Incidental Mutation 'R2409:Cyp3a16'
ID 248119
Institutional Source Beutler Lab
Gene Symbol Cyp3a16
Ensembl Gene ENSMUSG00000038656
Gene Name cytochrome P450, family 3, subfamily a, polypeptide 16
Synonyms
MMRRC Submission 040375-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R2409 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 145373119-145406533 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 145377177 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Arginine at position 470 (K470R)
Ref Sequence ENSEMBL: ENSMUSP00000031633 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031633]
AlphaFold Q64481
Predicted Effect probably benign
Transcript: ENSMUST00000031633
AA Change: K470R

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000031633
Gene: ENSMUSG00000038656
AA Change: K470R

DomainStartEndE-ValueType
low complexity region 3 22 N/A INTRINSIC
Pfam:p450 38 494 5.5e-132 PFAM
Meta Mutation Damage Score 0.0864 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency 100% (32/32)
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a C T 5: 8,788,747 (GRCm39) T1042I probably benign Het
Adamts13 A G 2: 26,868,374 (GRCm39) T162A probably benign Het
Adamts7 T A 9: 90,062,740 (GRCm39) I398N probably damaging Het
Cib2 A G 9: 54,452,751 (GRCm39) probably null Het
Dpy19l2 A G 9: 24,569,924 (GRCm39) M343T probably benign Het
Dyrk2 A G 10: 118,696,532 (GRCm39) V242A probably benign Het
Extl3 T C 14: 65,315,017 (GRCm39) D55G probably benign Het
Fabp7 A G 10: 57,661,772 (GRCm39) K82E possibly damaging Het
Fat1 G T 8: 45,493,567 (GRCm39) probably benign Het
Gen1 A G 12: 11,299,165 (GRCm39) I280T possibly damaging Het
Gm5117 T C 8: 32,227,306 (GRCm39) noncoding transcript Het
Gucy1b2 CCGTGTTT C 14: 62,643,628 (GRCm39) probably null Het
Il3ra G A 14: 14,349,377 (GRCm38) probably null Het
Myo1f A G 17: 33,795,641 (GRCm39) N66D probably damaging Het
Nfkb1 C T 3: 135,319,704 (GRCm39) E264K possibly damaging Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Or7d10 G T 9: 19,832,072 (GRCm39) R189L probably benign Het
Or7d10 G C 9: 19,832,077 (GRCm39) D191H probably damaging Het
Prdm10 A G 9: 31,260,418 (GRCm39) H624R possibly damaging Het
Rgs5 G T 1: 169,504,451 (GRCm39) V34F possibly damaging Het
Sec14l4 T C 11: 3,990,048 (GRCm39) S116P probably benign Het
Septin1 T C 7: 126,815,143 (GRCm39) probably null Het
Septin9 T A 11: 117,251,287 (GRCm39) I535N probably damaging Het
Sh2b1 C T 7: 126,070,651 (GRCm39) G350D probably damaging Het
Slc6a21 T C 7: 44,929,750 (GRCm39) V107A probably benign Het
Trim26 C A 17: 37,161,895 (GRCm39) H105N probably damaging Het
Trim71 A T 9: 114,342,781 (GRCm39) D500E possibly damaging Het
Vmn2r78 T A 7: 86,569,953 (GRCm39) probably benign Het
Vmn2r84 A G 10: 130,227,940 (GRCm39) S99P probably damaging Het
Other mutations in Cyp3a16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01386:Cyp3a16 APN 5 145,377,244 (GRCm39) missense probably damaging 0.98
IGL01964:Cyp3a16 APN 5 145,392,372 (GRCm39) missense probably benign 0.41
IGL02007:Cyp3a16 APN 5 145,378,758 (GRCm39) splice site probably benign
IGL02139:Cyp3a16 APN 5 145,392,290 (GRCm39) missense probably benign 0.10
IGL02177:Cyp3a16 APN 5 145,386,964 (GRCm39) missense probably benign 0.43
IGL02407:Cyp3a16 APN 5 145,388,652 (GRCm39) missense probably damaging 0.99
