Incidental Mutation 'R2334:Vmn2r70'
ID 246524
Institutional Source Beutler Lab
Gene Symbol Vmn2r70
Ensembl Gene ENSMUSG00000090806
Gene Name vomeronasal 2, receptor 70
Synonyms EG620835
Accession Numbers
Essential gene? Probably non essential (E-score: 0.130) question?
Stock # R2334 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 85207911-85218296 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85208800 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 559 (N559S)
Ref Sequence ENSEMBL: ENSMUSP00000129703 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168230]
AlphaFold K7N702
Predicted Effect probably benign
Transcript: ENSMUST00000168230
AA Change: N559S

PolyPhen 2 Score 0.048 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000129703
Gene: ENSMUSG00000090806
AA Change: N559S

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:ANF_receptor 77 468 2.5e-28 PFAM
Pfam:NCD3G 510 562 1.5e-19 PFAM
Pfam:7tm_3 592 830 1.2e-52 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl4fm1 A G 4: 144,255,429 (GRCm39) K283R probably damaging Het
Ceacam20 T C 7: 19,705,516 (GRCm39) F169S probably damaging Het
Clint1 A G 11: 45,799,855 (GRCm39) Q556R probably damaging Het
Cpa5 G A 6: 30,624,605 (GRCm39) W148* probably null Het
Cryz C T 3: 154,327,828 (GRCm39) A310V probably benign Het
Dlk1 T C 12: 109,419,614 (GRCm39) V10A probably damaging Het
Fbxw16 T G 9: 109,267,429 (GRCm39) L267F probably benign Het
Frmpd1 T C 4: 45,285,408 (GRCm39) S1410P probably damaging Het
Itgb4 A T 11: 115,884,261 (GRCm39) I982F probably damaging Het
Lrrfip2 G A 9: 111,048,793 (GRCm39) C250Y probably benign Het
Mia3 A G 1: 183,115,256 (GRCm39) probably null Het
Mlh3 T A 12: 85,314,851 (GRCm39) D445V probably benign Het
Ndst4 T A 3: 125,501,825 (GRCm39) N129K possibly damaging Het
Nlrp2 T A 7: 5,340,534 (GRCm39) E93D probably benign Het
Olfm3 T A 3: 114,895,608 (GRCm39) Y163* probably null Het
Or2ak5 A T 11: 58,611,288 (GRCm39) Y195* probably null Het
Or5p59 C T 7: 107,702,555 (GRCm39) T13I probably benign Het
Pdzph1 A G 17: 59,229,644 (GRCm39) S1005P probably damaging Het
Slc46a2 G A 4: 59,914,150 (GRCm39) P258S possibly damaging Het
Trappc9 G A 15: 72,897,816 (GRCm39) R377W probably damaging Het
Ttn T C 2: 76,556,138 (GRCm39) E21962G possibly damaging Het
Unc13a T C 8: 72,087,202 (GRCm39) D1515G probably damaging Het
Wwp1 A T 4: 19,662,032 (GRCm39) I158K probably benign Het
Other mutations in Vmn2r70
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00978:Vmn2r70 APN 7 85,213,007 (GRCm39) missense probably benign 0.00
IGL01140:Vmn2r70 APN 7 85,214,379 (GRCm39) nonsense probably null
IGL01287:Vmn2r70 APN 7 85,218,227 (GRCm39) nonsense probably null
IGL01581:Vmn2r70 APN 7 85,213,122 (GRCm39) splice site probably null
IGL01632:Vmn2r70 APN 7 85,215,280 (GRCm39) missense probably benign 0.00
IGL01725:Vmn2r70 APN 7 85,208,594 (GRCm39) missense probably damaging 1.00
IGL02244:Vmn2r70 APN 7 85,214,211 (GRCm39) missense probably benign
IGL02288:Vmn2r70 APN 7 85,214,342 (GRCm39) missense probably benign 0.31
IGL02313:Vmn2r70 APN 7 85,214,376 (GRCm39) missense probably damaging 0.99
IGL02591:Vmn2r70 APN 7 85,214,153 (GRCm39) missense probably damaging 0.96
IGL02725:Vmn2r70 APN 7 85,214,553 (GRCm39) missense possibly damaging 0.46
IGL02797:Vmn2r70 APN 7 85,208,295 (GRCm39) missense probably benign 0.00
R0045:Vmn2r70 UTSW 7 85,215,252 (GRCm39) missense probably damaging 1.00
R0729:Vmn2r70 UTSW 7 85,215,112 (GRCm39) missense probably benign 0.00
