Incidental Mutation 'R1458:Cic'
| ID |
247290 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cic
|
| Ensembl Gene |
ENSMUSG00000005442 |
| Gene Name |
capicua transcriptional repressor |
| Synonyms |
1200010B10Rik |
| MMRRC Submission |
039513-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.949)
|
| Stock # |
R1458 (G1)
|
| Quality Score |
34 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
24967129-24993584 bp(+) (GRCm39) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
T to C
at 24979162 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000132351
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005578]
[ENSMUST00000163320]
[ENSMUST00000165239]
[ENSMUST00000169266]
|
| AlphaFold |
Q924A2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000005578
|
| SMART Domains |
Protein: ENSMUSP00000005578
Gene: ENSMUSG00000005442
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4J2L|D
|
21 |
48 |
6e-12 |
PDB |
|
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
|
HMG
|
199 |
269 |
1.24e-17 |
SMART |
|
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
|
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
|
low complexity region
|
1065 |
1080 |
N/A |
INTRINSIC |
|
low complexity region
|
1118 |
1132 |
N/A |
INTRINSIC |
|
low complexity region
|
1135 |
1155 |
N/A |
INTRINSIC |
|
low complexity region
|
1223 |
1253 |
N/A |
INTRINSIC |
|
low complexity region
|
1280 |
1313 |
N/A |
INTRINSIC |
|
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
|
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
|
low complexity region
|
1524 |
1547 |
N/A |
INTRINSIC |
|
low complexity region
|
1568 |
1603 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000163320
|
| SMART Domains |
Protein: ENSMUSP00000126659
Gene: ENSMUSG00000005442
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4J2L|D
|
21 |
48 |
6e-12 |
PDB |
|
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
|
HMG
|
199 |
269 |
1.24e-17 |
SMART |
|
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
|
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
|
low complexity region
|
1064 |
1079 |
N/A |
INTRINSIC |
|
low complexity region
|
1117 |
1131 |
N/A |
INTRINSIC |
|
low complexity region
|
1134 |
1154 |
N/A |
INTRINSIC |
|
low complexity region
|
1222 |
1252 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
|
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
|
low complexity region
|
1524 |
1547 |
N/A |
INTRINSIC |
|
low complexity region
|
1568 |
1603 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163819
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164440
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165239
|
| SMART Domains |
Protein: ENSMUSP00000128071
Gene: ENSMUSG00000005442
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:4J2L|D
|
21 |
48 |
5e-12 |
PDB |
|
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
|
HMG
|
199 |
269 |
1.24e-17 |
SMART |
|
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
|
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
|
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
|
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
|
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
|
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
|
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
|
low complexity region
|
1065 |
1080 |
N/A |
INTRINSIC |
|
low complexity region
|
1118 |
1132 |
N/A |
INTRINSIC |
|
low complexity region
|
1135 |
1153 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168956
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000169266
|
| SMART Domains |
Protein: ENSMUSP00000132351
Gene: ENSMUSG00000005442
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
|
low complexity region
|
151 |
165 |
N/A |
INTRINSIC |
|
Pfam:DUF4819
|
249 |
346 |
1.8e-23 |
PFAM |
|
low complexity region
|
351 |
367 |
N/A |
INTRINSIC |
|
low complexity region
|
403 |
427 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
457 |
N/A |
INTRINSIC |
|
low complexity region
|
462 |
475 |
N/A |
INTRINSIC |
|
low complexity region
|
618 |
633 |
N/A |
INTRINSIC |
|
low complexity region
|
673 |
685 |
N/A |
INTRINSIC |
|
low complexity region
|
724 |
734 |
N/A |
INTRINSIC |
