Mutagenetix > Incidental Mutation

Incidental Mutation 'R2393:Fgfr2'

247864

Institutional Source

Beutler Lab

Gene Symbol

Fgfr2

Ensembl Gene

ENSMUSG00000030849

Gene Name

fibroblast growth factor receptor 2

Synonyms

KGFRTr, svs, Bek, Fgfr-2, Fgfr2b, Fgfr-7, Fgfr7

MMRRC Submission

040361-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R2393 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

129764181-129868538 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 129828968 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000130971 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000117073] [ENSMUST00000117089] [ENSMUST00000117357] [ENSMUST00000117691] [ENSMUST00000117754] [ENSMUST00000117858] [ENSMUST00000117872] [ENSMUST00000121064] [ENSMUST00000124096] [ENSMUST00000122054] [ENSMUST00000122448] [ENSMUST00000118296] [ENSMUST00000120187] [ENSMUST00000120141] [ENSMUST00000119260] [ENSMUST00000120715] [ENSMUST00000153166] [ENSMUST00000121080]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000117073

SMART Domains

Protein: ENSMUSP00000112672
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	55	123	4.66e-13	SMART
IGc2	154	234	7.41e-7	SMART
transmembrane domain	260	282	N/A	INTRINSIC
low complexity region	314	323	N/A	INTRINSIC
TyrKc	364	640	4.38e-152	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000117089

SMART Domains

Protein: ENSMUSP00000112992
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
IGc2	269	347	1.9e-4	SMART
transmembrane domain	376	398	N/A	INTRINSIC
low complexity region	430	439	N/A	INTRINSIC
TyrKc	480	756	4.38e-152	SMART
low complexity region	784	798	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117357

SMART Domains

Protein: ENSMUSP00000112580
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	55	123	4.66e-13	SMART
IGc2	154	232	1.9e-4	SMART
transmembrane domain	261	283	N/A	INTRINSIC
low complexity region	315	324	N/A	INTRINSIC
TyrKc	365	641	4.38e-152	SMART
low complexity region	669	683	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117691

SMART Domains

Protein: ENSMUSP00000113180
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
IGc2	269	347	1.9e-4	SMART
transmembrane domain	376	398	N/A	INTRINSIC
low complexity region	432	441	N/A	INTRINSIC
TyrKc	482	758	4.38e-152	SMART
low complexity region	786	800	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000117754

SMART Domains

Protein: ENSMUSP00000113187
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	56	136	7.41e-7	SMART
transmembrane domain	162	184	N/A	INTRINSIC
low complexity region	218	227	N/A	INTRINSIC
TyrKc	268	544	4.38e-152	SMART
low complexity region	572	586	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000117858

SMART Domains

Protein: ENSMUSP00000112623
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
IGc2	269	347	1.9e-4	SMART
transmembrane domain	376	398	N/A	INTRINSIC
low complexity region	432	441	N/A	INTRINSIC
TyrKc	482	758	4.38e-152	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000117872

SMART Domains

Protein: ENSMUSP00000113994
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
IGc2	74	142	4.66e-13	SMART
IGc2	173	253	7.41e-7	SMART
transmembrane domain	279	301	N/A	INTRINSIC
low complexity region	333	342	N/A	INTRINSIC
TyrKc	383	659	4.38e-152	SMART
low complexity region	687	701	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000127091

SMART Domains

Protein: ENSMUSP00000122856
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
Pfam:I-set	3	56	1.8e-7	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000121064

SMART Domains

Protein: ENSMUSP00000113452
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	56	134	1.9e-4	SMART
transmembrane domain	163	185	N/A	INTRINSIC
low complexity region	219	228	N/A	INTRINSIC
TyrKc	269	545	4.38e-152	SMART
low complexity region	573	587	N/A	INTRINSIC

Predicted Effect

probably null
Transcript: ENSMUST00000124096

SMART Domains

Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
Pfam:Pkinase	1	118	4.8e-19	PFAM
Pfam:Pkinase_Tyr	1	118	1.7e-50	PFAM
low complexity region	146	160	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000122054

