Incidental Mutation 'R2340:Lypd2'
ID 246726
Institutional Source Beutler Lab
Gene Symbol Lypd2
Ensembl Gene ENSMUSG00000022595
Gene Name Ly6/Plaur domain containing 2
Synonyms 0610005K03Rik
MMRRC Submission 040326-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.118) question?
Stock # R2340 (G1)
Quality Score 225
Status Validated
Chromosome 15
Chromosomal Location 74604096-74606178 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 74606103 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 12 (I12L)
Ref Sequence ENSEMBL: ENSMUSP00000023260 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023260]
AlphaFold Q9DD23
Predicted Effect probably benign
Transcript: ENSMUST00000023260
AA Change: I12L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000023260
Gene: ENSMUSG00000022595
AA Change: I12L

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
LU 23 114 1.5e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188716
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 97% (37/38)
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik G T 12: 71,211,320 (GRCm39) E685* probably null Het
2700049A03Rik A T 12: 71,211,321 (GRCm39) E685V possibly damaging Het
Abca13 A T 11: 9,349,165 (GRCm39) I3580F probably damaging Het
B3glct A G 5: 149,668,905 (GRCm39) K280E probably benign Het
Chd6 TG T 2: 160,807,679 (GRCm39) probably null Het
Clu T C 14: 66,218,358 (GRCm39) V406A probably damaging Het
D930020B18Rik A G 10: 121,490,741 (GRCm39) K114E probably damaging Het
Dsg1c T A 18: 20,400,945 (GRCm39) D149E probably damaging Het
Entrep2 A G 7: 64,425,565 (GRCm39) S176P probably benign Het
Fat2 A T 11: 55,160,922 (GRCm39) D3269E possibly damaging Het
Frmd4a A G 2: 4,591,187 (GRCm39) D69G probably damaging Het
Hacd1 G T 2: 14,040,698 (GRCm39) P186T probably damaging Het
Hlx G T 1: 184,464,184 (GRCm39) A52D probably damaging Het
Kif2c A G 4: 117,027,038 (GRCm39) V320A probably damaging Het
Midn G T 10: 79,985,946 (GRCm39) R12L possibly damaging Het
Or2b6 T C 13: 21,822,757 (GRCm39) K312R probably benign Het
Or8g34 A G 9: 39,373,105 (GRCm39) Y126C probably damaging Het
Or9q2 A G 19: 13,772,135 (GRCm39) V280A probably benign Het
Pkhd1 A T 1: 20,271,079 (GRCm39) V3158E probably damaging Het
Plxna2 C T 1: 194,431,625 (GRCm39) S538F probably damaging Het
Rad51d T C 11: 82,772,647 (GRCm39) D206G probably damaging Het
Rcan1 A G 16: 92,194,240 (GRCm39) F58L probably damaging Het
Rnf145 T C 11: 44,422,205 (GRCm39) I96T probably benign Het
Rnf216 A T 5: 143,066,089 (GRCm39) F500I probably damaging Het
Rph3al T C 11: 75,724,258 (GRCm39) T282A probably benign Het
Serpina11 T C 12: 103,951,002 (GRCm39) R240G probably benign Het
Slc12a2 T A 18: 58,033,122 (GRCm39) I400N probably benign Het
Slco1a4 C A 6: 141,787,103 (GRCm39) C28F probably benign Het
Sned1 T A 1: 93,184,174 (GRCm39) I134N probably damaging Het
Spock3 T A 8: 63,798,747 (GRCm39) M253K probably damaging Het
Tmem184b T A 15: 79,262,732 (GRCm39) M42L probably benign Het
Tnnt1 G A 7: 4,516,615 (GRCm39) probably benign Het
Ttll5 T A 12: 85,938,922 (GRCm39) S407T probably benign Het
Ugcg C T 4: 59,207,798 (GRCm39) P46S probably benign Het
Vmn2r112 T A 17: 22,822,096 (GRCm39) V258E probably damaging Het
Zfat T C 15: 67,973,390 (GRCm39) E1117G probably damaging Het
Zfp606 A G 7: 12,227,016 (GRCm39) E321G possibly damaging Het
Other mutations in Lypd2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03010:Lypd2 APN 15 74,606,102 (GRCm39) missense probably benign 0.00
R5124:Lypd2 UTSW 15 74,604,347 (GRCm39) missense probably benign 0.21
R5368:Lypd2 UTSW 15 74,604,908 (GRCm39) missense probably benign 0.01
R5493:Lypd2 UTSW 15 74,606,127 (GRCm39) missense probably benign 0.01
R7209:Lypd2 UTSW 15 74,604,266 (GRCm39) missense probably benign 0.22
R7363:Lypd2 UTSW 15 74,604,848 (GRCm39) missense probably damaging 1.00
R8119:Lypd2 UTSW 15 74,604,881 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- ACACACCAGTATCCTGAGGCTC -3'
(R):5'- AGCTCGAACAGTCTGAGAGG -3'

Sequencing Primer
(F):5'- AGTATCCTGAGGCTCTCCGC -3'
(R):5'- CAGTCTGAGAGGGCTGGGTAG -3'
Posted On 2014-10-30