386 |
408 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
414 |
436 |
2.09e-3 |
SMART |
|
ZnF_C2H2
|
442 |
464 |
4.79e-3 |
SMART |
|
ZnF_C2H2
|
470 |
492 |
2.2e-2 |
SMART |
|
ZnF_C2H2
|
498 |
520 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
526 |
548 |
4.72e-2 |
SMART |
|
ZnF_C2H2
|
554 |
576 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
583 |
605 |
5.06e-2 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000173151
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174417
|
| SMART Domains |
Protein: ENSMUSP00000134459
Gene: ENSMUSG00000055240
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
38 |
5e-16 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174512
|
| SMART Domains |
Protein: ENSMUSP00000133873
Gene: ENSMUSG00000055240
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
10 |
62 |
9.34e-15 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183047
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.8%
|
| Validation Efficiency |
100% (39/39) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 40 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A630091E08Rik |
G |
A |
7: 98,192,949 (GRCm39) |
|
noncoding transcript |
Het |
| Adamts5 |
C |
T |
16: 85,659,646 (GRCm39) |
G882D |
probably damaging |
Het |
| Arl6ip6 |
T |
C |
2: 53,082,379 (GRCm39) |
V82A |
probably benign |
Het |
| Brd10 |
A |
T |
19: 29,731,035 (GRCm39) |
I726N |
probably damaging |
Het |
| Cd38 |
T |
G |
5: 44,060,932 (GRCm39) |
|
probably benign |
Het |
| Cep250 |
G |
A |
2: 155,834,552 (GRCm39) |
R2159K |
probably damaging |
Het |
| Col6a6 |
C |
A |
9: 105,632,893 (GRCm39) |
G1457V |
probably damaging |
Het |
| Cyp2c69 |
T |
C |
19: 39,866,038 (GRCm39) |
N185S |
probably benign |
Het |
| Cyp2d12 |
T |
A |
15: 82,439,355 (GRCm39) |
L3Q |
probably damaging |
Het |
| Dnajc28 |
G |
A |
16: 91,413,755 (GRCm39) |
T187M |
probably damaging |
Het |
| Drc1 |
A |
G |
5: 30,523,894 (GRCm39) |
*754W |
probably null |
Het |
| Erbin |
G |
A |
13: 103,981,417 (GRCm39) |
H503Y |
probably damaging |
Het |
| F3 |
G |
A |
3: 121,526,194 (GRCm39) |
|
probably null |
Het |
| Gm10033 |
A |
T |
8: 69,826,232 (GRCm39) |
M112K |
unknown |
Het |
| Gps1 |
A |
C |
11: 120,678,945 (GRCm39) |
I404L |
probably damaging |
Het |
| Hc |
T |
C |
2: 34,903,648 (GRCm39) |
N1002S |
probably benign |
Het |
| Impg2 |
T |
C |
16: 56,080,236 (GRCm39) |
I571T |
probably benign |
Het |
| Knop1 |
C |
A |
7: 118,451,751 (GRCm39) |
V323F |
possibly damaging |
Het |
| Kntc1 |
C |
T |
5: 123,919,255 (GRCm39) |
L845F |
probably damaging |
Het |
| Lsm5 |
T |
C |
6: 56,680,003 (GRCm39) |
D53G |
probably damaging |
Het |
| Lzts1 |
T |
C |
8: 69,593,257 (GRCm39) |
|
probably null |
Het |
| Matr3 |
A |
T |
18: 35,721,448 (GRCm39) |
N473I |
probably damaging |
Het |
| Med1 |
A |
G |
11: 98,052,008 (GRCm39) |
V452A |
probably damaging |
Het |
| Napsa |
T |
A |
7: 44,231,909 (GRCm39) |
D44E |
probably damaging |
Het |
| Nbeal1 |
T |
C |
1: 60,290,511 (GRCm39) |
F1036S |
probably damaging |
Het |
| Ncapg2 |
G |
A |
12: 116,384,349 (GRCm39) |
W270* |
probably null |
Het |
| Nherf1 |
G |
A |
11: 115,054,454 (GRCm39) |
V35M |
probably benign |
Het |
| Or5af1 |
C |
A |
11: 58,722,039 (GRCm39) |
Q20K |
probably benign |
Het |
| Pik3ca |
G |
A |
3: 32,516,943 (GRCm39) |
W1057* |
probably null |
Het |
| Pkd1l2 |
A |
T |
8: 117,770,056 (GRCm39) |