|
low complexity region
|
740 |
751 |
N/A |
INTRINSIC |
|
low complexity region
|
779 |
786 |
N/A |
INTRINSIC |
|
low complexity region
|
858 |
883 |
N/A |
INTRINSIC |
|
low complexity region
|
898 |
911 |
N/A |
INTRINSIC |
|
PDB:4J2L|D
|
930 |
955 |
5e-10 |
PDB |
|
low complexity region
|
1013 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1031 |
1045 |
N/A |
INTRINSIC |
|
HMG
|
1106 |
1176 |
1.24e-17 |
SMART |
|
low complexity region
|
1322 |
1338 |
N/A |
INTRINSIC |
|
low complexity region
|
1380 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1415 |
1428 |
N/A |
INTRINSIC |
|
low complexity region
|
1432 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1490 |
N/A |
INTRINSIC |
|
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
|
low complexity region
|
1636 |
1647 |
N/A |
INTRINSIC |
|
low complexity region
|
1689 |
1710 |
N/A |
INTRINSIC |
|
low complexity region
|
1744 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1846 |
1858 |
N/A |
INTRINSIC |
|
low complexity region
|
1971 |
1986 |
N/A |
INTRINSIC |
|
low complexity region
|
2024 |
2038 |
N/A |
INTRINSIC |
|
low complexity region
|
2041 |
2061 |
N/A |
INTRINSIC |
|
low complexity region
|
2129 |
2159 |
N/A |
INTRINSIC |
|
low complexity region
|
2186 |
2219 |
N/A |
INTRINSIC |
|
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
|
low complexity region
|
2389 |
2400 |
N/A |
INTRINSIC |
|
low complexity region
|
2430 |
2453 |
N/A |
INTRINSIC |
|
low complexity region
|
2474 |
2509 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000169743
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.3%
- 20x: 92.8%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit partial postnatal lethality, decreased body size, and severe lung alveolarization defects. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(61) : Targeted, other(4) Gene trapped(57)
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700036A12Rik |
A |
G |
9: 60,677,043 (GRCm39) |
|
noncoding transcript |
Het |
| A430110L20Rik |
T |
A |
1: 181,055,423 (GRCm39) |
|
noncoding transcript |
Het |
| Abce1 |
T |
C |
8: 80,433,864 (GRCm39) |
K63R |
possibly damaging |
Het |
| Acp6 |
A |
G |
3: 97,081,104 (GRCm39) |
|
probably benign |
Het |
| Adamts13 |
T |
A |
2: 26,878,366 (GRCm39) |
L579Q |
probably damaging |
Het |
| Adamtsl3 |
T |
A |
7: 82,172,528 (GRCm39) |
M497K |
probably damaging |
Het |
| Adgrb2 |
T |
A |
4: 129,908,384 (GRCm39) |
M1042K |
possibly damaging |
Het |
| Akap12 |
A |
T |
10: 4,303,693 (GRCm39) |
S168C |
probably damaging |
Het |
| Akap3 |
A |
T |
6: 126,842,517 (GRCm39) |
M379L |
probably damaging |
Het |
| Aldh6a1 |
C |
T |
12: 84,486,437 (GRCm39) |
M135I |
probably null |
Het |
| Arhgef12 |
A |
G |
9: 42,900,294 (GRCm39) |
S860P |
probably damaging |
Het |
| Atp11b |
A |
C |
3: 35,843,707 (GRCm39) |
T185P |
probably damaging |
Het |
| Bcas1 |
T |
C |
2: 170,229,871 (GRCm39) |
D243G |
probably damaging |
Het |
| Cdhr2 |
T |
A |
13: 54,865,685 (GRCm39) |
S228T |
probably damaging |
Het |
| Cimap1d |
A |
T |
10: 79,481,392 (GRCm39) |
|
probably benign |
Het |
| Cmya5 |
T |
A |
13: 93,201,835 (GRCm39) |
I3376L |
probably benign |
Het |
| Ctrc |
C |
A |
4: 141,573,535 (GRCm39) |
|
probably null |
Het |
| Dchs1 |
G |
T |
7: 105,404,451 (GRCm39) |
P2697Q |
probably damaging |
Het |
| Dmbt1 |
A |
G |
7: 130,646,217 (GRCm39) |
|
probably benign |
Het |
| Drd2 |
G |
A |
9: 49,313,512 (GRCm39) |
R227H |
probably damaging |
Het |
| Dscc1 |
C |
A |
15: 54,950,160 (GRCm39) |
C195F |
probably damaging |
Het |
| Dzip1 |
T |
A |
14: 119,160,125 (GRCm39) |
M28L |
probably benign |
Het |
| Edar |
A |
T |
10: 58,443,188 (GRCm39) |
S313T |
probably benign |
Het |
| Eef1e1 |
C |
A |
13: 38,840,099 (GRCm39) |
A69S |
probably damaging |
Het |
| Fbn1 |
A |
G |
2: 125,143,849 (GRCm39) |
V2760A |
probably benign |
Het |
| Fez1 |
GACAAACA |
GACA |
9: 36,781,845 (GRCm39) |
|
probably null |
Het |
| Fgl1 |
C |
G |
8: 41,663,496 (GRCm39) |
A11P |
possibly damaging |
Het |
| Fras1 |
T |
C |
5: 96,748,592 (GRCm39) |
V689A |
probably benign |
Het |
| Fry |
T |
A |
5: 150,304,324 (GRCm39) |
D571E |
probably damaging |
Het |
| Gm11232 |
T |
A |
4: 71,675,450 (GRCm39) |
R104* |
probably null |
Het |
