Incidental Mutation 'R2409:Dyrk2'
ID 248136
Institutional Source Beutler Lab
Gene Symbol Dyrk2
Ensembl Gene ENSMUSG00000028630
Gene Name dual-specificity tyrosine phosphorylation regulated kinase 2
Synonyms 1810038L18Rik
MMRRC Submission 040375-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.572) question?
Stock # R2409 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 118691508-118706114 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118696532 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 242 (V242A)
Ref Sequence ENSEMBL: ENSMUSP00000004281 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004281]
AlphaFold Q5U4C9
Predicted Effect probably benign
Transcript: ENSMUST00000004281
AA Change: V242A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000004281
Gene: ENSMUSG00000028630
AA Change: V242A

DomainStartEndE-ValueType
S_TKc 220 533 1.16e-92 SMART
low complexity region 560 574 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191892
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218477
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218692
Meta Mutation Damage Score 0.0728 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 94.0%
Validation Efficiency 100% (32/32)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a C T 5: 8,788,747 (GRCm39) T1042I probably benign Het
Adamts13 A G 2: 26,868,374 (GRCm39) T162A probably benign Het
Adamts7 T A 9: 90,062,740 (GRCm39) I398N probably damaging Het
Cib2 A G 9: 54,452,751 (GRCm39) probably null Het
Cyp3a16 T C 5: 145,377,177 (GRCm39) K470R probably benign Het
Dpy19l2 A G 9: 24,569,924 (GRCm39) M343T probably benign Het
Extl3 T C 14: 65,315,017 (GRCm39) D55G probably benign Het
Fabp7 A G 10: 57,661,772 (GRCm39) K82E possibly damaging Het
Fat1 G T 8: 45,493,567 (GRCm39) probably benign Het
Gen1 A G 12: 11,299,165 (GRCm39) I280T possibly damaging Het
Gm5117 T C 8: 32,227,306 (GRCm39) noncoding transcript Het
Gucy1b2 CCGTGTTT C 14: 62,643,628 (GRCm39) probably null Het
Il3ra G A 14: 14,349,377 (GRCm38) probably null Het
Myo1f A G 17: 33,795,641 (GRCm39) N66D probably damaging Het
Nfkb1 C T 3: 135,319,704 (GRCm39) E264K possibly damaging Het
Nsf C T 11: 103,821,578 (GRCm39) E26K possibly damaging Het
Or7d10 G T 9: 19,832,072 (GRCm39) R189L probably benign Het
Or7d10 G C 9: 19,832,077 (GRCm39) D191H probably damaging Het
Prdm10 A G 9: 31,260,418 (GRCm39) H624R possibly damaging Het
Rgs5 G T 1: 169,504,451 (GRCm39) V34F possibly damaging Het
Sec14l4 T C 11: 3,990,048 (GRCm39) S116P probably benign Het
Septin1 T C 7: 126,815,143 (GRCm39) probably null Het
Septin9 T A 11: 117,251,287 (GRCm39) I535N probably damaging Het
Sh2b1 C T 7: 126,070,651 (GRCm39) G350D probably damaging Het
Slc6a21 T C 7: 44,929,750 (GRCm39) V107A probably benign Het
Trim26 C A 17: 37,161,895 (GRCm39) H105N probably damaging Het
Trim71 A T 9: 114,342,781 (GRCm39) D500E possibly damaging Het
Vmn2r78 T A 7: 86,569,953 (GRCm39) probably benign Het
Vmn2r84 A G 10: 130,227,940 (GRCm39) S99P probably damaging Het
Other mutations in Dyrk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00392:Dyrk2 APN 10 118,695,749 (GRCm39) missense probably damaging 1.00
IGL00536:Dyrk2 APN 10 118,696,097 (GRCm39) missense probably damaging 1.00
IGL01288:Dyrk2 APN 10 118,696,604 (GRCm39) missense probably damaging 1.00
IGL01375:Dyrk2 APN 10 118,696,592 (GRCm39) missense probably damaging 1.00
IGL01637:Dyrk2 APN 10 118,696,412 (GRCm39) missense probably damaging 1.00
IGL02052:Dyrk2 APN 10 118,696,448 (GRCm39) missense probably damaging 1.00
R0452:Dyrk2 UTSW 10 118,704,668 (GRCm39) missense possibly damaging 0.91
R0833:Dyrk2 UTSW 10 118,697,027 (GRCm39) missense probably benign 0.00
R0836:Dyrk2 UTSW 10 118,697,027 (GRCm39) missense probably benign 0.00
R1346:Dyrk2 UTSW 10 118,695,624 (GRCm39) missense possibly damaging 0.92
R1610:Dyrk2 UTSW 10 118,695,830 (GRCm39) missense probably benign 0.02
R2397:Dyrk2 UTSW 10 118,697,273 (GRCm39) intron probably benign
R2965:Dyrk2 UTSW 10 118,696,242 (GRCm39) nonsense probably null
R2966:Dyrk2 UTSW 10 118,696,242 (GRCm39) nonsense probably null
R4700:Dyrk2 UTSW 10 118,704,191 (GRCm39) missense probably benign
R4896:Dyrk2 UTSW 10 118,704,153 (GRCm39) missense probably damaging 0.96
R4978:Dyrk2 UTSW 10 118,696,252 (GRCm39) missense probably benign 0.00
R5393:Dyrk2 UTSW 10 118,695,753 (GRCm39) missense probably damaging 0.98
R5442:Dyrk2 UTSW 10 118,696,643 (GRCm39) missense possibly damaging 0.72
R5496:Dyrk2 UTSW 10 118,695,956 (GRCm39) missense probably damaging 1.00
R5810:Dyrk2 UTSW 10 118,696,245 (GRCm39) missense probably benign 0.16
R5875:Dyrk2 UTSW 10 118,696,602 (GRCm39) missense probably damaging 1.00
R5930:Dyrk2 UTSW 10 118,696,173 (GRCm39) missense probably damaging 1.00
R6877:Dyrk2 UTSW 10 118,696,328 (GRCm39) missense probably damaging 1.00
R7234:Dyrk2 UTSW 10 118,696,136 (GRCm39) missense possibly damaging 0.84
R7442:Dyrk2 UTSW 10 118,695,786 (GRCm39) missense probably damaging 1.00
R7741:Dyrk2 UTSW 10 118,695,594 (GRCm39) missense probably benign
R8108:Dyrk2 UTSW 10 118,695,734 (GRCm39) missense probably benign 0.27
R8137:Dyrk2 UTSW 10 118,695,789 (GRCm39) missense probably benign 0.00
R8347:Dyrk2 UTSW 10 118,695,888 (GRCm39) missense probably damaging 0.99
R8507:Dyrk2 UTSW 10 118,696,567 (GRCm39) missense probably damaging 1.00
R8517:Dyrk2 UTSW 10 118,696,926 (GRCm39) missense probably benign
R8695:Dyrk2 UTSW 10 118,696,922 (GRCm39) missense probably benign 0.00
R9018:Dyrk2 UTSW 10 118,696,014 (GRCm39) missense probably damaging 0.99
R9619:Dyrk2 UTSW 10 118,696,292 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGAACGTCATGCAGATGTGG -3'
(R):5'- CAGCCTTCGAACACCATGAG -3'

Sequencing Primer
(F):5'- GTTGCGGAAGGTGAAGTTCTCC -3'
(R):5'- CTTCTTGGGTCCAAATGCAAAG -3'
Posted On 2014-11-11