Incidental Mutation 'R2338:Or11g25'
ID 246646
Institutional Source Beutler Lab
Gene Symbol Or11g25
Ensembl Gene ENSMUSG00000095765
Gene Name olfactory receptor family 11 subfamily G member 25
Synonyms MOR106-15, MOR106-10, Olfr741, GA_x6K02T2PMLR-6197851-6198786
MMRRC Submission 040324-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R2338 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 50710514-50723852 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 50723097 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 61 (T61A)
Ref Sequence ENSEMBL: ENSMUSP00000151020 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071932] [ENSMUST00000205518] [ENSMUST00000213903]
AlphaFold L7N1Y5
Predicted Effect possibly damaging
Transcript: ENSMUST00000071932
AA Change: T61A

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000071824
Gene: ENSMUSG00000095765
AA Change: T61A

DomainStartEndE-ValueType
Pfam:7tm_4 35 311 1.2e-55 PFAM
Pfam:7tm_1 45 294 2.4e-20 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000205518
AA Change: T61A

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000213903
AA Change: T61A

PolyPhen 2 Score 0.466 (Sensitivity: 0.89; Specificity: 0.90)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.5%
Validation Efficiency 98% (53/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930474N05Rik A G 14: 35,817,109 (GRCm39) D53G probably benign Het
A1cf C T 19: 31,909,945 (GRCm39) P330S probably benign Het
Acta2 A G 19: 34,225,941 (GRCm39) probably benign Het
Actrt3 A G 3: 30,651,985 (GRCm39) *370R probably null Het
Aif1 G A 17: 35,391,127 (GRCm39) P44L probably benign Het
Btbd8 T C 5: 107,658,440 (GRCm39) L1158S probably damaging Het
Cadps2 C G 6: 23,838,977 (GRCm39) probably benign Het
Camsap3 C T 8: 3,656,808 (GRCm39) R1048C probably damaging Het
Cdkl2 C T 5: 92,181,538 (GRCm39) A148T possibly damaging Het
Dab2 T A 15: 6,464,733 (GRCm39) I395K possibly damaging Het
Dclk2 A G 3: 86,706,324 (GRCm39) F589S probably damaging Het
Ddx60 T C 8: 62,465,470 (GRCm39) S1376P possibly damaging Het
Eprs1 T C 1: 185,148,005 (GRCm39) F1256L probably damaging Het
Etaa1 A T 11: 17,895,605 (GRCm39) probably null Het
Fat2 T C 11: 55,202,727 (GRCm39) T116A possibly damaging Het
Fem1al C A 11: 29,773,718 (GRCm39) A580S probably benign Het
Fmnl3 T C 15: 99,268,108 (GRCm39) T26A probably benign Het
Foxp1 A G 6: 98,980,254 (GRCm39) V158A possibly damaging Het
G6pd2 T A 5: 61,967,351 (GRCm39) D375E probably benign Het
Gne C T 4: 44,042,196 (GRCm39) A460T probably damaging Het
Gprin1 T A 13: 54,886,238 (GRCm39) probably null Het
Hecw2 T C 1: 53,943,581 (GRCm39) M949V possibly damaging Het
Herc1 G A 9: 66,336,251 (GRCm39) V1599M possibly damaging Het
Hk2 A C 6: 82,708,096 (GRCm39) N628K probably damaging Het
Hmcn1 T C 1: 150,498,685 (GRCm39) T4065A possibly damaging Het
Ipo8 T A 6: 148,691,321 (GRCm39) Q683L probably benign Het
Krt81 A G 15: 101,361,217 (GRCm39) I121T probably benign Het
Lamb2 T C 9: 108,359,340 (GRCm39) L322P probably benign Het
Lilrb4a A G 10: 51,367,796 (GRCm39) M113V probably benign Het
Mnat1 G A 12: 73,265,917 (GRCm39) probably null Het