R0967:Vmn2r70 UTSW 7 85,208,827 (GRCm39) missense probably damaging 0.99
R1217:Vmn2r70 UTSW 7 85,208,269 (GRCm39) missense probably damaging 1.00
R1351:Vmn2r70 UTSW 7 85,214,262 (GRCm39) missense probably damaging 1.00
R1387:Vmn2r70 UTSW 7 85,207,969 (GRCm39) missense probably benign 0.12
R1483:Vmn2r70 UTSW 7 85,208,375 (GRCm39) missense probably benign 0.04
R1796:Vmn2r70 UTSW 7 85,213,011 (GRCm39) nonsense probably null
R1809:Vmn2r70 UTSW 7 85,215,130 (GRCm39) missense probably benign 0.23
R2154:Vmn2r70 UTSW 7 85,212,923 (GRCm39) missense possibly damaging 0.67
R2173:Vmn2r70 UTSW 7 85,214,290 (GRCm39) missense probably benign
R2871:Vmn2r70 UTSW 7 85,208,227 (GRCm39) missense probably damaging 1.00
R2871:Vmn2r70 UTSW 7 85,208,227 (GRCm39) missense probably damaging 1.00
R3975:Vmn2r70 UTSW 7 85,208,540 (GRCm39) missense probably benign 0.00
R4525:Vmn2r70 UTSW 7 85,208,787 (GRCm39) missense probably damaging 1.00
R4527:Vmn2r70 UTSW 7 85,208,787 (GRCm39) missense probably damaging 1.00
R4535:Vmn2r70 UTSW 7 85,214,541 (GRCm39) missense probably damaging 1.00
R5181:Vmn2r70 UTSW 7 85,208,387 (GRCm39) missense probably damaging 0.99
R5600:Vmn2r70 UTSW 7 85,212,935 (GRCm39) missense probably benign 0.07
R5641:Vmn2r70 UTSW 7 85,208,572 (GRCm39) missense probably damaging 0.99
R5726:Vmn2r70 UTSW 7 85,208,315 (GRCm39) missense probably damaging 1.00
R5943:Vmn2r70 UTSW 7 85,215,199 (GRCm39) missense probably benign 0.09
R6166:Vmn2r70 UTSW 7 85,215,189 (GRCm39) missense probably benign 0.25
R6272:Vmn2r70 UTSW 7 85,208,194 (GRCm39) missense probably damaging 1.00
R6324:Vmn2r70 UTSW 7 85,208,087 (GRCm39) missense probably benign 0.01
R6429:Vmn2r70 UTSW 7 85,208,276 (GRCm39) missense probably damaging 1.00
R6449:Vmn2r70 UTSW 7 85,214,157 (GRCm39) missense probably damaging 1.00
R6512:Vmn2r70 UTSW 7 85,215,305 (GRCm39) missense probably benign
R7000:Vmn2r70 UTSW 7 85,208,819 (GRCm39) missense probably damaging 0.99
R7141:Vmn2r70 UTSW 7 85,208,044 (GRCm39) missense probably benign
R7153:Vmn2r70 UTSW 7 85,214,262 (GRCm39) missense probably damaging 1.00
R7424:Vmn2r70 UTSW 7 85,213,076 (GRCm39) missense probably damaging 1.00
R7565:Vmn2r70 UTSW 7 85,214,499 (GRCm39) missense probably benign 0.35
R7567:Vmn2r70 UTSW 7 85,214,243 (GRCm39) missense probably benign 0.41
R7593:Vmn2r70 UTSW 7 85,215,312 (GRCm39) nonsense probably null
R7660:Vmn2r70 UTSW 7 85,218,130 (GRCm39) missense probably damaging 0.99
R7806:Vmn2r70 UTSW 7 85,208,401 (GRCm39) missense probably benign
R7892:Vmn2r70 UTSW 7 85,208,588 (GRCm39) missense possibly damaging 0.58
R7965:Vmn2r70 UTSW 7 85,211,071 (GRCm39) missense probably damaging 0.96
R8052:Vmn2r70 UTSW 7 85,212,923 (GRCm39) missense probably benign
R8251:Vmn2r70 UTSW 7 85,215,186 (GRCm39) nonsense probably null
R8814:Vmn2r70 UTSW 7 85,215,169 (GRCm39) missense probably benign 0.00
R8934:Vmn2r70 UTSW 7 85,211,188 (GRCm39) missense possibly damaging 0.87
R9225:Vmn2r70 UTSW 7 85,208,242 (GRCm39) missense probably damaging 1.00
R9322:Vmn2r70 UTSW 7 85,208,498 (GRCm39) missense possibly damaging 0.92
R9430:Vmn2r70 UTSW 7 85,215,240 (GRCm39) missense probably benign 0.10
R9477:Vmn2r70 UTSW 7 85,218,244 (GRCm39) missense possibly damaging 0.50
Z1088:Vmn2r70 UTSW 7 85,213,968 (GRCm39) missense possibly damaging 0.53
Z1176:Vmn2r70 UTSW 7 85,218,253 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ACAAAGCTGAGAGATTGGTTGTTG -3'
(R):5'- TAACATGTATGGACACAGCCC -3'

Sequencing Primer
(F):5'- GGCTTTGACTATGGGAGTATCTC -3'
(R):5'- GTATGGACACAGCCCATTTTAG -3'
Posted On 2014-10-30