Incidental Mutation 'R2374:Vmn1r25'
| ID |
248229 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn1r25
|
| Ensembl Gene |
ENSMUSG00000115668 |
| Gene Name |
vomeronasal 1 receptor 25 |
| Synonyms |
V1rc8 |
| MMRRC Submission |
040353-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.107)
|
| Stock # |
R2374 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
57955379-57956287 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 57955543 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 249
(S249T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154074
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176572]
[ENSMUST00000228585]
|
| AlphaFold |
H3BLP0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176572
AA Change: S249T
PolyPhen 2
Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000135860
Gene: ENSMUSG00000115668
AA Change: S249T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:V1R
|
29 |
293 |
5.4e-52 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228585
AA Change: S249T
PolyPhen 2
Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 92.7%
|
| Validation Efficiency |
97% (33/34) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 31 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adnp2 |
C |
T |
18: 80,174,202 (GRCm39) |
R69Q |
probably damaging |
Het |
| Bltp1 |
A |
G |
3: 36,939,545 (GRCm39) |
D133G |
probably benign |
Het |
| Celsr3 |
G |
A |
9: 108,719,751 (GRCm39) |
R2450H |
probably benign |
Het |
| Clec4b1 |
T |
G |
6: 123,027,597 (GRCm39) |
L18R |
probably damaging |
Het |
| Cntrl |
G |
A |
2: 35,043,288 (GRCm39) |
V706I |
possibly damaging |
Het |
| Dhx30 |
A |
G |
9: 109,920,632 (GRCm39) |
L294P |
probably damaging |
Het |
| Dnaaf9 |
A |
G |
2: 130,662,494 (GRCm39) |
Y60H |
probably damaging |
Het |
| Dysf |
T |
C |
6: 84,074,711 (GRCm39) |
L504P |
probably damaging |
Het |
| Gm10754 |
A |
G |
10: 97,518,013 (GRCm39) |
|
probably benign |
Het |
| Grid1 |
G |
A |
14: 35,043,764 (GRCm39) |
|
probably benign |
Het |
| Hydin |
A |
G |
8: 111,291,780 (GRCm39) |
N3424S |
probably damaging |
Het |
| Itgb2 |
G |
A |
10: 77,395,515 (GRCm39) |
V539I |
probably benign |
Het |
| Itgb5 |
T |
A |
16: 33,740,168 (GRCm39) |
V426E |
probably damaging |
Het |
| Ly6e |
A |
G |
15: 74,830,470 (GRCm39) |
S107G |
probably damaging |
Het |
| Mc3r |
G |
A |
2: 172,091,074 (GRCm39) |
A99T |
possibly damaging |
Het |
| Myo15a |
T |
G |
11: 60,369,669 (GRCm39) |
S810A |
possibly damaging |
Het |
| Neb |
A |
G |
2: 52,153,669 (GRCm39) |
W2419R |
probably damaging |
Het |
| Nkpd1 |
A |
T |
7: 19,257,900 (GRCm39) |
T560S |
possibly damaging |
Het |
| Or2n1c |
T |
C |
17: 38,519,958 (GRCm39) |
M274T |
probably damaging |
Het |
| Or4b1b |
A |
T |
2: 90,112,795 (GRCm39) |
S41R |
possibly damaging |
Het |
| Rasa3 |
A |
G |
8: 13,627,411 (GRCm39) |
L697P |
probably damaging |
Het |
| Sptbn4 |
A |
G |
7: 27,059,517 (GRCm39) |
Y2443H |
probably damaging |
Het |
| Steap2 |
A |
G |
5: 5,725,845 (GRCm39) |
I393T |
probably damaging |
Het |
| Tbc1d12 |
T |
A |
19: 38,825,614 (GRCm39) |
L155Q |
possibly damaging |
Het |
| Tnni3k |
A |
T |
3: 154,492,422 (GRCm39) |
M816K |
probably benign |
Het |
| Ugt2a3 |
T |
C |
5: 87,475,050 (GRCm39) |
D398G |
probably damaging |
Het |
| Vmn2r17 |
C |
A |
5: 109,575,104 (GRCm39) |
P137Q |
probably benign |
Het |
| Zbtb26 |
A |
G |
2: 37,326,497 (GRCm39) |
S180P |
probably benign |
Het |
| Zfy1 |
A |
T |
Y: 726,391 (GRCm39) |
L458Q |
probably damaging |
Het |
| Zfy1 |
G |
C |
Y: 726,392 (GRCm39) |
L458V |
possibly damaging |
Het |
| Zmpste24 |
T |
C |
4: 120,931,734 (GRCm39) |
E297G |
probably benign |
Het |
|
| Other mutations in Vmn1r25 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01867:Vmn1r25
|
APN |
6 |
57,956,196 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0299:Vmn1r25
|
UTSW |
6 |
57,955,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0401:Vmn1r25
|
UTSW |
6 |
57,955,696 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0499:Vmn1r25
|
UTSW |
6 |
57,955,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1294:Vmn1r25
|
UTSW |
6 |
57,955,464 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1562:Vmn1r25
|
UTSW |
6 |
57,955,786 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1661:Vmn1r25
|
UTSW |
6 |
57,955,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1665:Vmn1r25
|
UTSW |
6 |
57,955,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1879:Vmn1r25
|
UTSW |
6 |
57,955,912 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2221:Vmn1r25
|
UTSW |
6 |
57,956,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2223:Vmn1r25
|
UTSW |
6 |
57,956,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4073:Vmn1r25
|
UTSW |
6 |
57,955,572 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4398:Vmn1r25
|
UTSW |
6 |
57,955,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4590:Vmn1r25
|
UTSW |
6 |
57,955,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4779:Vmn1r25
|
UTSW |
6 |
57,956,011 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5397:Vmn1r25
|
UTSW |
6 |
57,956,060 (GRCm39) |
nonsense |
probably null |
|
|
R6113:Vmn1r25
|
UTSW |
6 |
57,955,557 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6858:Vmn1r25
|
UTSW |
6 |
57,955,996 (GRCm39) |
missense |
probably benign |
0.22 |
|
R7407:Vmn1r25
|
UTSW |
6 |
57,956,044 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7748:Vmn1r25
|
UTSW |
6 |
57,955,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8001:Vmn1r25
|
UTSW |
6 |
57,956,065 (GRCm39) |
nonsense |
probably null |
|
|
R8472:Vmn1r25
|
UTSW |
6 |
57,955,531 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9235:Vmn1r25
|
UTSW |
6 |
57,955,488 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9651:Vmn1r25
|
UTSW |
6 |
57,956,306 (GRCm39) |
unclassified |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CACTTTGCCCCTTGACAATTAAAG -3'
(R):5'- GGAGTCATGCTGATCACAAATG -3'
Sequencing Primer
(F):5'- TTGAAACTCCAGTTCCAGGGGATC -3'
(R):5'- TGCTGATCACAAATGCATATATAGTG -3'
|
| Posted On |
2014-11-11 |
Incidental Mutation