Incidental Mutation 'R2364:Zfp317'
ID 247276
Institutional Source Beutler Lab
Gene Symbol Zfp317
Ensembl Gene ENSMUSG00000057551
Gene Name zinc finger protein 317
Synonyms D230022C05Rik, KRAB9, Zfp67, Zfp75
MMRRC Submission 040345-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # R2364 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 19533398-19561027 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19559031 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 415 (D415G)
Ref Sequence ENSEMBL: ENSMUSP00000151161 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079042] [ENSMUST00000208694] [ENSMUST00000213725] [ENSMUST00000215372]
AlphaFold Q8C0Q5
Predicted Effect probably benign
Transcript: ENSMUST00000079042
AA Change: D504G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000078051
Gene: ENSMUSG00000057551
AA Change: D504G

DomainStartEndE-ValueType
KRAB 60 120 4.58e-32 SMART
ZnF_C2H2 223 245 1.79e-2 SMART
ZnF_C2H2 251 273 6.88e-4 SMART
ZnF_C2H2 279 301 2.24e-3 SMART
ZnF_C2H2 307 329 1.1e-2 SMART
ZnF_C2H2 335 357 7.37e-4 SMART
ZnF_C2H2 363 385 8.47e-4 SMART
ZnF_C2H2 391 413 1.3e-4 SMART
ZnF_C2H2 419 441 3.63e-3 SMART
ZnF_C2H2 447 469 3.34e-2 SMART
ZnF_C2H2 475 497 4.47e-3 SMART
ZnF_C2H2 503 525 9.73e-4 SMART
ZnF_C2H2 531 553 5.9e-3 SMART
ZnF_C2H2 559 581 1.72e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000208694
AA Change: D504G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000213725
AA Change: D415G

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
Predicted Effect probably benign
Transcript: ENSMUST00000215372
AA Change: D504G