Mucl1 T A 15: 103,783,964 (GRCm39) T68S possibly damaging Het
Npnt G T 3: 132,597,170 (GRCm39) D461E probably damaging Het
Nrp1 A T 8: 129,224,385 (GRCm39) Q716L probably benign Het
Or12k5 T G 2: 36,895,159 (GRCm39) S156R probably damaging Het
Or51b6b A T 7: 103,309,617 (GRCm39) I280N possibly damaging Het
Podxl2 T C 6: 88,826,178 (GRCm39) Q376R probably damaging Het
Pudp T C 18: 50,701,646 (GRCm39) D29G probably benign Het
Rrs1 C A 1: 9,616,026 (GRCm39) probably null Het
S1pr3 T C 13: 51,573,614 (GRCm39) I265T possibly damaging Het
Scgb1b2 A T 7: 30,991,038 (GRCm39) C23* probably null Het
Spag8 G T 4: 43,652,826 (GRCm39) R212S probably benign Het
Tacc2 A G 7: 130,335,299 (GRCm39) probably null Het
Trmt1l C T 1: 151,304,710 (GRCm39) probably benign Het
Trpa1 A T 1: 14,954,469 (GRCm39) L810Q probably damaging Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Ugt3a1 T A 15: 9,292,059 (GRCm39) probably benign Het
Vmn2r23 T G 6: 123,681,384 (GRCm39) I97M possibly damaging Het
Vmn2r65 A T 7: 84,590,051 (GRCm39) F622I possibly damaging Het
Vps13a C T 19: 16,697,817 (GRCm39) G766E probably damaging Het
Wnk1 T C 6: 119,946,495 (GRCm39) T553A probably benign Het
Xirp2 T A 2: 67,341,114 (GRCm39) D1118E probably damaging Het
Zfyve9 A C 4: 108,517,811 (GRCm39) D461E probably damaging Het
Other mutations in Or11g25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01773:Or11g25 APN 14 50,723,230 (GRCm39) missense probably damaging 0.98
IGL01796:Or11g25 APN 14 50,722,998 (GRCm39) missense probably benign 0.28
IGL01916:Or11g25 APN 14 50,722,950 (GRCm39) missense probably benign 0.01
IGL02686:Or11g25 APN 14 50,723,426 (GRCm39) missense probably benign 0.01
IGL02874:Or11g25 APN 14 50,723,686 (GRCm39) missense possibly damaging 0.57
IGL02898:Or11g25 APN 14 50,723,643 (GRCm39) missense probably damaging 1.00
PIT4515001:Or11g25 UTSW 14 50,723,536 (GRCm39) missense probably benign 0.03
R0085:Or11g25 UTSW 14 50,723,791 (GRCm39) missense probably benign 0.16
R1777:Or11g25 UTSW 14 50,723,757 (GRCm39) missense probably benign 0.08
R1850:Or11g25 UTSW 14 50,723,055 (GRCm39) missense probably benign
R2270:Or11g25 UTSW 14 50,723,494 (GRCm39) missense probably damaging 1.00
R2971:Or11g25 UTSW 14 50,723,065 (GRCm39) missense probably damaging 0.99
R4594:Or11g25 UTSW 14 50,723,619 (GRCm39) missense probably benign 0.00
R5383:Or11g25 UTSW 14 50,723,509 (GRCm39) nonsense probably null
R5708:Or11g25 UTSW 14 50,723,452 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R6038:Or11g25 UTSW 14 50,723,677 (GRCm39) missense probably damaging 1.00
R7116:Or11g25 UTSW 14 50,723,025 (GRCm39) missense probably benign 0.00
R7702:Or11g25 UTSW 14 50,723,751 (GRCm39) missense possibly damaging 0.79
R8169:Or11g25 UTSW 14 50,723,692 (GRCm39) missense probably benign 0.13
R9040:Or11g25 UTSW 14 50,722,995 (GRCm39) missense probably benign 0.00
R9139:Or11g25 UTSW 14 50,723,707 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGATGCTTTCACAGGTCACAGAC -3'
(R):5'- ATCAAATGCCATGACTGCCAG -3'

Sequencing Primer
(F):5'- GCTTTCACAGGTCACAGACAGATG -3'
(R):5'- CTGCCAGGAAAAAGCATTCTG -3'
Posted On 2014-10-30