IGL02473:Cyp3a16 APN 5 145,377,304 (GRCm39) missense possibly damaging 0.54
polywog UTSW 5 145,404,280 (GRCm39) nonsense probably null
R0363:Cyp3a16 UTSW 5 145,392,689 (GRCm39) splice site probably benign
R0556:Cyp3a16 UTSW 5 145,392,790 (GRCm39) missense probably benign 0.37
R0557:Cyp3a16 UTSW 5 145,406,398 (GRCm39) missense unknown
R0636:Cyp3a16 UTSW 5 145,399,895 (GRCm39) missense probably benign 0.03
R0749:Cyp3a16 UTSW 5 145,392,987 (GRCm39) critical splice acceptor site probably null
R0788:Cyp3a16 UTSW 5 145,401,886 (GRCm39) missense probably benign 0.00
R1552:Cyp3a16 UTSW 5 145,373,346 (GRCm39) missense probably benign 0.01
R1575:Cyp3a16 UTSW 5 145,373,267 (GRCm39) missense probably benign 0.01
R1580:Cyp3a16 UTSW 5 145,378,885 (GRCm39) missense probably damaging 1.00
R1580:Cyp3a16 UTSW 5 145,378,884 (GRCm39) missense possibly damaging 0.94
R1642:Cyp3a16 UTSW 5 145,406,399 (GRCm39) missense unknown
R1763:Cyp3a16 UTSW 5 145,401,841 (GRCm39) critical splice donor site probably null
R2029:Cyp3a16 UTSW 5 145,388,667 (GRCm39) missense probably damaging 0.96
R2144:Cyp3a16 UTSW 5 145,392,894 (GRCm39) missense probably damaging 1.00
R2473:Cyp3a16 UTSW 5 145,392,404 (GRCm39) missense possibly damaging 0.79
R2860:Cyp3a16 UTSW 5 145,392,309 (GRCm39) nonsense probably null
R2861:Cyp3a16 UTSW 5 145,392,309 (GRCm39) nonsense probably null
R3747:Cyp3a16 UTSW 5 145,378,881 (GRCm39) missense probably damaging 1.00
R4654:Cyp3a16 UTSW 5 145,373,267 (GRCm39) missense probably benign 0.01
R4781:Cyp3a16 UTSW 5 145,392,922 (GRCm39) missense possibly damaging 0.85
R4873:Cyp3a16 UTSW 5 145,389,659 (GRCm39) missense probably benign 0.01
R4875:Cyp3a16 UTSW 5 145,389,659 (GRCm39) missense probably benign 0.01
R4925:Cyp3a16 UTSW 5 145,389,644 (GRCm39) missense probably benign 0.00
R5365:Cyp3a16 UTSW 5 145,389,597 (GRCm39) missense probably damaging 1.00
R5496:Cyp3a16 UTSW 5 145,404,341 (GRCm39) missense probably damaging 1.00
R5640:Cyp3a16 UTSW 5 145,389,633 (GRCm39) missense possibly damaging 0.94
R5761:Cyp3a16 UTSW 5 145,378,843 (GRCm39) missense possibly damaging 0.79
R6401:Cyp3a16 UTSW 5 145,377,174 (GRCm39) missense probably damaging 1.00
R6526:Cyp3a16 UTSW 5 145,392,705 (GRCm39) missense probably benign 0.01
R6528:Cyp3a16 UTSW 5 145,377,241 (GRCm39) missense probably damaging 1.00
R7000:Cyp3a16 UTSW 5 145,399,980 (GRCm39) critical splice acceptor site probably null
R7268:Cyp3a16 UTSW 5 145,404,280 (GRCm39) nonsense probably null
R7630:Cyp3a16 UTSW 5 145,373,120 (GRCm39) splice site probably null
R7938:Cyp3a16 UTSW 5 145,389,666 (GRCm39) missense probably benign 0.00
R8827:Cyp3a16 UTSW 5 145,387,008 (GRCm39) missense probably benign 0.38
R9040:Cyp3a16 UTSW 5 145,392,922 (GRCm39) missense possibly damaging 0.85
R9137:Cyp3a16 UTSW 5 145,406,413 (GRCm39) missense unknown
R9139:Cyp3a16 UTSW 5 145,406,434 (GRCm39) missense unknown
R9140:Cyp3a16 UTSW 5 145,406,434 (GRCm39) missense unknown
R9284:Cyp3a16 UTSW 5 145,377,304 (GRCm39) missense probably damaging 1.00
R9657:Cyp3a16 UTSW 5 145,386,979 (GRCm39) missense probably null 1.00
R9680:Cyp3a16 UTSW 5 145,389,690 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTCTACTCTGACTCTTCATAATGC -3'
(R):5'- TTCACATGTGCAGCTCTTATGC -3'

Sequencing Primer
(F):5'- TCTGACTCTTCATAATGCTAAGTTTC -3'
(R):5'- ACATGTGCAGCTCTTATGCTTTTATC -3'
Posted On 2014-11-11