Incidental Mutation 'R2334:Olfm3'
ID 246514
Institutional Source Beutler Lab
Gene Symbol Olfm3
Ensembl Gene ENSMUSG00000027965
Gene Name olfactomedin 3
Synonyms B230206G02Rik, optimedin
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R2334 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 114697727-114919371 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 114895608 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 163 (Y163*)
Ref Sequence ENSEMBL: ENSMUSP00000121097 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051309] [ENSMUST00000081752] [ENSMUST00000149158]
AlphaFold P63056
Predicted Effect probably null
Transcript: ENSMUST00000051309
AA Change: Y196*
SMART Domains Protein: ENSMUSP00000060985
Gene: ENSMUSG00000027965
AA Change: Y196*

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Noelin-1 46 145 3.9e-52 PFAM
Blast:OLF 162 207 3e-8 BLAST
OLF 220 470 4.33e-114 SMART
Predicted Effect probably null
Transcript: ENSMUST00000081752
AA Change: Y176*
SMART Domains Protein: ENSMUSP00000080448
Gene: ENSMUSG00000027965
AA Change: Y176*

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:Noelin-1 25 125 7.6e-54 PFAM
Blast:OLF 142 187 3e-8 BLAST
OLF 200 450 4.33e-114 SMART
Predicted Effect probably null
Transcript: ENSMUST00000149158
AA Change: Y163*
SMART Domains Protein: ENSMUSP00000121097
Gene: ENSMUSG00000027965
AA Change: Y163*

