Incidental Mutation 'R2409:Or7d10'
ID 248127
Institutional Source Beutler Lab
Gene Symbol Or7d10
Ensembl Gene ENSMUSG00000051118
Gene Name olfactory receptor family 7 subfamily D member 10
Synonyms 18A, Olfr77, GA_x6K02T2PVTD-13660026-13660964, MOR143-1
MMRRC Submission 040375-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R2409 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 19828525-19833806 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 19832072 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Leucine at position 189 (R189L)
Ref Sequence ENSEMBL: ENSMUSP00000149055 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057596] [ENSMUST00000217347]
AlphaFold Q8VEY9
Predicted Effect probably benign
Transcript: ENSMUST00000057596
AA Change: R189L

PolyPhen 2 Score 0.315 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000058810
Gene: ENSMUSG00000051118
AA Change: R189L

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3e-53 PFAM
Pfam:7tm_1 41 290 1.2e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000217347
AA Change: R189L

PolyPhen 2 Score 0.315 (Sensitivity: 0.90; Specificity: 0.89)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency 100% (32/32)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a C T 5: 8,788,747 (GRCm39) T1042I probably benign Het
Adamts13 A G 2: 26,868,374 (GRCm39) T162A probably benign Het
Adamts7 T A 9: 90,062,740 (GRCm39) I398N probably damaging Het
Cib2 A G 9: 54,452,751 (GRCm39) probably null Het
Cyp3a16 T C 5: 145,377,177 (GRCm39) K470R probably benign Het
Dpy19l2 A G 9: 24,569,924 (GRCm39) M343T probably benign Het
Dyrk2 A G 10: 118,696,532 (GRCm39) V242A probably benign Het
Extl3 T C 14: 65,315,017 (GRCm39) D55G probably benign Het
Fabp7 A G 10: 57,661,772 (GRCm39) K82E possibly damaging Het
Fat1 G T 8: 45,493,567 (GRCm39) probably benign Het
Gen1 A G 12: 11,299,165 (GRCm39) I280T possibly damaging Het
Gm5117 T C 8: 32,227,306 (GRCm39) noncoding transcript Het
Gucy1b2 CCGTGTTT C 14: 62,643,628 (GRCm39) probably null Het
Il3ra G A 14: 14,349,377 (GRCm38) probably null Het
Myo1f A G 17: 33,795,641 (GRCm39) N66D probably damaging Het
Nfkb1 C T 3: 135,319,704 (GRCm39) E264K possibly damaging Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Prdm10 A G 9: 31,260,418 (GRCm39) H624R possibly damaging Het
Rgs5 G T 1: 169,504,451 (GRCm39) V34F possibly damaging Het
Sec14l4 T C 11: 3,990,048 (GRCm39) S116P probably benign Het
Septin1 T C 7: 126,815,143 (GRCm39) probably null Het
Septin9 T A 11: 117,251,287 (GRCm39) I535N probably damaging Het
Sh2b1 C T 7: 126,070,651 (GRCm39) G350D probably damaging Het
Slc6a21 T C 7: 44,929,750 (GRCm39) V107A probably benign Het
Trim26 C A 17: 37,161,895 (GRCm39) H105N probably damaging Het
Trim71 A T 9: 114,342,781 (GRCm39) D500E possibly damaging Het
Vmn2r78 T A 7: 86,569,953 (GRCm39) probably benign Het
Vmn2r84 A G 10: 130,227,940 (GRCm39) S99P probably damaging Het
Other mutations in Or7d10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Or7d10 APN 9 19,832,245 (GRCm39) missense possibly damaging 0.87
IGL01318:Or7d10 APN 9 19,832,054 (GRCm39) missense probably benign 0.44
IGL01547:Or7d10 APN 9 19,832,197 (GRCm39) missense probably benign 0.00
IGL01635:Or7d10 APN 9 19,831,780 (GRCm39) missense probably damaging 1.00
IGL02112:Or7d10 APN 9 19,831,821 (GRCm39) missense possibly damaging 0.48
IGL02858:Or7d10 APN 9 19,831,747 (GRCm39) missense probably damaging 0.99
IGL02904:Or7d10 APN 9 19,832,393 (GRCm39) missense probably damaging 1.00
IGL02956:Or7d10 APN 9 19,832,348 (GRCm39) missense possibly damaging 0.87
IGL03066:Or7d10 APN 9 19,831,667 (GRCm39) missense probably benign 0.12
R0662:Or7d10 UTSW 9 19,831,796 (GRCm39) missense probably damaging 1.00
R1222:Or7d10 UTSW 9 19,832,344 (GRCm39) missense possibly damaging 0.87
R1572:Or7d10 UTSW 9 19,832,208 (GRCm39) missense probably benign 0.35
R1761:Or7d10 UTSW 9 19,832,445 (GRCm39) makesense probably null
R2409:Or7d10 UTSW 9 19,832,077 (GRCm39) missense probably damaging 1.00
R3621:Or7d10 UTSW 9 19,832,209 (GRCm39) missense probably damaging 0.99
R3849:Or7d10 UTSW 9 19,832,105 (GRCm39) missense probably damaging 1.00
R3850:Or7d10 UTSW 9 19,832,105 (GRCm39) missense probably damaging 1.00
R4277:Or7d10 UTSW 9 19,831,685 (GRCm39) missense possibly damaging 0.91
R4768:Or7d10 UTSW 9 19,831,841 (GRCm39) missense possibly damaging 0.56
R4979:Or7d10 UTSW 9 19,831,655 (GRCm39) missense probably benign 0.03
R5276:Or7d10 UTSW 9 19,831,917 (GRCm39) missense possibly damaging 0.87
R5503:Or7d10 UTSW 9 19,831,675 (GRCm39) missense probably benign 0.36
R5760:Or7d10 UTSW 9 19,832,050 (GRCm39) missense probably benign 0.00
R5778:Or7d10 UTSW 9 19,832,337 (GRCm39) missense probably benign 0.20
R5930:Or7d10 UTSW 9 19,832,206 (GRCm39) missense probably damaging 0.99
R6012:Or7d10 UTSW 9 19,832,237 (GRCm39) missense probably damaging 0.99
R7269:Or7d10 UTSW 9 19,831,631 (GRCm39) missense possibly damaging 0.95
R7977:Or7d10 UTSW 9 19,831,610 (GRCm39) missense possibly damaging 0.48
R7987:Or7d10 UTSW 9 19,831,610 (GRCm39) missense possibly damaging 0.48
R8174:Or7d10 UTSW 9 19,832,020 (GRCm39) missense probably damaging 1.00
Z1088:Or7d10 UTSW 9 19,832,008 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACAGTCATCATGAACCCTCG -3'
(R):5'- TCTTGGATGAATGGGCTACAGC -3'

Sequencing Primer
(F):5'- ATGAACCCTCGAATCTGTGG -3'
(R):5'- TGAGATGAACTACAAATCCTGTCC -3'
Posted On 2014-11-11