SMART Domains

Protein: ENSMUSP00000112430
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
low complexity region	50	59	N/A	INTRINSIC
IGc2	72	133	6.59e-13	SMART
low complexity region	148	165	N/A	INTRINSIC
IGc2	189	257	4.66e-13	SMART
IGc2	288	368	7.41e-7	SMART
transmembrane domain	394	416	N/A	INTRINSIC
low complexity region	450	459	N/A	INTRINSIC
TyrKc	500	776	4.38e-152	SMART
low complexity region	804	818	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000122448

SMART Domains

Protein: ENSMUSP00000113993
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	55	123	4.66e-13	SMART
IGc2	154	232	1.9e-4	SMART
transmembrane domain	261	283	N/A	INTRINSIC
low complexity region	315	324	N/A	INTRINSIC
TyrKc	365	641	4.38e-152	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000118296

SMART Domains

Protein: ENSMUSP00000112471
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	36	57	N/A	INTRINSIC
IGc2	81	149	4.66e-13	SMART
IGc2	180	258	1.9e-4	SMART
transmembrane domain	287	309	N/A	INTRINSIC
low complexity region	343	352	N/A	INTRINSIC
TyrKc	393	669	4.38e-152	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000120187

SMART Domains

Protein: ENSMUSP00000113248
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
IGc2	74	142	4.66e-13	SMART
IGc2	173	251	1.9e-4	SMART
transmembrane domain	280	302	N/A	INTRINSIC
low complexity region	336	345	N/A	INTRINSIC
TyrKc	386	662	4.38e-152	SMART
low complexity region	690	704	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000120141

SMART Domains

Protein: ENSMUSP00000113415
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	36	57	N/A	INTRINSIC
IGc2	81	149	4.66e-13	SMART
IGc2	180	258	1.9e-4	SMART
transmembrane domain	287	309	N/A	INTRINSIC
low complexity region	341	350	N/A	INTRINSIC
TyrKc	391	667	4.38e-152	SMART
low complexity region	695	709	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000119260

SMART Domains

Protein: ENSMUSP00000113010
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
IGc2	269	349	7.41e-7	SMART
transmembrane domain	375	397	N/A	INTRINSIC
low complexity region	429	438	N/A	INTRINSIC
TyrKc	479	755	4.38e-152	SMART
low complexity region	783	797	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000120715

SMART Domains

Protein: ENSMUSP00000113474
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
low complexity region	31	40	N/A	INTRINSIC
IGc2	53	114	6.59e-13	SMART
low complexity region	129	146	N/A	INTRINSIC
IGc2	170	238	4.66e-13	SMART
transmembrane domain	263	285	N/A	INTRINSIC
low complexity region	319	328	N/A	INTRINSIC
TyrKc	369	645	4.38e-152	SMART
low complexity region	673	687	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000153166

SMART Domains

Protein: ENSMUSP00000120100
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
transmembrane domain	21	40	N/A	INTRINSIC
low complexity region	50	59	N/A	INTRINSIC
IGc2	72	133	6.59e-13	SMART
low complexity region	148	165	N/A	INTRINSIC
IGc2	189	257	4.66e-13	SMART
SCOP:d1ev2e1	269	311	1e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000121080

SMART Domains

Protein: ENSMUSP00000112585
Gene: ENSMUSG00000030849

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
IGc2	55	123	4.66e-13	SMART
IGc2	154	232	1.9e-4	SMART
transmembrane domain	261	283	N/A	INTRINSIC
low complexity region	317	326	N/A	INTRINSIC
TyrKc	367	643	4.38e-152	SMART

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.7%

Validation Efficiency

100% (54/54)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
PHENOTYPE: Mice homozygous for null mutations die as embryos. Isoform IIIb deficient mutants die at birth with defects in multiple organs and tissues. Isoform IIIc deficient mutants have defects in osteoblast and chondrocyte lineages, producing dwarfism. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	T	A	11: 9,225,057 (GRCm39)	L512*	probably null	Het
Adam4	A	T	12: 81,467,485 (GRCm39)	F379I	probably benign	Het
Ano6	C	G	15: 95,863,906 (GRCm39)		probably benign	Het
Apc2	A	G	10: 80,148,903 (GRCm39)	E1319G	possibly damaging	Het
Arfgef3	A	G	10: 18,473,535 (GRCm39)	V1588A	possibly damaging	Het
Arl8a	T	A	1: 135,080,604 (GRCm39)	V93E	probably damaging	Het
Arsi	G	A	18: 61,049,723 (GRCm39)	G202E	probably benign	Het
Cd200r2	T	A	16: 44,729,630 (GRCm39)	I95N	probably damaging	Het
Cd209d	A	G	8: 3,928,436 (GRCm39)		probably null	Het
Cep290	A	G	10: 100,397,100 (GRCm39)		probably null	Het
Chd2	G	T	7: 73,157,631 (GRCm39)	D171E	possibly damaging	Het
Chrna7	G	A	7: 62,748,994 (GRCm39)	A496V	probably damaging	Het
Col9a2	C	G	4: 120,911,455 (GRCm39)	R599G	probably damaging	Het
Colgalt1	C	G	8: 72,076,385 (GRCm39)	T612S	probably benign	Het
Copg2	T	C	6: 30,787,893 (GRCm39)	K602E	probably benign	Het
Crtc1	T	A	8: 70,840,808 (GRCm39)	T473S	probably benign	Het
Ctbp2	A	T	7: 132,625,290 (GRCm39)		probably null	Het
Edem1	T	G	6: 108,829,504 (GRCm39)	M541R	probably damaging	Het
Ehmt1	A	C	2: 24,696,229 (GRCm39)	V953G	probably damaging	Het
Fabp3	C	T	4: 130,206,180 (GRCm39)	T57I	probably benign	Het
Focad	A	G	4: 88,039,567 (GRCm39)	D10G	probably damaging	Het
Gfus	G	T	15: 75,798,200 (GRCm39)	L191I	probably damaging	Het
Gm5901	G	T	7: 105,026,996 (GRCm39)	V255F	possibly damaging	Het
Hsp90aa1	T	C	12: 110,659,840 (GRCm39)	N416S	probably damaging	Het
Hspb1	T	C	5: 135,917,950 (GRCm39)	F142L	probably benign	Het
Il17re	C	T	6: 113,439,314 (GRCm39)	H75Y	possibly damaging	Het
Kctd3	A	G	1: 188,713,568 (GRCm39)	I389T	probably damaging	Het
Lhx6	T	C	2: 35,981,402 (GRCm39)	D63G	probably benign	Het
Mepe	A	G	5: 104,485,327 (GRCm39)	T156A	possibly damaging	Het
Met	A	G	6: 17,534,197 (GRCm39)	Y680C	probably damaging	Het
Mrgpra3	T	C	7: 47,239,365 (GRCm39)	Y187C	possibly damaging	Het
Mst1	T	G	9: 107,960,151 (GRCm39)		probably null	Het
Myh13	T	A	11: 67,231,184 (GRCm39)	S394T	possibly damaging	Het
Nbeal1	T	A	1: 60,290,529 (GRCm39)	V1042E	probably damaging	Het
Ndrg4	T	A	8: 96,432,839 (GRCm39)	Y15*	probably null	Het
Neurl4	G	A	11: 69,797,900 (GRCm39)	R720H	probably damaging	Het
Nfkbia	A	G	12: 55,537,455 (GRCm39)		probably benign	Het
Nwd1	T	A	8: 73,389,055 (GRCm39)	M202K	probably benign	Het
Or10d4	G	T	9: 39,580,569 (GRCm39)	C72F	possibly damaging	Het
Or2av9	T	A	11: 58,381,546 (GRCm39)	I12F	probably benign	Het
Pate2	T	C	9: 35,581,036 (GRCm39)		probably benign	Het
Pibf1	A	G	14: 99,480,368 (GRCm39)	T715A	probably benign	Het
Pitpnm1	T	C	19: 4,160,935 (GRCm39)	L858P	probably benign	Het
Pla2g3	A	C	11: 3,443,115 (GRCm39)	S483R	probably benign	Het
Rad51ap2	T	A	12: 11,507,798 (GRCm39)	D573E	probably damaging	Het
Rho	T	C	6: 115,912,352 (GRCm39)		probably benign	Het
Rpl39l	A	T	16: 9,992,328 (GRCm39)	*52L	probably null	Het
Slco1a5	T	A	6: 142,194,501 (GRCm39)	R381W	possibly damaging	Het
Spns3	T	A	11: 72,441,059 (GRCm39)		probably benign	Het
Srgap2	A	G	1: 131,259,872 (GRCm39)	S493P	probably benign	Het
Tecpr2	T	C	12: 110,892,836 (GRCm39)	S293P	probably damaging	Het
Ttn	C	T	2: 76,583,211 (GRCm39)	V20815M	probably benign	Het
Ushbp1	T	C	8: 71,847,132 (GRCm39)	I167V	probably benign	Het
Wdr81	C	T	11: 75,340,231 (GRCm39)	A1296T	probably damaging	Het
Zmym2	A	G	14: 57,158,180 (GRCm39)	Y573C	probably benign	Het

Other mutations in Fgfr2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00514:Fgfr2	APN	7	129,769,441 (GRCm39)	missense	probably benign	0.45
IGL00594:Fgfr2	APN	7	129,830,453 (GRCm39)	missense	probably damaging	1.00
IGL00963:Fgfr2	APN	7	129,830,491 (GRCm39)	missense	probably damaging	0.99
IGL01968:Fgfr2	APN	7	129,786,978 (GRCm39)	missense	probably damaging	1.00
IGL02003:Fgfr2	APN	7	129,820,802 (GRCm39)	missense	probably damaging	1.00
IGL02063:Fgfr2	APN	7	129,769,485 (GRCm39)	missense	probably damaging	1.00
IGL02239:Fgfr2	APN	7	129,779,416 (GRCm39)	missense	probably damaging	1.00
IGL02349:Fgfr2	APN	7	129,844,336 (GRCm39)	missense	probably damaging	1.00
IGL02630:Fgfr2	APN	7	129,830,525 (GRCm39)	splice site	probably null
IGL02639:Fgfr2	APN	7	129,830,532 (GRCm39)	splice site	probably benign
IGL03058:Fgfr2	APN	7	129,784,422 (GRCm39)	missense	probably damaging	1.00
IGL03263:Fgfr2	APN	7	129,782,149 (GRCm39)	missense	probably benign	0.12
IGL03377:Fgfr2	APN	7	129,800,247 (GRCm39)	missense	probably damaging	0.98
R0048:Fgfr2	UTSW	7	129,782,218 (GRCm39)	splice site	probably benign
R0048:Fgfr2	UTSW	7	129,782,218 (GRCm39)	splice site	probably benign
R0078:Fgfr2	UTSW	7	129,802,805 (GRCm39)	missense	possibly damaging	0.95
R0085:Fgfr2	UTSW	7	129,797,993 (GRCm39)	missense	probably damaging	0.99
R0278:Fgfr2	UTSW	7	129,863,592 (GRCm39)	splice site	probably null
R0335:Fgfr2	UTSW	7	129,797,979 (GRCm39)	missense	probably benign	0.00
R0557:Fgfr2	UTSW	7	129,820,811 (GRCm39)	missense	probably damaging	1.00
R0631:Fgfr2	UTSW	7	129,828,969 (GRCm39)	intron	probably benign
R0637:Fgfr2	UTSW	7	129,773,354 (GRCm39)	missense	possibly damaging	0.89
R0841:Fgfr2	UTSW	7	130,373,737 (GRCm39)	unclassified	probably benign
R0841:Fgfr2	UTSW	7	129,863,635 (GRCm39)	missense	probably benign	0.03
R1646:Fgfr2	UTSW	7	129,844,374 (GRCm39)	missense	probably damaging	1.00
R1670:Fgfr2	UTSW	7	129,782,187 (GRCm39)	missense	probably damaging	1.00
R1678:Fgfr2	UTSW	7	129,830,350 (GRCm39)	splice site	probably null
R1950:Fgfr2	UTSW	7	129,800,211 (GRCm39)	missense	probably damaging	0.96
R3706:Fgfr2	UTSW	7	129,800,161 (GRCm39)	missense	probably benign	0.31
R3717:Fgfr2	UTSW	7	129,784,487 (GRCm39)	missense	probably damaging	1.00
R3808:Fgfr2	UTSW	7	129,801,578 (GRCm39)	missense	probably benign	0.01
R3945:Fgfr2	UTSW	7	129,779,485 (GRCm39)	missense	possibly damaging	0.71
R4438:Fgfr2	UTSW	7	129,774,660 (GRCm39)	nonsense	probably null
R4718:Fgfr2	UTSW	7	129,863,518 (GRCm39)	missense	probably damaging	1.00
R4779:Fgfr2	UTSW	7	129,786,923 (GRCm39)	intron	probably benign
R4925:Fgfr2	UTSW	7	129,787,002 (GRCm39)	missense	probably damaging	1.00
R4932:Fgfr2	UTSW	7	129,843,007 (GRCm39)	missense	probably damaging	1.00
R4941:Fgfr2	UTSW	7	129,800,175 (GRCm39)	missense	probably benign	0.21
R4980:Fgfr2	UTSW	7	129,802,810 (GRCm39)	missense	probably damaging	1.00
R5304:Fgfr2	UTSW	7	129,769,504 (GRCm39)	missense	probably damaging	1.00
R5313:Fgfr2	UTSW	7	129,842,970 (GRCm39)	missense	probably benign	0.01
R5375:Fgfr2	UTSW	7	129,842,945 (GRCm39)	missense	possibly damaging	0.65
R5652:Fgfr2	UTSW	7	129,863,593 (GRCm39)	missense	probably damaging	1.00
R6120:Fgfr2	UTSW	7	129,830,420 (GRCm39)	missense	probably benign	0.24
R6347:Fgfr2	UTSW	7	129,863,487 (GRCm39)	missense	probably damaging	1.00
R6375:Fgfr2	UTSW	7	129,769,475 (GRCm39)	missense	probably damaging	1.00
R6475:Fgfr2	UTSW	7	129,802,850 (GRCm39)	missense	probably benign	0.03
R6481:Fgfr2	UTSW	7	129,787,008 (GRCm39)	missense	possibly damaging	0.85
R6494:Fgfr2	UTSW	7	129,800,280 (GRCm39)	missense	probably damaging	1.00
R6542:Fgfr2	UTSW	7	129,802,853 (GRCm39)	missense	probably benign	0.02
R7246:Fgfr2	UTSW	7	129,844,136 (GRCm39)
R7937:Fgfr2	UTSW	7	129,820,823 (GRCm39)	missense	probably damaging	1.00
R7976:Fgfr2	UTSW	7	129,787,074 (GRCm39)	missense	probably damaging	0.99
R8007:Fgfr2	UTSW	7	129,765,719 (GRCm39)	nonsense	probably null
R8189:Fgfr2	UTSW	7	129,774,629 (GRCm39)	missense	probably damaging	1.00
R8430:Fgfr2	UTSW	7	129,765,708 (GRCm39)	missense	probably damaging	1.00
R8486:Fgfr2	UTSW	7	129,765,745 (GRCm39)	missense	possibly damaging	0.93
R8489:Fgfr2	UTSW	7	129,769,534 (GRCm39)	missense	probably benign	0.01
R8776:Fgfr2	UTSW	7	129,798,002 (GRCm39)	missense	possibly damaging	0.64
R8776-TAIL:Fgfr2	UTSW	7	129,798,002 (GRCm39)	missense	possibly damaging	0.64
R9338:Fgfr2	UTSW	7	129,863,561 (GRCm39)	nonsense	probably null
R9340:Fgfr2	UTSW	7	129,782,136 (GRCm39)	missense	probably damaging	1.00
R9497:Fgfr2	UTSW	7	129,765,763 (GRCm39)	missense	probably damaging	1.00
RF016:Fgfr2	UTSW	7	129,779,410 (GRCm39)	missense	probably benign	0.03
X0024:Fgfr2	UTSW	7	129,787,059 (GRCm39)	missense	probably damaging	0.99
Z1088:Fgfr2	UTSW	7	129,771,529 (GRCm39)	missense	probably damaging	1.00
Z1177:Fgfr2	UTSW	7	129,800,187 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

Posted On

2014-11-11