| Gm1527 |
A |
G |
3: 28,972,199 (GRCm39) |
I439V |
possibly damaging |
Het |
| Gm4922 |
C |
A |
10: 18,659,640 (GRCm39) |
G361* |
probably null |
Het |
| Gm7052 |
T |
A |
17: 22,259,447 (GRCm39) |
|
probably benign |
Het |
| Gpatch8 |
A |
T |
11: 102,372,055 (GRCm39) |
S494R |
unknown |
Het |
| Gria2 |
A |
T |
3: 80,639,352 (GRCm39) |
V220E |
possibly damaging |
Het |
| Grik4 |
G |
A |
9: 42,432,418 (GRCm39) |
H860Y |
probably benign |
Het |
| Gtpbp1 |
A |
C |
15: 79,591,930 (GRCm39) |
S93R |
probably damaging |
Het |
| Gucy2g |
C |
A |
19: 55,203,468 (GRCm39) |
|
probably benign |
Het |
| H2ac8 |
C |
A |
13: 23,755,221 (GRCm39) |
|
probably benign |
Het |
| Hmcn1 |
G |
A |
1: 150,485,451 (GRCm39) |
R4384C |
probably damaging |
Het |
| Hspa12b |
G |
C |
2: 130,987,112 (GRCm39) |
A678P |
probably damaging |
Het |
| Igsf21 |
T |
A |
4: 139,755,435 (GRCm39) |
N407Y |
probably damaging |
Het |
| Insig2 |
A |
G |
1: 121,234,885 (GRCm39) |
Y174H |
probably benign |
Het |
| Itpr3 |
T |
A |
17: 27,337,346 (GRCm39) |
M2413K |
probably benign |
Het |
| Kalrn |
A |
T |
16: 33,994,857 (GRCm39) |
I1322N |
probably damaging |
Het |
| Klk1b24 |
T |
A |
7: 43,840,890 (GRCm39) |
M106K |
possibly damaging |
Het |
| Krt81 |
G |
T |
15: 101,358,198 (GRCm39) |
Q352K |
probably benign |
Het |
| Lca5l |
A |
T |
16: 95,961,059 (GRCm39) |
S468T |
possibly damaging |
Het |
| Lvrn |
T |
C |
18: 47,015,452 (GRCm39) |
|
probably benign |
Het |
| Mcpt1 |
T |
A |
14: 56,256,621 (GRCm39) |
|
probably benign |
Het |
| Med13l |
T |
C |
5: 118,876,524 (GRCm39) |
M900T |
probably benign |
Het |
| Med16 |
A |
G |
10: 79,743,312 (GRCm39) |
|
probably benign |
Het |
| Megf6 |
G |
T |
4: 154,261,578 (GRCm39) |
V68L |
probably benign |
Het |
| Mep1a |
T |
C |
17: 43,802,563 (GRCm39) |
H154R |
probably damaging |
Het |
| Mrc2 |
A |
T |
11: 105,228,598 (GRCm39) |
D659V |
probably benign |
Het |
| Mroh8 |
T |
A |
2: 157,063,224 (GRCm39) |
E799V |
probably damaging |
Het |
| Mrpl21 |
A |
G |
19: 3,334,808 (GRCm39) |
Y50C |
possibly damaging |
Het |
| Msl1 |
A |
G |
11: 98,694,808 (GRCm39) |
|
probably benign |
Het |
| Myo1a |
C |
A |
10: 127,555,806 (GRCm39) |
Q932K |
probably benign |
Het |
| Nav3 |
A |
C |
10: 109,555,905 (GRCm39) |
S1675R |
probably damaging |
Het |
| Neurl2 |
A |
G |
2: 164,674,666 (GRCm39) |
V232A |
possibly damaging |
Het |
| Nfatc1 |
T |
A |
18: 80,708,482 (GRCm39) |
|
probably benign |
Het |
| Or2w4 |
C |
T |
13: 21,795,992 (GRCm39) |
C49Y |
probably benign |
Het |
| Or5k8 |
T |
A |
16: 58,645,039 (GRCm39) |
E11V |
probably null |
Het |
| P4hb |
A |
G |
11: 120,453,381 (GRCm39) |
|
probably benign |
Het |
| Papss1 |
T |
G |
3: 131,311,615 (GRCm39) |
I281S |
probably damaging |
Het |
| Pde10a |
A |
T |
17: 9,183,540 (GRCm39) |
D832V |
probably damaging |
Het |
| Pfkfb2 |
A |
T |
1: 130,635,927 (GRCm39) |
Y35N |
possibly damaging |
Het |
| Phaf1 |
T |
C |
8: 105,973,188 (GRCm39) |
|
probably null |
Het |
| Phf20l1 |
T |
A |
15: 66,476,662 (GRCm39) |
F253Y |
probably damaging |
Het |
| Pkhd1l1 |
G |
A |
15: 44,379,511 (GRCm39) |
V1046I |
probably benign |
Het |
| Plin3 |
C |
T |
17: 56,591,337 (GRCm39) |
A148T |
probably benign |
Het |
| Ppp1r8 |
T |
C |
4: 132,567,942 (GRCm39) |
|
probably benign |
Het |
| Ppp2r3d |
A |
G |
9: 101,088,511 (GRCm39) |
L604P |
probably damaging |
Het |
| Prdm5 |
T |
C |
6: 65,860,585 (GRCm39) |
V239A |
probably damaging |
Het |
| Prickle1 |
A |
G |
15: 93,398,519 (GRCm39) |
S770P |
probably damaging |
Het |
| Prl2c5 |
T |
A |
13: 13,365,310 (GRCm39) |
I155N |
probably benign |
Het |
| Prom1 |
T |
C |
5: 44,190,274 (GRCm39) |
|
probably benign |
Het |
| Psg25 |
C |
T |
7: 18,263,512 (GRCm39) |
G104R |
probably damaging |
Het |
| Rbm19 |
T |
C |
5: 120,282,094 (GRCm39) |
V817A |
probably benign |
Het |
| Ryr2 |
T |
A |
13: 11,741,908 (GRCm39) |
Y2091F |
probably damaging |
Het |
| Slc16a4 |
A |
G |
3: 107,208,248 (GRCm39) |
T253A |
probably benign |
Het |
| Smg7 |
A |
T |
1: 152,731,594 (GRCm39) |
|
probably null |
Het |
| Spink5 |
C |
A |
18: 44,140,786 (GRCm39) |
H662N |
probably benign |
Het |
| Taf2 |
A |
T |
15: 54,923,311 (GRCm39) |
M322K |
probably damaging |
Het |
| Tmc2 |
T |
C |
2: 130,090,682 (GRCm39) |
F676S |
probably damaging |
