Incidental Mutation 'R2385:Abra'
ID 247686
Institutional Source Beutler Lab
Gene Symbol Abra
Ensembl Gene ENSMUSG00000042895
Gene Name actin-binding Rho activating protein
Synonyms C130068O12Rik, STARS
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.311) question?
Stock # R2385 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 41728689-41733116 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41732749 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 106 (T106A)
Ref Sequence ENSEMBL: ENSMUSP00000051973 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054742]
AlphaFold Q8BUZ1
Predicted Effect probably damaging
Transcript: ENSMUST00000054742
AA Change: T106A

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000051973
Gene: ENSMUSG00000042895
AA Change: T106A

DomainStartEndE-ValueType
Costars 298 374 6.22e-45 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired arteriogenesis following occlusion. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra3 A T 5: 50,136,908 (GRCm39) I595N possibly damaging Het
Aox3 A G 1: 58,177,448 (GRCm39) E221G probably damaging Het
Arpc1a T A 5: 145,041,333 (GRCm39) probably null Het
Cd180 A G 13: 102,841,691 (GRCm39) T246A probably benign Het
Cep250 A G 2: 155,816,261 (GRCm39) E672G probably damaging Het
Cyp2d12 A T 15: 82,442,696 (GRCm39) I380F probably benign Het
Dock3 A T 9: 106,868,324 (GRCm39) D653E probably damaging Het
Fbxw22 A G 9: 109,211,210 (GRCm39) S364P probably damaging Het
Ift122 T C 6: 115,889,483 (GRCm39) Y823H probably benign Het
Kif20b T C 19: 34,936,819 (GRCm39) S1365P probably damaging Het
Nol11 C T 11: 107,080,032 (GRCm39) G18R probably benign Het
Or8k3 A T 2: 86,058,817 (GRCm39) L166* probably null Het
Pde8a T G 7: 80,932,740 (GRCm39) M134R probably benign Het
Pmepa1 G A 2: 173,069,926 (GRCm39) R210W probably damaging Het
Polr3gl A G 3: 96,485,862 (GRCm39) F135L probably damaging Het
Sdr16c6 T A 4: 4,062,671 (GRCm39) I216F probably damaging Het
Slc23a2 T C 2: 131,931,121 (GRCm39) D126G probably benign Het
Snx13 A T 12: 35,169,792 (GRCm39) Y579F probably benign Het
Vcan T C 13: 89,837,568 (GRCm39) T1699A probably damaging Het
Other mutations in Abra
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01512:Abra APN 15 41,729,413 (GRCm39) missense probably damaging 0.99
IGL02022:Abra APN 15 41,732,802 (GRCm39) missense probably benign
IGL02370:Abra APN 15 41,732,640 (GRCm39) missense probably damaging 1.00
IGL02406:Abra APN 15 41,732,583 (GRCm39) missense probably damaging 1.00
R1860:Abra UTSW 15 41,732,430 (GRCm39) missense probably damaging 1.00
R1861:Abra UTSW 15 41,732,430 (GRCm39) missense probably damaging 1.00
R3718:Abra UTSW 15 41,729,689 (GRCm39) missense probably benign
R4582:Abra UTSW 15 41,732,681 (GRCm39) missense probably benign 0.16
R4621:Abra UTSW 15 41,732,620 (GRCm39) missense probably benign 0.10
R4724:Abra UTSW 15 41,729,302 (GRCm39) missense probably damaging 1.00
R5926:Abra UTSW 15 41,729,650 (GRCm39) missense probably damaging 1.00
R6417:Abra UTSW 15 41,729,452 (GRCm39) missense probably benign 0.01
R6649:Abra UTSW 15 41,732,629 (GRCm39) missense probably benign
R7348:Abra UTSW 15 41,729,555 (GRCm39) missense probably damaging 1.00
R7487:Abra UTSW 15 41,732,949 (GRCm39) missense probably damaging 1.00
R7997:Abra UTSW 15 41,729,593 (GRCm39) missense probably damaging 1.00
R8785:Abra UTSW 15 41,729,656 (GRCm39) missense probably damaging 0.99
R9171:Abra UTSW 15 41,732,512 (GRCm39) missense possibly damaging 0.92
RF053:Abra UTSW 15 41,729,695 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- TTTGGTCAGCTCAGACACC -3'
(R):5'- TCAATTTGGCCCGAGGTTGG -3'

Sequencing Primer
(F):5'- TCAGCTCAGACACCAGGTTG -3'
(R):5'- AAACAGGCCCAGGAGCCTG -3'
Posted On 2014-11-11