D1133E |
probably benign |
Het |
| Pramel39-ps |
T |
C |
5: 94,450,972 (GRCm39) |
K385E |
probably benign |
Het |
| Prox1 |
T |
A |
1: 189,894,079 (GRCm39) |
E122V |
probably damaging |
Het |
| Rest |
C |
A |
5: 77,416,034 (GRCm39) |
H83N |
probably benign |
Het |
| Rundc3a |
A |
G |
11: 102,288,491 (GRCm39) |
I68V |
probably damaging |
Het |
| Stx6 |
A |
T |
1: 155,077,706 (GRCm39) |
I238L |
probably benign |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Ubqln3 |
C |
A |
7: 103,790,256 (GRCm39) |
Q611H |
probably damaging |
Het |
| Usp6nl |
T |
A |
2: 6,445,770 (GRCm39) |
H559Q |
probably benign |
Het |
| Vipr1 |
T |
G |
9: 121,494,250 (GRCm39) |
V277G |
probably benign |
Het |
| Zfp398 |
C |
T |
6: 47,840,143 (GRCm39) |
T124I |
possibly damaging |
Het |
|
| Other mutations in Zfp101 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0189:Zfp101
|
UTSW |
17 |
33,601,213 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0254:Zfp101
|
UTSW |
17 |
33,599,952 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0448:Zfp101
|
UTSW |
17 |
33,601,295 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0696:Zfp101
|
UTSW |
17 |
33,600,401 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0834:Zfp101
|
UTSW |
17 |
33,601,418 (GRCm39) |
missense |
probably benign |
0.33 |
|
R2000:Zfp101
|
UTSW |
17 |
33,600,491 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2471:Zfp101
|
UTSW |
17 |
33,599,950 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R3713:Zfp101
|
UTSW |
17 |
33,600,880 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3857:Zfp101
|
UTSW |
17 |
33,601,405 (GRCm39) |
nonsense |
probably null |
|
|
R4537:Zfp101
|
UTSW |
17 |
33,601,466 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4712:Zfp101
|
UTSW |
17 |
33,613,457 (GRCm39) |
splice site |
probably null |
|
|
R5049:Zfp101
|
UTSW |
17 |
33,600,872 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5241:Zfp101
|
UTSW |
17 |
33,601,210 (GRCm39) |
missense |
probably benign |
|
|
R5499:Zfp101
|
UTSW |
17 |
33,601,318 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5587:Zfp101
|
UTSW |
17 |
33,600,295 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5694:Zfp101
|
UTSW |
17 |
33,599,919 (GRCm39) |
missense |
probably benign |
|
|
R5994:Zfp101
|
UTSW |
17 |
33,599,936 (GRCm39) |
missense |
probably benign |
|
|
R6193:Zfp101
|
UTSW |
17 |
33,600,720 (GRCm39) |
nonsense |
probably null |
|
|
R7331:Zfp101
|
UTSW |
17 |
33,601,559 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7393:Zfp101
|
UTSW |
17 |
33,605,674 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7434:Zfp101
|
UTSW |
17 |
33,600,564 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7922:Zfp101
|
UTSW |
17 |
33,600,511 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8087:Zfp101
|
UTSW |
17 |
33,599,977 (GRCm39) |
missense |
probably benign |
|
|
R8684:Zfp101
|
UTSW |
17 |
33,600,977 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9443:Zfp101
|
UTSW |
17 |
33,601,418 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9581:Zfp101
|
UTSW |
17 |
33,605,730 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TACCTCACAATAAAGGCAAGTTG -3'
(R):5'- CCCAGTGACTATAATAGTTGTGAAAG -3'
Sequencing Primer
(F):5'- GGCAAGTTGACCACACAGTTTATAG -3'
(R):5'- TTCACACTGGAGAGAAGCCTTATGC -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation