Mutagenetix > Incidental Mutation

Incidental Mutation 'R2338:Scgb1b2'

246628

Institutional Source

Beutler Lab

Gene Symbol

Scgb1b2

Ensembl Gene

ENSMUSG00000062556

Gene Name

secretoglobin, family 1B, member 2

Synonyms

lacrimal gland protein, Abpa2, Abph, Scgb1b1, Apbh, Mja1l, LGP

MMRRC Submission

040324-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.054) question?

Stock #

R2338 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

30989944-30991241 bp(-) (GRCm39)

Type of Mutation

nonsense

DNA Base Change (assembly)

A to T at 30991038 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Stop codon at position 23 (C23*)

Ref Sequence

ENSEMBL: ENSMUSP00000079468 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080635] [ENSMUST00000205821]

AlphaFold

O35176

Predicted Effect

probably null
Transcript: ENSMUST00000080635
AA Change: C23*

SMART Domains

Protein: ENSMUSP00000079468
Gene: ENSMUSG00000062556
AA Change: C23*

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
UTG	24	93	3.02e-19	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000205821

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 94.5%

Validation Efficiency

98% (53/54)

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930474N05Rik	A	G	14: 35,817,109 (GRCm39)	D53G	probably benign	Het
A1cf	C	T	19: 31,909,945 (GRCm39)	P330S	probably benign	Het
Acta2	A	G	19: 34,225,941 (GRCm39)		probably benign	Het
Actrt3	A	G	3: 30,651,985 (GRCm39)	*370R	probably null	Het
Aif1	G	A	17: 35,391,127 (GRCm39)	P44L	probably benign	Het
Btbd8	T	C	5: 107,658,440 (GRCm39)	L1158S	probably damaging	Het
Cadps2	C	G	6: 23,838,977 (GRCm39)		probably benign	Het
Camsap3	C	T	8: 3,656,808 (GRCm39)	R1048C	probably damaging	Het
Cdkl2	C	T	5: 92,181,538 (GRCm39)	A148T	possibly damaging	Het
Dab2	T	A	15: 6,464,733 (GRCm39)	I395K	possibly damaging	Het
Dclk2	A	G	3: 86,706,324 (GRCm39)	F589S	probably damaging	Het
Ddx60	T	C	8: 62,465,470 (GRCm39)	S1376P	possibly damaging	Het
Eprs1	T	C	1: 185,148,005 (GRCm39)	F1256L	probably damaging	Het
Etaa1	A	T	11: 17,895,605 (GRCm39)		probably null	Het
Fat2	T	C	11: 55,202,727 (GRCm39)	T116A	possibly damaging	Het
Fem1al	C	A	11: 29,773,718 (GRCm39)	A580S	probably benign	Het
Fmnl3	T	C	15: 99,268,108 (GRCm39)	T26A	probably benign	Het
Foxp1	A	G	6: 98,980,254 (GRCm39)	V158A	possibly damaging	Het
G6pd2	T	A	5: 61,967,351 (GRCm39)	D375E	probably benign	Het
Gne	C	T	4: 44,042,196 (GRCm39)	A460T	probably damaging	Het
Gprin1	T	A	13: 54,886,238 (GRCm39)		probably null	Het
Hecw2	T	C	1: 53,943,581 (GRCm39)	M949V	possibly damaging	Het
Herc1	G	A	9: 66,336,251 (GRCm39)	V1599M	possibly damaging	Het
Hk2	A	C	6: 82,708,096 (GRCm39)	N628K	probably damaging	Het
Hmcn1	T	C	1: 150,498,685 (GRCm39)	T4065A	possibly damaging	Het
Ipo8	T	A	6: 148,691,321 (GRCm39)	Q683L	probably benign	Het
Krt81	A	G	15: 101,361,217 (GRCm39)	I121T	probably benign	Het
Lamb2	T	C	9: 108,359,340 (GRCm39)	L322P	probably benign	Het
Lilrb4a	A	G	10: 51,367,796 (GRCm39)	M113V	probably benign	Het
Mnat1	G	A	12: 73,265,917 (GRCm39)		probably null	Het
Mucl1	T	A	15: 103,783,964 (GRCm39)	T68S	possibly damaging	Het
Npnt	G	T	3: 132,597,170 (GRCm39)	D461E	probably damaging	Het
Nrp1	A	T	8: 129,224,385 (GRCm39)	Q716L	probably benign	Het
Or11g25	A	G	14: 50,723,097 (GRCm39)	T61A	possibly damaging	Het
Or12k5	T	G	2: 36,895,159 (GRCm39)	S156R	probably damaging	Het
Or51b6b	A	T	7: 103,309,617 (GRCm39)	I280N	possibly damaging	Het
Podxl2	T	C	6: 88,826,178 (GRCm39)	Q376R	probably damaging	Het
Pudp	T	C	18: 50,701,646 (GRCm39)	D29G	probably benign	Het
Rrs1	C	A	1: 9,616,026 (GRCm39)		probably null	Het
S1pr3	T	C	13: 51,573,614 (GRCm39)	I265T	possibly damaging	Het
Spag8	G	T	4: 43,652,826 (GRCm39)	R212S	probably benign	Het
Tacc2	A	G	7: 130,335,299 (GRCm39)		probably null	Het
Trmt1l	C	T	1: 151,304,710 (GRCm39)		probably benign	Het
Trpa1	A	T	1: 14,954,469 (GRCm39)	L810Q	probably damaging	Het
Ugcg	C	T	4: 59,207,798 (GRCm39)	P46S	probably benign	Het
Ugt3a1	T	A	15: 9,292,059 (GRCm39)		probably benign	Het
Vmn2r23	T	G	6: 123,681,384 (GRCm39)	I97M	possibly damaging	Het
Vmn2r65	A	T	7: 84,590,051 (GRCm39)	F622I	possibly damaging	Het
Vps13a	C	T	19: 16,697,817 (GRCm39)	G766E	probably damaging	Het
Wnk1	T	C	6: 119,946,495 (GRCm39)	T553A	probably benign	Het
Xirp2	T	A	2: 67,341,114 (GRCm39)	D1118E	probably damaging	Het
Zfyve9	A	C	4: 108,517,811 (GRCm39)	D461E	probably damaging	Het

Other mutations in Scgb1b2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01804:Scgb1b2	APN	7	30,991,155 (GRCm39)	intron	probably benign
R0239:Scgb1b2	UTSW	7	30,991,155 (GRCm39)	intron	probably benign
R1564:Scgb1b2	UTSW	7	30,991,200 (GRCm39)	intron	probably benign
R2143:Scgb1b2	UTSW	7	30,991,188 (GRCm39)	intron	probably benign
R2144:Scgb1b2	UTSW	7	30,991,188 (GRCm39)	intron	probably benign
R2145:Scgb1b2	UTSW	7	30,991,188 (GRCm39)	intron	probably benign
R2268:Scgb1b2	UTSW	7	30,991,201 (GRCm39)	intron	probably benign
R4386:Scgb1b2	UTSW	7	30,990,089 (GRCm39)	missense	possibly damaging	0.90
R4801:Scgb1b2	UTSW	7	30,990,998 (GRCm39)	missense	possibly damaging	0.78
R4802:Scgb1b2	UTSW	7	30,990,998 (GRCm39)	missense	possibly damaging	0.78
R8188:Scgb1b2	UTSW	7	30,990,946 (GRCm39)	missense	possibly damaging	0.95

Predicted Primers

PCR Primer
(F):5'- ATAAAAGCAGCCGCATGTTC -3'
(R):5'- ACCAAGCTGGGTAGGAGTAC -3'

Sequencing Primer
(F):5'- AGCCGCATGTTCCTTGTTTTC -3'
(R):5'- TACCATGAAGCTCACTGGTG -3'

Posted On

2014-10-30