Incidental Mutation 'R2360:Or14j6'
ID 247135
Institutional Source Beutler Lab
Gene Symbol Or14j6
Ensembl Gene ENSMUSG00000058114
Gene Name olfactory receptor family 14 subfamily J member 6
Synonyms MOR218-7, Olfr127, GA_x6K02T2PSCP-2354126-2355093
MMRRC Submission 040342-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R2360 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 38214439-38215410 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 38215345 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 303 (K303E)
Ref Sequence ENSEMBL: ENSMUSP00000149133 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076331] [ENSMUST00000217223]
AlphaFold Q8VF25
Predicted Effect possibly damaging
Transcript: ENSMUST00000076331
AA Change: K303E

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000075669
Gene: ENSMUSG00000058114
AA Change: K303E

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.7e-46 PFAM
Pfam:7tm_1 41 290 1.4e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217223
AA Change: K303E

PolyPhen 2 Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 93% (37/40)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik A T 7: 29,274,214 (GRCm39) noncoding transcript Het
Abca14 A G 7: 119,850,431 (GRCm39) E761G probably benign Het
Apc C T 18: 34,394,179 (GRCm39) T35I probably damaging Het
Arhgef2 T A 3: 88,541,723 (GRCm39) I228N probably damaging Het
Atp6v1g2 A G 17: 35,456,638 (GRCm39) E74G probably damaging Het
Ccdc70 A G 8: 22,463,447 (GRCm39) E79G probably damaging Het
Cdc42ep4 A G 11: 113,619,528 (GRCm39) S288P probably damaging Het
Cip2a C T 16: 48,837,828 (GRCm39) Q843* probably null Het
Cpn2 T C 16: 30,078,321 (GRCm39) D460G probably benign Het
Crtam A G 9: 40,884,811 (GRCm39) *393Q probably null Het
Cwc22 A G 2: 77,757,591 (GRCm39) I179T probably damaging Het
Cyp3a41b T C 5: 145,507,221 (GRCm39) M240V probably benign Het
Dnah8 A T 17: 30,896,178 (GRCm39) D864V probably benign Het
Map3k7 T C 4: 31,964,302 (GRCm39) S14P unknown Het
Med25 A G 7: 44,534,566 (GRCm39) S150P probably damaging Het
Mex3b T C 7: 82,517,070 (GRCm39) V71A probably benign Het
Morc3 T C 16: 93,638,275 (GRCm39) L19S probably damaging Het
Morn1 T A 4: 155,176,770 (GRCm39) S98T probably damaging Het
Mthfd1l G T 10: 4,006,771 (GRCm39) A678S probably damaging Het
Napa A G 7: 15,848,083 (GRCm39) Y200C probably damaging Het
Nr5a2 T C 1: 136,876,565 (GRCm39) I33V probably benign Het
Pcnx1 A G 12: 81,996,960 (GRCm39) D952G probably damaging Het
Phf20l1 G A 15: 66,466,769 (GRCm39) R66Q probably damaging Het
Resf1 A G 6: 149,236,145 (GRCm39) I1488M probably benign Het
Rfk A G 19: 17,375,960 (GRCm39) T85A probably benign Het
Sbno2 T C 10: 79,893,855 (GRCm39) D1179G possibly damaging Het
Serpina3k C T 12: 104,307,166 (GRCm39) Q133* probably null Het
Setd4 T C 16: 93,383,122 (GRCm39) probably benign Het
Sh2d4b C T 14: 40,582,548 (GRCm39) probably null Het
Slc1a6 G A 10: 78,648,718 (GRCm39) V480I possibly damaging Het
Slc39a3 A T 10: 80,867,104 (GRCm39) V214E possibly damaging Het
Tll1 A G 8: 64,504,435 (GRCm39) Y654H probably damaging Het
Traf3ip1 T A 1: 91,427,374 (GRCm39) C115S unknown Het
Vmn1r209 T A 13: 22,989,836 (GRCm39) I285F probably damaging Het
Vmn2r87 G T 10: 130,315,631 (GRCm39) T145K probably damaging Het
Zan T C 5: 137,394,388 (GRCm39) T4484A unknown Het
Zfp768 T C 7: 126,943,810 (GRCm39) E106G probably benign Het
Zfp984 A G 4: 147,839,234 (GRCm39) I539T possibly damaging Het
Other mutations in Or14j6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00901:Or14j6 APN 17 38,215,148 (GRCm39) missense probably damaging 0.98
IGL00981:Or14j6 APN 17 38,215,072 (GRCm39) missense probably benign 0.03
IGL02271:Or14j6 APN 17 38,215,134 (GRCm39) missense probably benign 0.22
IGL02409:Or14j6 APN 17 38,214,679 (GRCm39) missense probably damaging 0.99
R1649:Or14j6 UTSW 17 38,215,060 (GRCm39) missense probably benign 0.09
R1808:Or14j6 UTSW 17 38,214,661 (GRCm39) missense probably damaging 1.00
R3808:Or14j6 UTSW 17 38,214,464 (GRCm39) missense probably benign 0.00
R3809:Or14j6 UTSW 17 38,214,464 (GRCm39) missense probably benign 0.00
R3953:Or14j6 UTSW 17 38,214,500 (GRCm39) missense probably benign 0.00
R3955:Or14j6 UTSW 17 38,214,500 (GRCm39) missense probably benign 0.00
R3957:Or14j6 UTSW 17 38,214,500 (GRCm39) missense probably benign 0.00
R4683:Or14j6 UTSW 17 38,215,039 (GRCm39) missense probably benign
R5430:Or14j6 UTSW 17 38,215,304 (GRCm39) missense probably damaging 1.00
R5716:Or14j6 UTSW 17 38,214,719 (GRCm39) missense probably benign 0.00
R5866:Or14j6 UTSW 17 38,214,700 (GRCm39) nonsense probably null
R7074:Or14j6 UTSW 17 38,214,718 (GRCm39) missense possibly damaging 0.80
R7238:Or14j6 UTSW 17 38,215,328 (GRCm39) missense probably benign 0.37
R8098:Or14j6 UTSW 17 38,215,250 (GRCm39) missense probably damaging 1.00
R8212:Or14j6 UTSW 17 38,215,148 (GRCm39) missense probably benign 0.00
R8559:Or14j6 UTSW 17 38,214,719 (GRCm39) missense probably benign 0.00
R8865:Or14j6 UTSW 17 38,215,115 (GRCm39) missense probably damaging 1.00
R9046:Or14j6 UTSW 17 38,215,145 (GRCm39) missense probably damaging 1.00
R9049:Or14j6 UTSW 17 38,214,764 (GRCm39) nonsense probably null
R9371:Or14j6 UTSW 17 38,214,962 (GRCm39) missense probably benign 0.10
X0021:Or14j6 UTSW 17 38,214,647 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTGAAGGCCGATCTAAGG -3'
(R):5'- ACATATCTACCAGTGAGGCAATG -3'

Sequencing Primer
(F):5'- AGGCCGATCTAAGGTCTTCTC -3'
(R):5'- GAACTCACTTTGTAGACCAGGCTG -3'
Posted On 2014-10-30