DomainStartEndE-ValueType
Pfam:Noelin-1 12 112 2.5e-51 PFAM
Blast:OLF 129 174 1e-8 BLAST
Blast:OLF 187 210 1e-7 BLAST
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm1 A G 4: 144,255,429 (GRCm39) K283R probably damaging Het
Ceacam20 T C 7: 19,705,516 (GRCm39) F169S probably damaging Het
Clint1 A G 11: 45,799,855 (GRCm39) Q556R probably damaging Het
Cpa5 G A 6: 30,624,605 (GRCm39) W148* probably null Het
Cryz C T 3: 154,327,828 (GRCm39) A310V probably benign Het
Dlk1 T C 12: 109,419,614 (GRCm39) V10A probably damaging Het
Fbxw16 T G 9: 109,267,429 (GRCm39) L267F probably benign Het
Frmpd1 T C 4: 45,285,408 (GRCm39) S1410P probably damaging Het
Itgb4 A T 11: 115,884,261 (GRCm39) I982F probably damaging Het
Lrrfip2 G A 9: 111,048,793 (GRCm39) C250Y probably benign Het
Mia3 A G 1: 183,115,256 (GRCm39) probably null Het
Mlh3 T A 12: 85,314,851 (GRCm39) D445V probably benign Het
Ndst4 T A 3: 125,501,825 (GRCm39) N129K possibly damaging Het
Nlrp2 T A 7: 5,340,534 (GRCm39) E93D probably benign Het
Or2ak5 A T 11: 58,611,288 (GRCm39) Y195* probably null Het
Or5p59 C T 7: 107,702,555 (GRCm39) T13I probably benign Het
Pdzph1 A G 17: 59,229,644 (GRCm39) S1005P probably damaging Het
Slc46a2 G A 4: 59,914,150 (GRCm39) P258S possibly damaging Het
Trappc9 G A 15: 72,897,816 (GRCm39) R377W probably damaging Het
Ttn T C 2: 76,556,138 (GRCm39) E21962G possibly damaging Het
Unc13a T C 8: 72,087,202 (GRCm39) D1515G probably damaging Het
Vmn2r70 T C 7: 85,208,800 (GRCm39) N559S probably benign Het
Wwp1 A T 4: 19,662,032 (GRCm39) I158K probably benign Het
Other mutations in Olfm3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01656:Olfm3 APN 3 114,916,282 (GRCm39) missense probably damaging 1.00
IGL01686:Olfm3 APN 3 114,916,497 (GRCm39) missense probably benign 0.00
IGL01732:Olfm3 APN 3 114,890,649 (GRCm39) missense possibly damaging 0.82
IGL02539:Olfm3 APN 3 114,895,579 (GRCm39) missense possibly damaging 0.93
IGL02580:Olfm3 APN 3 114,916,157 (GRCm39) missense probably damaging 1.00
IGL02999:Olfm3 APN 3 114,916,397 (GRCm39) missense probably damaging 1.00
IGL03142:Olfm3 APN 3 114,890,679 (GRCm39) missense probably damaging 0.97
IGL03239:Olfm3 APN 3 114,916,243 (GRCm39) missense probably damaging 0.99
R0361:Olfm3 UTSW 3 114,914,622 (GRCm39) missense probably damaging 1.00
R0373:Olfm3 UTSW 3 114,916,454 (GRCm39) missense probably damaging 0.99
R0505:Olfm3 UTSW 3 114,916,330 (GRCm39) missense possibly damaging 0.46
R0689:Olfm3 UTSW 3 114,916,194 (GRCm39) missense probably benign 0.28
R0973:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R0973:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R0974:Olfm3 UTSW 3 114,895,635 (GRCm39) missense probably benign 0.00
R1253:Olfm3 UTSW 3 114,916,418 (GRCm39) missense probably damaging 0.98
R1293:Olfm3 UTSW 3 114,895,579 (GRCm39) missense possibly damaging 0.93
R1952:Olfm3 UTSW 3 114,895,589 (GRCm39) missense probably null 1.00
R2255:Olfm3 UTSW 3 114,915,842 (GRCm39) splice site probably null
R2510:Olfm3 UTSW 3 114,915,959 (GRCm39) missense probably damaging 1.00
R4222:Olfm3 UTSW 3 114,883,820 (GRCm39) nonsense probably null
R4716:Olfm3 UTSW 3 114,874,755 (GRCm39) missense probably benign 0.00
R4912:Olfm3 UTSW 3 114,895,589 (GRCm39) missense probably damaging 1.00
R5084:Olfm3 UTSW 3 114,698,202 (GRCm39) critical splice donor site probably null
R5649:Olfm3 UTSW 3 114,890,573 (GRCm39) missense probably damaging 0.99
R5681:Olfm3 UTSW 3 114,915,924 (GRCm39) missense probably benign 0.28
R5861:Olfm3 UTSW 3 114,916,052 (GRCm39) missense probably damaging 1.00
R5924:Olfm3 UTSW 3 114,916,187 (GRCm39) missense probably benign 0.44
R5929:Olfm3 UTSW 3 114,895,529 (GRCm39) missense probably damaging 0.97
R5958:Olfm3 UTSW 3 114,915,955 (GRCm39) missense probably damaging 0.99
R6166:Olfm3 UTSW 3 114,916,074 (GRCm39) missense probably damaging 1.00
R6299:Olfm3 UTSW 3 114,914,632 (GRCm39) missense probably damaging 1.00
R6804:Olfm3 UTSW 3 114,916,328 (GRCm39) missense probably benign 0.10
R7032:Olfm3 UTSW 3 114,883,805 (GRCm39) missense probably damaging 1.00
R7565:Olfm3 UTSW 3 114,916,393 (GRCm39) missense probably damaging 0.98
R7600:Olfm3 UTSW 3 114,890,589 (GRCm39) missense possibly damaging 0.65
R7976:Olfm3 UTSW 3 114,874,794 (GRCm39) missense probably benign 0.00
R8070:Olfm3 UTSW 3 114,895,604 (GRCm39) missense probably damaging 0.96
R8334:Olfm3 UTSW 3 114,916,206 (GRCm39) missense probably damaging 0.96
R8527:Olfm3 UTSW 3 114,916,196 (GRCm39) missense probably benign 0.10
R8542:Olfm3 UTSW 3 114,916,196 (GRCm39) missense probably benign 0.10
R8835:Olfm3 UTSW 3 114,916,061 (GRCm39) missense probably damaging 1.00
R9063:Olfm3 UTSW 3 114,914,582 (GRCm39) missense probably benign 0.36
R9594:Olfm3 UTSW 3 114,883,785 (GRCm39) missense probably damaging 1.00
R9690:Olfm3 UTSW 3 114,890,594 (GRCm39) nonsense probably null
R9690:Olfm3 UTSW 3 114,890,593 (GRCm39) missense probably benign 0.39
R9719:Olfm3 UTSW 3 114,916,091 (GRCm39) nonsense probably null
Z1088:Olfm3 UTSW 3 114,698,317 (GRCm39) start gained probably benign
Z1177:Olfm3 UTSW 3 114,874,750 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACACTCTATTGCTTTCTCCAGGAG -3'
(R):5'- TTCTCAGCCATGCTCACGTG -3'

Sequencing Primer
(F):5'- GCTTTCTCCAGGAGTTGAAAGAG -3'
(R):5'- GAGACACTTGGCCCTGTAATTCAG -3'
Posted On 2014-10-30