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930579F01Rik A G 3: 137,871,584 (GRCm39) S268P probably benign Het
Adam6a A G 12: 113,508,250 (GRCm39) K208E probably benign Het
Anks6 A G 4: 47,027,248 (GRCm39) S725P possibly damaging Het
Asb3 A G 11: 31,051,192 (GRCm39) I549V probably benign Het
Blvrb A G 7: 27,147,558 (GRCm39) I6V possibly damaging Het
Cabs1 A T 5: 88,128,092 (GRCm39) T248S probably benign Het
Cdk5rap2 A G 4: 70,279,046 (GRCm39) probably null Het
Cep250 G A 2: 155,834,552 (GRCm39) R2159K probably damaging Het
Dnajc28 G A 16: 91,413,755 (GRCm39) T187M probably damaging Het
Fpr1 A T 17: 18,097,872 (GRCm39) L39* probably null Het
Gstm5 A G 3: 107,803,687 (GRCm39) E40G probably benign Het
Hnrnpr A G 4: 136,054,640 (GRCm39) M97V possibly damaging Het
Hs6st1 T C 1: 36,107,800 (GRCm39) V21A probably benign Het
Hsp90aa1 A T 12: 110,659,187 (GRCm39) F537I probably damaging Het
Insr T C 8: 3,224,820 (GRCm39) D216G probably benign Het
Kif2a A T 13: 107,113,344 (GRCm39) N428K probably damaging Het
Mapk10 G T 5: 103,186,507 (GRCm39) N38K possibly damaging Het
Myh8 A G 11: 67,185,344 (GRCm39) E865G probably benign Het
Or10ak7 C T 4: 118,791,230 (GRCm39) E272K probably benign Het
Or1q1 T C 2: 36,887,577 (GRCm39) Y252H probably damaging Het
Or4k6 A T 14: 50,475,612 (GRCm39) H243Q probably damaging Het
Or5b104 A G 19: 13,072,118 (GRCm39) V298A probably damaging Het
Os9 T A 10: 126,955,007 (GRCm39) K180N possibly damaging Het
Pcdhb20 A T 18: 37,638,991 (GRCm39) I506F probably damaging Het
Pros1 T G 16: 62,734,211 (GRCm39) L339R probably damaging Het
Srp72 A G 5: 77,132,209 (GRCm39) I266V probably benign Het
Tmem245 A G 4: 56,899,391 (GRCm39) V632A probably damaging Het
Tpcn1 G T 5: 120,691,559 (GRCm39) C298* probably null Het
Ubfd1 T A 7: 121,668,167 (GRCm39) D232E probably benign Het
Vamp1 A T 6: 125,217,306 (GRCm39) I117L probably benign Het
Wwtr1 T C 3: 57,370,024 (GRCm39) T364A possibly damaging Het
Zbtb47 C T 9: 121,596,660 (GRCm39) P672L probably damaging Het
Zfp143 C A 7: 109,682,449 (GRCm39) T339K probably damaging Het
Zfp628 A G 7: 4,923,686 (GRCm39) H636R probably damaging Het
Other mutations in Zfp317
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02425:Zfp317 APN 9 19,554,909 (GRCm39) nonsense probably null
R1520:Zfp317 UTSW 9 19,559,144 (GRCm39) missense possibly damaging 0.95
R1646:Zfp317 UTSW 9 19,558,608 (GRCm39) missense probably damaging 1.00
R1860:Zfp317 UTSW 9 19,553,280 (GRCm39) missense possibly damaging 0.85
R2029:Zfp317 UTSW 9 19,556,532 (GRCm39) missense probably benign 0.13
R4006:Zfp317 UTSW 9 19,559,333 (GRCm39) missense possibly damaging 0.82
R4031:Zfp317 UTSW 9 19,558,008 (GRCm39) missense possibly damaging 0.53
R4293:Zfp317 UTSW 9 19,557,990 (GRCm39) splice site probably null
R4897:Zfp317 UTSW 9 19,558,143 (GRCm39) missense probably benign 0.28
R5593:Zfp317 UTSW 9 19,558,584 (GRCm39) missense probably damaging 1.00
R6077:Zfp317 UTSW 9 19,558,184 (GRCm39) missense probably benign 0.00
R6573:Zfp317 UTSW 9 19,556,550 (GRCm39) missense probably damaging 0.99
R6652:Zfp317 UTSW 9 19,558,335 (GRCm39) missense probably damaging 1.00
R6750:Zfp317 UTSW 9 19,559,100 (GRCm39) missense probably damaging 1.00
R6875:Zfp317 UTSW 9 19,554,961 (GRCm39) missense probably damaging 0.98
R7688:Zfp317 UTSW 9 19,559,251 (GRCm39) missense probably damaging 1.00
R8054:Zfp317 UTSW 9 19,553,265 (GRCm39) missense probably benign 0.00
R8900:Zfp317 UTSW 9 19,558,708 (GRCm39) nonsense probably null
R8927:Zfp317 UTSW 9 19,552,521 (GRCm39) start codon destroyed probably null
R8928:Zfp317 UTSW 9 19,552,521 (GRCm39) start codon destroyed probably null
R9052:Zfp317 UTSW 9 19,556,568 (GRCm39) missense probably benign 0.03
R9176:Zfp317 UTSW 9 19,559,163 (GRCm39) missense probably damaging 1.00
R9210:Zfp317 UTSW 9 19,558,442 (GRCm39) nonsense probably null
R9212:Zfp317 UTSW 9 19,558,442 (GRCm39) nonsense probably null
Z1177:Zfp317 UTSW 9 19,558,326 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTGTGATCTCTGCGGCAAAG -3'
(R):5'- GTGGGTTTTCACATGACTCCTAAG -3'

Sequencing Primer
(F):5'- GGCAAAGCCTTCAGTGCTAGTTC -3'
(R):5'- GTTTTCACATGACTCCTAAGGGACG -3'
Posted On 2014-10-30