Het |
| Tmem177 |
A |
G |
1: 119,837,915 (GRCm39) |
S255P |
possibly damaging |
Het |
| Trim46 |
A |
T |
3: 89,142,375 (GRCm39) |
|
probably null |
Het |
| Tubb1 |
T |
A |
2: 174,292,596 (GRCm39) |
|
probably null |
Het |
| Upf1 |
T |
C |
8: 70,796,904 (GRCm39) |
T110A |
probably benign |
Het |
| Vmn2r9 |
T |
A |
5: 108,996,850 (GRCm39) |
I140L |
probably benign |
Het |
| Zfp638 |
T |
A |
6: 83,921,638 (GRCm39) |
H588Q |
probably damaging |
Het |
| Zfp780b |
T |
A |
7: 27,664,252 (GRCm39) |
N101I |
probably damaging |
Het |
| Zpld2 |
T |
C |
4: 133,924,144 (GRCm39) |
D467G |
probably benign |
Het |
|
| Other mutations in Cic |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00092:Cic
|
APN |
7 |
24,991,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01668:Cic
|
APN |
7 |
24,990,629 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL02229:Cic
|
APN |
7 |
24,990,375 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02506:Cic
|
APN |
7 |
24,990,282 (GRCm39) |
missense |
probably benign |
|
|
IGL02794:Cic
|
APN |
7 |
24,985,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03065:Cic
|
APN |
7 |
24,985,246 (GRCm39) |
splice site |
probably benign |
|
|
IGL03304:Cic
|
APN |
7 |
24,984,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Capuccino
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Cassock
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
|
Monkey
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4850_Cic_466
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
1mM(1):Cic
|
UTSW |
7 |
24,990,214 (GRCm39) |
splice site |
probably benign |
|
|
IGL03046:Cic
|
UTSW |
7 |
24,990,500 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0012:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0027:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0027:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0038:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0038:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0063:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0064:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0064:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0118:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0193:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0241:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0241:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0377:Cic
|
UTSW |
7 |
24,985,224 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0462:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0462:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0800:Cic
|
UTSW |
7 |
24,984,662 (GRCm39) |
missense |
probably benign |
|
|
R1253:Cic
|
UTSW |
7 |
24,990,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1519:Cic
|
UTSW |
7 |
24,993,235 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1586:Cic
|
UTSW |
7 |
24,985,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Cic
|
UTSW |
7 |
24,987,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Cic
|
UTSW |
7 |
24,986,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cic
|
UTSW |
7 |
24,970,961 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2063:Cic
|
UTSW |
7 |
24,972,876 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2161:Cic
|
UTSW |
7 |
24,987,559 (GRCm39) |
splice site |
probably null |
|
|
R2495:Cic
|
UTSW |
7 |
24,991,201 (GRCm39) |
splice site |
probably benign |
|
|
R2865:Cic
|
UTSW |
7 |
24,972,646 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R3692:Cic
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
|
R3709:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3710:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3872:Cic
|
UTSW |
7 |
24,971,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R3946:Cic
|
UTSW |
7 |
24,971,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4199:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4426:Cic
|
UTSW |
7 |
24,993,433 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4502:Cic
|
UTSW |
7 |
24,987,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4586:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4614:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4664:Cic
|
UTSW |
7 |
24,990,099 (GRCm39) |
small deletion |
probably benign |
|
|
R4688:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
|
R4695:Cic
|
UTSW |
7 |
24,973,013 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4696:Cic
|
UTSW |
7 |
24,987,908 (GRCm39) |
missense |
probably benign |
|
|
R4746:Cic
|
UTSW |
7 |
24,987,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4758:Cic
|
UTSW |
7 |
24,991,636 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R4767:Cic
|
UTSW |
7 |
24,971,025 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4776:Cic
|
UTSW |
7 |
24,982,308 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4820:Cic
|
UTSW |
7 |
24,971,157 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4850:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4851:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4922:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
|
R4989:Cic
|
UTSW |
7 |
24,986,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5131:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
|
R5718:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5801:Cic
|
UTSW |
7 |
24,970,863 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5949:Cic
|
UTSW |
7 |
24,971,730 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6000:Cic
|
UTSW |
7 |
24,971,423 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6246:Cic
|
UTSW |
7 |
24,971,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6283:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6364:Cic
|
UTSW |
7 |
24,972,248 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6481:Cic
|
UTSW |
7 |
24,987,706 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6919:Cic
|
UTSW |
7 |
24,971,202 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6920:Cic
|
UTSW |
7 |
24,990,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6995:Cic
|
UTSW |
7 |
24,970,736 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7002:Cic
|
UTSW |
7 |
24,971,621 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7113:Cic
|
UTSW |
7 |
24,972,869 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7560:Cic
|
UTSW |
7 |
24,972,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7680:Cic
|
UTSW |
7 |
24,991,856 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7698:Cic
|
UTSW |
7 |
24,972,597 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7746:Cic
|
UTSW |
7 |
24,988,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7841:Cic
|
UTSW |
7 |
24,985,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7879:Cic
|
UTSW |
7 |
24,984,551 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7916:Cic
|
UTSW |
7 |
24,987,715 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7920:Cic
|
UTSW |
7 |
24,971,384 (GRCm39) |
missense |
probably benign |
|
|
R8056:Cic
|
UTSW |
7 |
24,990,366 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8226:Cic
|
UTSW |
7 |
24,987,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8281:Cic
|
UTSW |
7 |
24,971,249 (GRCm39) |
missense |
probably benign |
|
|
R8847:Cic
|
UTSW |
7 |
24,970,631 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8991:Cic
|
UTSW |
7 |
24,988,885 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9083:Cic
|
UTSW |
7 |
24,985,470 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9140:Cic
|
UTSW |
7 |
24,985,165 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9200:Cic
|
UTSW |
7 |
24,971,940 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9208:Cic
|
UTSW |
7 |
24,987,502 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9301:Cic
|
UTSW |
7 |
24,991,117 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9408:Cic
|
UTSW |
7 |
24,971,414 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9569:Cic
|
UTSW |
7 |
24,972,120 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9752:Cic
|
UTSW |
7 |
24,971,403 (GRCm39) |
missense |
probably damaging |
0.96 |
|
V7732:Cic
|
UTSW |
7 |
24,991,670 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Cic
|
UTSW |
7 |
24,970,444 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGCGGCTAGTGGAAAATCTCGTG -3'
(R):5'- GCTTTAGCCCAAAACTAAGTAGCTCCC -3'
Sequencing Primer
(F):5'- TAGCTTGGCGCACACTGAC -3'
(R):5'- CTAAGTAGCTCCCAACAAAACAC -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation