Incidental Mutation 'R2370:Noxred1'
ID 247505
Institutional Source Beutler Lab
Gene Symbol Noxred1
Ensembl Gene ENSMUSG00000072919
Gene Name NADP+ dependent oxidoreductase domain containing 1
Synonyms 4933437F05Rik
MMRRC Submission 040350-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R2370 (G1)
Quality Score 225
Status Not validated
Chromosome 12
Chromosomal Location 87267897-87285375 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87273820 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 74 (T74A)
Ref Sequence ENSEMBL: ENSMUSP00000152360 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021423] [ENSMUST00000221768] [ENSMUST00000222480]
AlphaFold Q9D3S5
Predicted Effect probably benign
Transcript: ENSMUST00000021423
AA Change: T74A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000021423
Gene: ENSMUSG00000072919
AA Change: T74A

DomainStartEndE-ValueType
Pfam:F420_oxidored 80 173 1.1e-9 PFAM
low complexity region 261 269 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000221768
AA Change: T74A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000222480
AA Change: T74A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 92.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 C T 6: 128,557,349 (GRCm39) A115T probably benign Het
Abca13 A G 11: 9,206,185 (GRCm39) T162A possibly damaging Het
Adamts9 T A 6: 92,837,184 (GRCm39) D578V probably damaging Het
Atp6v1a T C 16: 43,927,403 (GRCm39) T295A probably benign Het
Brinp1 A G 4: 68,681,184 (GRCm39) S449P probably damaging Het
Ccdc40 A G 11: 119,153,943 (GRCm39) T1072A probably benign Het
Chil4 C A 3: 106,121,616 (GRCm39) E78* probably null Het
Cul7 A G 17: 46,972,567 (GRCm39) Y1250C probably damaging Het
Dock3 T C 9: 106,829,554 (GRCm39) D1120G probably damaging Het
Gfod1 A G 13: 43,354,621 (GRCm39) M118T probably benign Het
Ints5 A G 19: 8,874,143 (GRCm39) T701A probably benign Het
Map4k2 G T 19: 6,391,958 (GRCm39) E91* probably null Het
Mast4 T A 13: 102,910,695 (GRCm39) E457D probably damaging Het
Mettl4 T C 17: 95,040,576 (GRCm39) D404G probably damaging Het
Mgat4a A G 1: 37,503,614 (GRCm39) F58L probably damaging Het
Myh4 A G 11: 67,146,454 (GRCm39) K1476E probably damaging Het
Myl7 T C 11: 5,846,684 (GRCm39) E175G probably damaging Het
Myo18a A G 11: 77,668,596 (GRCm39) E152G probably benign Het
Ncan G A 8: 70,565,463 (GRCm39) T187I probably benign Het
Nfatc3 A G 8: 106,835,087 (GRCm39) Y803C probably damaging Het
Nlrp4f T C 13: 65,338,660 (GRCm39) Y659C probably damaging Het
Ntrk2 A T 13: 59,202,248 (GRCm39) M619L probably benign Het
Or5w18 A T 2: 87,633,159 (GRCm39) N142I probably benign Het
Orc4 A G 2: 48,823,111 (GRCm39) V120A probably benign Het
Polq T A 16: 36,894,301 (GRCm39) Y2037N probably damaging Het
Rimbp2 A G 5: 128,880,908 (GRCm39) C160R probably damaging Het
Rps6ka4 T C 19: 6,807,468 (GRCm39) S721G possibly damaging Het
Skap2 C T 6: 51,898,310 (GRCm39) R140Q probably damaging Het
Srprb C T 9: 103,074,755 (GRCm39) R838H probably damaging Het
Other mutations in Noxred1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01943:Noxred1 APN 12 87,269,955 (GRCm39) missense probably benign 0.05
IGL01950:Noxred1 APN 12 87,268,190 (GRCm39) missense probably damaging 1.00
IGL02381:Noxred1 APN 12 87,271,776 (GRCm39) missense probably damaging 0.98
IGL03109:Noxred1 APN 12 87,280,212 (GRCm39) missense probably damaging 1.00
PIT4402001:Noxred1 UTSW 12 87,273,855 (GRCm39) missense probably benign 0.00
PIT4504001:Noxred1 UTSW 12 87,271,653 (GRCm39) missense possibly damaging 0.89
R0242:Noxred1 UTSW 12 87,273,753 (GRCm39) missense probably benign 0.02
R0242:Noxred1 UTSW 12 87,273,753 (GRCm39) missense probably benign 0.02
R0514:Noxred1 UTSW 12 87,273,838 (GRCm39) missense probably benign 0.01
R0992:Noxred1 UTSW 12 87,271,000 (GRCm39) missense probably benign 0.15
R1626:Noxred1 UTSW 12 87,268,029 (GRCm39) makesense probably null
R3692:Noxred1 UTSW 12 87,280,240 (GRCm39) missense probably benign 0.26
R4084:Noxred1 UTSW 12 87,280,258 (GRCm39) missense possibly damaging 0.67
R5868:Noxred1 UTSW 12 87,270,976 (GRCm39) missense possibly damaging 0.54
R6856:Noxred1 UTSW 12 87,273,810 (GRCm39) missense probably benign 0.00
R6977:Noxred1 UTSW 12 87,268,091 (GRCm39) missense probably null 0.00
R7388:Noxred1 UTSW 12 87,273,799 (GRCm39) missense probably damaging 0.99
R7535:Noxred1 UTSW 12 87,280,206 (GRCm39) missense probably benign 0.00
R7737:Noxred1 UTSW 12 87,268,136 (GRCm39) nonsense probably null
R7877:Noxred1 UTSW 12 87,271,761 (GRCm39) missense probably benign 0.34
R7939:Noxred1 UTSW 12 87,268,105 (GRCm39) missense probably benign 0.00
R8772:Noxred1 UTSW 12 87,273,867 (GRCm39) missense probably benign 0.14
R8785:Noxred1 UTSW 12 87,270,940 (GRCm39) missense probably benign 0.00
R9470:Noxred1 UTSW 12 87,269,829 (GRCm39) missense possibly damaging 0.74
R9718:Noxred1 UTSW 12 87,271,692 (GRCm39) missense possibly damaging 0.91
Z1176:Noxred1 UTSW 12 87,269,831 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCCCACACCCACTGTCTAG -3'
(R):5'- CCCTGAAATACTGCTGCAGAAAACTAT -3'

Sequencing Primer
(F):5'- CACTGTCTAGCATTCCCTGG -3'
(R):5'- AGAGGTCCTGAGTTCAATTCCCAG -3'
Posted On 2014-11-11