Incidental Mutation 'R2369:Zfp11'
| ID |
246425 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp11
|
| Ensembl Gene |
ENSMUSG00000051034 |
| Gene Name |
zinc finger protein 11 |
| Synonyms |
Zfp-11, Krox-6 |
| MMRRC Submission |
040349-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R2369 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
129731659-129747152 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 129733529 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Leucine
at position 644
(P644L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000051861
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049778]
|
| AlphaFold |
P10751 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000049778
AA Change: P644L
PolyPhen 2
Score 0.401 (Sensitivity: 0.89; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000051861
Gene: ENSMUSG00000051034
AA Change: P644L
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
57 |
79 |
1.03e-2 |
SMART |
|
ZnF_C2H2
|
85 |
107 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
113 |
135 |
2.91e-2 |
SMART |
|
ZnF_C2H2
|
141 |
163 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
169 |
191 |
4.47e-3 |
SMART |
|
ZnF_C2H2
|
197 |
219 |
6.78e-3 |
SMART |
|
ZnF_C2H2
|
225 |
247 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
253 |
275 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
281 |
303 |
8.34e-3 |
SMART |
|
ZnF_C2H2
|
309 |
331 |
9.08e-4 |
SMART |
|
ZnF_C2H2
|
337 |
359 |
7.37e-4 |
SMART |
|
ZnF_C2H2
|
365 |
387 |
4.94e-5 |
SMART |
|
ZnF_C2H2
|
393 |
415 |
9.58e-3 |
SMART |
|
ZnF_C2H2
|
421 |
443 |
1.28e-3 |
SMART |
|
ZnF_C2H2
|
449 |
471 |
6.32e-3 |
SMART |
|
ZnF_C2H2
|
477 |
499 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
505 |
527 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
533 |
555 |
3.16e-3 |
SMART |
|
ZnF_C2H2
|
561 |
583 |
1.45e-2 |
SMART |
|
ZnF_C2H2
|
589 |
611 |
5.5e-3 |
SMART |
|
ZnF_C2H2
|
617 |
639 |
1.58e-3 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 28 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700066M21Rik |
A |
T |
1: 57,421,950 (GRCm39) |
N109Y |
possibly damaging |
Het |
| 9230112D13Rik |
A |
T |
14: 34,233,913 (GRCm39) |
I126N |
unknown |
Het |
| A2ml1 |
C |
T |
6: 128,557,349 (GRCm39) |
A115T |
probably benign |
Het |
| Ahcyl1 |
T |
C |
3: 107,577,556 (GRCm39) |
D288G |
probably damaging |
Het |
| Atxn7l1 |
T |
C |
12: 33,408,849 (GRCm39) |
|
probably null |
Het |
| Ccdc33 |
A |
T |
9: 57,983,913 (GRCm39) |
S220T |
probably benign |
Het |
| Celsr3 |
G |
A |
9: 108,719,751 (GRCm39) |
R2450H |
probably benign |
Het |
| Cubn |
T |
A |
2: 13,496,028 (GRCm39) |
K69N |
probably damaging |
Het |
| Dclk3 |
A |
G |
9: 111,317,610 (GRCm39) |
R749G |
probably benign |
Het |
| Dip2a |
T |
C |
10: 76,149,030 (GRCm39) |
N207S |
probably benign |
Het |
| Dok6 |
G |
C |
18: 89,432,988 (GRCm39) |
R274G |
probably null |
Het |
| Esco2 |
G |
A |
14: 66,059,189 (GRCm39) |
A496V |
probably damaging |
Het |
| Gbp5 |
A |
T |
3: 142,206,480 (GRCm39) |
M55L |
possibly damaging |
Het |
| Grik5 |
T |
C |
7: 24,757,962 (GRCm39) |
Y373C |
probably damaging |
Het |
| Hbs1l |
T |
A |
10: 21,183,644 (GRCm39) |
S128R |
probably benign |
Het |
| Ing3 |
A |
G |
6: 21,950,090 (GRCm39) |
M28V |
probably damaging |
Het |
| Lmtk3 |
A |
T |
7: 45,444,512 (GRCm39) |
|
probably benign |
Het |
| Met |
G |
A |
6: 17,531,527 (GRCm39) |
V602I |
probably benign |
Het |
| Ndufaf7 |
C |
A |
17: 79,252,461 (GRCm39) |
A290E |
probably damaging |
Het |
| Notch4 |
A |
G |
17: 34,804,924 (GRCm39) |
Q1593R |
probably benign |
Het |
| Npl |
A |
G |
1: 153,394,623 (GRCm39) |
|
probably null |
Het |
| Paqr6 |
T |
C |
3: 88,273,260 (GRCm39) |
L84P |
probably damaging |
Het |
| Pros1 |
A |
G |
16: 62,748,432 (GRCm39) |
Y635C |
probably damaging |
Het |
| Rad1 |
C |
A |
15: 10,486,745 (GRCm39) |
N47K |
probably damaging |
Het |
| Rassf4 |
A |
G |
6: 116,615,258 (GRCm39) |
F304L |
probably damaging |
Het |
| Tmem232 |
A |
T |
17: 65,709,992 (GRCm39) |
V432E |
probably damaging |
Het |
| Wdr72 |
A |
G |
9: 74,117,457 (GRCm39) |
K723R |
possibly damaging |
Het |
| Xpo7 |
G |
A |
14: 70,925,171 (GRCm39) |
R493* |
probably null |
Het |
|
| Other mutations in Zfp11 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00847:Zfp11
|
APN |
5 |
129,734,978 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0190:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0239:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0239:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0419:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0423:Zfp11
|
UTSW |
5 |
129,735,302 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0601:Zfp11
|
UTSW |
5 |
129,734,971 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0731:Zfp11
|
UTSW |
5 |
129,734,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0826:Zfp11
|
UTSW |
5 |
129,734,589 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1467:Zfp11
|
UTSW |
5 |
129,735,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1467:Zfp11
|
UTSW |
5 |
129,735,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1613:Zfp11
|
UTSW |
5 |
129,735,431 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1711:Zfp11
|
UTSW |
5 |
129,733,737 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1770:Zfp11
|
UTSW |
5 |
129,734,822 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2155:Zfp11
|
UTSW |
5 |
129,734,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5597:Zfp11
|
UTSW |
5 |
129,734,166 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5902:Zfp11
|
UTSW |
5 |
129,734,976 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6324:Zfp11
|
UTSW |
5 |
129,733,587 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6768:Zfp11
|
UTSW |
5 |
129,735,415 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6943:Zfp11
|
UTSW |
5 |
129,735,152 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7782:Zfp11
|
UTSW |
5 |
129,734,027 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8144:Zfp11
|
UTSW |
5 |
129,733,694 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8813:Zfp11
|
UTSW |
5 |
129,735,278 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8980:Zfp11
|
UTSW |
5 |
129,737,843 (GRCm39) |
start codon destroyed |
probably benign |
0.05 |
|
R9173:Zfp11
|
UTSW |
5 |
129,734,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9283:Zfp11
|
UTSW |
5 |
129,734,748 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Zfp11
|
UTSW |
5 |
129,734,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTATCGTCTCCCCTCATAGATG -3'
(R):5'- AGCTGCTCCTCATACCTGAC -3'
Sequencing Primer
(F):5'- CCCTCATAGATGGGCCTTTTTGG -3'
(R):5'- ACACCAGAGGATCCATGCTGG -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation